Immunology and Inflammation

Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and

BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.

SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.

α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.

Adrenalone HCl: α1-adrenoceptor agonist, topical hemostatic, vasoconstrictor, prolongs local anesthesia.

2-ABT: nitrogen-rich heterocycle used in drug synthesis, inhibits P450, with anti-inflammatory, anticonvulsant, anticancer properties.

TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.

Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.

Tildrakizumab (SCH 900222) is a humanized antibody against IL-23, with a 136 pM Kd, used for psoriasis research.

Xanthone (Xanthenone) is currently used as ovicide for codling moth eggs and as a larvicide.

Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.

Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.

iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase activity of nNOS.

Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.

N-Demethylricinine (4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile) was reported as xanthine oxidase inhibitor.

Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!

TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.

BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.

APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.

CP-28888 (CP 28888-27) is an interferon inducer, a lipoamine with antitumor activity.

Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.

Sifalimumab (MEDI-545), a monoclonal antibody, inhibits IFNα to treat moderate-severe SLE.

Ibuprofen, an NSAID, reduces pain, inflammation, and fever by limiting prostaglandin production.

4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.

Diclofenac Amide is used as a intermediates of Diclofenac.

Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity.

GATA4-NKX2-5-IN-1 inhibits GATA4-NKX2-5 synergy (IC50=3μM), doesn't affect related kinases, and modulates cardiac gene expression.

Anifrolumab（MEDI-546） is a potent type I interferon (IFN) receptor antagonist, a human monoclonal antibody that targets IFN.Anifrolumab inhibits the activity of

Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.

Talacotuzumab, an IgG1 monoclonal antibody, blocks IL-3/CD123 and boosts ADCC, targeting AML with high CD123 affinity.

Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.

Aluminum Hydroxide: oral adjuvant, aids vaccine potency, enhances immune response.

Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.

LR-90, an AGE inhibitor, aids in diabetic research by limiting inflammation in human monocytes.

Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity.

Siltuximab（CNTO-328） is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19.

Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine.

Carboxyebselen (HOOC-Ebs) is an endothelial nitric oxide synthase (eNOS) inhibitor that is potent and selective.

DUPA(OtBu)-OH, a DUPA precursor, targets PSMA with high affinity (Ki=8nM) to deliver Docetaxel for prostate cancer therapy.

Tolfenamic Acid (GEA 6414) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.

HIF-PHD-IN-3 is a hiPSC-CM cardioprotective scaffold with potential inhibitory effects on HIF-PHD, regulates heme oxygenase-1, and can be used to study anaemia.

Flunixin meglumine (Banamine) is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.

DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.

Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor and .

Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.

4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.

CD38 inhibitor 1 is a potent CD38 inhibitor that is effective against human CD38 and mouse CD38.Cost-effective and quality-assured.

Tesidolumab, a fully human IgG1/λ anti-C5 monoclonal antibody, inhibits crovalimab and C5, preventing membrane attack complex formation.

AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-

SN50 acetate is a cell permeable inhibitor of NF-κB translocation.

IMD-0560 is a novel inhibitor of IκB kinase β.

Theralizumab (TGN1412) is a monoclonal antibody for treating leukemia and arthritis by stimulating T cells.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CD248. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CD248. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human CD248, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CD248 in the samples is then determined by comparing the OD of the samples to the standard curve.

IL-15-IN-1 is a selective and potent Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells (IC50: 0.8 μM).

Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.