Metabolismo

<p>Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.</p>

<p>Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.</p>

<p>MK 0434 is a steroid 5α-reductase inhibitor and hormone antagonist associated with a significant reduction in DHT.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse PP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.</p>

<p>10,12-Tricosadiynoic acid: orally active ACOX1 inhibitor, treats metabolic diseases by enhancing lipid/ROS metabolism in mitochondria.</p>

<p>Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.</p>

<p>Etofylline (Oxyphylline) is used for difficulty in breathing, asthma, breathing difficulty and other conditions.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PL in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>

<p>Denatonium benzoate, a salt with an inert anion, resembles lidocaine but has a benzyl group on its amino nitrogen.</p>

<p>Cyclandelate (BS 572), a direct-acting smooth muscle relaxant, is used to dilate blood vessels.</p>

<p>CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat PP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor.</p>

<p>Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain.</p>

<p>XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).</p>

<p>Pitavastatin lactone, a major human metabolite, potently inhibits HMG-CoA reductase with minimal hepatic microsome metabolism.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>

<p>Acarbose (BAY g 5421) is a hypoglycemic agent that is an inhibitor of orally active alpha-glucosidase (IC50=11 nM). High-Quality, Low-Cost!</p>

<p>Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES.</p>

<p>CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.</p>

<p>ML390 exerts its potent differentiation effect on multiple leukemia models.</p>

<p>Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.</p>

<p>Amylase (Diastase) is any one of a group of enzymes which catalyses the breakdown of starch into maltose.</p>

<p>KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.</p>

<p>Ranolazine 2HCl, an antianginal, treats arrhythmia by inhibiting sodium current without changing blood pressure or heart rate.</p>

<p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>

<p>P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.</p>

<p>Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate), an active metabolites of norgestimate, is a steroidal progestin used in contraceptive patches.</p>

<p>Garcinone B, a xanthone derivative naturally isolated from the pericarp of Mangosteen, serves as a potent inhibitor of ACE2 and Mpro, and is utilized in COVID-</p>

<p>Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.</p>

<p>(Ile8)-Oxytocin acetate is a neurohypophysial hormone analog of oxytocin produced in marsupials.</p>

<p>PDE1-IN-8 (Compound 3f) acts as an inhibitor of PDE1, with an IC50 of 11 nM. It hinders cAMP and cGMP signaling pathways, impeding the differentiation and proliferation of cells into myofibroblasts, and demonstrates antifibrotic effects in the Bleomycin-induced rat model of pulmonary fibrosis.</p>

<p>Endogenous metabolite: 1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine, a phosphatidylcholine example.</p>

<p>Imperatoxin A, a peptide toxin sourced from the African scorpion Pandinus imperator, functions as an activator of Ca2+-release channels/ryanodine receptors (</p>

<p>sEH Inhibitor-16, a potent soluble epoxide hydrolase (sEH) inhibitor, exhibits an IC50 of 2 nM.</p>

<p>L-Isoleucyl-L-arginine, a dipeptide composed of L-isoleucine and L-arginine, acts as a potent angiotensin-converting enzyme (ACE) inhibitor and is utilized in</p>

<p>ω-Conotoxin CVIF is a selective inhibitor of Ca v 2.2 channels, demonstrating an IC50 value of 34.3 nM in isolated rat DRG neurons.</p>

<p>PTPσ Inhibitor ISP is a compound that binds to recombinant human PTPs, thereby inhibiting PTPσ signaling.</p>

<p>SR-4995 (CID 16016685) is an ABHD5 ligand, directly binding to ABHD5 and stimulating lipolysis by releasing it from PLIN.</p>

<p>MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.</p>

<p>LYP-IN-3 (compound D34) is a selective Lymphoid-tyrosine phosphatase (LYP) inhibitor (Ki=0.93 μM) that modulates the T-cell receptor (TCR) signaling pathway</p>

<p>Potassium erythronate is an intrinsic carbohydrate metabolite utilized in researching metabolic diseases.</p>

<p>Compound 1, 6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone, is an anthraquinone α-glucosidase inhibitor with an IC50 of 185 μM, and it can be isolated</p>

<p>2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a type of polychlorinated dibenzofuran (PCDF). It induces the expression of aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-o-deethylase (EROD) genes in H-4-II-E rat hepatoma cells, with EC50 values of 0.687 and 0.575 nM, respectively.</p>

<p>Edoxaban Isomer is an impurity of Edoxaban, which is a novel inhibitor of factor Xa.</p>

<p>SHP2-IN-34 (compound A8) is a phenylurea SHP2 inhibitor with anti-cancer properties. It significantly suppresses tumor growth in CT26 mouse models.</p>

<p>SH7s is an effective carbonic anhydrase inhibitor, exhibiting Ki values of 15.9 nM for hCA IX and 55.2 nM for hCA XII. Additionally, SH7s acts as a hypoxia-mediated chemosensitizer in colorectal cancer cells.</p>

<p>BtGH84 Activator I is a BtGH84 activator. It is the small molecule activator of a glycoside hydrolase.</p>

<p>α-Glucosidase-IN-77 (Compound H7) is a non-competitive α-glucosidase inhibitor with an IC50 of 1.25 μM. It reduces blood glucose levels, improves glucose tolerance, regulates gut microbiota, and exhibits hepatoprotective effects in a mouse model of type 2 diabetes.</p>

<p>N-Desmethyl clotiazepam (Desmethylclotiazepam) is an active metabolite of Clotiazepam.</p>

<p>(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.</p>

<p>α-Glucosidase-IN-58 (Compound 6d) is an α-glucosidase inhibitor with an IC50 of 1.47 μM.</p>

<p>Girentuximab (G250) is an anti-carbonic anhydrase IX (CAIX) monoclonal antibody with anti-cancer activity for the study of uroepithelial carcinoma PET (ZiPUP).</p>

<p>16α-hydroxy Dehydroepiandrosterone (16α-OH-DHEA) is a neurosteroid found in the brain and a precursor in the biosynthesis of placental estriol.</p>

<p>Arachidonoyl-L-carnitine chloride is an endogenous metabolite and acylcarnitine widely used in biochemical experiments and studies of metabolic disorders.</p>

<p>α-glucosidase/PTP1B-IN-1 (compound 8a) is an effective inhibitor of both α-glucosidase and PTP1B, with IC50 values of 66.3 μM and 47.0 μM, respectively. It also exhibits strong inhibitory activity against α-amylase, having an IC50 of 30.62 μM. This compound is capable of binding to the active sites of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 holds potential for reducing postprandial blood glucose levels and may be useful in managing type 2 diabetes.</p>

<p>Resinacein L is an inhibitor of α-glucosidase with an IC50 of 0.635 mM. This compound can slow the digestion and absorption of carbohydrates, thereby reducing postprandial blood glucose levels.</p>

<p>O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of Carvedilol, a non-selective β-adrenergic receptor (β-AR) antagonist. This compound inhibits store overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation (IC50= 7.62 µM). Additionally, O-Desmethylcarvedilol slows the increase in heart rate and prevents diastolic pressure reduction induced by Isoproterenol in conscious rabbits (ED50s = 32 and 5 µg/kg).</p>

<p>LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-</p>

<p>Pepsin A is a protease and endopeptidase in the stomach, capable of breaking down proteins in food into small peptide fragments.</p>

<p>11-Hydroxy cannabinol (Compound 5b) is an active metabolite of cannabinol.</p>

<p>4''-C18 EGCG is an effective inhibitor of α-amylase and α-glucosidase, with IC50 values of 3.74 and 0.81 μM, respectively. This compound suppresses carbohydrate-hydrolyzing enzymes, reduces oxidative stress and inflammation, and exhibits anti-diabetic activity. Moreover, 4''-C18 EGCG downregulates pro-inflammatory cytokines and demonstrates cytotoxicity at 50 μM against primary human peripheral blood mononuclear cells (PBMC), as well as non-cancerous cell lines 3T3-L1 and HEK 293.</p>

<p>Photo-DL-lysine is a photo-reactive amino acid based on DL-lysine used to capture proteins that are post-translationally modified by lysine binding.</p>

<p>CAⅡ-IN-1 (compound 2i) is an inhibitor of the CA Ⅱ isozyme, exhibiting an IC50 of 0.44 µM. This compound is utilized in metabolic research.</p>

<p>APP-018 (D-4F) is an 18 D-amino acid peptide that mimics apolipoprotein A-I (apoA-I). It enhances the anti-inflammatory properties of high-density lipoprotein (HDL) and is applicable in cardiovascular disease research.</p>

<p>PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.</p>

<p>Z-2-Octenoic acid, the Z-isomer of 2-Octenoic acid, is also known as trans-2-Octenoic acid and serves as a metabolite in Mucor species.</p>

<p>MPO-IN-6 (compound ADC) is an electrophilic agent with excellent antioxidant and anti-inflammatory properties. It acts as an inhibitor of myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD), with IC50 values of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 may serve as a potential cardiovascular protective agent.</p>

<p>N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.</p>

<p>Dihydrocarminomycin is an anthracycline antibiotics.</p>

<p>a1,3GalT (GGTA1) synthesizes α-gal glycan by adding galactose from UDP to glycoproteins.</p>

<p>GLUT inhibitor-1: oral, targets GLUT1/3 (IC50: 242/179 nM), for cancer/autoimmune research.</p>

<p>Galactose 1-phosphate, an intermediate substance in both galactose metabolism and nucleotide sugar processes, plays a crucial role in the biochemical pathways</p>

<p>Tajixanthone is the fungus metabolite from Aspergillus variecolor [1] .</p>

<p>Phytin has a wide range of applications in life science related research.</p>

<p>DPTIP hydrochloride is a potent inhibitor of neutral sphingomyelinase (N-SMase 2) that can cross the blood-brain barrier. It acts as an exosome inhibitor with an IC50 value of 30 nM.</p>

<p>Conagenin is a small molecular immunomodulator isolated by Streptomyces roseosporus.</p>

<p>Nedosiran sodium, a GalNAc-dsRNA conjugate, is engineered to suppress the synthesis of the hepatic lactate dehydrogenase (LDH) enzyme.</p>

<p>Triethyl phosphate is a chemical compound. It can be called "phosphoric acid, triethyl ester".</p>

<p>PDE11A4-IN-1 (compound 23b) is a potent, selective inhibitor of PDE11A4, demonstrating an IC50 of 12 nM and exhibiting high selectivity against PDE1, PDE2,</p>

<p>Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver and has exhibited anticancer activity.</p>

<p>DiNAC is a disulphide dimer with immune-modulating effects and reduces atherosclerosis in WHHL rabbits; also modulates rodent sensitivity reactions.</p>

<p>Methylbenzethonium chloride hydrate exhibits broad-spectrum antimicrobial activity against bacteria, viruses, and fungi. Additionally, it is utilized as a preservative in cosmetics and pharmaceutical formulations to inhibit microbial growth.</p>

<p>M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor.</p>

<p>Neohydroxyaspergillic acid, a fungal product from A. sclerotiorum, combats various bacteria and fungi with MICs ranging from 125-700 μg/ml.</p>

<p>(R)-AS-1 is a selective positive allosteric modulator of excitatory amino acid transporter 2 (EAAT2), with an EC50 of 11 nM. At doses of 60 and 90 mg/kg, (R)-AS-1 enhances spontaneous locomotor activity in mice. It demonstrates anticonvulsant properties in mouse seizure models induced by maximal electroshock (MES), pentylenetetrazole (PTZ), or electric current stimulation (32 or 44 mA), with ED50 values of 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively. This compound is applicable in neurological disease research.</p>

<p>Compound Z10 (PKM2 activator 6) serves as both a PKM2 activator and a PDK1 inhibitor, exhibiting dissociation constants (K D ) of 121 μM and 19.6 μM,</p>

<p>Folitixorin calcium is an antineoplastic enhancing agent.</p>

<p>PFKFB3-IN-2 is a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) inhibitor.</p>

<p>2'-Rhamnoechinacoside is a naturally occurring compound sourced from Cistanche tubulosa.</p>

<p>h-NTPDase-IN-4, a pan-inhibitor, targets h-NTPDase1/2/3/8 with IC50s: 3.58, 10.21, 0.13, 13.57 μM.</p>

<p>8-iso PGA1: an isoprostane, non-COX prostanoid, minor PGE1 impurity, biological effects unstudied.</p>

<p>IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).</p>

<p>8-Isoprostaglandin F2α is a natural product for research related to life sciences. The catalog number is T37164 and the CAS number is 27415-26-5.</p>

<p>Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.</p>

<p>PDE4-IN-3, a new oral drug, potently blocks PDE4 enzyme with 4.2 nM IC50.</p>

<p>Compound 21, an orally active and selective RARα antagonist, exhibits a potent inhibition of the retinoic acid receptor α with an IC50 of 4.6 nM [1].</p>