Metabolismo

<p>Acetazolamide D3 is a deuterium-labeled Acetazolamide. Acetazolamide is a potent carbonic anhydrase inhibitor.</p>

<p>SN-38 glucuronide, inactive product of Irinotecan, aids in colon/rectal cancer research as a topoisomerase I inhibitor.</p>

<p>Fmoc-Dab(Boc)-OH is a chemical intermediate used for chemical synthesis.</p>

<p>Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.</p>

<p>Maltose phosphorylase (MP) is a dimeric enzyme that catalyzes the conversion of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose.</p>

<p>Compound 9j inhibits Glyoxalase I with 1.13 μM IC50, showing anticancer potential and low toxicity.</p>

<p>21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.</p>

<p>Lysine monohydrate is a bioactive chemical.</p>

<p>NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of inhibitor of Eya2(Eya2 ED and MBP-Eya2 FL with IC50s of 3 μM and 6.9 μM ).</p>

<p>N-Desethyl Oxybutynin D5 hydrochloride is the the active metabolite Oxybutynin, is deuterium labeled N-Desethyl Oxybutynin hydrochloride.</p>

<p>CP-316819 (GPi 819) is a glycogen phosphorylase (GPase) inhibitor with hypoglycemic properties and is used in the study of hyperglycemia.</p>

<p>Debrisoquine is an antihypertensive drug similar to guanethidine.</p>

<p>PKUMDL-WQ-2201 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with Anti-tumor Activity, it binds to site II.</p>

<p>Pravastatin lactone, a non-enzymatic stomach derivative of pravastatin, inhibits HMG-CoA reductase and stems from mevastatin.</p>

<p>4-Carboxypyrazole is an endogenous metabolite.</p>

<p>Fmoc-N(Hmb)-Gly-OH (Fmoc-(Hmb)Gly-OH) is a glycine derivative that can be used to synthesize peptide compounds.</p>

<p>1,10-Diiododecane: Crosslinks polygalacturonic acid, alkylates bis-cryptophanes, produces decane at 20°C.</p>

<p>Glyoxalase I inhibitor (free base), a candidate for anticancer agents, is a potent Glyoxalase I (GLO1) inhibitor.</p>

Acetaminophen metabolite 3-hydroxy-acetaminophen is an antioxidant and a non-toxic microsomal metabolite of acetaminophen, suitable for metabolic studies.

<p>alpha-Amyl cinnamaldehyde is a common additive in the perfume and cosmetic industry as an aroma substance.</p>

<p>Fmoc-Lys(Tfa)-OH is a peptide, a lysine derivative with an Fmoc protective group on the α-amino group, widely used in biochemical experiments.</p>

<p>N'-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N'-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N'-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2<br>1.Hecht, S.S.Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesChem. Res. Toxicol.11(6)559-603(1998) 2.Yuan, J.-M., Knezevich, A.D., Wang, R., et al.Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersCarcinogenesis32(9)1366-1371(2011)</p>

<p>Migalastat hydrochloride (GR181413A) 是一种可口服且具有有效和竞争性的 α-galactosidase A 抑制剂，可促进α-半乳糖苷酶A向溶酶体的运输，可用于研究法布里病。</p>

<p>L,L-Dityrosine hydrochloride, also known as o,o'-Dityrosine hydrochloride, is a compound found in acid hydrolysates of various biological materials, notably the</p>

<p>Glycerophosphoinositol lysine fights dandruff, inflammation, aging, and reduces UVB-induced PGE in NHEK cells.</p>

<p>Malondialdehyde tetrabutylammonium serves as a biomarker with antioxidant properties, and is extensively used in both the food and cosmetics industries primarily for monitoring and assessing product stability and safety. It acts as an indicator of lipid peroxidation, aiding in the evaluation of oxidative stress levels. Additionally, this compound has significant implications for indicating cellular damage and is investigated as a potential biomarker for various diseases.</p>

<p>Atrial natriuretic factor (1-28) (human, porcine) TFA exhibits antihypertensive activity by promoting sodium and urine excretion. It inhibits the release of adrenocorticotropic hormone (ACTH) and β-endorphin by suppressing pro-opiomelanocortin (POMC) expression. Additionally, it elevates cGMP levels in RMIC cells, with an IC50 of 1.2 nM.</p>

<p>Isethionic acid, organosulfur, in F. cylindrus, forms biodegradable surfactants; water-soluble, high-foaming.</p>

<p>HFI-142 is a inhibitor to aminopeptidase N; inhibit leukotriene A4 biosynthesis in red blood cells; inhibit dditional aminopeptidases.</p>

<p>3-Phenoxybenzoic acid is a natural product for research related to life sciences. The catalog number is T35359 and the CAS number is 3739-38-6.</p>

<p>Z-Asn-OH (N-Cbz-L-asparagine) is a glycine derivative mainly used in peptide synthesis.Cbz-Asn-OH prevents unwanted reactions.</p>

<p>ALDH3A1-IN-1 (Compound 18) is a potent inhibitor of ALDH3A1 with IC50 of 1.61 μM, outperforms DEAB in prostate cancer cells.</p>

<p>Vitamin D3-d3 is a deuterated compound of Vitamin D3.</p>

<p>NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is used in the study of diabetes.</p>

<p>2-Amino-3-mercaptopropanoic acid hydrochloride hydrate is a cysteine derivative, widely used in biochemical experiments and drug synthesis research.</p>

<p>Lead salicylate is a combustion chemical.</p>

Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.

<p>Diacetolol is the major metabolite of acebutolol, a selective beta blockers used to treat hypertension, angina pectoris and arrhythmia.</p>

<p>BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.</p>

<p>Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH aids in creating SiFA-octreotate, used for PET tumor imaging.</p>

<p>Isavuconazole D4 is a deuterium labeled Isavuconazole. Isavuconazole is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi.</p>

<p>Enalaprilat D5 Sodium Salt is the deuterium labeled Enalaprilat, which is an angiotensin-converting enzyme (ACE) inhibitor.</p>

<p>Crocin IV (Dicrocin), a crocetin glycoside belonging to the carotenoid pigments, exhibits significant antioxidant activity [1].</p>

<p>Angiotensin-converting enzyme (Kininase II) is a zinc-dependent peptidase and extracellular enzyme that is a potent vasoconstrictor.</p>

<p>SDH-IN-1 (compound 4i) is an SDH (succinate dehydrogenase) inhibitor (IC50 = 4.53 μM) with antifungal activity against S. sclerotiorum fungicidal purposes.</p>

<p>Autotaxin modulator 1 is a new modulator of Autotaxin.</p>

<p>Cadisegliatin (TTP-399) may activate liver GK to lower blood sugar in type 2 diabetes studies.</p>

Diethyl terephthalate is an agent that is used in the production of polyesters.

<p>Gemcitabine triphosphate (dFdCTP), a cell metabolite, aids tumor imaging and measures drug uptake/retention.</p>

<p>Lauroyl alanine is a fatty acid amide. It may be used to support the physical gelation of binary mixtures of aliphatic and aromatic hydrocarbon solvents.</p>

<p>N-Hippuryl-His-Leu hydrate (N-Benzoyl-Gly-His-Leu hydrate) is an ACE substrate and can be used as a model peptide for measuring ACE-I inhibitory activity.</p>

<p>A12B4C3 is a selective inhibitor of hPNKP phosphatase.</p>

<p>Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH is a dipeptide.</p>

<p>D-Gluconic acid (D-Gluco-hexonic acid) is a carboxylic acid that has antiseptic and chelating properties through oxidation.</p>

<p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>

<p>PACOCF3, a phospholipase A2 inhibitor, hinders Ca2+ signaling with an IC50 of 3.8 μM in renal cells.</p>

<p>Imidazol-1-yl-acetic acid is a natural product used in life sciences research (Catalog No. T67657, CAS No. 22884-10-2).</p>

<p>ALDH1A3-IN-3 inhibits ALDH1A3 (IC50: 0.26 μM), acts on ALDH3A1, and is used in prostate cancer research.</p>

<p>4-(Trifluoromethyl)-L-phenylalanine is a phenylalanine derivative suitable for biochemical experiments and drug synthesis research.</p>

<p>Dihydrotachysterol (HSDB 3314) is a vitamin D analog.Dihydrotachysterol has been used to study hypocalcemic hypoparathyroidism after surgical removal of the parathyroid glands and growth impairment in children with chronic renal insufficiency.</p>

<p>3,5-Dimethylbenzaldehyde has broad-spectrum antimicrobial activity, inhibiting Bacillus subtilis, Pseudomonas albicans, Escherichia coli, Pseudomonas aeruginosa</p>

<p>Fmoc-N-Me-Val-OH is a modified peptide.</p>

<p>Cyhalofop-butyl is an ACCase (acetyl-coenzyme A carboxylase) inhibitor and herbicide that suppresses plant lipid synthesis at the meristematic level.</p>

<p>Fmoc-Ala-OH is a protected alanine derivative used in solid-phase peptide synthesis, solar cell studies, and charge transfer and recombination.</p>

Protoporphyrin IX disodium, as a radiation sensitizer, enhances the production of ROS and induces DNA damage even under hypoxic conditions. It also acts as a photosensitizer, undergoing direct degradation through photobleaching upon light exposure. This compound accumulates in rat tumor cells following administration of 5-aminolevulinic acid (5-ALA). When activated with a peak wavelength of 405 nm, Protoporphyrin IX disodium selectively improves basal cell carcinoma. It shows promise in pharmacological research of sonodynamic and photodynamic therapy for cancers such as bladder cancer and nodular basal cell carcinoma.

<p>(R)-Methyl 2-amino-2-cyclohexylacetate HCl is a glycine derivative that can be used to synthesize biologically active molecules such as inhibitors.</p>

<p>D-Leu-Ty hydrateis a tyrosine derivative commonly used in drug synthesis and biochemistry research.</p>

<p>Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin.</p>

<p>D,L-3-indolylglycine, a tryptophan analog, is used in protein design and can replace tryptophan in peptidomimetics.</p>

<p>N-Acetyl-L-histidine monohydrate is a natural product for research related to life sciences. The catalog number is T38094 and the CAS number is 39145-52-3.</p>

<p>M6, an oxidative metabolite of Dasatinib, is a potent oral inhibitor of Bcr-Abl and Src tyrosine kinases.</p>

<p>Fmoc-L-glutamic acid 5-tert-butyl ester (Fmoc-Glu(OtBu)-OH) is a glutamic acid derivative.</p>

<p>Calcium Stearate is a potent Alternative to Poly(vinyl alcohol) in Poly-Lactic-co-Glycolic Acid Nanoparticles Synthesis.</p>

<p>11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid capable of being found in Saccharomyces cerevisiae (KD115).</p>

<p>2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos), a fucosyltransferase inhibitor, inhibits salivary acidification in an inflammatory mode</p>

<p>Mebeverine alcohol D5 is the deuterium labeled Mebeverine alcohol.</p>

<p>Compound Fr14500 is a natural product for research related to life sciences. The catalog number is Fr14500 and the CAS number is 14667-55-1.</p>

<p>Bz-Arg-OEt.HCl is an amino acid derivative of L-arginine exhibiting binding activity towards Protein-arginine deiminase type-4 (Km=475.2 µM).</p>

<p>TMX-4100,PDE6D degrader (DC50 &lt;200 nM). Used in multiple myeloma research.</p>

<p>Boc-His-OH is a protected amino acid derivative.N-Boc-L-Histidine is used as an intermediate in peptide synthesis with good chemical stability and solubility.</p>

<p>Fmoc-N-Me-Ile-OH is a used in peptide synthesis.</p>

<p>Methyl acetyl-L-cysteinate (N-Acetyl-L-cysteine methyl ester) is a cysteine derivative that is used in biosynthesis and is associated with body metabolism and</p>

<p>N-Desmethyl Clomipramine-d is the deuterium labeled N-Desmethyl Clomipramine.</p>

<p>IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO.</p>

<p>BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.</p>

<p>T-2307 is an antibiotic commonly used against Candida, exhibiting broad-spectrum antifungal activity against most pathogenic fungi in vitro and in vivo</p>

<p>DL-Homocysteic acid is a useful organic compound for research related to life sciences. The catalog number is T124757 and the CAS number is 504-33-6.</p>

<p>(R)-Leucic acid is an metabolite of amino acid.</p>

Glycyl-L-phenylalanine (Gly-L-Phe) is a dipeptide peptide transport in tracheal epithelial cells degraded in mucosal fluids skin aging and moisturizing.

<p>Fmoc-Tyr(tBu)-OH is a protected amino acid for solid-phase peptide synthesis, enabling Leu-EnkephalinAmide formation and versatile amino acid derivatives.</p>

<p>(R,R)-(+)-Hydrobenzoin is a organocatalysts.</p>

<p>β-Methyl L-aspartate hydrochloride (L-Aspartic acid β-methyl ester hydrochloride) is an aspartic acid derivative commonly used to synthesize various compounds</p>

<p>Anselamimab is a humanized IgG1κ monoclonal antibody targeting SAA1 and removes amyloid depositss and is an APP(β-amyloid A4 Protein Precursor ) inhibitor.</p>

<p>Metoxuron is a phenylurea herbicide. It is used to control annual gramineous weeds and broadleaf weeds in wheat, barley and carrot fields.</p>

<p>(E)-10-Hydroxynortriptyline (E-10-OH-NT) has anxiolytic activity with affinity for muscarinic acetylcholine receptors.</p>

<p>TLK117 is an inhibitor of GSTs that reduces the severity of pulmonary fibrosis and may be used in the study of idiopathic pulmonary fibrosis.</p>

<p>L-Homocysteine thiolactone hydrochloride is neurotoxic and can induce epilepsy and Alzheimer's disease.</p>

<p>Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl) compound inhibits coagulation factor Xa, useful for thrombotic conditions study.</p>

<p>Fmoc-Phe(4-NH2)-OH (Fmoc-4-Amino-L-phenylalanine) is a phenylalanine derivative used in research on supramolecular hydrogels.</p>