GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(942 products)
- Adenosine Receptor(242 products)
- Adrenergic Receptor(2,949 products)
- Bombesin Receptor(30 products)
- Bradykinin Receptor(59 products)
- CXCR(149 products)
- CaSR(32 products)
- Cannabinoid Receptor(195 products)
- Dopamine Receptor(410 products)
- Endothelin Receptor(75 products)
- GNRH Receptor(73 products)
- GPCR19(31 products)
- GRK(32 products)
- GTPase(21 products)
- Glucagon Receptor(166 products)
- Hedgehog/Smoothened(45 products)
- Histamine Receptor(359 products)
- LPA Receptor(21 products)
- Melatonin Receptor(24 products)
- OX Receptor(40 products)
- Opioid Receptor(298 products)
- PAFR(11 products)
- PKA(49 products)
- S1P Receptor(17 products)
- SGLT(30 products)
- Sigma receptor(46 products)
Show 18 more subcategories
Found 5378 products of "GPCR/G-Protein"
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Galanin Receptor Ligand M35 TFA
<p>Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM).</p>Formula:C109H154N27F3O28Purity:99.45%Color and Shape:SolidMolecular weight:2347.62F-15599
CAS:<p>F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM).</p>Formula:C19H21ClF2N4OPurity:98.72%Color and Shape:SolidMolecular weight:394.85S1RA hydrochloride
CAS:<p>S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki ></p>Formula:C20H24ClN3O2Purity:98% - 99.84%Color and Shape:SolidMolecular weight:373.87Tolnapersine
CAS:<p>Tolnapersine is a mixed dopamine agonist and alpha-adrenoceptor antagonist.</p>Formula:C21H26N2OPurity:98%Color and Shape:SolidMolecular weight:322.44AM095
CAS:AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.Formula:C27H23N2NaO5Purity:98.87%Color and Shape:SolidMolecular weight:478.47Neurotensin(8-13) 3TFA(60482-95-3(free base))
CAS:<p>Neurotensin(8-13) 3TFA is Neurotensin (NT) fragment. Neurotensin(8-13) 3TFA results in a decrease in cell-surface NT1 receptors (NTR1) density.</p>Formula:C40H65F3N12O10Purity:98.31%Color and Shape:SolidMolecular weight:931.03JNJ-7777120
CAS:<p>JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist, exhibits >1000-fold selectivity over the other histamin receptors.</p>Formula:C14H16ClN3OPurity:99.83% - 99.96%Color and Shape:SolidMolecular weight:277.75CGP71683 hydrochloride
CAS:<p>CGP71683 hydrochloride: NPY5 receptor antagonist, Ki=1.3 nM; inactive at Y1 (Ki >4000 nM) and Y2 (Ki=200 nM).</p>Formula:C26H30ClN5O2SPurity:99.92%Color and Shape:SolidMolecular weight:512.07carfenazine
CAS:<p>carfenazine targets the Dopamine receptor and is used for schizophrenia research.</p>Formula:C24H31N3O2SPurity:98.06%Color and Shape:SolidMolecular weight:425.59Bevantolol hydrochloride
CAS:<p>Bevantolol hydrochloride (NC-1400 hydrochloride) is a β1-adrenoceptor antagonist that treatment angina pectoris and hypertension.</p>Formula:C20H28ClNO4Purity:99.49%Color and Shape:SolidMolecular weight:381.9Pimozide
CAS:<p>Pimozide: antipsychotic that blocks type 2 dopamine, alpha-adrenergic, and 5-HT2 receptors, reducing tics and delusions.</p>Formula:C28H29F2N3OPurity:99.63% - >99.99%Color and Shape:SolidMolecular weight:461.55MK 212 hydrochloride
CAS:<p>MK 212 hydrochloride is a 5-HT2C receptor agonist</p>Formula:C8H11ClN4·HClPurity:99.88%Color and Shape:SolidMolecular weight:235.12OXOMEMAZINE
CAS:<p>Oxomemazine: a phenothiazine antihistamine H1-blocker with strong antimuscarinic and selective M1 antagonist properties, used in cough research.</p>Formula:C18H22N2O2SPurity:99.58%Color and Shape:SolidMolecular weight:330.44Ziprasidone mesylate
CAS:<p>Ziprasidone mesylate (CP-88059), an oral 5-HT & dopamine blocker, binds D2, 5-HT2A, 5-HT1A with Ki values: 4.8, 0.42, 3.4 nM.</p>Formula:C22H25ClN4O4S2Color and Shape:SolidMolecular weight:509.04C-021
CAS:C 021 dihydrochloride is a potent CCR4 antagonist.Formula:C27H41N5O2Purity:99.74% - 99.90%Color and Shape:SolidMolecular weight:467.65Nitrobenzylthioinosine
CAS:<p>Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.</p>Formula:C17H17N5O6SPurity:99.69% - 99.74%Color and Shape:Off-White SolidMolecular weight:419.41Chlorprothixene
CAS:<p>Chlorprothixene (Truxal) is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized.</p>Formula:C18H18ClNSPurity:98.77% - 99.756%Color and Shape:Pale Yellow Crystals SolidMolecular weight:315.86DPCPX
CAS:<p>DPCPX (PD 116948) is an A1 adenosine receptor antagonist</p>Formula:C16H24N4O2Purity:99.23% - 99.93%Color and Shape:White SolidMolecular weight:304.39M871 acetate
<p>M871 acetate is a selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM at GAL2 and GAL1 receptors, respectively).It blocks pronociceptive</p>Formula:C110H167N27O30Purity:99.84%Color and Shape:SolidMolecular weight:2347.67HhAntag
CAS:<p>HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity</p>Formula:C24H23ClN4O3Purity:95.73%Color and Shape:SolidMolecular weight:450.92Vercirnon sodium
CAS:Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.Formula:C22H21ClN2NaO4SColor and Shape:SolidMolecular weight:467.92Thozalinone
CAS:<p>Thozalinone is a psychostimulant agent inducing the release of norepinephrine and dopamine.</p>Formula:C11H12N2O2Purity:99.68%Color and Shape:SolidMolecular weight:204.23Vercirnon
CAS:<p>Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.</p>Formula:C22H21ClN2O4SPurity:99.23%Color and Shape:SolidMolecular weight:444.93Otenabant hydrochloride
CAS:<p>Otenabant hydrochloride (Otenabant) (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM).</p>Formula:C25H26Cl3N7OPurity:99.79% - ≥95%Color and Shape:SolidMolecular weight:546.88Terutroban
CAS:<p>Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis.</p>Formula:C20H22ClNO4SPurity:99.53%Color and Shape:SolidMolecular weight:407.91SB297006
CAS:<p>SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.</p>Formula:C18H18N2O5Purity:99.59%Color and Shape:SolidMolecular weight:342.35GSK2018682
CAS:<p>GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).</p>Formula:C22H21ClN4O4Purity:99.04%Color and Shape:SolidMolecular weight:440.88Nelotanserin
CAS:<p>Nelotanserin (APD125): strong 5-HT2A inverse agonist (IC50: 1.7 nM), moderate 5-HT2C (79 nM), weak 5-HT2B (791 nM).</p>Formula:C18H15BrF2N4O2Purity:98.42% - 99.88%Color and Shape:SolidMolecular weight:437.24Nelociguat
CAS:<p>Nelociguat (BAY60-4552) is an sGC stimulator, crucial in NO signal pathways.</p>Formula:C19H17FN8O2Purity:99.19%Color and Shape:SolidMolecular weight:408.39Sarpogrelate hydrochloride
CAS:<p>Sarpogrelate hydrochloride (MCI-9042), a 5-HT2 antagonist with high affinity (Ki=8.39nM), is used as an anti-platelet for PAD, improving vascular function.</p>Formula:C24H32ClNO6Purity:99.73%Color and Shape:Colorless LiquidMolecular weight:465.97M40 acetate(143896-17-7 free base)
<p>M40 acetate is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29)</p>Formula:C96H149N23O26Purity:99.88%Color and Shape:SolidMolecular weight:2041.38Gastrin I (human) acetate
Gastrin I (human) acetate (Gastrin-17 acetate) is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (Formula:C99H128N20O33SPurity:98.84%Color and Shape:SolidMolecular weight:2158.25ML-184
CAS:<p>ML-184 (CID2440433) is a potent synthetic agonist of GPR55 with EC50 of 0.26 μM.</p>Formula:C25H34N4O3SPurity:99.45%Color and Shape:SolidMolecular weight:470.63Motilin (26-47), human, porcine
CAS:<p>Motilin (26-47) binds Motilin receptors in hamster cells; Ki=2.3 nM, EC50=0.3 nM; same for humans, pigs.</p>Formula:C120H188N34O35SPurity:98%Color and Shape:SolidMolecular weight:2699.07Senktide
CAS:<p>Senktide is an agonist of tachykinin NK3 receptor.</p>Formula:C40H55N7O11SPurity:99.84% - >99.99%Color and Shape:White PowderMolecular weight:841.97ACTH (1-17) acetate
<p>ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM).</p>Formula:C97H149N29O25SPurity:98.53%Color and Shape:SolidMolecular weight:2153.47JNJ-31020028
CAS:<p>JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity (pIC50=8.07, human; pIC50=8.22, rat).</p>Formula:C34H36FN5O2Purity:95.92% - 99.65%Color and Shape:SolidMolecular weight:565.68Rimegepant
CAS:<p>View and buy Rimegepant from TargetMol.BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.Cited in 1 publications.</p>Formula:C28H28F2N6O3Purity:99.1% - 99.99%Color and Shape:SolidMolecular weight:534.56Elinzanetant
CAS:<p>Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion.</p>Formula:C33H35F7N4O3Purity:98% - 99.13%Color and Shape:SolidMolecular weight:668.64Ondansetron hydrochloride
CAS:<p>Ondansetron hydrochloride (Zofran) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation</p>Formula:C18H19N3O·HClPurity:99.78%Color and Shape:White PowderMolecular weight:329.82RO1138452
CAS:<p>RO1138452 (CAY10441) blocks prostacyclin receptor; orally active, high affinity (Ki: 1.5 nM), analgesic in rats (2-20 mg/kg).</p>Formula:C19H23N3OPurity:97.01% - 99.34%Color and Shape:SolidMolecular weight:309.41PF-04418948
CAS:<p>PF-04418948 is a potent EP2 receptor antagonist. Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors.</p>Formula:C23H20FNO5Purity:98.67% - 99.45%Color and Shape:SolidMolecular weight:409.41Lys-Bradykinin acetate(342-10-9 free base)
CAS:<p>Lys-Bradykinin acetate is an endogenous bradykinin receptor agonist.</p>Formula:C58H89N17O14Purity:99.86%Color and Shape:SolidMolecular weight:1248.43Brexpiprazole HCl
CAS:<p>Brexpiprazole HCl (OPC 34712 dihydrochloride) is a new antipsychotic drug.</p>Formula:C25H27N3O2S·xHClPurity:99.05%Color and Shape:SolidMolecular weight:433.6Levalbuterol tartrate
CAS:<p>Levalbuterol tartrate is a short-acting β2-adrenergic receptor agonist and the R enantiomer of salbutamol.Cost-effective and quality-assured.</p>Formula:C17H27NO9Purity:98.97% - 99.79%Color and Shape:SolidMolecular weight:389.39Taminadenant
CAS:<p>Taminadenant is an adenosine receptor antagonist.</p>Formula:C10H8BrN7Purity:99.11%Color and Shape:SolidMolecular weight:306.123-AQC
CAS:<p>3-AQC is a competitive antagonist of 5-HT3.</p>Formula:C20H21N5O4Purity:99.45%Color and Shape:SolidMolecular weight:395.41BAR 501 impurity
CAS:<p>BAR 501 impurity 在 BAR501 制剂中发现的一种杂质，可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。</p>Formula:C26H46O3Purity:98.78%Color and Shape:SolidMolecular weight:406.64ARN272
CAS:<p>ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor (IC50: 1.8 μM).</p>Formula:C27H20N4O2Purity:98.23%Color and Shape:SolidMolecular weight:432.47ABT-724
CAS:<p>ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM)</p>Formula:C17H19N5Purity:99.73%Color and Shape:SolidMolecular weight:293.37
