DNA/RNA Synthesis

<p>Folic acid (Vitamin B9) is a vitamin B9 that is essential for the synthesis of DNA/RNA and for the production new cells. Cost-effective and quality-assured.</p>

<p>DNA2 inhibitor C5 is a specific cancer sensitizer with an IC50 of 20 μM, targeting multiple DNA2 activities.</p>

<p>5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine.</p>

<p>Famciclovir (BRL 42810) inhibits Herpes virus DNA polymerase by mimicking nucleosides.</p>

<p>Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.</p>

<p>BAY-2402234: a selective DHODH inhibitor targeting myeloid cancers with low-nanomolar potency.</p>

<p>Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.</p>

<p>PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA</p>

<p>Procaine HCl is a benzoic acid derivative used as a local anesthetic, blocking nerve impulses and sensation.</p>

<p>DI-87 (TRE-515) is a novel and orally available dCK (deoxycytidine kinase) inhibitor. DI-87 binds to dCK reduces the production of dNTP inhibits tumor growth.</p>

<p>MALAT1-IN-1 is an effective dose-dependent Malat1 inhibitor, not altering Neat1 expression.</p>

<p>Ergocaliferol (Vitamin D2), derived from ergosterol by UV, inhibits bladder tumor promotion and leukemia, and blocks DNA Polymerase.</p>

<p>RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.</p>

<p>Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.</p>

<p>Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective and quality-assured.</p>

<p>Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein</p>

<p>Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.</p>

<p>DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.</p>

<p>TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.</p>

<p>Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.</p>

<p>Xanthopterin Hydrate is isolated from butterfly wings and could replace folic acid in the nutrition of many animal species.</p>

<p>Procaine (Vitamin H3) is a slow-acting ester local anesthetic with a short effect, used for infiltration, nerve, and spinal blocks.</p>

<p>Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.</p>

<p>Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM).</p>

<p>NMDI14 is an inhibitor of nonsense mediated RNA decay (NMD).</p>

<p>Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.</p>

<p>Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis.</p>

<p>Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially</p>

<p>Nedaplatin, a cisplatin derivative, induces tumor DNA damage (IC50: 94 μM) through platinum-DNA cross-links, causing apoptosis.</p>

<p>Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.</p>

<p>JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ.</p>

<p>Cinoxacin (Compound 64716), an older synthetic antimicrobial, was related to the quinolone class of antibiotics.</p>

<p>Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.</p>

<p>BMVC-8C3O is a DNA G-quadruplex (G4) ligand.Cost-effective and quality-assured.</p>

<p>N-Dodecyl-β-D-maltoside (Lauryl Maltoside) has also been employed in applications such as in the purification and stabilization of RNA polymerase and the</p>

<p>Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.</p>

<p>Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.</p>

<p>PZL-A, PZL-A, an activator of mtDNA synthesis, restored the activity of POLγ mutant variant.</p>

<p>Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH with antitumor activity. It has the potential to be a first-in-class candidate in AML.</p>

<p>Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.</p>

<p>Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage.</p>

<p>ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM).</p>

<p>Oxolinic acid (Nidantin) is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.</p>

<p>Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.</p>

<p>Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>

<p>Capecitabine is a prodrug in the antimetabolite class, transformed into cytotoxic 5-FU by tumor cells, inhibiting DNA and RNA synthesis.</p>

<p>Adenine: a purine nucleobase vital for ATP, NAD, FAD production, and DNA/RNA synthesis.</p>

<p>Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis.</p>

<p>Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.</p>

<p>Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.</p>

<p>Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis.</p>

<p>FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.</p>

<p>12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.</p>

<p>RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>

<p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>

<p>Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.</p>

<p>DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.</p>

<p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>

<p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>

<p>Remdesivir metabolite, antiviral nucleoside analog, effective against SARS-CoV and MERS-CoV.</p>

<p>Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.</p>

<p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>

<p>HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt inhibits pre-miR-21 RNA, potential for cancer research.</p>

<p>wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.</p>

<p>5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1].</p>

<p>16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.</p>

<p>Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.</p>

<p>5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.</p>

<p>R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.</p>

<p>5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.</p>

<p>5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.</p>

<p>5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.</p>

<p>Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].</p>

<p>Nitrosofolic acid is a folic acid derivaive.</p>

<p>GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.</p>

<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>

<p>5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>

<p>2'-(2-Nitrobenzyl)-ATP trisodium is an rATP analogue that acts as a transcription terminator. It inhibits T7 RNA polymerase from continuing RNA chain extension.</p>

<p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>

<p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>

<p>RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.</p>

<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>

<p>HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.</p>

<p>WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.</p>

<p>Chrexanthomycin C, orally active, binds DNA (G4C2)4 G4, Kd 2.8 mM, potential in ALS research.</p>

<p>IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.</p>

<p>Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.</p>

<p>Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.</p>

<p>ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.</p>

<p>SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.</p>

<p>PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.</p>

<p>5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while</p>

<p>Carbazole belongs to the class of carbazole-based organic compounds. Carbazole can form novel DNA small groove complexes, inhibiting the synthesis of new DNA or RNA.</p>

<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>

<p>CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infections</p>

<p>Lorutengitide is a transcription-regulating peptide with antiproliferative activity.</p>

<p>Ac-rC Phosphoramidite can modify phosphodisulfide oligonucleotides.</p>

<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>