Organometallic Ligands
In this category, you will be able to find a large number of organometallic molecules used as ligands in biomolecules. These organometallic ligands can be used in organic chemistry and synthesis in the laboratory. They play a critical role in forming coordination complexes and catalyzing various chemical reactions. At CymitQuimica, we offer a diverse selection of high-quality organometallic ligands to support your research and industrial needs.
Subcategories of "Organometallic Ligands"
- Buchwald Ligands(22 products)
- DPEN(4 products)
- DPHEN(4 products)
- JOSIPHOS(4 products)
- Phosphine(497 products)
- Porphirines(75 products)
Found 2889 products of "Organometallic Ligands"
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NAcM-OPT
CAS:Inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line.Formula:C23H29Cl2N3OPurity:Min. 95%Color and Shape:solid.Molecular weight:434.4 g/mol6-Thioguanine - Bio-X ™
CAS:6-Thioguanine is a purine analog used in the therapy for leukemia and for remission consolidation in patients with acute nonlymphocytic anemia. This drug also has antimetabolite action. It replaces guanine during DNA replication. This substitution disrupts the accurate pairing of DNA bases, leading to errors in DNA replication and hinders cell division.Formula:C5H5N5SPurity:Min. 95%Color and Shape:PowderMolecular weight:167.19 g/molML 210
CAS:Inhibitor of glutathione peroxidase GPX4Formula:C22H20Cl2N4O4Purity:Min. 95%Color and Shape:SolidMolecular weight:475.32 g/molPF 05214030
CAS:PF 05214030 is a biosimilar monoclonal antibody, which is sourced from recombinant DNA technology and designed to inhibit tumor necrosis factor-alpha (TNF-α). This product functions by binding to TNF-α, a cytokine that plays a critical role in mediating inflammation. By preventing TNF-α from interacting with its receptors on cell surfaces, PF 05214030 effectively reduces the inflammatory response associated with various autoimmune and inflammatory conditions.
Formula:C17H13Cl2FN2O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:431.3 g/molFTBMT
CAS:FTBMT is a GPR52 receptor agonist with an EC50 value of 71 nM. Studies demonstrate antipsychotic-like effects of FTBMT in murine models of schizophrenia. FTBMT elicits beneficial effects on cognitive processes such as spatial working memory and long-term memory in mice.Formula:C19H16F4N4OPurity:Min. 95%Color and Shape:PowderMolecular weight:392.35 g/molEptifibatide acetate
CAS:Controlled ProductInhibits platelet glycoprotein IIb/IIIa receptorsFormula:C35H49N11O9S2·xC2H4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:831.96 g/molLY 411575
CAS:Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.Formula:C26H23F2N3O4Purity:Min. 95%Color and Shape:SolidMolecular weight:479.48 g/molNicardipine HCl - Bio-X ™
CAS:Nicardipine is calcium channel blocker drug that is used for the treatment of hypertension and angina. This drug can also be used in the treatment of asthma and is said to enhance the action of various antineoplastic agents.Formula:C26H29N3O6•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:515.99 g/molAtorvastatin sodium salt - Bio-X ™
CAS:Atorvastatin is an HMG-CoA reductase inhibitor which is used to lower lipid levels and to reduce the risk of cardiovascular disease. This drug belongs to the class of medicines called statins. It lowers abnormal levels of cholesterol and lipids to reduce the risk of cardiovascular disease by inhibiting the enzyme HMG-CoA.Formula:C33H35FN2O5•NaPurity:(%) Min. 95%Color and Shape:PowderMolecular weight:581.63 g/molEnzalutamide
CAS:Androgen receptor antagonist
Formula:C21H16F4N4O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:464.4 g/molBenazepril HCl - Bio-X ™
CAS:Benazepril is a nonsteroidal anti-inflammatory drug that can be used to treat hypertension, heart failure and renal failure. It is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II. This inhibition prevents the vasoconstrictive effects of this peptide, which are mediated through activation of the renin-angiotensin system.Formula:C24H28N2O5•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:460.95 g/molPentoxifylline
CAS:Controlled ProductPhosphodiesterase inhibitorFormula:C13H18N4O3Purity:Min. 95%Color and Shape:White PowderMolecular weight:278.31 g/molAnabaseine
CAS:Natural neurotoxinFormula:C10H12N2Purity:Min. 95%Color and Shape:Dark Green To Brown LiquidMolecular weight:160.22 g/molAmlodipine besylate - Bio-X ™
CAS:Amlodipine is a calcium channel blocker that is used to treat hypertension and angina. This drug inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle.
Formula:C20H25ClN2O5•C6H6O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:567.05 g/molt-TUCB
CAS:t-TUCB is a potent soluble epoxide hydrolase (sEH) inhibitor, which is a chemically synthesized compound. The mode of action of t-TUCB involves the inhibition of sEH, an enzyme responsible for the degradation of epoxyeicosatrienoic acids (EETs). By inhibiting sEH, t-TUCB effectively increases the levels of EETs, which are signaling molecules involved in numerous physiological processes, including inflammation, blood pressure regulation, and pain perception.Formula:C21H21F3N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:438.4 g/molPYR 41
CAS:PYR-41 is a small molecule inhibitor, which is sourced from chemical synthesis. It functions primarily by targeting ubiquitin-activating enzymes, particularly the E1 enzyme, to disrupt the ubiquitination process. This mechanism effectively hampers the transfer of ubiquitin to substrate proteins, thereby modulating protein degradation and signaling pathways.Formula:C17H13N3O7Purity:Min. 95%Molecular weight:371.3 g/molTriptolide
CAS:Inhibits RNAPII-mediated trasncription; immunosuppressant; anti-inflammatoryFormula:C20H24O6Purity:Min. 97 Area-%Color and Shape:PowderMolecular weight:360.4 g/molMPEP
CAS:mGluR5 antagonist
Formula:C14H11NPurity:Min. 95%Color and Shape:White/Off-White SolidMolecular weight:193.24 g/molBuserelin acetate
CAS:Controlled ProductAgonist of hypothalamic neuropeptide LHRHFormula:C62H90N16O15Purity:Min. 95%Color and Shape:PowderMolecular weight:1,299.48 g/molMianserin HCl - Bio-X ™
CAS:Controlled ProductMianserin is a tetracyclic antidepressant drug that has antihistaminic and hypnosedative properties. It is used to treat depression in adults and children, as well as other disorders such as chronic pain and irritable bowel syndrome. This drug’s mechanism of action is not fully understood but is said to block alpha-adrenergic, histamine H1 and serotonin receptors.Formula:C18H20N2•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:300.83 g/molMethotrexate
CAS:Methotrexate is a chemotherapeutic and immunosuppressive medication, which is a synthetic analog of folic acid. Its source is through chemical synthesis, mimicking the structure of dihydrofolate in order to exert its effects. Methotrexate acts primarily by inhibiting the enzyme dihydrofolate reductase (DHFR), leading to a decrease in tetrahydrofolate production. This disruption in folate metabolism results in the inhibition of DNA, RNA, and protein synthesis, which affects rapidly dividing cells.Methotrexate is employed broadly in clinical oncology as an antineoplastic agent, particularly in the treatment of leukemias, lymphomas, breast cancer, and osteosarcoma. Additionally, it serves as a cornerstone for managing autoimmune diseases such as rheumatoid arthritis and psoriasis, where it helps modulate the aberrant immune response. The dual role of Methotrexate in oncology and immunosuppression underscores its versatility and critical importance in therapeutic regimens. However, its use demands careful monitoring due to potential adverse effects on non-cancerous cells and organ systems, necessitating precise dosage management and patient evaluation.Formula:C20H22N8O5Color and Shape:Yellow PowderMolecular weight:454.44 g/molNaftopidil - Bio-X ™
CAS:Naftopidil is an alpha adrenergic antagonist drug that is used to treat urinary symptoms and conditions related to benign prostatic hypertrophy. This drug works to relax smooth muscles by inhibiting alpha adrenergic receptors, thus allowing an improvement in urine flow.Formula:C24H28N2O3Purity:Min. 95%Color and Shape:PowderMolecular weight:392.49 g/molAZD 9291
CAS:A potent inhibitor of EGFR with sensitizing and T790M resistance mutations, selective over the wild-type form of the receptor. Causes tumour regression in EGFR mutant T790M transgenic and xenograft models in vivo.Formula:C28H33N7O2Purity:Min. 97%Color and Shape:SolidMolecular weight:499.61 g/molTafluprost
CAS:Prostanoid receptor agonist
Formula:C25H34F2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:452.53 g/molSB 269970 hydrochloride
CAS:Serotonin (5-HT7) receptor antagonist; anti-psychoticFormula:C18H28N2O3S·HClPurity:Min. 95%Color and Shape:PowderMolecular weight:388.95 g/molSAG
CAS:Smoothened agonist and activator of the Hedgehog signalling pathway with EC50 of 3 nM. SAG binds to the Smoothened heptahelical bundle and antagonises effects of the Smoothened antagonist cyclopamine. In previous studies, SAG activated neurogenesis and neuronal survival in cell and animal models as well as improved cell differentiation of human induced pluripotent cells into the neuronal lineage.Formula:C28H28ClN3OSPurity:Min. 95%Color and Shape:White PowderMolecular weight:490.06 g/molAMG 9810
CAS:Vanilloid receptor 1 antagonistFormula:C21H23NO3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:337.41 g/mol(-)-Huperzine A
CAS:Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFormula:C15H18N2OPurity:(%) Min. 98%Color and Shape:PowderMolecular weight:242.32 g/molPD 169316
CAS:Inhibitor of p38 kinase
Formula:C20H13FN4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:360.34 g/molVerapamil HCl - Bio-X ™
CAS:Verapamil is drug that belongs to the class of drugs known as calcium channel blockers. It is used to treat high blood pressure, angina and other cardiovascular disorders. It works by relaxing the blood vessels so that blood can flow more easily. It does this by inhibiting the calcium ion influx through slow channels into conductile, contractile myocardial cells and vascular smooth muscle cells.Formula:C27H38N2O4•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:491.06 g/molPimasertib
CAS:A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Formula:C15H15FIN3O3Purity:Min. 95%Color and Shape:White To Yellow SolidMolecular weight:431.2 g/molFeprazone
CAS:Anti-inflammatory; inducer of P450 II B familyFormula:C20H20N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:320.39 g/molA 769662
CAS:Allosteric activator of AMP-activated protein kinase (AMPK) acting on the AMPK-β subunit with therapeutic potential in metabolic disorders such as diabetes, obesity, etc. A769662 also blocks the differentiation of mouse embryonic stem cells (mESCs) and maintains the mESCs in naïve state even in the absence of leukemia inhibitory factor (2i/L).Formula:C20H12N2O3SPurity:Min. 95%Color and Shape:SolidMolecular weight:360.39 g/molGW 833972A
CAS:A cannabinoid receptor agonist, which binds more selectively to CB2 than CB1 receptors (1000-fold). GW833972A inhibits vagus nerve depolarization induced by tussive agents, such as hypertonic saline (EC50 = 6.5 μM), capsaicin (EC50 = 33.9 μM) or PGE2 (EC50 = 15.9 μM).Formula:C18H13ClF3N5OPurity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:407.78 g/molFluvastatin sodium
CAS:Fluvastatin is a statin that lowers blood cholesterol and triglycerides by inhibiting HMG-CoA reductase, an enzyme that plays a critical role in the synthesis of cholesterol. Fluvastatin has also been shown to reduce the incidence of myocardial infarction, and to reduce atherosclerotic lesions in animal models, reducing the incidence of cardiovascular disease. Fluvastatin also has been shown to inhibit the activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS), which may be related to its anti-inflammatory effects. Furthermore, through lowering blood cholesterol, Fluvastatin also inhibits tubulointerstitial injury and prevents renal damage caused by high concentrations of the lipid.
Formula:C24H25FNNaO4Purity:Min. 98%Color and Shape:Off-White PowderMolecular weight:433.45 g/molFurosemide - Bio-X ™
CAS:Controlled ProductFurosemide is a potent loop diuretic that is used in the treatment of hypertension, liver cirrhosis, renal disease and heart failure. This drug acts on the kidney to increase water loss from the body. It inhibits electrolyte reabsorption. Furosemide also exerts vasodilatory effects.
Formula:C12H11ClN2O5SPurity:Min. 95%Color and Shape:PowderMolecular weight:330.74 g/molTacrolimus - Bio-X ™
CAS:Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.
Formula:C44H69NO12Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:804.02 g/molLoratadine - Bio-X ™
CAS:Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.Loratadine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C22H23ClN2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:382.88 g/molMalotilate - Bio-X ™
CAS:Malotilate is a pharmacological agent that is used to treat symptoms of hepatitis, bowel disease, and collagen diseases. This drug reduces collagen synthesis and cell migration activity of fibroblasts in vitro. It also has been shown to facilitate liver regeneration in rats.Formula:C12H16O4S2Purity:(%) Min. 95%Color and Shape:PowderMolecular weight:288.39 g/molI-RW
The peptide IRW, characterised from egg protein, exhibits inhibitory properties against the angiotensin converting enzyme (ACE2) and could be used to prevent cardiovascular disease with further research. Treatment of hypertensive mice with IRW induced endothelium-dependent vasorelaxation and reduced vascular inflammation. The IRW tripeptide acts as anti-hypertensive by upregulating ACE2 activity via the Mas receptor (MasR) and upregulating Akt/eNOS signalling in the aorta. IRW also induces superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity. These may play a factor in IRW's role as an anti-inflammatory. IRW shows promise as a nutraceutical for inflammatory conditions and a tool for drug development in cardiovascular disease.Purity:Min. 95%Molecular weight:1,830.9 g/molRamipril - Bio-X ™
CAS:Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. It is used in the treatment of high blood pressure, congestive heart failure and other cardiovascular diseases. Ramipril inhibits the conversion of angiotensin I to angiotensin II by blocking ACE, which lowers blood pressure and reduces fluid retention.This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C23H32N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:416.51 g/molNalmefene hydrochloride
CAS:Controlled ProductOpioid receptor antagonistFormula:C21H25NO3•HClPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:375.89 g/molR-Rolipram
CAS:Inhibitor of PDE4 enzyme; anti-inflammatory
Formula:C16H21NO3Purity:Min. 95%Color and Shape:PowderMolecular weight:275.34 g/mol(S)-Mephenytoin - Bio-X ™
CAS:(S)-Mephenytoin is a substrate of cytochrome P450 enzyme CYP2C19 (a hydroxylase). It is an effective anticonvulsant that improves control of seizures in patients. According to studies, the drug exhibits a genetic polymorphism in CYP2C19 that results in reduced metabolism in some individuals.Formula:C12H14N2O2Purity:Min. 97 Area-%Color and Shape:White PowderMolecular weight:218.25 g/molDocetaxel - Bio-X ™
CAS:Docetaxel is an antineoplastic agent that is used to treat various cancers such as breast and prostate cancer. This drug interferes with the normal function of microtubule growth. It is an anti-mitotic drug used in chemotherapy. Research has shown that this drug also induces programmed cell death in cancer cells.Formula:C43H53NO14Purity:Min. 90 Area-%Color and Shape:White/Off-White SolidMolecular weight:807.88 g/molAcid alpha-glucosidase (83-99), human
Acid α-glucosidase (83-99) (human) is derived from the exogenous enzyme which degrades glycogen, maltose and isomaltose through targeting alpha -1,4 and alpha -1,6 linkages. Once synthesised in its precursor form, within the Golgi it is glycosylated and acquires mannose 6-phosphate residues. This allows it to be transported to the Lysosome in a multistep process.Pompe disease, also known as glycogen storage disease type II, can be diagnosed through the absence of acid α-glucosidase activity within patients. Therefore glycogen degradation in the lysosome is inhibited by this autosomal recessive disorder. This results in the accumulation of glycogen and tissue destruction, hence contributing to the pathologies of muscle weakness and respiratory failure, associated with infantile onset and adult onset Pompe disease.Purity:Min. 95%Molecular weight:1,844.9 g/molAminopterin
CAS:Aminopterin is an antineoplastic agent and antifolate, which is a synthetic derivative of pteroylglutamic acid. It functions as a chemotherapeutic agent by inhibiting dihydrofolate reductase, an enzyme crucial in the folic acid pathway, thereby preventing the conversion of dihydrofolate to tetrahydrofolate. This disruption leads to impaired synthesis of purine nucleotides and thymidylate, which are essential for DNA synthesis and cell division.Formula:C19H20N8O5Purity:Min. 97 Area-%Color and Shape:Slightly Yellow PowderMolecular weight:440.41 g/molN-Trityl candesartan cilexetil
CAS:Angiotensin II receptor antagonist
Formula:C52H48N6O6Purity:Min. 95%Color and Shape:PowderMolecular weight:852.97 g/molOxaprozin - Bio-X ™
CAS:Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis and rheumatoid arthritis. This drug relieves swelling and inflammation by inhibiting the enzyme cyclooxygenase which in turn inhibits prostaglandin synthesis.Formula:C18H15NO3Purity:Min. 95%Color and Shape:PowderMolecular weight:293.32 g/mol
