Potassium Channel
Potassium channels are a diverse group of membrane proteins that facilitate the flow of potassium ions (K+) across the cell membrane. These channels play a crucial role in maintaining the resting membrane potential, regulating cell volume, and controlling the excitability of neurons and muscle cells. Potassium channels are involved in various physiological processes, including cardiac rhythm regulation, insulin secretion, and neurotransmitter release. Dysregulation of potassium channels is linked to conditions such as arrhythmias, epilepsy, and hypertension. At CymitQuimica, we offer a wide range of potassium channel modulators to support your research in electrophysiology, cardiovascular health, and neurobiology.
Found 276 products of "Potassium Channel"
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4-Aminopyridine
CAS:<p>4-Aminopyridine (Dalfampridine) is a nonselective potassium (K+) channel blocker that binds to the cytoplasmic side of the cell membrane.</p>Formula:C5H6N2Purity:91.61%Color and Shape:SolidMolecular weight:94.11Ropivacaine hydrochloride
CAS:<p>Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity</p>Formula:C17H26N2O·HClPurity:99.85% - 99.95%Color and Shape:SolidMolecular weight:310.861-EBIO
CAS:<p>1-EBIO (1-EBIO) is a calium channel agonist.</p>Formula:C9H10N2OPurity:98.75%Color and Shape:SolidMolecular weight:162.19Oxybutynin
CAS:<p>Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.</p>Formula:C22H31NO3Purity:97.81% - 99.57%Color and Shape:White To Off-White Crystalline PowderMolecular weight:357.49Quinine
CAS:<p>Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria.</p>Formula:C20H24N2O2Purity:99.93% - 99.97%Color and Shape:White Solid PowderMolecular weight:324.42Ketanserin
CAS:<p>Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.</p>Formula:C22H22FN3O3Purity:99.19% - 99.73%Color and Shape:SolidMolecular weight:395.43Halothane
CAS:<p>Halothane (Anestan) 可以减弱内皮依赖性舒张作用。</p>Formula:C2HBrClF3Purity:98.50% - >99.99%Color and Shape:Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustibleMolecular weight:197.38VU6036720
<p>VU6036720 is a potent and selective inhibitor of the isomeric Kir4.1/5.1.VU6036720 inhibits Kir4.1/5.1 activity by decreasing the channel open-circuit</p>Formula:C20H22ClFN4O2SPurity:98.1%Color and Shape:SoildMolecular weight:436.93Minoxidil
CAS:<p>Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.</p>Formula:C9H15N5OPurity:99.885% - >99.99%Color and Shape:Crystals From Methanol-Acetonitrile SolidMolecular weight:209.25Clofilium tosylate
CAS:<p>Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.</p>Formula:C28H44ClNO3SPurity:99.68%Color and Shape:SolidMolecular weight:510.17Mefloquine
CAS:<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Formula:C17H16F6N2OPurity:99.89%Color and Shape:SolidMolecular weight:378.31Rosuvastatin calcium
CAS:<p>Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic</p>Formula:(C22H27FN3O6S)CaPurity:98.21% - 99.68%Color and Shape:White To Off-White Crystalline SolidMolecular weight:1001.14Miconazole
CAS:<p>Miconazole (R18134) is an imidazole antifungal agent that is used topically and by intravenous infusion.</p>Formula:C18H14Cl4N2OPurity:98% - >99.99%Color and Shape:SolidMolecular weight:416.13Flindokalner
CAS:<p>Flindokalner (BMS-204352) modulates potassium channels, enhances Kv7 subtypes and BKca, inhibits Kv7.1 (Ki=3.7μM), GABAA; has anxiolytic effects in vivo.</p>Formula:C16H10ClF4NO2Purity:99.96%Color and Shape:SolidMolecular weight:359.7Topiramate
CAS:<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>Formula:C12H21NO8SPurity:99.79% - 99.92%Color and Shape:White To Off-White Crystalline PowderMolecular weight:339.36Nicorandil
CAS:<p>Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system.</p>Formula:C8H9N3O4Purity:98.14% - >99.99%Color and Shape:White Or Off-White PowderMolecular weight:211.17Dequalinium chloride
CAS:<p>Dequalinium chloride: topical bacteriostat, blocks apamin-sensitive K+ channels, used for wounds, oral infections, potential antifungal, risk of skin ulcers.</p>Formula:C30H40Cl2N4Purity:99.79% - 99.9%Color and Shape:SolidMolecular weight:527.59NS3623
CAS:<p>NS3623 is an activator of human ether-a-go-go-related gene potassium channels.</p>Formula:C15H10BrF3N6OPurity:97.06%Color and Shape:SolidMolecular weight:427.18Tannic acid
CAS:<p>Tannic acid (Gallotannic acid) is a novel hERG channel blocker.</p>Formula:C76H52O46Purity:AR - ARColor and Shape:Light Yellow To Light Brown Solid Solid Particulate/PowderMolecular weight:1701.2Glibenclamide
CAS:<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494.00VU591 hydrochloride
CAS:<p>VU591 hydrochloride is a selective Kir1.1 (ROMK) blocker with IC50 of 0.24 μM, not affecting Kir7.1, Kir2.1, Kir2.3, or Kir4.1, similar to VU 590.</p>Formula:C16H13ClN6O5Purity:98.93% - 99.22%Color and Shape:SolidMolecular weight:404.76Terfenadine
CAS:<p>Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.</p>Formula:C32H41NO2Purity:98.76% - 99.75%Color and Shape:SolidMolecular weight:471.67Butamben
CAS:<p>Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.</p>Formula:C11H15NO2Purity:99.43%Color and Shape:Crystals From Alc Physical Description Yellow Powder Insoluble In Water (Ntp 1992)Molecular weight:193.24Oxybutynin chloride
CAS:<p>Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties.</p>Formula:C22H32ClNO3Purity:99.27% - >99.99%Color and Shape:White PowderMolecular weight:393.96Diazoxide
CAS:<p>Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.</p>Formula:C8H7ClN2O2SPurity:99% - 99.83%Color and Shape:SolidMolecular weight:230.67ICA-27243
CAS:<p>ICA-27243: Potent KCNQ2/Q3 opener, oral, EC50 0.38 μM; less effective on KCNQ4, KCNQ3/Q5; antiepileptic.</p>Formula:C12H7ClF2N2OPurity:99.54%Color and Shape:SolidMolecular weight:268.65Hydrochlorothiazide
CAS:<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Formula:C7H8ClN3O4S2Purity:99.43% - 99.50%Color and Shape:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Molecular weight:297.74NS5806
CAS:<p>NS5806 activates K+ currents, slows KV4.2/4.3 decay with KChIP2, and boosts KV4.3/KChIP2 peaks (EC50=5.3μM).</p>Formula:C16H8Br2F6N6OPurity:97.95%Color and Shape:SolidMolecular weight:574.07Proflavine Hemisulfate
CAS:<p>Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt of proflavine, an acridine-derived fluorescent contrast and disinfectant agent.</p>Formula:C13H12N3O2S0Purity:99.55%Color and Shape:Orange To Red PowderMolecular weight:258.29Ropivacaine
CAS:<p>Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.</p>Formula:C17H26N2OPurity:97.75% - >99.99%Color and Shape:SolidMolecular weight:274.40Repaglinide
CAS:<p>Repaglinide, a benzoic acid derivative, stimulates insulin, treats type 2 diabetes, and may rarely cause acute liver injury.</p>Formula:C27H36N2O4Purity:99.73% - >99.99%Color and Shape:White To Off-White SolidMolecular weight:452.59N-Acetylprocainamide
CAS:<p>N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic</p>Formula:C15H23N3O2Purity:99.65% - 99.74%Color and Shape:SolidMolecular weight:277.36Cloperastine hydrochloride
CAS:<p>Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.</p>Formula:C20H25Cl2NOPurity:97.74% - 99.42%Color and Shape:SolidMolecular weight:366.33VU591
CAS:<p>VU591 is a selective extra-renal potassium channel inhibitor with an IC₅₀ of 0.24 μM.</p>Formula:C16H12N6O5Purity:99.29% - 99.53%Color and Shape:SolidMolecular weight:368.3BMS-394136
CAS:<p>BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation.</p>Formula:C24H21Cl2FN4OPurity:98.19% - 98.67%Color and Shape:SolidMolecular weight:471.35Quinidine hydrochloride monohydrate
CAS:<p>Quinidine hydrochloride monohydrate is an optical isomer of quinine. Quinidine prolongs cellular action potential and decreases automaticity.</p>Formula:C20H27ClN2O3Purity:94.4% - 99.68%Color and Shape:SolidMolecular weight:378.89AZD 7009
CAS:<p>AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM.</p>Formula:C23H34N4O5Purity:98.42% - 98.51%Color and Shape:SoildMolecular weight:446.54Propafenone
CAS:<p>Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.</p>Formula:C21H27NO3Purity:99.02%Color and Shape:SolidMolecular weight:341.44Ifenprodil Tartrate
CAS:<p>Ifenprodil is a selective NMDA receptor (glutamate) antagonist.</p>Formula:C21H27NO2C4H6O6Purity:99.02% - 99.55%Color and Shape:SolidMolecular weight:400.49DCPIB
CAS:<p>DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM</p>Formula:C22H28Cl2O4Purity:99.79% - 99.87%Color and Shape:SolidMolecular weight:427.36Astemizole
CAS:<p>Astemizole (Laridal) is a long-acting antihistamine for allergies like rhinitis and asthma, with fewer anticholinergic effects.</p>Formula:C28H31FN4OPurity:98.24% - 99.67%Color and Shape:White Crystals SolidMolecular weight:458.57Linoleoyl glycine
CAS:<p>Linoleoyl glycine activates hKCNQ1/hKCNE1 channels, has analgesic properties, and is found in skin, spinal cord, and brain.</p>Formula:C20H35NO3Purity:98.96%Color and Shape:SolidMolecular weight:337.5Minocycline hydrochloride
CAS:<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>Formula:C23H28ClN3O7Purity:99.28% - >99.99%Color and Shape:Bright Yellow-Orange Amorphous Solid Crystalline YellowMolecular weight:493.94Gliclazide
CAS:<p>Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the</p>Formula:C15H21N3O3SPurity:99.58%Color and Shape:SolidMolecular weight:323.41Linopirdine
CAS:<p>Linopirdine (DuP 996) is a TRPV1 agonist.</p>Formula:C26H21N3OPurity:99.45% - 99.78%Color and Shape:SolidMolecular weight:391.46Tipepidine hydrochloride
CAS:<p>Tipepidine hydrochloride: reversible DA D2 receptor inhibitor, IC50 7.0 μM, with antidepressant effects.</p>Formula:C15H18ClNS2Purity:99.97%Color and Shape:SolidMolecular weight:311.89Amiodarone hydrochloride
CAS:<p>Amiodarone HCl: Antianginal, class III antiarrhythmic. Lengthens heart muscle action, slows heart rate, reduces vascular resistance.</p>Formula:C25H29I2NO3·HClPurity:99.82% - ≥95%Color and Shape:White To Cream Crystalline PowderMolecular weight:681.78NS19504
CAS:<p>NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM.</p>Formula:C10H9BrN2SPurity:99.87%Color and Shape:SolidMolecular weight:269.16NS8593 hydrochloride
CAS:<p>NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .</p>Formula:C17H18ClN3Purity:99.77%Color and Shape:SolidMolecular weight:299.8Bupivacaine hydrochloride
CAS:<p>Bupivacaine hydrochloride (Vivacaine) is a long-lasting, amide local anesthetic that blocks sodium channels, inhibiting nerve impulses and sensation.</p>Formula:C18H28N2O·HClPurity:99.9% - >99.99%Color and Shape:SolidMolecular weight:324.89Glipizide
CAS:<p>Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.</p>Formula:C21H27N5O4SPurity:99.67% - 99.75%Color and Shape:SolidMolecular weight:445.54Phenformin hydrochloride
CAS:<p>Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.</p>Formula:C10H16ClN5Purity:97.11% - 99.80%Color and Shape:Lactic AcidosisMolecular weight:241.72Disopyramide
CAS:<p>Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.</p>Formula:C21H29N3OPurity:99.62%Color and Shape:SolidMolecular weight:339.47NS13001
CAS:<p>NS13001, an oral SK channel modulator, shows promise for SCA2 therapy; EC50: 1.8 µM (SK2), 0.14 µM (SK3).</p>Formula:C17H16ClN7Purity:99.55%Color and Shape:SolidMolecular weight:353.81Mefloquine hydrochloride
CAS:<p>Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.</p>Formula:C17H17ClF6N2OPurity:99% - 99.74%Color and Shape:Off-White To Yellow SolidMolecular weight:414.77Brompheniramine maleate
CAS:<p>Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.</p>Formula:C16H19BrN2·C4H4O4Purity:99.80%Color and Shape:Crystal PowderMolecular weight:435.31Dronedarone hydrochloride
CAS:<p>Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.</p>Formula:C31H44N2O5S·HClPurity:99.61%Color and Shape:SolidMolecular weight:593.22DCEBIO
CAS:<p>DCEBIO, a 1-EBIO derivative, enhances Cl- secretion via hIK1 K+ channel and apical conductance in T84 cells.</p>Formula:C9H8Cl2N2OPurity:99.89%Color and Shape:SolidMolecular weight:231.08Tolbutamide
CAS:<p>Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.</p>Formula:C12H18N2O3SPurity:99.80% - 99.93%Color and Shape:White Crystalline PowderMolecular weight:270.35Flufenamic acid
CAS:<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>Formula:C14H10F3NO2Purity:98.68%Color and Shape:White To Light Yellow Crystalline PowderMolecular weight:281.23VU0134992 hydrochloride
CAS:<p>VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 μM).</p>Formula:C20H32BrClN2O2Purity:>99.99%Color and Shape:SolidMolecular weight:447.84BMS-191095
CAS:<p>BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.</p>Formula:C22H21ClN4O2Purity:>99.99%Color and Shape:SolidMolecular weight:408.88IK1 inhibitor PA-6
CAS:<p>IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse</p>Formula:C31H32N4O2Purity:98.9%Color and Shape:SolidMolecular weight:492.61ML418
CAS:<p>ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.</p>Formula:C19H24ClN3O3Purity:99.3%Color and Shape:SolidMolecular weight:377.87Eleclazine hydrochloride
CAS:<p>Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).</p>Formula:C21H17ClF3N3O3Purity:99.86%Color and Shape:SolidMolecular weight:451.83Doxapram hydrochloride hydrate
CAS:<p>Doxapram hydrochloride hydrate (Doxapram HCl) inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 0.41, 37, 9 μM, respectively.</p>Formula:C24H33ClN2O3C24H30N2O2·ClH·H2OPurity:99.64% - >99.99%Color and Shape:SolidMolecular weight:432.99Hydroxyhexamide
CAS:<p>Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.</p>Formula:C15H22N2O4SPurity:98.91%Color and Shape:SolidMolecular weight:326.41ADWX 1 TFA
<p>ADWX 1 TFA is a novel peptide that potently targets and inhibits the Kv1.3 channel, with an IC50 of 1.89 pM. It specifically suppresses the activity of the Kv1.3 channel, in addition to inhibiting initial calcium signaling and NF-κB activation. This compound has been shown to ameliorate symptoms in rats with experimental autoimmune encephalomyelitis (EAE). ADWX 1 TFA is utilized in research focused on T-cell-mediated autoimmune diseases.</p>Formula:C169H281N57O46S7·xC2HF3O2Color and Shape:SolidMolecular weight:4071.85 (free base)Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Formula:C179H274N50O55S7Purity:98%Color and Shape:SolidMolecular weight:4230CHET3
CAS:<p>CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels. CHET3 has shown potent in vivo analgesic effects. Cost-effective and quality-assured.</p>Formula:C21H21N5O3SPurity:99.64% - >99.99%Color and Shape:SoildMolecular weight:423.49Cesium chloride
CAS:<p>Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.</p>Formula:ClCsPurity:98%Color and Shape:White Solid CrystallineMolecular weight:168.36Tertiapin LQ
<p>Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.</p>Formula:C106H179N33O24S4Purity:98%Color and Shape:SolidMolecular weight:2428.03Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Color and Shape:Odour SolidMyomodulin
CAS:<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Formula:C36H67N11O8S2Purity:98%Color and Shape:SolidMolecular weight:846.12Mesoridazine Besylate
CAS:<p>Mesoridazine Besylate (Serentil), a piperidine antipsychotic and phenothiazine, treats schizophrenia; it's a thioridazine metabolite.</p>Formula:C27H32N2O4S3Purity:99.58%Color and Shape:SolidMolecular weight:544.75Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Purity:96.97%Color and Shape:SolidPhe-Met-Arg-Phe amide trifluoroacetate
CAS:<p>Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.</p>Formula:C33H44F6N8O8SPurity:98%Color and Shape:SolidMolecular weight:826.81Dalazatide HCl
<p>Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,</p>Color and Shape:SolidMolecular weight:4317.53 (Free base)Pinacidil monohydrate
CAS:<p>Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.</p>Formula:C13H21N5OPurity:99.94% - 99.98%Color and Shape:PowderMolecular weight:263.34Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Formula:C17H19F2N3O2Color and Shape:SolidMolecular weight:335.349BeKm-1
CAS:<p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>Formula:C174H261N51O52S6Purity:98%Color and Shape:SolidMolecular weight:4091.65Dendrotoxin K
CAS:<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Formula:C294H462N84O75S6Color and Shape:SolidMolecular weight:6559.66MASP-2-IN-1
<p>MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.</p>Formula:C22H21N7O3SColor and Shape:SolidMolecular weight:463.512Guangxitoxin 1E
CAS:<p>Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.</p>Formula:C178H248N44O45S7Purity:98%Color and Shape:SolidMolecular weight:3948.61Phe-Met-Arg-Phe, amide
CAS:<p>Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.</p>Formula:C29H42N8O4SPurity:98%Color and Shape:SolidMolecular weight:598.76Lei-Dab7
CAS:<p>Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.</p>Formula:C141H236N46O39S6Purity:98%Color and Shape:SolidMolecular weight:3392.06GsAF-II
<p>GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodium</p>Formula:C176H261N47O45S7Purity:98%Color and Shape:SolidMolecular weight:3979.7Potassium Channel Targeted Library
<p>A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;</p>Color and Shape:Odour SolidHeteropodatoxin-1
<p>Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9</p>Formula:C168H238N46O51S6Purity:98%Color and Shape:SolidMolecular weight:3910.35Guanfu base A
CAS:<p>Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.</p>Formula:C24H31NO6Purity:99.71% - 99.85%Color and Shape:SolidMolecular weight:429.5AmmTX3
<p>KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.</p>Formula:C158H262N50O48S6Purity:98%Color and Shape:SolidMolecular weight:3822.47HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Formula:C337H503N103O97S6Molecular weight:7736.59176GsAF-I
<p>GsAF-I is a potent blocker of Na_v and hERG1 channels, exhibiting half-maximal inhibitory concentrations (IC50s) of 0.36 μM (Na_v 1.1), 0.6 μM (Na_v 1.2), 1.28</p>Formula:C160H244N46O42S7Purity:98%Color and Shape:SolidMolecular weight:3708.39Aekatperone
<p>Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).</p>Formula:C20H25N5O2SColor and Shape:SolidMolecular weight:399.51Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Formula:C19H23F2N3O2Color and Shape:SolidMolecular weight:363.4BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formula:C22H23F7N2O3Color and Shape:SolidMolecular weight:496.418RU-TRAAK-2
CAS:<p>RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.</p>Formula:C19H17N3OSPurity:99.81%Color and Shape:SolidMolecular weight:335.42Agitoxin-2
CAS:<p>Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).</p>Formula:C169H278N54O48S8Purity:98%Color and Shape:SolidMolecular weight:4090.87Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Formula:C79H131N31O24S4Purity:98%Color and Shape:SolidMolecular weight:2027.34ADWX 1
<p>Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.</p>Formula:C169H281N57O46S7Purity:98%Color and Shape:SolidMolecular weight:4071.86
