GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(249 products)
- Adrenergic Receptor(3,018 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(158 products)
- CaSR(34 products)
- Cannabinoid Receptor(217 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(194 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(327 products)
- PAFR(14 products)
- PKA(60 products)
- S1P Receptor(18 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5983 products of "GPCR/G-Protein"
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PHI-27 (porcine)
CAS:PHI-27 (porcine) is a porcine-derived peptide consisting of 27 amino acids, utilized in the identification of peptide hormones and other bioactive peptides [1].Formula:C136H216N36O40Color and Shape:SolidMolecular weight:2995.39GEP44
GEP44 is a peptide-biased triple agonist targeting the glucagon-like peptide-1 receptor (GLP-1R), neuropeptide Y1 receptor (Y1-R), and neuropeptide Y2 receptor (Y2-R). It induces GLP-1R-dependent insulin secretion in rat and human islets by offsetting the actions of Y1-R and GLP-1R agonism, controlled by Y1-R antagonists. Additionally, GEP44 enhances glucose uptake in muscle tissue through Y1-R mediation independent of insulin and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 is utilized in studies related to obesity and type 2 diabetes.Color and Shape:Odour SolidBiotinyl-neuropeptide W-23 (human)
CAS:Biotinyl-neuropeptide W-23 (human) is a biotinylated form of neuropeptide W-23 (human), which functions as an agonist for the NPBW1 (GPR7) and NPBW2 (GPR8)Formula:C129H197N37O30S2Color and Shape:SolidMolecular weight:2810.3DD202-114
CAS:DD202-114 is an effective and selective agonist of GLP1R. It promotes the accumulation of cAMP, reduces blood glucose levels, and decreases food intake. Additionally, DD202-114 holds potential for research in type 2 diabetes mellitus (T2DM) and obesity studies.Formula:C33H35FN4O5Color and Shape:SolidMolecular weight:586.65N-desmethyl Zolmitriptan
CAS:DZT, an active metabolite of zolmitriptan, agonizes 5-HT1B/D receptors; contracts human cerebral arteries (EC50=100nM).Formula:C15H19N3O2Color and Shape:SolidMolecular weight:273.33A11
CAS:A11 (ANXA1-derived 11 amino acid–long peptide) serves as an inhibitor of the ANXA1-EphA2 interaction, reducing ANXA1 attachment to EphA2 while promoting the association of Cbl (an E3 ubiquitin ligase of EphA2) with EphA2. This peptide also effectively lowers EphA2 levels, greatly enhances EphA2 ubiquitination, and stimulates EphA2 internalization along with the colocalization of EphA2 and Cbl in nasopharyngeal carcinoma (NPC) cells. Moreover, A11 curtails NPC cell proliferation, migration, and invasion, and it suppresses angiogenesis.Formula:C53H88N14O19Color and Shape:SolidMolecular weight:1225.35[Lys8, Lys9]-Neurotensin (8-13)
CAS:[JMV438] is a Neurotensin analog, analgesic via NTS1/NTS2 activation, with K i of 0.33 nM (hNTS1) and 0.95 nM (hNTS2).Formula:C38H64N8O8Molecular weight:760.978Neuromedin S (human)
CAS:Neuromedin S (human) is a 33-amino acid neuropeptide identified as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1, acting onColor and Shape:SolidAP 811
CAS:AP 811: Selective NPR3 antagonist, Ki of 0.48 nM, >20,000x selective over NPR1, blocks ANP-induced pump stimulation.Formula:C46H66N12O8Color and Shape:SolidMolecular weight:915.11VIP(6-28)(human, rat, porcine, bovine)
CAS:VIP(6-28) blocks VIP-induced cAMP signaling in humans, rats, pigs, and cows.Formula:C126H207N37O34SPurity:98%Color and Shape:SolidMolecular weight:2816.28Vedaprofen
CAS:Vedaprofen (PM 150) is a COX-1 inhibitor with anti-inflammatory effects, blocking E. coli clamp at IC50 222 μM, Ki 131 μM.
Formula:C19H22O2Purity:99.24% - 99.70%Color and Shape:SolidMolecular weight:282.38LH-RH (4-10)
CAS:LH-RH (4-10), a heptapeptide from LHRH degradation, is made in macrophages and type II pneumocytes.Formula:C33H53N11O9Color and Shape:SolidMolecular weight:747.84MRS8209
MRS8209 is an antagonist of the serotonin receptor (serotonin receptor), with a Ki value of 4.27 nM specifically for 5-HT2BR. It provides protective effects on pulmonary airway opening pressure (PAO) and is applicable in pulmonary fibrosis studies.Formula:C17H19IN6O2Color and Shape:SolidMolecular weight:466.276Acetyl-(D-Arg2)-GRF (1-29) amide (human)
CAS:Acetyl-(D-Arg2)-GRF (1-29) amide (human) serves as an antagonist to growth hormone-releasing factor (GRF) and inhibits growth hormone (GH) secretion, withFormula:C154H255N47O43SMolecular weight:3485.03Neuropeptide W-23 (human) (TFA)
Neuropeptide W-23 (human) (NPW-23) TFA, representing the active form of Neuropeptide W, functions as an endogenous agonist for both NPBW1 (GPR7) and NPBW2 (GPR8Color and Shape:Odour Solid(D-His(Bzl)6)-LHRH (1-7) (free acid)
CAS:(D-His(Bzl)6)-LHRH (1-7) free acid is a synthetic peptide derived from luteinizing hormone-releasing hormone (LHRH). It achieves enhanced stability and biological activity through the introduction of non-natural amino acid residues at specific positions within the LHRH molecule. This modification extends the drug's half-life in the body, reduces its rate of rapid metabolism and clearance, and subsequently increases its efficacy in inhibiting cell proliferation.Formula:C53H62N12O11Molecular weight:1043.13PAMP-12(human, porcine) TFA
PAMP-12(human, porcine) TFA, a significant constituent of immunoreactive (ir)-PAMP, derives from the adrenomedullin precursor and functions as a potentColor and Shape:Odour SolidDapoxetine
CAS:Dapoxetine (Dapoxetina) is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.Formula:C21H23NOPurity:99.73%Color and Shape:White To Off-White Crystalline PowderMolecular weight:305.42AMK (hydrochloride)
CAS:AMK, a melatonin metabolite, scavenges oxygen, inhibits prostaglandin production, reduces lipid peroxidation, and affects Parkinson's in mouse studies.Formula:C12H17ClN2O3Color and Shape:SolidMolecular weight:272.73Atenolol
CAS:Atenolol (Tenormin) is a selective β1 receptor antagonist.Formula:C14H22N2O3Purity:99.07% - 99.95%Color and Shape:White Crystalline Powder SolidMolecular weight:266.34
