Organometallic Ligands

<p>eIF4A3-IN-2 is a small molecule inhibitor targeting eIF4A3, which is a DEAD-box RNA helicase. This compound is synthesized from a chemical library designed to modulate RNA-binding proteins. Its mode of action involves binding to eIF4A3 to inhibit its helicase activity, thereby disrupting the process of nonsense-mediated mRNA decay and pre-mRNA splicing. This specific inhibition is particularly valuable for exploring the regulation of gene expression at the post-transcriptional level.</p>

<p>Please enquire for more information about PPZ2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>AMG 487 (S-enantiomer) is a selective CCR9 antagonist, which is a compound that inhibits the chemokine receptor CCR9. This receptor is primarily expressed in the gastrointestinal tract and is involved in the migration of T-cells. AMG 487 is synthesized through enantioselective methods in a laboratory setting, providing a high-purity compound suitable for research purposes.</p>

<p>Isatoribine monohydrate is a synthetic nucleoside analog, which is a derivative of the naturally occurring compound prodrug. It is sourced from the chemical modification of inosine, an endogenous compound in the body involved in purine metabolism. The mode of action of Isatoribine monohydrate involves the activation of the toll-like receptor 7 (TLR7) pathway, which is integral to the innate immune response. This activation results in the production of type I interferons and other cytokines that bolster antiviral defense mechanisms.</p>

<p>Aminopeptidase N inhibitor is a biochemical compound, often derived from synthetic sources, that selectively inhibits the activity of the enzyme aminopeptidase N (APN). APN is a metalloprotease involved in the hydrolysis of N-terminal amino acids from peptides and proteins. By binding to the active site of APN, this inhibitor effectively obstructs the enzyme's function, which can modulate a variety of physiological processes.</p>

<p>GSK2807 Trifluoroacetate is a selective inhibitor, specifically targeting the lysine acetyltransferase MYST3 (MOZ), which is derived synthetically through medicinal chemistry. This compound functions by competitively inhibiting the acetylation of histone lysine residues, crucial components in the regulation of gene expression through chromatin modification. The inhibition of MYST3 disrupts its role in facilitating transcriptional activation by modulating chromatin structure, thereby impairing the recruitment of transcription factors and other co-regulatory proteins essential for gene expression.</p>

<p>SG3199 is an advanced agricultural plant growth regulator, which is synthetically derived with effects mimicking those of natural auxins. Auxins are a class of plant hormones essential for growth regulation, so SG3199 provides critical support for optimizing developmental processes in crops. As a synthetic analog, it functions by modulating cell elongation and division through targeted interaction with cellular auxin receptors, thereby enhancing phenotypic characteristics, such as stem elongation, root initiation, and overall plant vigor.</p>

<p>BAY-545 is a small molecule inhibitor, which is synthetically developed with precise activity targeting cyclin-dependent kinases (CDKs). It serves as a critical advancement in understanding the pharmacological modulation of key regulatory proteins involved in cell cycle progression. BAY-545 exerts its effects by selectively inhibiting specific CDKs, thereby altering the phosphorylation status of downstream targets. This inhibition disrupts the cell cycle, leading to cell cycle arrest and potentially inducing apoptosis in cancerous cells.</p>

<p>SBI-0640756 is a chemical compound, which is derived from novel synthesis techniques with a specific focus on targeting cellular pathways. It functions as a small molecule modulator that influences lysosomal homeostasis by interacting with specific molecular targets involved in autophagy and cellular degradation processes.</p>

<p>18:1 PI(3,4,5)P3 is a phosphatidylinositol polyphosphate, which is a signaling lipid molecule derived from a glycerophospholipid source, commonly used in biochemical research. It is a product of the PI3K (phosphoinositide 3-kinase) pathway, where it acts as a secondary messenger involved in various cellular processes. This lipid plays a critical role in signal transduction by recruiting proteins with pleckstrin homology (PH) domains to the cell membrane, thereby modulating cell growth, proliferation, survival, and migration.</p>

<p>CXCR2 Antagonist IV, Sch527123, is a small molecule antagonist, which is a synthetic chemical compound with high specificity and affinity for the CXCR2 receptor. This receptor is primarily sourced from the leukocyte population, playing a significant role in the inflammatory response and immune cell trafficking.</p>

<p>GSK2981278 is a novel investigational product developed by GlaxoSmithKline. It is a potent and selective activator of the transcription factor Nrf2, derived through advanced medicinal chemistry and designed for targeted pharmacological effects. This compound functions by modulating the Nrf2 pathway, which plays a pivotal role in the cellular response to oxidative stress. By activating Nrf2, GSK2981278 aims to enhance the cellular defense systems, thereby mitigating oxidative damage.</p>

<p>M-110 is a high-pressure homogenizer, which is an advanced instrument primarily derived from mechanical engineering principles. This device operates by rapidly pushing a liquid sample through a narrow orifice under extremely high pressure, typically up to tens of thousands of psi, causing cell disruption and micronization due to intense shear forces and impact mechanisms. The high-pressure action facilitates precise particle size reduction and emulsification, allowing a uniform distribution of particles at the nanoscale.</p>

<p>CG347B is a synthetic glucocorticoid-receptor-binding molecule, which is derived from laboratory-based chemical synthesis focused on modulating glucocorticoid receptor pathways. This compound works through selective glucocorticoid receptor engagement, inducing changes in gene expression that replicate aspects of natural hormone binding but with distinct specificity and kinetics.</p>

<p>Irindalone is a pharmacological compound, classified as a dopamine antagonist, which is developed from synthetic chemical processes. Its mode of action involves the inhibition of dopamine receptors, particularly in the central nervous system. By blocking these receptors, Irindalone alters dopamine-mediated neurotransmission, which may modulate various neurological pathways.</p>

<p>BAY 1000394 is an investigational drug compound that functions as an oral anticoagulant. It originates from synthetic chemical processes designed to create potent and selective inhibitors of specific targets within the coagulation cascade. The mode of action involves the inhibition of Factor Xa, an essential enzyme in the coagulation pathway that catalyzes the conversion of prothrombin to thrombin, ultimately leading to fibrin clot formation. By targeting Factor Xa, BAY 1000394 effectively reduces the generation of thrombin, thereby diminishing the formation of pathologic clots without markedly altering existing fibrinogen levels.</p>

<p>GSK-239512 is a potent and selective histamine H3 receptor antagonist, which is a compound developed by GSK, derived from extensive pharmacological research. This organic compound acts by selectively inhibiting the H3 receptor subtype, which modulates the release of neurotransmitters in the central nervous system, including histamine, acetylcholine, and norepinephrine.<br><br>The pharmacological action of GSK-239512 involves attenuating the inhibitory action of histamine on neurotransmitter release, thereby increasing wakefulness and enhancing cognitive processes. This mechanism makes it a compelling candidate in the context of researching treatments for cognitive disorders such as Alzheimer's disease and attention-deficit hyperactivity disorder (ADHD).<br><br>In preclinical studies, GSK-239512 has demonstrated encouraging results in improving cognition and memory. Its application extends to experimental models where modulating central histaminergic pathways is explored for therapeutic benefits. Current investigations aim to determine its efficacy and safety profiles in human clinical trials, where it continues to be pivotal in understanding histaminergic neuromodulation's role in cognitive enhancement and neuroprotection.</p>

<p>SKA-121 is a synthetic antimicrobial peptide, which is derived from a combinatorial library of synthetic peptides. The source of SKA-121 involves bioengineering techniques to mimic naturally occurring antimicrobial peptides, enhancing their stability and efficacy. Its mode of action involves disrupting bacterial cell membranes, leading to cell lysis and death. This disruption is primarily due to the peptide's amphipathic nature, allowing it to integrate into lipid bilayers, destabilizing the membrane structure. SKA-121 is utilized in various applications including antibacterial coatings, infection control, and as a research tool to study microbial resistance mechanisms. Its versatile application extends to medical devices, surfaces, and potential therapeutic options where bacterial infection poses substantial challenges. The efficacy of SKA-121 against multidrug-resistant strains underlines its importance as a research focus for developing next-generation antimicrobials.</p>

<p>Glutathione S-transferase is an enzyme, which is a member of a family of enzymes found in many organisms, including humans, plants, and bacteria. It plays a crucial role in the detoxification process by catalyzing the conjugation of the antioxidant molecule glutathione to various electrophilic compounds. This conjugation reaction facilitates the conversion of lipophilic toxins and metabolites into more water-soluble forms, which can then be excreted from the body.</p>

<p>Pentapotassium, 2-[2-[2-[6-[bis(carboxylatomethyl)amino]-2,3-difluorophenoxy]ethoxy]-N-(carboxylatomethyl)-4-(2,7-dichloro-3-oxido-6-oxoxanthen-9-yl)anilino]acetate is a specialized chemical compound used in advanced biochemical and biomedical research. This compound is synthesized through a series of complex organic reactions involving the integration of carboxylate groups, fluorinated aromatic structures, and xanthenes. Such structural components are critical for its ion-binding properties and fluorescent characteristics.</p>

<p>3-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-yne is a polyether-based alkyne azide compound, which is a synthetic chemical reagent commonly used within the fields of chemical biology and materials science. This compound is derived from the azide-alkyne Huisgen cycloaddition reaction principles, often known as "click chemistry." Its mode of action involves the azide group, which can participate in efficient and selective reactions with terminal alkynes under copper-catalyzed conditions, leading to the formation of stable 1,2,3-triazole linkages.</p>

<p>TC-G 1000 is a thermoconductive gel, synthesized from synthetic polymer composites with high thermal conductivity properties. This product is designed to enhance heat dissipation in high-performance electronic devices. Leveraging advanced polymer technology, TC-G 1000 effectively bridges the gap between heat-generating components and cooling solutions, ensuring optimal thermal management.</p>

<p>K 114 is a selective herbicide, which is a synthetic chemical intervention designed to target and manage unwanted plant species in agricultural settings. Derived from advanced chemical synthesis processes, it ensures high purity and efficacy in real-world applications. The mode of action involves the inhibition of key enzymatic pathways crucial for the survival and growth of broadleaf and grassy weeds, thereby effectively hindering their development without affecting the desired crops.</p>

<p>Please enquire for more information about FGTI-2734 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Asp 2535 is a sodium hypochlorite-based compound, which is a chlorine-releasing agent with potent antimicrobial properties. It originates from the oxidation of sodium chloride and displays its efficacy through the release of hypochlorous acid upon dissolution in water. This mode of action involves the disruption of essential cellular processes in microorganisms, including protein synthesis and nucleic acid structure, ultimately leading to cell death.</p>

<p>FGH10019 is an enzyme formulation, which is derived from recombinant DNA technology, with a highly specific catalytic mode of action. This enzyme functions by selectively cleaving peptide bonds in protein substrates, enabling precise modification and degradation of target proteins. The source of FGH10019 is a genetically engineered strain of *Escherichia coli*, optimized for high yield and activity.</p>

<p>CDKI-73 is a selective cyclin-dependent kinase (CDK) inhibitor, which originates from targeted medicinal chemistry efforts aimed at modulating cell cycle progression. This compound operates through the inhibition of specific CDK enzymes, crucial regulators of the cell cycle, and transcriptional processes. By selectively targeting these kinases, CDKI-73 disrupts the phosphorylation events necessary for cell cycle progression, thereby inducing cell cycle arrest and promoting apoptosis in cancer cells.</p>

<p>PCNA, His tagged human, is a recombinant protein that plays a critical role in DNA replication and repair, serving as a pivotal component of the DNA replication machinery. It is derived from a human source and is produced using recombinant DNA technology, with a His-tag for purification and detection purposes. The His-tag is a polyhistidine sequence that facilitates purification through affinity chromatography, allowing for high purity and specificity in experimental applications.</p>

<p>Paricalcitol-d6 is a stable isotope-labeled analog of paricalcitol, which is a synthetic vitamin D analog. It is designed with deuterium atoms, serving as an isotopic variant to assist in precise analytical measurements. The source of Paricalcitol-d6 involves synthetic chemical processes, meticulously incorporating six deuterium atoms to replace hydrogen atoms in the original paricalcitol structure.</p>

<p>DPM-1001 is a bioactive synthetic compound, classified as a small molecule inhibitor, which is derived from targeted chemical synthesis and optimization processes. It functions through the inhibition of specific enzymatic pathways that are critical in cellular signaling cascades. The mode of action involves binding to the active site of the target enzyme, thereby preventing its normal substrate interaction and subsequent downstream signaling. This mechanism allows for the modulation of specific biochemical pathways, making it a powerful tool in cellular research.</p>

<p>AMG 337 is a small molecule inhibitor, which is derived from synthetic chemical processes, with a mode of action involving the selective inhibition of the c-Met receptor tyrosine kinase. The c-Met receptor, also known as hepatocyte growth factor receptor, plays a critical role in various cellular processes such as proliferation, survival, and motility. Dysregulation of c-Met signaling is implicated in several types of cancers, making it a significant therapeutic target.</p>

<p>Gardiquimod is a synthetic imidazoquinoline, which is a small molecule produced through chemical synthesis. Its primary mode of action involves binding to Toll-like receptor 7 (TLR7), a pattern recognition receptor that plays a pivotal role in the innate immune response. Through this interaction, Gardiquimod activates antigen-presenting cells such as dendritic cells and macrophages, leading to the production of type I interferons and other inflammatory cytokines.</p>

<p>MM-589 TFA is a synthetic compound, which is an engineered chemical designed for biochemical research. It is derived from synthetic organic chemistry, providing a pure and controlled source for experimental applications. The mode of action for MM-589 TFA involves the modulation of the biosynthesis pathway of fatty acids. It acts by interfering with key enzymes involved in the elongation and desaturation steps, thereby altering lipid profiles within cells.</p>

<p>1-tert-Butyl-3-[2-(3-methoxyphenoxy)-5-nitrophenyl]sulfonylurea is a highly specialized sulfonylurea herbicide. It is synthetically derived from intricate chemical processes involving phenoxy and nitrophenyl compounds. The mode of action involves the inhibition of the acetolactate synthase (ALS) enzyme in susceptible plants. This inhibition disrupts the biosynthesis of branched-chain amino acids, leading to the cessation of cell division and growth in the targeted weed species.</p>

<p>(E)-2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one is a synthetically derived organic compound, which serves as a selective inhibitor of specific protein kinases. It is synthesized through a series of organic reactions including condensation and amination, primarily in research laboratories focusing on medicinal chemistry.</p>

<p>Inhibitor of ADAM10 metalloprotease</p>

<p>N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(pyridin-4-yl)benzoyl)piperidine-3-carboxamide is an advanced fluorinated piperidine derivative often used in biochemical research and drug development. This compound is synthesized through intricate organic chemistry techniques that typically involve multi-step processes designed to achieve precise structural functionalities. Its mode of action is based on interacting with target receptors or enzymes in biological systems, possibly altering their activity in a highly selective manner.</p>

<p>Velagliflozin is an investigational pharmaceutical compound, which is a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is derived from synthetic chemical sources, specifically designed for the modulation of glucose levels in the bloodstream. Velagliflozin functions by inhibiting the SGLT2 protein in the proximal renal tubules, thereby preventing glucose reabsorption in the kidney and promoting its excretion through urine. This mechanism of action effectively lowers blood glucose levels and provides an adjunct therapeutic approach in the management of type 2 diabetes mellitus.</p>

<p>Erk1/2 inhibitor 2 is a selective small molecule inhibitor designed to target and inhibit the activity of the extracellular signal-regulated kinases 1 and 2 (Erk1/2). These kinases are critical components of the mitogen-activated protein kinase (MAPK) signaling pathway, which is integral to regulating various cellular processes, including proliferation, differentiation, and survival. The source of Erk1/2 inhibitor 2 is synthetic, produced through meticulous organic synthesis techniques specifically tailored to enhance its selectivity and potency.</p>

<p>Tenidap is a synthetic anti-inflammatory drug, which is derived from the chemical modification of nonsteroidal anti-inflammatory drugs (NSAIDs). It functions as both a cyclooxygenase (COX) inhibitor and a modulator of cytokine production. This dual mode of action allows Tenidap to simultaneously reduce the synthesis of prostaglandins by inhibiting COX enzymes and suppress the production of pro-inflammatory cytokines like interleukin-1 and tumor necrosis factor. This makes it unique compared to traditional NSAIDs.</p>

<p>Ren-1869 hydrochloride is a highly selective renin inhibitor, which is a synthetic compound used extensively in cardiovascular research. As a chemically synthesized molecule, it is designed to specifically target and inhibit renin, an enzyme critical in the renin-angiotensin-aldosterone system (RAAS). This system plays a significant role in blood pressure regulation and electrolyte balance.</p>

<p>Inhibitor of calpain and cathepsin B</p>

<p>1,2-Distearoyl-sn-glycero-3-phosphoinositol ammonium is a synthetic phospholipid utilized in numerous scientific and medical applications. It is derived from glycerophospholipids, which are integral components of cellular membranes. These phospholipids can be synthesized to include specific fatty acids like stearic acid to enhance their functional properties.</p>

<p>Cevipabulin fumarate is a synthetic chemical compound, which is a small molecule derived from chemical synthesis with potent antineoplastic properties. It functions as a microtubule stabilizer, binding to the colchicine binding site on beta-tubulin, thereby disrupting the dynamic instability of microtubules. This disruption inhibits the polymerization and depolymerization of tubulin dimers, ultimately arresting the cell cycle and inducing apoptosis in cancer cells.</p>

<p>Pep2m, myristoylated, is a synthetic lipopeptide that acts as a research tool, derived from biochemical synthesis methods. It is myristoylated to facilitate membrane association, utilizing the lipophilic properties of the myristoyl group, which enhance its interaction with cell membranes or synthetic vesicles. The primary mode of action involves the insertion of the myristoylated moiety into lipid bilayers, influencing membrane dynamics and protein-membrane interactions.</p>

<p>Brilacidin is a synthetic antimicrobial peptide mimetic, which is derived from the host defense proteins found in nature. It functions by mimicking the mechanism of these peptides, disrupting microbial cell membranes and inhibiting biofilm formation. The compound destabilizes the phospholipid bilayer of bacterial membranes, leading to increased permeability and subsequent cell death.</p>

<p>Tryphos(R) is a specialized solvent and extractant, derived from organophosphorus compounds. This product originates from a chemically synthesized source, characterized by the complex manipulation of phosphorus chemistry to achieve its specific functional properties. Its mode of action involves the selective solvation and coordination with target molecules, which facilitates the separation or purification of specific compounds via liquid-liquid extraction processes.</p>

<p>1-Desoxymethylsphinganine-d5 is a deuterated sphingolipid analog, which is synthesized as an isotopically labeled compound for use in advanced biochemical research. The analog is derived from natural sphingolipids, with the hydrogen atoms replaced by deuterium to facilitate tracking and quantification in mass spectrometry applications. This modification allows researchers to discriminate the labeled compound from endogenous sphingolipids within cellular systems.</p>

<p>LY2794193 is a dual inhibitor that serves as a small molecule compound, which is synthesized through advanced organic chemistry techniques. Its mode of action involves the inhibition of specific protein tyrosine kinases, which are critical in the signaling pathways that regulate cellular proliferation and survival. These kinases play significant roles in oncogenic processes and immune responses.</p>

<p>GSK-J5 Hydrochloride is a potent small-molecule inhibitor, which is synthesized through chemical processes aimed at targeting specific inflammatory pathways. The source of this compound lies in its development from molecular research focused on modulating the bromodomain and extra-terminal (BET) family of proteins.</p>

<p>ML241 is a small molecule inhibitor, which is derived from a chemical synthesis process aimed at developing compounds for targeted cancer therapies. With a specific mode of action as a selective antagonist, ML241 inhibits cancer cell growth by targeting a specific signaling pathway or protein involved in cell proliferation. This targeted inhibition allows scientists to explore the molecular mechanisms within tumor environments and investigate potential therapeutic strategies that could be extended to clinical applications. ML241 is utilized primarily in preclinical studies, serving as a crucial tool in elucidating the pathways contributing to oncogenesis and evaluating the efficacy and specificity of cancer therapeutics. Researchers employ this compound to analyze cellular responses, genetic expressions, and the impact of pathway interference, thereby advancing our understanding of cancer biology and potential treatment avenues.</p>

<p>3a-MPLA is a synthetic lipid A derivative, which is derived from the lipopolysaccharide of Gram-negative bacterial outer membranes, specifically from the lipid A structure. Its mode of action involves the modulation of the immune response through interaction with Toll-like receptor 4 (TLR4) on immune cells. By activating TLR4, 3a-MPLA stimulates a controlled release of pro-inflammatory cytokines, aiding in the fine-tuning of the immune system without overactivation.</p>

<p>PF-06305591 is an investigational drug that functions as a selective antagonist of the neuronal nitric oxide synthase (nNOS) enzyme. It is derived from synthetic chemical sources designed to inhibit the production of nitric oxide in neural tissues. By specifically inhibiting nNOS, this compound reduces the nociceptive signaling pathways associated with pain and inflammation.</p>

<p>CMK is a potent cell-permeable protein kinase inhibitor, derived from a synthetic chemical source, designed to effectively intervene in kinase signaling pathways. Its mode of action involves specific inhibition of protein kinases through competitive binding at the ATP-binding site, thus preventing phosphorylation events critical to numerous cellular processes.</p>

<p>Proxalutamide is a non-steroidal antiandrogen, which is a compound derived from synthetic chemical processes with a mode of action that involves selective antagonism of androgen receptors. This action effectively inhibits the binding of androgen hormones, such as testosterone, which are critical for the growth and survival of certain types of cancer cells, particularly in prostate cancer.</p>

<p>SA 57 is a synthetic antimicrobial agent, which is a laboratory-engineered compound with a specialized mode of action targeting bacterial cell wall synthesis. By disrupting the structural integrity of the bacterial cell wall, SA 57 effectively compromises cellular stability, leading to bacterial cell death. Its precise interference with peptidoglycan synthesis confers it high specificity and efficacy against a broad spectrum of bacterial strains.</p>

<p>LP 533401 is a small molecule compound, which functions as a selective antagonist of the lysophosphatidic acid receptor 1 (LPA1). This compound is derived through synthetic chemical processes designed to interact specifically with the G protein-coupled receptor LPA1. By competitively inhibiting the binding of lysophosphatidic acid (LPA) to LPA1, LP 533401 effectively alters downstream signaling pathways.</p>

<p>GSK3145095 is a small molecule inhibitor, which is a synthetic compound developed by GlaxoSmithKline. It functions as a targeted inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1), a crucial mediator in the signaling pathways that control inflammation and cell death. The source of GSK3145095 is a chemical synthesis designed to inhibit the kinase activity associated with RIPK1.</p>

<p>MLCK inhibitor peptide 18 is a synthetic peptide, which is derived from a specific sequence known to inhibit myosin light chain kinase (MLCK) activity. This peptide is designed based on a targeted approach to block the enzymatic functions of MLCK, a critical enzyme involved in phosphorylating myosin light chains, which plays a fundamental role in regulating smooth muscle contraction and cell motility.</p>

<p>(2R)-N-[4-[2-[(4-Morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide is a small molecule inhibitor, which is synthetically derived and designed to interfere with specific protein kinase pathways that are crucial for cancer cell proliferation. The compound exerts its effect by targeting and inhibiting the activity of a distinct set of kinases, thereby disrupting downstream signaling pathways essential for tumor growth and survival.</p>

<p>GNE-495 is a small molecule inhibitor, which is synthetically derived through medicinal chemistry processes. Its mode of action involves targeting specific kinase pathways that are crucial for the proliferation and survival of cancer cells. By inhibiting these kinases, GNE-495 disrupts signaling pathways, leading to reduced tumor growth and potential apoptosis in malignant cells.</p>

<p>AT-007 is an investigational pharmaceutical compound, which is a small molecule inhibitor derived from advanced synthetic chemistry processes. It functions through the inhibition of aldose reductase, a key enzyme involved in the polyol pathway. By impeding this enzyme, AT-007 effectively reduces the accumulation of harmful sugar alcohols in cells, which otherwise contribute to cellular damage and the pathophysiology of certain metabolic disorders.</p>

<p>CGP 52411 is an experimental monoclonal antibody, which is a biologically derived product designed to interact with specific molecular targets in the body. It acts by binding to certain neuroreceptors or proteins, potentially modulating neurological pathways and processes. This mode of action makes it a prime candidate for exploring neuroprotection and therapeutic interventions in neurology research.</p>

<p>TyK2-IN-2 is a selective inhibitor that targets the Tyrosine Kinase 2 (TYK2) signaling pathway, a critical component of the Janus kinase (JAK) family involved in cytokine signaling. This compound has been derived through meticulous chemical synthesis, aimed at achieving high specificity and potency. Its mode of action involves selectively inhibiting the TYK2 enzyme, thereby disrupting the downstream signaling cascades that are pivotal in various immune responses.</p>

<p>Please enquire for more information about GNE-3511 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>WY 45233 Succinate is a pharmacological compound, specifically an experimental hypolipidemic agent. It is derived from synthetic medicinal chemistry efforts aimed at modulating lipid profiles in the body. The compound operates by activating peroxisome proliferator-activated receptors (PPARs), which play a crucial role in the regulation of lipid metabolism and adipogenesis. Through this mechanism, WY 45233 Succinate enhances the oxidation of fatty acids and modulates the expression of genes involved in lipid transport and homeostasis.</p>

<p>Desacetyloxyethyl (E)-cefuroxime axetil is a semi-synthetic cephalosporin antibiotic, which is derived from naturally occurring cephalosporins and modified to enhance its pharmacokinetic properties. This compound is an orally administrable prodrug of cefuroxime, which is itself a second-generation cephalosporin. The prodrug form ensures better absorption in the gastrointestinal tract, leading to higher bioavailability of the active antibiotic.</p>

<p>Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene is an organic compound, which is a synthetic derivative of naphthalene. It is commonly synthesized through sulfonation processes that incorporate methoxybenzenesulfonamide groups into the naphthalene structure. This compound functions by facilitating interactions with specific molecular targets, which may enable further modifications or explorations within a research context.</p>

<p>Jatropholone B is a diterpenoid compound, which is a type of organic substance characterized by its multi-ring chemical structure. It is sourced from plants belonging to the genus Jatropha, commonly found in tropical and subtropical regions. The mode of action of Jatropholone B involves disrupting cellular processes, particularly by inhibiting cellular proliferation and inducing apoptosis in cancer cells. This is achieved through the modulation of various signaling pathways, leading to its potential use as an anticancer agent.</p>

<p>Resmetirom, also known as MGL-3196, is a promising drug for the treatment of hyperlipidemia and nonalcoholic steatohepatitis (NASH)(now known as metabolic dysfunction-associated steatohepatitis (MASH). It is an orally active, liver-directed, selective thyroid hormone receptor-beta agonist. Resmetirom works by targeting the thyroid hormone receptor-beta to regulate hepatic triglyceride and cholesterol metabolism, thereby reducing hepatic fat content. In clinical trials, resmetirom has shown significant reductions in liver fat content in patients with NASH without major side effects. Additionally, resmetirom has been found to improve atherogenic dyslipidemia associated with NASH by positively impacting triglyceride and LDL cholesterol levels.</p>

<p>AMBMP Hydrochloride is a synthetic compound, specifically designed for research purposes in the field of neuroscience. This compound is derived from a series of carefully crafted chemical reactions, typically originating from a laboratory setting specializing in organic synthesis. Its primary mode of action is as a selective ligand targeting specific receptors within the central nervous system, allowing researchers to investigate receptor function and signaling pathways with precision.</p>

<p>CATPB is an arylphosphobetaine, which is a zwitterionic compound, synthesized through advanced chemical synthesis techniques. This product functions by facilitating controlled radical polymerization processes. Its mechanism involves transitioning between different ionic states, which acts as a regulatory process permitting precise control over polymer growth and architecture.</p>

<p>Cardanol monoene is a phenolic lipid, which is a natural derivative obtained from cashew nut shell liquid. It is sourced from the renewable agricultural by-product of the Anacardium occidentale, allowing for a sustainable means of production. Its chemical structure features a phenolic ring with an aliphatic chain, which imparts unique properties that facilitate its mode of action.</p>

<p>13:0 Lyso PC is a lysophosphatidylcholine, which is a phospholipid derivative. It is typically sourced from natural phospholipids that undergo enzymatic hydrolysis, resulting in the removal of one fatty acid chain. This process leaves behind a single fatty acid chain attached to the glycerophosphocholine backbone. The specific fatty acid associated with 13:0 Lyso PC is tridecanoic acid.</p>

<p>The (rac)-PT2399 is an integrated circuit that functions as an analog/digital delay processor. It is sourced from audio electronics and designed with a focus on low-cost applications where time-based audio effects are needed. The mode of action involves using its internal digital processing capabilities to delay audio signals, typically in the range of 30 to 340 milliseconds. This is achieved by sampling the input audio signal, converting it into a digital format, processing the delay, and then reverting it back to an analog output.</p>

<p>Super-TDU is a synthetic transcriptional modeling compound derived from plant-based precursors, designed to facilitate the study of gene expression regulation. It functions by mimicking natural transcription factors, permitting detailed exploration of transcriptional control mechanisms.</p>

<p>JAK2 inhibitor with potential antineoplastic activity</p>

<p>Bunaprolast is a pharmaceutical compound that serves as a potent phosphodiesterase inhibitor. It is synthetically derived and exhibits its action by selectively inhibiting the breakdown of cyclic nucleotides, such as cyclic AMP (cAMP) and cyclic GMP (cGMP), within the cell. This mechanism effectively elevates the intracellular concentrations of these second messengers, leading to physiological effects such as vasodilation and reduction in inflammatory responses.</p>

<p>Roflumilast-d4 is a deuterium-labeled derivative of the PDE4 inhibitor roflumilast, which is commonly used as a stable isotope-labeled internal standard in pharmacokinetic and metabolic studies. This compound is synthesized through the strategic incorporation of deuterium atoms, providing enhanced stability and traceability while maintaining the pharmacological properties of its non-labeled analog.</p>

<p>Please enquire for more information about MSP3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Methyl gamma-linolenyl fluorophosphonate is a specialized biochemical tool utilized within scientific research. This compound is synthesized through the chemical modification of gamma-linolenic acid, a fatty acid predominantly sourced from plant oils such as evening primrose oil, borage oil, and black currant seed oil. The fluorophosphonate group is strategically incorporated to inhibit serine hydrolases, a class of enzymes involved in various metabolic pathways.</p>

<p>2-(2,2,2-Trifluoroethyl)-5'-[(E)-3-[4-(trifluoromethyl)piperidin-1-yl]prop-1-enyl]spiro[1,2,5-thiadiazolidine-4,13'-tricyclo[8.2.1.0^3,8^]trideca-3(8),4,6-triene] 1,1-dioxide is a synthetic compound characterized by its complex spirocyclic structure and multiple trifluoromethyl groups. This type of compound is typically derived through a series of advanced organic synthesis techniques involving multiple reaction steps to achieve its intricate molecular architecture. The presence of trifluoromethyl groups suggests enhanced metabolic stability and increased lipophilicity, which are desirable traits in drug design.</p>

<p>AZ 6102 is a photoresist, typically utilized in the photolithography process. It is a chemically synthesized material, tailored for the precise patterning required in microfabrication. Its mode of action involves a photosensitive chemical composition that undergoes a structural change upon exposure to specific wavelengths of light, often ultraviolet. This change in molecular structure allows the exposed areas to be selectively dissolved by a developer solution, while the unexposed areas remain intact.</p>

<p>CCF-642 is a synthetic antimicrobial compound designed for use in laboratory and clinical research settings. It is derived through chemical synthesis, utilizing a combination of heterocyclic structures and functional groups that enhance its activity against a range of bacterial pathogens. CCF-642 operates by disrupting bacterial cell wall synthesis, interfering with peptidoglycan cross-linking, which ultimately leads to cell lysis and death. It maintains efficacy in both gram-positive and gram-negative bacteria, making it a versatile tool in microbiological studies.</p>

<p>AP20187 is a synthetic small molecule that functions as a chemical dimerizer, originating from the FKBP-binding domain technology. Its mode of action relies on promoting the dimerization of proteins fused with FKBP domains. This dimerization process triggers downstream signaling pathways or protein interactions within cells, providing a tool for controlled manipulation of cellular processes.</p>

<p>06:0 PI(3,4,5)P3 is a synthetic phosphoinositide analog, which is typically obtained from laboratory synthesis utilizing phospholipid precursor molecules. Its mode of action involves mimicking the naturally occurring phosphatidylinositol (3,4,5)-trisphosphate (PIP3), allowing it to interact with specific intracellular signaling proteins. This product serves as a valuable tool for scientists investigating cellular signaling pathways, especially those involving the regulation of diverse cellular processes such as cell growth, proliferation, and survival.</p>

<p>Cjb 090 dihydrochloride hydrate is a potent inhibitor of Protein Kinase C (PKC), which plays a crucial role in cellular signaling pathways. Derived through chemical synthesis, Cjb 090 selectively targets and inhibits PKC activity, thereby disrupting signal transduction mechanisms involved in cell growth, differentiation, and apoptosis.</p>

<p>TC-I 2014 is a specific chemical compound known as a selective inhibitor, which is derived from microbial sources. It operates by selectively inhibiting a particular protein or signaling pathway, thereby modulating cellular processes. This compound is often used in biochemical and cellular biology research to dissect and understand complex signaling networks within cells. By selectively blocking certain pathways, researchers can identify and study the role of specific proteins in biological processes and disease mechanisms.</p>

<p>GDC-0575 is a small molecule inhibitor that specifically targets the Ataxia-Telangiectasia and Rad3-related protein (ATR) kinase. This compound, developed from a synthetic chemical source, functions by selectively inhibiting the ATR kinase, a key regulator of the DNA damage response pathway. By binding to the active site of ATR, GDC-0575 disrupts its ability to activate downstream effectors involved in DNA repair processes.</p>

<p>Ceapin-A7 is a small molecule inhibitor, which is derived from chemical synthesis, targeting the ATF6 arm of the unfolded protein response (UPR). It functions by selectively inhibiting ATF6α signaling, a critical pathway activated during endoplasmic reticulum (ER) stress. The mode of action involves binding to ATF6α, preventing its transport to the Golgi apparatus, and thereby inhibiting its subsequent cleavage and activation.</p>