GPCR/G-Protein

Hydroxyzine-d8 DiHCl is a deuterated compound of Hydroxyzine DiHCl. Hydroxyzine DiHCl has a CAS number of 2192-20-3.

(S)-Pramipexole-(N-Propyl-2,2,3,3,3-d5) Dihydrochloride is a deuterated compound of (S)-Pramipexole Dihydrochloride. (S)-Pramipexole Dihydrochloride has a CAS number of 104632-25-9. Pramipexole dihydrochloride could be used to treat Parkinson disease.

Ropinirole, D2-like agonist, no D1 affinity, Ki 29 nM for D2, treats Parkinson's.

L-745870 is a D4 receptor antagonist that also inhibits D2 receptors, 5-HT2 receptors, and α-adrenergic receptors.

R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.

SR59230A hydrochloride (SR59230A HCl) is a beta3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis.

Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.

PACAP (1-38), human, ovine, rat (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a neuropeptide with 38 amino acid residues.

Arazasetron is an antiemetic which acts as a 5-HT3 receptor antagonist, pKi = 9.27.

Olopatadine is an antihistamine and anti-allergy medication for itchy eyes, also possibly treats red skin syndrome.

Ziprasidone, an antipsychotic agent, functions as a dual antagonist of 5-HT (serotonin) and dopamine receptors.

Metoxibutropate is a biochemical.

Escitalopram (Seroplex), a serotonin inhibitor for depression, curbs alcohol intake and is favored over tricyclics for tardive dyskinesia.

Methicillin: Narrow-spectrum beta-lactam, penicillin-type antibiotic for certain gram-positive bacterial infections.

17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan

DL-Phenylephrine HCl is a selective agonist of the alpha1-adrenergic receptor.

Mibavademab is a humanized anti-leptin receptor (LEPR) mAb under investigation for treating congenital leptin deficiency.

Risperidone Mesylate is a selective serotonin 5-HT2 receptor and dopamine D2 receptor blocker.

N-Methyl amisulpride (Amisulpride impurity H) is a 5-HT7 receptor, D2 receptor, and D3 receptor antagonist used in the study of acute schizophrenia.

GPR183-IN-1 (compound 15) is an effective orally active inhibitor of GPR183. It inhibits Ca2+ mobilization with an IC50 value of 39.97 nM. GPR183-IN-1 holds potential for research in cancer, autoimmune diseases, pain, and osteoporosis.

P2Y14R antagonist 1 (compound I-17) is a selective oral that inhibits inflammatory response in acute gouty arthritis the NLRP3/GSDMD y and cellular pyroptosis.

GLP-1 Receptormodulator 1 (Compound 7) is an effective positive allosteric modulator of the GLP-1 receptor. It is utilized in the research of obesity and type 2 diabetes.

Buflomedil is a vasoactive compound. Buflomedil has been used for peripheral arterial diseases.

Tulobuterol is mainly used for the prevention and treatment of bronchial asthma, asthmatic bronchitis and chronic bronchitis. Research shows that it could inhibit rhinovirus infection in primary cultures of human tracheal epithelial cells.

Methaphenilene hydrochloride is an H1 receptor antagonist with antihistaminic and anticholinergic activity, in allergic inflammation and autonomic research.

Triflupromazine is a dopamine receptor D1/D2 antagonist and LHDA inhibitor that suppresses dopamine activity in (CNS)mental disorders, sedation, and antiemesis.

15-keto Prostaglandin F2α is a metabolite of Prostaglandin F2α that lowers intraocular pressure in rabbits.

Cinnarizine D8 is a deuterium-labeled Cinnarizine which is an antihistamine and a calcium channel blocker.

Dapagliflozin D5 (BMS-512148 D5) is deuterated Dapagliflozin. Dapagliflozin is a competitive SGLT2 inhibitor.

Amitriptyline-d6 Hydrochloride is a deuterated compound of Amitriptyline Hydrochloride. Amitriptyline Hydrochloride has a CAS number of 549-18-8. Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.

Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor .

Brexpiprazole D8 is a deuterium-modified partial agonist of 5-HT1A and dopamine receptors, with Ki values of 0.12 nM and 0.3 nM respectively.

Mianserin-d3 is a deuterated compound of Mianserin. Mianserin has a CAS number of 24219-97-4. Mianserin, an H1 receptor reverse agonist, is a psychoactive compound in the tetracyclic antidepressant (TeCA) treatment family. Mianserin has antidepressant, antianxiety, antiemetic, hypotrophic, hypnotic and antihistamine effects, and can be used as a combination of norepinephrine and specific serotonin to treat depression.

Amidephrine is an adrenergic agent.

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist (IC50: 3.1 μM).

7-Desmethyl-3-hydroxyagomelatine, less active than parent drug Agomelatine, is a melatonergic agonist and 5-HT2C antagonist.

Norreticuline is a potential adrenoceptor-α/β agonist and CYP2D6 and D2 receptor inhibitor for the study of neurodegenerative diseases.

Proxyfan Oxalate is a potent antagonist of the histamine H3 receptor (histamine H3 receptor), with Ki values of 2.9 nM for rats and 2.7 nM for humans. Its inhibitory effect on H3 receptors is over 1000 times stronger than its effect on other histamine receptors.

Compound 17, a dopamine D4 receptor ligand, exhibits high potency and selectivity with IC 50 values of 0.057 nM for D4, and >1000, 220, and 270 nM for D2, 5-HT1A, and α1 receptors, respectively [1].

Ridazolol HCl (CAS 413) is a novel β-adrenoceptor (β-AR) blocker with α-adrenerolytic activity.

SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist and is > 200-fold selective over 55 other receptors, enzymes and ion channels.

6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4.

ICI-118551 Hydrochloride (ICI-118,551) is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3

Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neuron blockers exhibiting sympathomimetic effects similar to those of bromobenzamine and guanethidine in various animal models, particularly in cats. These compounds inhibit the release of norepinephrine during neural stimulation and enhance the responsiveness of smooth muscle to epinephrine and norepinephrine. Notably, bethanidine sulfate increases the pressor response to tyramine, although this effect diminishes with higher doses. Unlike guanethidine, bethanidine sulfate does not deplete pressor amines in the iris of cats following administration. Additionally, it temporarily suppresses autonomic cholinergic mechanisms and can cause transient neuromuscular paralysis at large doses, contrasting its long-term adrenergic neuron blocking effects.

MCI-225 dehydratase is an oral, selective inhibitor of noradrenaline reuptake, and functions as a 5-HT3 antagonist, exhibiting antidepressant effects in vivo .

5-Methyltryptamine hydrochloride is a high-affinity 5-HT1C receptor ligand and a partial agonist of 5-HT. 5-Methyltryptamine hydrochloride protects mice subjected to burn, tourniquet and endotoxin shock.

Roxatidine acetate: anti-ulcer, blocks histamine, reduces acid. Safer at lower doses.

Isoproterenol sulfate anhydrous is a useful alkaloid. It is used for biological research.

Dehydroabiethylamine (NSC-2955) boosts liver CYP2B, blocks PDKs & cholesterol transport, and has anti-tumor effects.

R-138727 is a novel P2Y12 receptor inhibitor.

Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.

Diclofensine (Ro 8-4650) inhibits the uptake of serotonin, noradrenaline and dopamine.

AR244555 is a bioactive chemical.

Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a 5-HT and dopamine receptor antagonist.

Atenolol Hydrochloride is a selective antagonist of ß1 receptor.

Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).

Caerulein, desulfated (FI-6934, desulfated) is a desulfated compound formed after caerulein hydrolysis, a neuropeptide with lower smooth muscle activity.

MK-447 is a nonsteroidal antiinflammatory agent.

Compound AMTHAMINE DIHYDROBROMIDE is a useful organic compound for research related to life sciences.

Penbutolol sulfate ((-)-Terbuclomine) is able to bind to both β2-adrenergic receptor and β1-adrenergic receptor, thus making it a non-selective β blocker.

Amidephrine hydrochloride is a biochemical.

S 25585 is a neuropeptide Y (NPY) Y5 receptor antagonist.

Ciproxifan (FUB-359) is a highly effective and specific histamin H3-receptor antagonist (IC50: 9.2 nM).

Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumour

Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties.

Litorin suppresses appetite and stimulates smooth muscle, gastrin, gastric acid, and pancreatic secretion.

PSB-KK1445 is a potent and selective agonist of GPR18, exhibiting EC50 values of 45.4 nM for humans and 124 nM for mice. The selectivity of PSB-KK1445 for GPR18 over the CB receptor subtypes GPR55 and GPR183 exceeds 200-fold.

MK-5046 is a novel BRS-3 agonist, binding to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).

Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI).

LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.

Dolasetron Mesylate (MDL-73147EF) is an antagonist of the 5-HT3 receptor and can be used in research on the treatment of vomiting and nausea following

Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic

ICI 162,846 is an orally active and potent H2 receptor antagonist that inhibits gastric secretion and may be used in the study of duodenal ulcers.

Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].

Deramciclane fumarate is a 5-HT(2A/C) antagonist with putative anxiolytic activity.

Etersalate inhibits platelet function. It also reduces thromboxane A2 (TXA2) levels.

MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.