Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(116 products)
- CDK(547 products)
- Cell Cycle Arrest(5 products)
- Chk(48 products)
- DYRK(46 products)
- Dynamin(27 products)
- Ferroptosis(227 products)
- HSP(180 products)
- Integrin(276 products)
- Kinesin(87 products)
- LIM Kinase(21 products)
- Microtubule Associated(273 products)
- PKC(127 products)
- PLK(25 products)
- ROCK(61 products)
- Rho(6 products)
- Wee1(14 products)
- c-Myc(77 products)
Show 10 more subcategories
Found 3923 products of "Cell Cycle/Checkpoint"
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FDI-6
CAS:FDI-6 is an effective and selective inhibitor of FOXM1 that blocks DNA binding. FDI-6 binds to the FOXM1 protein and downregulates FOXM1-activated genes.Formula:C19H11F4N3OS2Purity:98.92% - >99.99%Color and Shape:SolidMolecular weight:437.43Ref: TM-T4005
1mg34.00€5mg74.00€1mL*10mM (DMSO)84.00€10mg114.00€25mg192.00€50mg274.00€100mg408.00€200mg597.00€Aplidine
CAS:Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM).Formula:C57H87N7O15Purity:99.86%Color and Shape:SolidMolecular weight:1110.34Ref: TM-T9715
1mg235.00€5mg588.00€10mg787.00€1mL*10mM (DMSO)938.00€25mg1,216.00€50mg1,568.00€100mg2,527.00€Levofloxacin hydrochloride
CAS:Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Formula:C18H21ClFN3O4Purity:99.78% - 99.98%Color and Shape:SolidMolecular weight:397.8Clevudine
CAS:Clevudine (Levovir) fights HBV, blocks viral DNA synthesis, and has a long half-life reducing relapse risk after treatment.Formula:C10H13FN2O5Purity:99.88% - 99.97%Color and Shape:SolidMolecular weight:260.22Ara-G
CAS:Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.Formula:C10H13N5O5Purity:98.74%Color and Shape:Slightly Off White To White PowderMolecular weight:283.24Simeprevir
CAS:Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.Formula:C38H47N5O7S2Purity:99.45% - 99.92%Color and Shape:SolidMolecular weight:749.94Quarfloxin
CAS:Quarfloxin (CX-3543), a fluoroquinolone, inhibits neuroblastoma with nanomolar IC50, disrupting nucleolin and G-quadruplex DNA.Formula:C35H33FN6O3Purity:99.77%Color and Shape:SolidMolecular weight:604.67Ref: TM-T16703
1mg71.00€2mg92.00€5mg152.00€1mL*10mM (DMSO)212.00€10mg236.00€25mg380.00€50mg530.00€100mg708.00€CID-797718
CAS:CID-797718 is a protein kinase D1 (PKD1) inhibitor.Formula:C12H11NO3Purity:98.91% - 99.21%Color and Shape:SolidMolecular weight:217.22Ref: TM-T1858
1mg62.00€5mg138.00€1mL*10mM (DMSO)152.00€10mg200.00€25mg339.00€50mg482.00€100mg665.00€200mg893.00€MNS
CAS:MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.Formula:C9H7NO4Purity:98.53%Color and Shape:Yellow PowderMolecular weight:193.16Carotegrast methyl HCl
CAS:Carotegrast methyl (AJM300/PTC-100) is an oral α4 integrin blocker reducing inflammation and experimental colitis.Formula:C25H20Cl3N3O5Color and Shape:SolidMolecular weight:548.801CID755673
CAS:CID755673 inhibits PKD (IC50: 182 nM), with selectivity over PLK1, AKT, CAMKIIα, CAK, PKC.Formula:C12H11NO3Purity:97.68% - 99.84%Color and Shape:SolidMolecular weight:217.22URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formula:C27H27N5Purity:99.32% - 99.98%Color and Shape:SolidMolecular weight:421.54APY29
CAS:APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.Formula:C17H16N8Purity:96.51% - 98.46%Color and Shape:SolidMolecular weight:332.36Ref: TM-T3654
2mg40.00€5mg62.00€1mL*10mM (DMSO)67.00€10mg90.00€25mg167.00€50mg285.00€100mg515.00€500mg1,071.00€iRGD peptide
CAS:iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Formula:C35H57N13O14S2Purity:98.77%Color and Shape:SolidMolecular weight:948.04Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Formula:C29H26FN5O4SPurity:97.45% - 99.4%Color and Shape:SolidMolecular weight:559.61CX-5461 dihydrochloride
CX-5461 dihydrochloride: Oral Pol I inhibitor, HCT-116 (IC50: 142 nM), A375 (IC50: 113 nM), MIA PaCa-2 (IC50: 54 nM), weak on Pol II (IC50 ≥ 25 μM).Formula:C27H29Cl2N7O2SColor and Shape:SolidMolecular weight:586.54Favipiravir
CAS:Favipiravir is a potent and selective RNA-dependent RNA polymerase inhibitor for the treatment of influenza virus infections.Cost-effective and quality-assured.Formula:C5H4FN3O2Purity:97.32% - 99.90%Color and Shape:SolidMolecular weight:157.1SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Formula:C18H15ClN6OS2·CH4O3SPurity:99.44% - 99.92%Color and Shape:SolidMolecular weight:527.04WR99210 hydrochloride(47326-86-3 free base)
CAS:WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.Formula:C14H19Cl4N5O2Purity:97.77% - 99.8%Color and Shape:SolidMolecular weight:431.14Ref: TM-T17257L
1mg62.00€5mg132.00€1mL*10mM (DMSO)157.00€10mg200.00€25mg338.00€50mg497.00€100mg708.00€200mg954.00€WNK-IN-11
CAS:WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)Formula:C21H21Cl2N5OSPurity:98.32%Color and Shape:SolidMolecular weight:462.4Ref: TM-T5456
1mg87.00€5mg172.00€1mL*10mM (DMSO)188.00€10mg280.00€25mg474.00€50mg683.00€100mg964.00€500mg1,918.00€3'-Deoxyguanosine
CAS:3'-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors.Formula:C10H13N5O4Purity:98.85% - 98.96%Color and Shape:SolidMolecular weight:267.24NU2058
CAS:NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.Formula:C12H17N5OPurity:99.34% - 99.92%Color and Shape:SolidMolecular weight:247.3Ref: TM-T3186
10mg42.00€1mL*10mM (DMSO)47.00€25mg78.00€50mg106.00€100mg160.00€200mg230.00€500mg378.00€DHFR-IN-3
CAS:DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.Formula:C8H7BrN4Purity:99.521% - 99.65%Color and Shape:SolidMolecular weight:239.07Didox
CAS:Didox (NSC-324360), a synthetic RR inhibitor, lowers oxidative injury markers in HIV-related dementia.Formula:C7H7NO4Purity:99.83%Color and Shape:SolidMolecular weight:169.13Phosphonoformic acid trisodium salt hexa
CAS:Phosphonoformic acid trisodium salt hexa (Sodium phosphonatoformate hexahydrate) is an antiviral drug for the treatment of CMV retinitis.Formula:CH12Na3O11PPurity:98%Color and Shape:SolidMolecular weight:300.03BSJ-03-123
CAS:BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.Formula:C47H56N10O11Purity:97.78% - 99.38%Color and Shape:SolidMolecular weight:937.01Ref: TM-T5395
1mg87.00€2mg113.00€5mg177.00€10mg259.00€25mg409.00€50mg560.00€100mg800.00€500mg1,611.00€T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Formula:C19H14F3N3O3Purity:98.39% - 99.57%Color and Shape:SolidMolecular weight:389.33NSAH
CAS:NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Formula:C18H14N2O3Purity:99.27%Color and Shape:SolidMolecular weight:306.32Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Formula:C31H43F6N9O12Purity:95.28% - ≥95%Color and Shape:SolidMolecular weight:847.72PfDHODH-IN-1
CAS:PfDHODH-IN-1 is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase(PfDHODH) which catalyzes the rate-limiting step for DNA and RNA biosynthesis.Formula:C14H11F3N2O2Purity:99.87%Color and Shape:SolidMolecular weight:296.24Ref: TM-T12438
1mg52.00€1mL*10mM (DMSO)92.00€5mg101.00€10mg152.00€25mg295.00€50mg447.00€100mg658.00€200mg888.00€HALOFUGINONE LACTATE
CAS:HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.Formula:C19H23BrClN3O6Purity:99.70% - 99.96%Color and Shape:SolidMolecular weight:504.8Ref: TM-T8785
2mg39.00€5mg56.00€1mL*10mM (DMSO)63.00€10mg89.00€25mg123.00€50mg197.00€100mg294.00€200mg437.00€GAK inhibitor 49 hydrochloride
Potent GAK inhibitor 49 hydrochloride: ATP-competitive, highly selective, Ki=0.54 nM, IC50=56 nM, binds to RIPK2.Formula:C20H23ClN2O5Color and Shape:SolidMolecular weight:406.86STF-083010
CAS:STF-083010 is a selective inhibitor of the IRE1α endonuclease.Formula:C15H11NO3S2Purity:98.09% - 99.45%Color and Shape:SolidMolecular weight:317.38Ref: TM-T6681
5mg49.00€1mL*10mM (DMSO)55.00€10mg75.00€25mg114.00€50mg193.00€100mg349.00€200mg527.00€500mg767.00€TP-353
CAS:TP-353 (EOS-61973) is a CDK7 inhibitor.Formula:C35H30FNO3Purity:99.12%Color and Shape:SolidMolecular weight:531.62Ref: TM-T22440
1mg43.00€5mg80.00€1mL*10mM (DMSO)105.00€10mg129.00€25mg225.00€50mg314.00€100mg432.00€200mg597.00€Tirapazamine
CAS:Tirapazamine (Win59075) triggers apoptosis in hypoxic cells by damaging DNA and enhances effects of radiation and cisplatin.Formula:C7H6N4O2Purity:96.65% - 99.87%Color and Shape:Orange-Red Crystalline PowderMolecular weight:178.15LDN-192960 hydrochloride
CAS:LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.Formula:C18H22Cl2N2O2SPurity:98%Color and Shape:SolidMolecular weight:401.35Ro5-3335
CAS:Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins.Formula:C13H10ClN3OPurity:99.42% - 99.87%Color and Shape:SolidMolecular weight:259.69LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Formula:C16H12FN5OColor and Shape:SolidMolecular weight:309.3ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formula:C21H25N7Purity:97.63% - ≥95%Color and Shape:SolidMolecular weight:375.47AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Formula:C18H18Cl2F3N5O4Color and Shape:SolidMolecular weight:496.27IXA4
CAS:IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1.Formula:C24H28N4O4Purity:99.8% - 99.85%Color and Shape:SolidMolecular weight:436.5BI-1347
CAS:BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.Formula:C22H20N4OPurity:96.7% - 99.63%Color and Shape:SolidMolecular weight:356.42Ref: TM-T5405
1mg40.00€1mL*10mM (DMSO)87.00€5mg88.00€10mg126.00€25mg240.00€50mg439.00€100mg647.00€500mg1,359.00€COH29
CAS:COH29 is an oral RNR-blocking thiazole that may reduce DNA synthesis and promote apoptosis, with potential cancer-treating properties.Formula:C22H16N2O5SPurity:97.04% - 98.92%Color and Shape:SolidMolecular weight:420.44Ref: TM-T3157
1mg34.00€2mg49.00€5mg74.00€1mL*10mM (DMSO)82.00€10mg113.00€25mg178.00€50mg334.00€100mg557.00€200mg790.00€Fialuridine
CAS:Fialuridine (DRG-0098), a DNA polymerase inhibitor, shows strong anti-HBV effects both in vitro and in vivo.Formula:C9H10FIN2O5Purity:99.71% - 99.88%Color and Shape:Less Crystals Colourless CrystalsMolecular weight:372.09XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Ref: TM-T17267
1mg52.00€2mg73.00€5mg94.00€1mL*10mM (DMSO)104.00€10mg141.00€25mg244.00€50mg371.00€100mg552.00€5'-Deoxy-5-fluorocytidine
CAS:5'-Deoxy-5-fluorocytidine is an intermediate metabolite of the DNA synthesis inhibitor capecitabine.Formula:C9H12FN3O4Purity:99.67%Color and Shape:White SolidMolecular weight:245.21SRI-29329
CAS:SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Formula:C20H26ClN7Purity:99.18%Color and Shape:SolidMolecular weight:399.92BRD32048
CAS:BRD32048 is a top candidate ETV1 perturbagen. BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation.Formula:C16H22N6OPurity:99.87%Color and Shape:SolidMolecular weight:314.39Ref: TM-T23820
1mL*10mM (DMSO)44.00€2mg50.00€5mg105.00€10mg172.00€25mg304.00€50mg485.00€100mg782.00€200mg1,054.00€NSC23005
CAS:NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).Formula:C13H17NO4SPurity:>99.99%Color and Shape:SolidMolecular weight:283.34Ibezapolstat
CAS:Ibezapolstat (ACX-362E) is an antibiotic with antibacterial activity that inhibits Clostridium difficile.Formula:C18H20Cl2N6O2Purity:98% - 99.429%Color and Shape:SolidMolecular weight:423.3Ref: TM-T10243
1mg50.00€5mg105.00€1mL*10mM (DMSO)117.00€10mg170.00€25mg340.00€50mg557.00€100mg893.00€Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.
Formula:C29H24Cl2N2O7SPurity:99.39% - 99.66%Color and Shape:SolidMolecular weight:615.484μ8C
CAS:4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Formula:C11H8O4Purity:97.48% - 98.45%Color and Shape:SolidMolecular weight:204.18TH287 hydrochloride
CAS:TH287 inhibits MTH1 (IC50: 0.8 nM), causing DNA damage in cancer cells through oxidized dNTP incorporation, leading to cytotoxicity in mouse xenografts.Formula:C11H11Cl3N4Purity:>99.99%Color and Shape:SolidMolecular weight:305.59ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurity:99.69%Color and Shape:SolidMolecular weight:232.24Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formula:C23H28N8OSPurity:99.99%Color and Shape:SolidMolecular weight:464.59Palbociclib dihydrochloride
Palbociclib, oral CDK4/6 inhibitor (IC50: 11/16 nM), targets HR+/HER2- breast cancer and hepatocellular carcinoma.Formula:C24H31Cl2N7O2Color and Shape:SolidMolecular weight:520.45SAR-020106
CAS:SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Formula:C19H19ClN6OPurity:97.78%Color and Shape:SolidMolecular weight:382.85LY3177833
CAS:LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Formula:C16H12FN5OPurity:99.87%Color and Shape:SolidMolecular weight:309.3Ref: TM-T7810
1mg38.00€5mg80.00€1mL*10mM (DMSO)87.00€10mg109.00€25mg212.00€50mg318.00€100mg477.00€200mg677.00€Trilaciclib
CAS:Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. enhances antitumour immunity.Formula:C24H30N8OPurity:99.624%Color and Shape:SolidMolecular weight:446.55Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formula:C27H20ClFN4O4Purity:98.31% - >99.99%Color and Shape:SolidMolecular weight:518.92Ref: TM-T2241
5mg52.00€1mL*10mM (DMSO)59.00€10mg92.00€25mg146.00€50mg215.00€100mg334.00€200mg430.00€500mg705.00€JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Formula:C24H33ClN6O2SPurity:99.96% - 99.96%Color and Shape:SolidMolecular weight:505.08BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Formula:C18H17F2N3O2Purity:99.25% - 99.57%Color and Shape:SolidMolecular weight:345.34Ref: TM-T2679
1mg34.00€5mg71.00€1mL*10mM (DMSO)78.00€10mg110.00€25mg210.00€50mg318.00€100mg455.00€200mg617.00€Tipiracil hydrochloride
CAS:Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI).Formula:C9H12Cl2N4O2Purity:98.13% - ≥95%Color and Shape:SolidMolecular weight:279.12THZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Formula:C31H28ClN7O2Purity:98.28%Color and Shape:SolidMolecular weight:566.05Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formula:C27H40N8O7Purity:98% - 99.8%Color and Shape:SolidMolecular weight:588.66Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Formula:C16H11N3O2Purity:98.34%Color and Shape:SolidMolecular weight:277.28Ref: TM-T9138
1mg44.00€1mL*10mM (DMSO)92.00€5mg93.00€10mg120.00€25mg236.00€50mg356.00€100mg532.00€200mg772.00€LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Formula:C20H21BrN8Purity:99.165%Color and Shape:SolidMolecular weight:453.34KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Formula:C16H27Cl2N5Purity:99.79%Color and Shape:SolidMolecular weight:360.33Ref: TM-T9446
1mg90.00€2mg136.00€5mg222.00€1mL*10mM (DMSO)235.00€10mg358.00€25mg597.00€50mg850.00€100mg1,153.00€Folinic acid calcium hydrate
CAS:Folinic acid (Leucovorin) calcium hydrate is a biofolic acid often used as a rescue agent with methotrexate (MTX) to reduce MTX-induced toxicity.Formula:C20H23CaN7O8Color and Shape:SolidMolecular weight:529.523Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formula:C32H46O8Purity:97.1% - 99.93%Color and Shape:SolidMolecular weight:558.70GSK2850163 hydrochloride
CAS:GSK2850163 hydrochloride is a novel IRE1α inhibitor with IC50 of 20 nM for kinase and 200 nM for RNA enzyme.Formula:C24H30Cl3N3OColor and Shape:SolidMolecular weight:482.87LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formula:C19H23N7O2Purity:99.77%Color and Shape:SolidMolecular weight:381.43N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine
CAS:Novel 2,6-naphthyridine inhibits PKC/PKD, identified by HTS.Formula:C23H28N6Purity:98.35%Color and Shape:SolidMolecular weight:388.51Thiazovivin
CAS:Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.Formula:C15H13N5OSPurity:98.00%Color and Shape:SolidMolecular weight:311.36Ref: TM-T2155
1mg34.00€2mg46.00€5mg64.00€1mL*10mM (DMSO)70.00€10mg98.00€25mg180.00€50mg304.00€100mg444.00€Madrasin
CAS:Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.Formula:C16H17N5O2Purity:99.06% - 99.61%Color and Shape:SolidMolecular weight:311.34Dimethylenastron
CAS:Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Formula:C16H18N2O2SPurity:98.07%Color and Shape:SolidMolecular weight:302.39Ref: TM-T3118
1mg34.00€2mg46.00€5mg58.00€1mL*10mM (DMSO)64.00€10mg93.00€25mg147.00€50mg222.00€100mg334.00€SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formula:C15H18BrN7Purity:99.88%Color and Shape:SolidMolecular weight:376.25Ref: TM-T3700
1mg50.00€2mg66.00€5mg90.00€1mL*10mM (DMSO)108.00€10mg146.00€25mg250.00€50mg403.00€100mg593.00€THZ531
CAS:THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).Formula:C30H32ClN7O2Purity:97.17% - 99.86%Color and Shape:SolidMolecular weight:558.07Ref: TM-T4293
1mg59.00€2mg86.00€5mg105.00€1mL*10mM (DMSO)130.00€10mg144.00€25mg313.00€50mg447.00€100mg650.00€500mg1,341.00€VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formula:C23H17F2N3O6Purity:98.53% - 99.91%Color and Shape:SolidMolecular weight:469.39Ref: TM-T4067
1mg90.00€2mg146.00€5mg245.00€1mL*10mM (DMSO)251.00€10mg385.00€25mg645.00€50mg888.00€100mg1,234.00€Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
Formula:C27H32F2N8·CH4O3SPurity:98.69% - 99.44%Color and Shape:SolidMolecular weight:602.7Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Formula:C28H26Cl2N4O5Purity:99.26% - 99.72%Color and Shape:SolidMolecular weight:569.44Levomefolate calcium
CAS:Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.Formula:C20H23CaN7O6Purity:97.35%Color and Shape:Off-White To Pale Yellow SolidMolecular weight:497.52CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurity:98.28% - 99.93%Color and Shape:SolidMolecular weight:379.34Ref: TM-T7080
1mg37.00€2mg49.00€5mg79.00€1mL*10mM (DMSO)87.00€10mg113.00€25mg213.00€50mg350.00€100mg523.00€Isoindigotin
CAS:Isoindigotin is used in the therapy of Y.
Formula:C16H10N2O2Purity:98.14% - ≥95%Color and Shape:SolidMolecular weight:262.26WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Formula:C28H31N7O2Purity:98.33%Color and Shape:SolidMolecular weight:497.59Ref: TM-T8916
1mg66.00€5mg147.00€1mL*10mM (DMSO)161.00€10mg225.00€25mg398.00€50mg532.00€100mg767.00€200mg1,018.00€Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)
Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin.Formula:C19H34N8O11Purity:99.81%Color and Shape:SolidMolecular weight:550.52Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Formula:C18H18FN5O2SPurity:98.8%Color and Shape:SolidMolecular weight:387.43Ref: TM-T10464L
1mg84.00€2mg114.00€5mg192.00€1mL*10mM (DMSO)212.00€10mg313.00€25mg580.00€50mg773.00€100mg1,063.00€SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.Formula:C9H8N2OS2Purity:99.88% - >99.99%Color and Shape:SolidMolecular weight:224.3GRGDSP acetate(91037-75-1 free base)
GRGDSP acetate(91037-75-1 free base) is a synthetic linear RGD peptide and is an integrin inhibitor.Formula:C24H41N9O12Purity:99.77%Color and Shape:SolidMolecular weight:647.64AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Formula:C17H19FN4O2SPurity:98.96% - 99.19%Color and Shape:SolidMolecular weight:362.42Ref: TM-T6093
1mg35.00€2mg50.00€5mg77.00€1mL*10mM (DMSO)84.00€10mg90.00€25mg167.00€50mg265.00€100mg424.00€Pyridostatin Trihydrochloride
CAS:Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.Formula:C31H35Cl3N8O5Purity:99.69%Color and Shape:SolidMolecular weight:706.02Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.
Formula:C18H22BrN5O3Purity:98.86% - 99.87%Color and Shape:SolidMolecular weight:436.3Bredinin aglycone
CAS:Bredinin aglycone (SM-108) is a purine nucleotide analog.Formula:C4H5N3O2Purity:99.06%Color and Shape:SolidMolecular weight:127.1PTC-209 hydrobromide
CAS:PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in
Formula:C17H13Br2N5OS·HBrPurity:99.91%Color and Shape:SolidMolecular weight:576.1Ref: TM-T6178
1mg37.00€5mg78.00€1mL*10mM (DMSO)89.00€10mg124.00€25mg265.00€50mg465.00€100mg753.00€200mg1,035.00€THAL-SNS-032
CAS:THAL-SNS-032 is a selective CDK9 degrader PROTAC.Formula:C40H52N8O10S2Purity:99.68%Color and Shape:SolidMolecular weight:869.02Ref: TM-T17069
1mg110.00€5mg259.00€10mg389.00€1mL*10mM (DMSO)389.00€25mg622.00€50mg884.00€100mg1,198.00€DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formula:C16H9N5OPurity:99.34%Color and Shape:SolidMolecular weight:287.28Ref: TM-T11112
1mg130.00€2mg178.00€5mg309.00€1mL*10mM (DMSO)324.00€10mg442.00€25mg705.00€50mg982.00€100mg1,333.00€500mg2,655.00€CW-069
CAS:CW-069 (IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Formula:C23H21IN2O3Purity:97.52% - 99.52%Color and Shape:SolidMolecular weight:500.33Ref: TM-T6209
1mg40.00€5mg86.00€1mL*10mM (DMSO)94.00€10mg118.00€25mg205.00€50mg290.00€100mg409.00€500mg888.00€P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formula:C12H7F2NO3S2Purity:97.9% - 99.64%Color and Shape:SolidMolecular weight:315.326-Thioinosine
CAS:6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Formula:C10H12N4O4SPurity:97.74%Color and Shape:SolidMolecular weight:284.29CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formula:C23H21ClN2O3Purity:98.82% - 99.50%Color and Shape:SolidMolecular weight:408.88
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