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GPCR/G-Protein

GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

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Found 5962 products of "GPCR/G-Protein"

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  • PF-00446687
    Targetmol
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    PF-00446687

    CAS:
    PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).
    Formula:C28H36F2N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:470.59

    Ref: TM-T12415

  • CymitQuimica logo
    Targetmol
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    Cannabigerovarin

    CAS:
    Cannabigerovarin (CBGV) is a compound categorized as a phytocannabinoid.
    Formula:C19H28O2
    Molecular weight:288.42

    Ref: TM-T208697

  • BI 703704
    Targetmol
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    BI 703704

    CAS:
    BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].
    Formula:C32H37N3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:559.72

    Ref: TM-T10536

  • H3R antagonist 1
    Targetmol
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    H3R antagonist 1

    CAS:
    H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).
    Formula:C19H23N3O3
    Color and Shape:Solid
    Molecular weight:341.4

    Ref: TM-T200063

  • TAAR1 agonist 3
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    TAAR1 agonist 3

    CAS:
    TAAR1 agonist 3 is a potent agonist of Trace Amine-Associated Receptor 1 (TAAR1) with a pEC50 value of 7.6. Additionally, it acts as a full agonist at the α2AR with a pEC50 of 6. TAAR1 agonist 3 is utilized in the research of neuropsychiatric disorders.
    Formula:C10H13NO
    Color and Shape:Solid
    Molecular weight:163.22

    Ref: TM-T200046

  • Spns2-IN-3
    Targetmol
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    Spns2-IN-3

    CAS:
    Spns2-IN-3 (compound 510) is an SPNS2 inhibitor with an IC50 value of 1.2 μM for hSPNS2. It is applicable in research on autoimmune diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD), as well as fibrosis, muscle atrophy, metastasis, acute lung injury, rheumatoid arthritis, colitis, Alzheimer's disease, and other conditions linked to SPNS2 activity.
    Formula:C25H25F5N4O3
    Color and Shape:Solid
    Molecular weight:524.48

    Ref: TM-T210592

  • Aclidinium
    Targetmol
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    Aclidinium

    CAS:
    Aclidinium, a dual-action compound, serves as a long-acting muscarinic antagonist and a β2-adrenoceptor (β2-AR) agonist, exhibiting bronchodilator properties. It effectively reduces lung hyperinflation, enhances lung function, and prolongs exercise endurance time. This compound is commonly utilized in studies focusing on chronic obstructive pulmonary disease (COPD).
    Formula:C26H30NO4S2
    Color and Shape:Solid
    Molecular weight:484.65

    Ref: TM-T200043

  • YGZ-331
    Targetmol
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    YGZ-331

    CAS:
    YGZ-331, a sedative hypnotic, acts by elevating GABA levels as a derivative of the adenosine nucleoside NGBA. It functions through activating A1R and A2aR, and inhibiting the phosphorylation of CaMKII (pCaMKII), thereby exerting its calming effects. Additionally, YGZ-331 reduces spontaneous motor activity in mice.
    Formula:C19H23N5O4
    Color and Shape:Solid
    Molecular weight:385.42

    Ref: TM-T200016

  • SST1 receptor antagonist-1
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    SST1 receptor antagonist-1

    CAS:
    SST1 receptor antagonist-1 (Compound 23) is a selective antagonist of the somatostatin receptor 1 (SST1), showing a pKd of 9.11 for rSST1 and 8.79 for hSST1. This compound is applicable in research related to retinal and endocrine dysfunction, cancer, and neuropsychiatric disorders.
    Formula:C29H31F2N3O2
    Color and Shape:Solid
    Molecular weight:491.57

    Ref: TM-T212134

  • VA012
    Targetmol
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    VA012

    CAS:
    VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.
    Formula:C21H19N3
    Color and Shape:Solid
    Molecular weight:313.40

    Ref: TM-T200241

  • (S)-Bucindolol
    Targetmol
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    (S)-Bucindolol

    CAS:
    (S)-Bucindolol is an enantiomer of bucindolol, specifically a β1-adrenergic receptor antagonist. It is primarily utilized in research related to heart failure.
    Formula:C22H25N3O2
    Color and Shape:Solid
    Molecular weight:363.45

    Ref: TM-T200285

  • CGRP antagonist 7
    Targetmol
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    CGRP antagonist 7

    CAS:
    CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki value of 0.029 nM. It effectively inhibits CGRP receptor-mediated cyclic adenosine monophosphate (cAMP) production, with an IC50 value of 1.5 nM. This compound is useful in migraine research.
    Formula:C30H32FN5O3
    Color and Shape:Solid
    Molecular weight:529.61

    Ref: TM-T211975

  • AM9405
    Targetmol
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    AM9405

    AM9405: peripheral CB1/5-HT3 agonist, suppresses gut motility, relieves GI disorder symptoms in mice.
    Formula:C24H33BrN2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:461.44

    Ref: TM-T10294

  • TAAR1 agonist 2
    Targetmol
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    TAAR1 agonist 2

    CAS:
    TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.
    Formula:C9H11NO
    Color and Shape:Solid
    Molecular weight:149.19

    Ref: TM-T200140

  • 5-HT2A/5-HT2C inverse agonist 1
    Targetmol
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    5-HT2A/5-HT2C inverse agonist 1

    CAS:
    5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.
    Formula:C24H35N5O2
    Color and Shape:Solid
    Molecular weight:425.57

    Ref: TM-T200089

  • MRGPRX2 modulator-3
    Targetmol
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    MRGPRX2 modulator-3

    CAS:
    MRGPRX2 modulator-3 (Compound 4-400) is a quinoline derivative and an MRGPRX2 regulator. It is utilized in the investigation of MRGPRX2-related conditions, including allergies, itching, pain, inflammation, and autoimmune diseases.
    Formula:C21H21ClF3N5O
    Color and Shape:Solid
    Molecular weight:451.87

    Ref: TM-T211385

  • BQ-788
    Targetmol
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    BQ-788

    CAS:
    BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.
    Formula:C34H51N5O7
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:641.8

    Ref: TM-T10595

  • Dersimelagon
    Targetmol
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    Dersimelagon

    CAS:
    <p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>
    Formula:C36H45F4N3O5
    Purity:97.35% - 98.23%
    Color and Shape:Solid
    Molecular weight:675.75

    Ref: TM-T25310

  • PF-07258669
    Targetmol
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    PF-07258669

    CAS:
    PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.
    Formula:C25H27FN6O2
    Purity:99.9%
    Color and Shape:Solid
    Molecular weight:462.52

    Ref: TM-T69526

  • AZD-5672
    Targetmol
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    AZD-5672

    CAS:
    AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.
    Formula:C32H38F2N2O5S2
    Purity:98.1%
    Color and Shape:Solid
    Molecular weight:632.78

    Ref: TM-T30260