GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(942 products)
- Adenosine Receptor(242 products)
- Adrenergic Receptor(2,949 products)
- Bombesin Receptor(30 products)
- Bradykinin Receptor(59 products)
- CXCR(149 products)
- CaSR(32 products)
- Cannabinoid Receptor(195 products)
- Dopamine Receptor(410 products)
- Endothelin Receptor(75 products)
- GNRH Receptor(73 products)
- GPCR19(31 products)
- GRK(32 products)
- GTPase(21 products)
- Glucagon Receptor(166 products)
- Hedgehog/Smoothened(45 products)
- Histamine Receptor(359 products)
- LPA Receptor(21 products)
- Melatonin Receptor(24 products)
- OX Receptor(40 products)
- Opioid Receptor(298 products)
- PAFR(11 products)
- PKA(49 products)
- S1P Receptor(17 products)
- SGLT(30 products)
- Sigma receptor(46 products)
Show 18 more subcategories
Found 5378 products of "GPCR/G-Protein"
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VGD071
CAS:<p>VGD071, a compound that targets sortilin, presents a promising avenue for forthcoming research utilizing mouse models of breast cancer.</p>Formula:C32H41N3O4S2Color and Shape:SolidMolecular weight:595.82A1AR antagonist 1
<p>Compound 18g, a potent A1AR blocker with Ki: 2.08 nM (hA1), 6.91 nM (hA2A), 31.2 nM (hA2B).</p>Formula:C18H14N4OColor and Shape:SolidMolecular weight:302.33Teoprolol
CAS:<p>Teoprolol is a blocker of β-adrenergic receptor.</p>Formula:C23H30N6O4Purity:98%Color and Shape:SolidMolecular weight:454.52YM158 free base
CAS:<p>YM158 free base is a potent and selective antagonist of TXA2 and LTD4 receptor (pA2s: about 8.81 and 8.87).</p>Formula:C32H33ClN6O5S2Purity:98%Color and Shape:SolidMolecular weight:681.22Serlopitant
CAS:<p>Serlopitant is a selective antagonist of Neurokinin-1 (NK-1) receptor.</p>Formula:C29H28F7NO2Color and Shape:SolidMolecular weight:555.53Danavorexton
CAS:Danavorexton is an orexin receptor agonist.Formula:C21H32N2O5SColor and Shape:SolidMolecular weight:424.55CP-199330
CAS:<p>CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.</p>Formula:C28H24ClF3N2O6SColor and Shape:SolidMolecular weight:609.01Beloxepin
CAS:<p>Beloxepin is an oral dual selective inhibitor of serotonin and norepinephrine uptake.</p>Formula:C19H21NO2Purity:98%Color and Shape:SolidMolecular weight:295.38Cendifensine
CAS:<p>Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).</p>Formula:C14H17Cl2NOColor and Shape:SolidMolecular weight:286.197SR 142948-C3-NHMe
CAS:<p>SR 142948-C3-NHMe is the methylated form of SR 142948.</p>Formula:C42H58N6O6Color and Shape:SolidMolecular weight:742.946MK-3207
CAS:<p>MK-3207 is a potent, oral CGRP receptor antagonist with high selectivity for human and monkey receptors, inhibiting blood flow in vivo.</p>Formula:C31H29F2N5O3Color and Shape:SolidMolecular weight:557.59MK-3207 Hydrochloride
CAS:<p>MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.</p>Formula:C31H30ClF2N5O3Purity:98.19%Color and Shape:SolidMolecular weight:594.05LK 11
CAS:LK-11, an alkaloid derivative, inhibits the passive uptake of norepinephrine (NA) by synaptic vesicles in the thalamus, similarly to cocaine.Formula:C15H26N2O3Color and Shape:SolidMolecular weight:282.38RGS10 modulator-1
CAS:<p>RGS10 modulator-1 (compound 15) is an effective regulator of RGS10. It significantly reverses IFNγ-induced expression of both RGS10 protein and mRNA, as well as COX-2 mRNA and iNOS expression triggered by IFNγ.</p>Formula:C16H15BrN2O3S2Color and Shape:SolidMolecular weight:427.336K-8794
CAS:<p>K-8794 is an orally active and selective endothelin receptor ETB antagonist that can be utilized in cardiovascular disease research.</p>Formula:C36H38N6O6SColor and Shape:SolidMolecular weight:682.789Dopamine D4 receptor ligand 3
CAS:<p>Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.</p>Formula:C28H31N3O5Color and Shape:SolidMolecular weight:489.56BMS-741672
CAS:<p>BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.</p>Formula:C25H33F3N6O2Color and Shape:SolidMolecular weight:506.56MDMB-FUBICA
CAS:<p>MDMB-FUBICA is a potent agonist of the cannabinoid receptors and exhibits psychoactive properties. It can be utilized in e-cigarettes.</p>Formula:C23H25FN2O3Color and Shape:SolidMolecular weight:396.455SphK2-IN-2
<p>SphK2-IN-2 (21g) is a potent and selective inhibitor of SphK2 (IC50: 0.23 μM).</p>Formula:C21H25ClN10OColor and Shape:SolidMolecular weight:468.94Serotonin maleate
CAS:<p>Serotonin hydrogen maleate serves as a monoaminergic neurotransmitter and an endogenous 5-HT receptor agonist within the central nervous system (CNS). It also functions as an inhibitor of catechol O-methyltransferase (COMT), exhibiting a Ki value of 44 μM.</p>Formula:C14H16N2O5Color and Shape:SolidMolecular weight:292.287Opipramol dihydrochloride
CAS:<p>Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) primarily functioning as a sigma (σ) receptor agonist. It interacts effectively with sigma recognition sites, having a Ki value of 50 nM. Opipramol is applicable in the study of generalized anxiety disorder (GAD).</p>Formula:C23H31Cl2N3OColor and Shape:SolidMolecular weight:436.418Org 274179-0
CAS:<p>Org 274179-0 is an effective allosteric antagonist of the thyroid-stimulating hormone (TSH) receptor, with an IC50 in the nanomolar range. It fully inhibits TSH (and TSI)-mediated activation of the TSH receptor with minimal impact on the efficacy of TSH. This compound can be utilized in studies of Graves' disease (GD).</p>Formula:C28H27F3N2O2Color and Shape:SolidMolecular weight:480.521CRHR1 antagonist 1
CAS:<p>CRHR1 antagonist 1 (compound 10a) is a non-peptide antagonist of corticotropin-releasing hormone receptor 1 (CRHR1). It serves as a useful tool in the study of psychiatric disorders.</p>Formula:C24H34N4OColor and Shape:SolidMolecular weight:394.553SGLT1/2-IN-8
CAS:<p>SGLT1/2-IN-8 (compound 8) is a potent and orally active dual inhibitor of SGLT1/2, exhibiting IC50 values of 4 nM and 1 nM, respectively. It shows antihyperglycemic properties, making it suitable for related research.</p>Formula:C22H26O6Color and Shape:SolidMolecular weight:386.438NMDAR antagonist 5
CAS:<p>NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.</p>Formula:C17H21N3Color and Shape:SolidMolecular weight:267.369Mafoprazine
CAS:<p>Mafoprazine, a phenylpiperazine derivative, exhibits varying affinities for neuronal receptors, primarily exerting its antipsychotic effects through blocking D2 receptors and enhancing α-adrenergic activity. It also increases the activity of dopamine metabolites.</p>Formula:C22H28FN3O3Color and Shape:SolidMolecular weight:401.47ONO-9780307
CAS:<p>ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM).</p>Formula:C30H35NO7Color and Shape:SolidMolecular weight:521.6Oral antiplatelet agent 1
CAS:<p>Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro.</p>Formula:C23H24N4O5SPurity:98%Color and Shape:SolidMolecular weight:468.53INCB-9471 dihydrochloride
CAS:<p>INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration & HIV-1.</p>Formula:C30H42Cl2F3N5O2Purity:98%Color and Shape:SolidMolecular weight:632.59U91356
CAS:U91356 is an agonist of the dopamine receptors.Formula:C13H17N3OPurity:98%Color and Shape:SolidMolecular weight:231.29Leukotriene F4
CAS:<p>LTF4, made in vitro from LTE4 with enzymes, contracts vascular muscle weakly; potency is LTD4 > LTC4 > LTE4 >> LTF4.</p>Formula:C28H44N2O8SColor and Shape:SolidMolecular weight:568.72U92016A hydrochloride
CAS:<p>U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.</p>Formula:C19H26ClN3Color and Shape:SolidMolecular weight:331.89TAK-024
CAS:TAK-024 is an inhibitor of platelet(IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively).Formula:C27H34N10O6Purity:98%Color and Shape:SolidMolecular weight:594.62AL 8810
CAS:<p>AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].</p>Formula:C24H31FO4Color and Shape:SolidMolecular weight:402.5SB-423557
CAS:SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nMFormula:C28H36N2O4Purity:98%Color and Shape:SolidMolecular weight:464.60U75302
CAS:<p>U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes.</p>Formula:C22H35NO3Purity:98%Color and Shape:Light Yellow OilMolecular weight:361.52PF-4693627
CAS:<p>PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM).</p>Formula:C26H29Cl2N3O3Purity:98%Color and Shape:SolidMolecular weight:502.43Rocavorexant
CAS:<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Formula:C18H19F3N8OColor and Shape:SolidMolecular weight:420.392AH22921
CAS:<p>AH22921 is an EP4 prostaglandin receptor antagonist with the ability to antagonize the activation of adenylyl cyclase by prostaglandins in CHO cells. It induces a rightward shift in the PGE? concentration-response curve in these cells, functioning as a non-competitive antagonist. AH22921 is selective for the EP4 receptor, inhibiting its activity in CHO cells without affecting the PGE? concentration-response curve in NPE cells that contain the EP2 receptor.</p>Formula:C29H35NO5Color and Shape:SolidMolecular weight:477.59SB 243213 dihydrochloride
CAS:<p>SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for</p>Formula:C22H21Cl2F3N4O2Purity:98%Color and Shape:SolidMolecular weight:501.33Butaprost
CAS:<p>Butaprost: EP2 receptor agonist, EC50=33 nM, Ki=2.4 μM (murine), reduces fibrosis via TGF-β/Smad2.</p>Formula:C24H40O5Purity:98%Color and Shape:SolidMolecular weight:408.57P2Y14R antagonist 4
CAS:<p>Compound 25l, also known as P2Y14R antagonist 4, is an orally active antagonist of the P2Y14R receptor with an IC50 of 5.6 nM. It exhibits higher binding affinity for P2Y14R compared to other PPTN receptors. P2Y14R antagonist 4 also possesses anti-inflammatory properties, reducing the release of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) induced by LPS.</p>Formula:C27H27F3N2O4SColor and Shape:SolidMolecular weight:532.574S1PR1 agonist 1
CAS:<p>S1PR1 agonist 1 is a potent agonist of S1PR1. S1PR1 agonist 1 has potential in autoimmune diseases.</p>Formula:C29H30N4O4Color and Shape:SolidMolecular weight:498.57H3R antagonist 1
CAS:H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).Formula:C19H23N3O3Color and Shape:SolidMolecular weight:341.4BMS-986104 HCl
CAS:<p>BMS-986104 is a potent and selective S1P1 receptor modulator.</p>Formula:C22H36ClNOPurity:98%Color and Shape:SolidMolecular weight:365.98MRS7799
CAS:<p>MRS7799 is a selective A3 Adenosine Receptor antagonist with Kd values of 0.55 nM for humans, 3.74 nM for mice, and 2.80 nM for rats. MRS7799 can be utilized in research related to neurodegenerative diseases, cancer, cardiac and cerebral ischemia, and autoimmune inflammatory diseases.</p>Formula:C22H18N4OSColor and Shape:SolidMolecular weight:386.47Metrazoline
CAS:<p>Metrazoline (o-Methyl-tracizoline) acts as a ligand for adrenergic receptors (low affinity) and imidazoline I2 receptors.</p>Formula:C14H16N2O4Color and Shape:SolidMolecular weight:276.288PD 136450
CAS:<p>PD-136,450: partial stomach secretory agonist, full pancreas agonist in rats; potential acid-reducing drug, adjuvant for gastrin-sensitive tumors.</p>Formula:C35H40N4O6Purity:98%Color and Shape:SolidMolecular weight:612.72UK-432097
CAS:<p>UK 432097 is an adenosine A2A agonist.</p>Formula:C40H47N11O6Color and Shape:SolidMolecular weight:777.87(1R,2S,3R)-Aprepitant
CAS:<p>(1R,2S,3R)-Aprepitant (Compound ent-4) is a competitive antagonist of the human neurokinin-1 (NK-1) receptor. It holds potential for research in the treatment of nausea and vomiting related to cancer or postoperative conditions.</p>Formula:C23H21F7N4O3Color and Shape:SolidMolecular weight:534.427LY210073
CAS:<p>LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).</p>Formula:C30H28O8Purity:98%Color and Shape:SolidMolecular weight:516.54SR 140333
CAS:<p>SR 140333 is a NK1 receptor antagonist.</p>Formula:C37H45Cl3N2O2Purity:98%Color and Shape:SolidMolecular weight:656.12BNS808
CAS:<p>BNS808 is an orally active, selective CB1R antagonist with an IC50 of 0.8 nM, demonstrating significant selectivity for CB2R and minimal brain penetration. It is being studied for the treatment of obesity and related metabolic complications, such as metabolic dysfunction-associated steatotic liver disease (MASLD). BNS808 reduces drug exposure to the central nervous system, enhancing safety, and minimizes drug interactions through high plasma protein binding.</p>Formula:C25H20Cl3N3O3SColor and Shape:SolidMolecular weight:548.869SGL5213
CAS:<p>SGL5213 is a potent oral SGLT1 inhibitor (IC50: 29 nM) with potential for treating type 2 diabetes.</p>Formula:C37H55N3O8Purity:98%Color and Shape:SolidMolecular weight:669.85Tezosentan
CAS:<p>Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively).</p>Formula:C27H27N9O6SPurity:98%Color and Shape:SolidMolecular weight:605.63BAY-899
CAS:<p>BAY-899, oral LH-R antagonist, IC50: 185 nM (hLH), 46 nM (rLH), lowers sex hormones in vivo.</p>Formula:C25H19F2N5O2Purity:98%Color and Shape:SolidMolecular weight:459.45PF-9404C
CAS:<p>PF-9404C: S-S diastereoisomer, beta-blocker with vasodilation, boosts cyclic GMP in rat aorta cells from 3 to 53 pmol/mg protein.</p>Formula:C16H25N3O9Purity:98%Color and Shape:SolidMolecular weight:403.38Taprostene
CAS:<p>Taprostene (CG-4203), a stable Prostacyclin analogue, protects endothelium and myocardium post-ischemia in cats, with minimal hemodynamic impact.</p>Formula:C24H30O5Color and Shape:SolidMolecular weight:398.49CS-0777
CAS:<p>CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator).</p>Formula:C21H31N2O5PColor and Shape:SolidMolecular weight:422.45MED 27
CAS:<p>MED 27 is an inhibitor of thromboxane synthase and thromboxane A2 receptors. It effectively inhibits rat platelet aggregation at doses significantly lower than those required for acetylsalicylic acid.</p>Formula:C24H25N5O5Color and Shape:SolidMolecular weight:463.49AAZ-A 154 mesylate
CAS:<p>AAZ-A 154 mesylate mesylate is a selective, competitive, and non-hallucinogenic antagonist of 5-HT2AR. It enhances neuronal growth in rodents and produces enduring beneficial behavioral effects.</p>Formula:C15H24N2O4SColor and Shape:SolidMolecular weight:328.43AAZ-A 154
CAS:<p>AAZ-A 154 is a selective, competitive, and non-hallucinogenic antagonist of the 5-HT2AR. It promotes neuronal growth in rodents and results in lasting beneficial behavioral effects.</p>Formula:C14H20N2OColor and Shape:SolidMolecular weight:232.32ATX inhibitor 27
CAS:<p>ATX inhibitor 27 (Compound 31) is an ATX inhibitor. It demonstrates IC50 values of 13 nM against human autotaxin (hATX) and 23 nM against lysophosphatidylcholine (LPC). By inhibiting the ATX enzyme, ATX inhibitor 27 reduces LPA levels in the body. This compound is applicable in research related to ATX-LPA-associated conditions such as inflammation, neurodegenerative disorders, and cancer.</p>Formula:C26H26ClN5O3Color and Shape:SolidMolecular weight:491.97AAZ-A 154 benzoate
CAS:<p>AAZ-A 154 benzoate is a selective, competitive, and non-hallucinogenic 5-HT2AR antagonist. This compound facilitates neuronal growth in rodents and produces lasting beneficial behavioral effects.</p>Formula:C21H26N2O3Color and Shape:SolidMolecular weight:354.44Protease-Activated Receptor-1 antagonist 3
<p>PAR-1 antagonist 3: potent (IC50: 7 nM), binds hERG K+ channels (IC50: 9 μM).</p>Formula:C30H34N4O3Color and Shape:SolidMolecular weight:498.621'-Naphthoyl-2-methylindole
CAS:<p>1'-Naphthoyl-2-methylindole (Compound 88) acts as a cannabinoid mimic and an inhibitor of Win 55212-2, displaying a 34% inhibition of [3H]Win 55212-2 binding to cannabinoid receptors at a concentration of 3 μM.</p>Formula:C20H15NOColor and Shape:SolidMolecular weight:285.34MDA77
CAS:<p>MDA77 is a CB2 agonist with an EC50 value of 5.82 nM and exhibits no activity towards CB1.</p>Formula:C21H23N3O3Color and Shape:SolidMolecular weight:365.43UR-AK49
CAS:<p>UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.</p>Formula:C16H27N5OColor and Shape:SolidMolecular weight:305.42L-657926
CAS:<p>L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid. The IC50 values for the (-) and (+) configurations against TxA2 are 0.27 nM and 124 nM, respectively.</p>Formula:C21H19ClFNO2Color and Shape:SolidMolecular weight:371.832BI-685509
CAS:<p>BI-685509: potent, oral sGC activator, boosts cGMP, enhances NO pathways, for CKD/DKD research.</p>Formula:C34H38N4O5Color and Shape:SolidMolecular weight:582.69Netupitant metabolite Monohydroxy Netupitant
CAS:Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite.Formula:C30H32F6N4O2Purity:98%Color and Shape:SolidMolecular weight:594.59O-1269
CAS:<p>O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.</p>Formula:C22H22Cl3N3OColor and Shape:SolidMolecular weight:450.79FK-3657
CAS:<p>FK-3657 is a non-peptide antagonist of bradykinin (BK)-B2 receptor.</p>Formula:C30H27Cl2N5O4Color and Shape:SolidMolecular weight:592.47AB-FUBINACA 3-fluorobenzyl isomer
CAS:<p>AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.</p>Formula:C20H21FN4O2Color and Shape:SolidMolecular weight:368.41FR-145715
CAS:<p>FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.</p>Formula:C16H21N5O2SColor and Shape:SolidMolecular weight:347.44ATL444
CAS:<p>ATL444 is an adenosine receptor antagonist with affinity (Ki values) for rA1AR, rA2AAR, rA2BAR, and rA3AR of 7.0, 2.5, 61.8, and >1000 nM, respectively.</p>Formula:C17H19N5OColor and Shape:SolidMolecular weight:309.37R-137696
CAS:<p>R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.</p>Formula:C17H23N3O2Color and Shape:SolidMolecular weight:301.38Flucopride
CAS:<p>Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.</p>Formula:C22H33FN2O2Color and Shape:SolidMolecular weight:376.51AGH-107
CAS:<p>AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.</p>Formula:C13H12IN3Color and Shape:SolidMolecular weight:337.16Tipindole
CAS:<p>Tipindole is a serotonin antagonist utilized in research related to depression.</p>Formula:C16H20N2O2SColor and Shape:SolidMolecular weight:304.41Sulfinalol hydrochloride
CAS:<p>Sulfinalol hydrochloride is an orally active β-adrenoceptor (β-adrenoceptor) antagonist that exhibits direct vasodilatory activity. It is also classified as an antihypertensive agent.</p>Formula:C20H28ClNO4SColor and Shape:SolidMolecular weight:413.96TAK-661
CAS:<p>TAK-661 is an inhibitor of eosinophil chemotaxis (eosinophil chemotaxis) that significantly alleviates late-phase bronchoconstriction while inhibiting the proliferation of eosinophils in bronchoalveolar lavage (BAL) and their infiltration into the airway walls.</p>Formula:C13H21N5O3SColor and Shape:SolidMolecular weight:327.40PD 135158
CAS:PD 135158 is a CCK2 receptor antagonist.Formula:C42H61N5O11Purity:98%Color and Shape:SolidMolecular weight:811.965-HT1A modulator 4
CAS:<p>5-HT1A modulator 4 (Compound 1) is a ligand for the 5-HT receptor, with Ki values of 2.18 μM for 5-HT1A and 19.7 μM for 5-HT2A.</p>Formula:C9H14N4Color and Shape:SolidMolecular weight:178.234SB 224289
CAS:<p>SB 224289: selective 5-HT1B antagonist, pKi 8.2, 60x selectivity, effective orally.</p>Formula:C32H32N4O3Purity:98%Color and Shape:SolidMolecular weight:520.62SphK2-IN-1
CAS:<p>SphK2-IN-1 is an SphK2 inhibitor with an IC50 value of 0.359 μM. SphK2-IN-1 can be used to study cancer, inflammation, neurological and cardiovascular diseases.</p>Formula:C23H22ClF3N8OColor and Shape:SolidMolecular weight:518.92MK-8825
CAS:<p>MK-8825 is a CGRP receptor antagonist.</p>Formula:C31H30F2N6O3Color and Shape:SolidMolecular weight:572.61BMS-986120
CAS:BMS-986120: Oral, reversible PAR4 antagonist. IC50: 9.5 nM (human), 2.1 nM (monkey). Potent, selective antiplatelet.Formula:C23H23N5O5S2Color and Shape:SolidMolecular weight:513.59Lp(a)-IN-8
CAS:<p>LPA2 antagonist 3 (compound 15) serves as an Lp(a) antagonist. Lp(a) is a pathogenic risk factor for atherosclerotic cardiovascular disease (ASCVD).</p>Formula:C21H40Cl2N4O5Color and Shape:SolidMolecular weight:499.472CS-003 Free base
CAS:<p>CS-003: Triple neurokinin receptor antagonist; Ki=2.3 nM (NK1), 0.54 nM (NK2), 0.74 nM (NK3); treats respiratory diseases.</p>Formula:C34H38Cl2N2O6SPurity:98%Color and Shape:SolidMolecular weight:673.65BD-1047
CAS:<p>BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.</p>Formula:C13H20Cl2N2Color and Shape:SolidMolecular weight:275.217CM699
CAS:<p>CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.</p>Formula:C24H29N3O2Color and Shape:SolidMolecular weight:391.51Burapitant
CAS:<p>Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.</p>Formula:C31H35Cl2F6N3O3Purity:>99.99% - >99.99%Color and Shape:SolidMolecular weight:682.52GRK6-IN-4
CAS:<p>GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Formula:C15H15N5Color and Shape:SolidMolecular weight:265.313D4R antagonist-1
<p>Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.</p>Formula:C21H25F2NO2Color and Shape:SolidMolecular weight:361.43LPA2 antagonist 6
CAS:<p>LPA2 antagonist 6 (example 2) acts as an antagonist of Lp(a). It inhibits the formation of Lp(a) with an IC50 value of 2.33 nM, making it useful for cardiovascular disease research.</p>Formula:C26H34Cl2N2O6Color and Shape:SolidMolecular weight:541.464MSX-3
CAS:<p>MSX-3 is an antagonist of the A2A adenosine receptor and a prodrug of MSX-2.</p>Formula:C21H23N4Na2O7PPurity:98%Color and Shape:SolidMolecular weight:520.389L 668750
CAS:<p>L 668750 is an inhibitor of platelet-activating factor.</p>Formula:C25H34O9SPurity:98%Color and Shape:SolidMolecular weight:510.6CCR7 Ligand 1
CAS:<p>CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.</p>Formula:C22H29N5O5SColor and Shape:SolidMolecular weight:475.56L-796778 acetate
CAS:<p>L-796778 acetate is a selective sst3 receptor agonist. In CHO-K1 cells expressing hsst3 receptors, it acts as a partial agonist that inhibits Forskolin-induced cAMP production, with an IC50 value of 18 nM. Additionally, L-796778 acetate exhibits anticonvulsant properties.</p>Formula:C31H44N6O9Color and Shape:SolidMolecular weight:644.716AL 6598
CAS:<p>AL 6598, a prodrug of PGD2 agonist AL 6556, reduces IOP by 53% at 1μg twice daily in monkeys; binds DP receptors with Ki of 3.2μM.</p>Formula:C23H39ClO5Color and Shape:SolidMolecular weight:431.01CI-624
CAS:<p>CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.</p>Formula:C8H8N2SColor and Shape:SolidMolecular weight:164.228Nocloprost
CAS:<p>Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing effects.</p>Formula:C22H37ClO4Color and Shape:SolidMolecular weight:400.98(Rac)-BI 703704
CAS:<p>(Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC).</p>Formula:C32H37N3O4SPurity:98%Color and Shape:SolidMolecular weight:559.72AFP-07 free acid
CAS:<p>AFP 07 free acid is a 7,7-difluoroprostacyclin derivative. It also acts as a selective and highly potent agonist for the IP receptor.</p>Formula:C22H30F2O5Purity:98%Color and Shape:SolidMolecular weight:412.47CB1/2 receptor-1
CAS:<p>CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.</p>Formula:C33H48O2Color and Shape:SolidMolecular weight:476.73Bzo-poxizid
CAS:<p>Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.</p>Formula:C20H21N3O2Color and Shape:SolidMolecular weight:335.40LB-102
CAS:<p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>Formula:C18H29N3O4SColor and Shape:SolidMolecular weight:383.51Sigma-2 Radioligand 2
CAS:Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).Formula:C23H28FN3O3Color and Shape:SolidMolecular weight:413.49RS 61756-007
CAS:<p>RS 61756-007 is a selective thromboxane receptor (TP) agonist.</p>Formula:C23H28O5Purity:98%Color and Shape:SolidMolecular weight:384.47(R)-BAY-899
<p>(R)-BAY-899: R-isomer, selective LH-R antagonist, effective on hLH (IC50: 185 nM) and rLH (IC50: 46 nM), orally active.</p>Formula:C25H19F2N5O2Color and Shape:SolidMolecular weight:459.45Kendomycin
CAS:<p>Kendomycin is a proteasome inhibitor and endothelin receptor antagonist. It induces apoptosis in lymphoma.</p>Formula:C29H42O6Color and Shape:SolidMolecular weight:486.64CB2 receptor antagonist 1
CAS:<p>Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.</p>Formula:C28H47NO3Color and Shape:SolidMolecular weight:445.68Neflumozide
CAS:<p>Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.</p>Formula:C22H23FN4O2Color and Shape:SolidMolecular weight:394.44Cloprostenol
CAS:<p>Cloprostenol is a synthetic prostaglandin and PGF2α analogue used in animals to terminate pregnancy and induce corpus luteum dissolution.</p>Formula:C22H29ClO6Purity:99.81%Color and Shape:Clear Colorless To Light Yellowish LiquidMolecular weight:424.92MRS2279 diammonium
CAS:<p>MRS2279 diammonium, a P2Y1 antagonist with K i 2.5 nM, IC 50 51.6 nM, blocks ADP-induced platelet aggregation, pK b 8.05.</p>Formula:C13H24ClN7O8P2Color and Shape:SolidMolecular weight:503.77Apafant
CAS:<p>Apafant (WEB 2086) is a PAF antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.</p>Formula:C22H22ClN5O2SPurity:99.56%Color and Shape:SolidMolecular weight:455.96CVT-5440
CAS:<p>CVT-5440 is a selective, high-affinity (2B) adenosine receptor antagonist with good selectivity.</p>Formula:C27H28N6O5Color and Shape:SolidMolecular weight:516.55Remlifanserin
CAS:Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).Formula:C24H29F2N3O2Color and Shape:SolidMolecular weight:429.50Lisuride
CAS:<p>Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.</p>Formula:C20H26N4OColor and Shape:SolidMolecular weight:338.45Fasitibant
CAS:<p>Fasitibant is a potent and selective nonpeptide kinin B2 receptor antagonist.</p>Formula:C36H49Cl2N6O6SColor and Shape:SolidMolecular weight:764.78Enprostil
CAS:<p>Enprostil: synthetic PGE2 analog, reduces gastric acid, protects mucosa, lowers post-meal gastrin, treats ulcers effectively and safely.</p>Formula:C23H28O6Purity:98%Color and Shape:SolidMolecular weight:400.46YNT-3708
CAS:<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Formula:C35H36N4O6SColor and Shape:SolidMolecular weight:640.749Protease-Activated Receptor-1 antagonist 1
<p>Compound 13 is a PAR-1 antagonist with a 3 nM IC50, useful for thrombosis and heart disease research.</p>Formula:C25H24F2N2O3Color and Shape:SolidMolecular weight:438.47Inupadenant HCl
CAS:<p>Inupadenant (EOS-850) is a selective A2a receptor antagonist, targeting immunosuppression in tumors.</p>Formula:C25H27ClF2N8O4S2Color and Shape:SolidMolecular weight:641.11GAT564
<p>GAT564, an allosteric CB1R modulator, shows EC50s of 87 nM (cAMP) & 320 nM (β-arrestin2) and lowers IOP effectively in glaucoma mice.</p>Formula:C20H16N2O2SColor and Shape:SolidMolecular weight:348.42A1/A3 AR antagonist 1
<p>Compound 10 is a potent dual A1/A3 AR antagonist, with Ki values of 37.6 nM (hA1), 25.4 nM (hA3), and 1.47 nM (rA1), studied in renal, lung, and Alzheimer's.</p>Formula:C24H18N2O3SColor and Shape:SolidMolecular weight:414.48Disulergine
CAS:<p>Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.</p>Formula:C17H24N4O2SPurity:98%Color and Shape:SolidMolecular weight:348.46(S)-Praziquantel
CAS:<p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>Formula:C19H24N2O2Color and Shape:SolidMolecular weight:312.406DM-4111
CAS:<p>DM-4111, one of the primary monohydroxy metabolites of Tolvaptan, is an effective vasopressin V2 receptor (vasopressin V2 receptor) inhibitor. By inhibiting water reabsorption in renal tubules, it facilitates the excretion of electrolyte-free water. DM-4111 holds potential for research in cardiovascular diseases.</p>Formula:C26H25ClN2O4Color and Shape:SolidMolecular weight:464.94GLP-1 receptor agonist 16
CAS:<p>GLP-1 receptoragonist 16 (Example 53) is a GLP-1 agonist applicable for research in diabetes, obesity, or diseases related to non-alcoholic steatohepatitis.</p>Formula:C33H31ClFN3O4Color and Shape:SolidMolecular weight:588.068PD 140376
CAS:<p>PD 140376: Selective CCK-B/gastrin receptor antagonist radioligand for guinea pig stomach & brain.</p>Formula:C33H40N4O5Purity:98%Color and Shape:SolidMolecular weight:572.698-iso Prostaglandin F3α
CAS:<p>8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA.</p>Formula:C20H32O5Color and Shape:SolidMolecular weight:352.47Sigma-1 receptor antagonist 6
CAS:<p>Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.</p>Formula:C32H34N6Color and Shape:SolidMolecular weight:502.65CHF-6366
CAS:<p>CHF-6366: M3 antagonist & β2 agonist (pKi 10.4/11.4), mild Ca channel blocker, used in COPD study.</p>Formula:C42H48N6O8Color and Shape:SolidMolecular weight:764.87NK1 receptor antagonist 2
CAS:<p>NK1 Receptor Antagonist 2, a compound targeting the NK1 receptor, holds potential for tinnitus and hearing loss research.</p>Formula:C31H35F7N4O2Color and Shape:SolidMolecular weight:628.62BW A868C
CAS:BW A868C is a potent, selective PGD2 antagonist and a BW245C analogue, inert to other prostaglandin receptors.Formula:C25H37N3O5Color and Shape:SolidMolecular weight:459.58VA012
CAS:<p>VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.</p>Formula:C21H19N3Color and Shape:SolidMolecular weight:313.40Ophiobolin C
CAS:<p>inhibitor of human CCR5 binding to HIV-1 gp120</p>Formula:C25H38O3Purity:98%Color and Shape:SolidMolecular weight:386.57SGLT inhibitor-1
CAS:<p>SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively).</p>Formula:C24H27FO8Purity:98%Color and Shape:SolidMolecular weight:462.46Thielavin B
CAS:<p>Thielavin B, from Thielavia terricola, inhibits prostaglandin E2 synthesis and reduces rat oedema.</p>Formula:C31H34O10Color and Shape:SolidMolecular weight:566.6Rodatristat ethyl
CAS:<p>Rodatristat ethyl is an oral TPH1 inhibitor reducing 5-HT levels & lowering PAH at low doses.</p>Formula:C29H31ClF3N5O3Purity:98%Color and Shape:SolidMolecular weight:590.04Dopamine D3 receptor ligand-1
<p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>Formula:C27H29N5OColor and Shape:SolidMolecular weight:439.55Delmadinone acetate
CAS:<p>Delmadinone acetate is an orally active compound used to control estrus and ovulation in both female and male pets. It induces adrenal suppression by inhibiting the pituitary release of ACTH.</p>Formula:C23H27ClO4Color and Shape:SolidMolecular weight:402.911BI-44370
CAS:<p>BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.</p>Formula:C35H47N5O6Color and Shape:SolidMolecular weight:633.78(S)-Bucindolol
CAS:(S)-Bucindolol is an enantiomer of bucindolol, specifically a β1-adrenergic receptor antagonist. It is primarily utilized in research related to heart failure.Formula:C22H25N3O2Color and Shape:SolidMolecular weight:363.45Etoperidone
CAS:<p>Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).</p>Formula:C19H28ClN5OColor and Shape:SolidMolecular weight:377.91UMB24
CAS:<p>UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.</p>Formula:C17H21N3Color and Shape:SolidMolecular weight:267.37FDU-PB-22
CAS:<p>FDU-PB-22, a novel synthetic cannabinoid, undergoes rapid metabolism in human liver microsomes (HLM) with a half-life of 12.4 minutes.</p>Formula:C26H18FNO2Color and Shape:SolidMolecular weight:395.43Tofogliflozin
CAS:Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).Formula:C22H26O6Purity:98%Color and Shape:SolidMolecular weight:386.44NCATS-SM4420
CAS:<p>NCATS-SM4420 (Compound A35) is an orally effective ligand for the thyroid-stimulating hormone receptor (TSHR) that inhibits the proliferation of MDA-T32 and MDA-T85 cells both in vitro and in vivo, with IC50 values of 0.71 μM and 0.38 μM, respectively. Additionally, it suppresses the metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds potential for research in the field of thyroid cancer.</p>Formula:C31H27N3O5Color and Shape:SolidMolecular weight:521.56TAAR1 agonist 3
CAS:<p>TAAR1 agonist 3 is a potent agonist of Trace Amine-Associated Receptor 1 (TAAR1) with a pEC50 value of 7.6. Additionally, it acts as a full agonist at the α2AR with a pEC50 of 6. TAAR1 agonist 3 is utilized in the research of neuropsychiatric disorders.</p>Formula:C10H13NOColor and Shape:SolidMolecular weight:163.222,3-dinor-11β-Prostaglandin F2α
CAS:<p>2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where</p>Formula:C18H30O5Color and Shape:SolidMolecular weight:326.43Zafirlukast metabolite M1
CAS:<p>Zafirlukast metabolite M1 (compound 15) is an inhibitor used in the treatment of asthma and other allergic pulmonary conditions, effectively antagonizing leukotriene activity.</p>Formula:C25H25N3O4SColor and Shape:SolidMolecular weight:463.549Revexepride
CAS:<p>Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.</p>Formula:C21H32ClN3O4Purity:98%Color and Shape:SolidMolecular weight:425.95SCH-900822
CAS:<p>SCH-900822 is a potent and selective glucagon receptor antagonist.</p>Formula:C34H43Cl2N7O2Color and Shape:SolidMolecular weight:652.66PF-06372222
CAS:<p>PF-06372222: a small-molecule that modulates GCGR and antagonizes GLP-1R, affecting insulin and glucagon.</p>Formula:C26H28F3N5O3Purity:98%Color and Shape:SolidMolecular weight:515.53CI-988
CAS:<p>CCK2 (CCK-B) receptor antagonist</p>Formula:C35H42N4O6Purity:98%Color and Shape:SolidMolecular weight:614.73SSR-241586
CAS:<p>SSR-241586: Neurokinin antagonist, treats depression, schizophrenia, urinary issues, emesis, IBS.</p>Formula:C32H42Cl2N4O3Purity:98%Color and Shape:SolidMolecular weight:601.61Mesulergine hydrochloride
CAS:<p>5-HT2A and 2C receptor antagonist</p>Formula:C18H27ClN4O2SPurity:98%Color and Shape:SolidMolecular weight:398.95ADORA2A/PDE4D-IN-1
CAS:<p>ADORA2A/PDE4D-IN-1 (Compound 9) is a dual inhibitor of the adenosine A2a receptor (ADORA2A) and phosphodiesterase 4D (PDE4D). This compound is applicable for research in bronchial asthma.</p>Formula:C14H11N5Color and Shape:SolidMolecular weight:249.271S1P1 agonist 5
<p>Selective oral S1P1 agonist 5 inhibits lymphocyte drainage, potential for MS research.</p>Formula:C23H24ClN2NaO4Color and Shape:SolidMolecular weight:450.895-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Formula:C23H29ClN6O2Color and Shape:SolidMolecular weight:456.97MK-8318
CAS:<p>MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).</p>Formula:C27H26F4N2O5Purity:98%Color and Shape:SolidMolecular weight:534.5Bometolol Hydrochloride
CAS:<p>Bometolol Hydrochloride is a beta-adrenergic blocking compound used for the treatment of cardiovascular disease.</p>Formula:C25H33ClN2O7Purity:98%Color and Shape:SolidMolecular weight:508.99MK-0812
CAS:<p>MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.</p>Formula:C24H34F3N3O3Purity:98%Color and Shape:SolidMolecular weight:469.54MRS2179 tetrasodium hydrate
<p>MRS2179 blocks turkey P2Y1 receptor (Kb 102 nM, pA2 6.99), affects platelet aggregation, and has varying IC50s on P2 receptors.</p>Formula:C11H15N5Na4O10P2Color and Shape:SolidMolecular weight:576.21(-)-5-HT2C agonist-3
CAS:<p>Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.</p>Formula:C19H23ClFNO2Color and Shape:SolidMolecular weight:351.84GHSR-1a agonist-1
CAS:<p>GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a) with an EC50 of 0.49 nM. It effectively stimulates the release of endogenous growth hormone by activating GHSR-1a. Doses as low as 0.1 mg/kg (administered orally) can increase body weight and length in 4-week-old rats. GHSR-1a agonist-1 is applicable in research on pediatric growth and developmental delays.</p>Formula:C30H37N5O4Color and Shape:SolidMolecular weight:531.646Henagliflozin
CAS:<p>Henagliflozin (SHR3824): an oral, selective SGLT2 inhibitor, weak on SGLT1.</p>Formula:C22H24ClFO7Color and Shape:SolidMolecular weight:454.87BRD50837
CAS:<p>BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).</p>Formula:C26H32ClN3O6SPurity:98%Color and Shape:SolidMolecular weight:550.07TGR5 Receptor Agonist 3
CAS:<p>TGR5 Receptor Agonist 3 is a GPBAR1 agonist with EC50 of 16.4 nM (hTGR5) & 209 nM (mTGR5), ensures gallbladder safety and reduces filling.</p>Formula:C29H27N3O6Color and Shape:SolidMolecular weight:513.54Aclidinium
CAS:<p>Aclidinium, a dual-action compound, serves as a long-acting muscarinic antagonist and a β2-adrenoceptor (β2-AR) agonist, exhibiting bronchodilator properties. It effectively reduces lung hyperinflation, enhances lung function, and prolongs exercise endurance time. This compound is commonly utilized in studies focusing on chronic obstructive pulmonary disease (COPD).</p>Formula:C26H30NO4S2Color and Shape:SolidMolecular weight:484.65A3AR antagonist 5
CAS:<p>A3AR antagonist 5 (Compound 16) acts as a selective antagonist for the human adenosine A3 receptor (human adenosine A3 receptor), with an affinity expressed as a pC value of 4.542 μM.</p>Formula:C18H16N2O2SColor and Shape:SolidMolecular weight:324.40BRL-37344
CAS:<p>BRL-37344 is a selective β3-adrenergic receptor agonist. It significantly reduces the body weight of obese mice.</p>Formula:C19H22ClNO4Color and Shape:SolidMolecular weight:363.84K-14585
CAS:<p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>Formula:C51H56Cl2N8O4Color and Shape:SolidMolecular weight:915.95IRL 2500
CAS:<p>IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.</p>Formula:C36H35N3O4Purity:99.36%Color and Shape:White Crystalline SolidMolecular weight:573.68BI 639667
CAS:BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Formula:C22H18FN5O3SPurity:99.86%Color and Shape:SolidMolecular weight:451.47L-365260 hemihydrate
<p>L-365260 hemihydrate: selective oral CCK-B/gastrin blocker, Ki=1.9/2.0 nM, competes with guinea pig receptors.</p>Formula:C24H24N4O3Color and Shape:SolidMolecular weight:407.47CCR5 antagonist 1
CAS:<p>CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.</p>Formula:C39H46ClF2N5O3SPurity:98%Color and Shape:SolidMolecular weight:738.33BI 703704
CAS:<p>BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].</p>Formula:C32H37N3O4SPurity:98%Color and Shape:SolidMolecular weight:559.72AAZ-A 154 hydrobromide
CAS:<p>AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.</p>Formula:C14H21BrN2OColor and Shape:SolidMolecular weight:313.23AAZ-A 154 hydrochloride
CAS:<p>AAZ-A 154 hydrochloride is a selective, competitive, non-hallucinogenic antagonist of 5-HT2AR. It promotes neuronal growth in rodents and results in enduring beneficial behavioral effects.</p>Formula:C14H21ClN2OColor and Shape:SolidMolecular weight:268.78S1P1 agonist 4
CAS:<p>S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating</p>Formula:C24H31NO3Color and Shape:SolidMolecular weight:381.51CCR4 antagonist 2
CAS:<p>CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg</p>Formula:C26H28Cl2N6OPurity:98%Color and Shape:SolidMolecular weight:511.45LRH-1 modulator-1
CAS:LRH-1 modulator-1: potent agonist, boosts IL-10, reduces IL-1b/TNFa, anti-inflammatory in gut.Formula:C28H36N2O2SColor and Shape:SolidMolecular weight:464.66Atumelnant
CAS:Atumelnant (CRN04894) is an MC2R antagonist used in the study of congenital adrenocortical hyperplasia (CAH) and Cushing's disease (CD).Formula:C33H42F3N5O3Purity:98.41%Color and Shape:SolidMolecular weight:613.71R-96544 hydrochloride
CAS:<p>5-HT2 receptor antagonist</p>Formula:C22H29NO3Purity:98%Color and Shape:SolidMolecular weight:355.47PF-00446687
CAS:PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).Formula:C28H36F2N2O2Purity:98%Color and Shape:SolidMolecular weight:470.59Rivenprost
CAS:<p>Rivenprost, selective EP4 agonist (Ki: 0.7 nM), promotes bone growth, osteoblast differentiation, and aids wound healing.</p>Formula:C24H34O6SColor and Shape:SolidMolecular weight:450.59(E/Z)-Ozagrel sodium
CAS:<p>(E/Z)-Ozagrel (sodium) [(E/Z)-OKY-046 (sodium)] is a mixture of the EZ isomers of Ozagrel (sodium). It acts as a thromboxane A2 (TXA2) synthase inhibitor. As an antiplatelet agent, Ozagrel (sodium) selectively inhibits human platelet aggregation, with an IC50 of 53.12 μM.</p>Formula:C13H11N2NaO2Color and Shape:SolidMolecular weight:250.228GLP-1R agonist 8
CAS:<p>GLP-1R agonist 8 is a potent agonist of GLP-1R (EC50 < 2 nM).</p>Formula:C33H32N4O5Color and Shape:SolidMolecular weight:564.63CP-865569
CAS:<p>CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.</p>Formula:C22H26ClFN2O5SColor and Shape:SolidMolecular weight:484.969COX-2-IN-6
CAS:<p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>Formula:C20H27NO6SPurity:99.29% - 99.69%Color and Shape:SoildMolecular weight:409.5Sulprostone
CAS:<p>EP3 and EP1 receptor agonist</p>Formula:C23H31NO7SPurity:98%Color and Shape:White To Off-White SolidMolecular weight:465.56LY 292728
CAS:<p>LY 292728 is a highly potent antagonist of leukotriene B4 receptor.</p>Formula:C34H29FO9Purity:98%Color and Shape:SolidMolecular weight:600.59HU-308
CAS:<p>HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.</p>Formula:C27H42O3Color and Shape:SolidMolecular weight:414.62Histamine H3 antagonist-1
CAS:<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Formula:C24H28F3N3O2Color and Shape:SolidMolecular weight:447.49Neladenoson
CAS:<p>Neladenoson is an effective and selective agonist of the Adenosine A1 Receptor (A1R). EGFR-IN-162 shows potential for research in heart failure.</p>Formula:C29H24ClN5O2S2Color and Shape:SolidMolecular weight:574.12CCR1 antagonist 13
CAS:<p>CCR1 antagonist13 is a selective small molecule antagonist of CCR1.</p>Formula:C25H27ClFN3O4Color and Shape:SolidMolecular weight:487.95
