Metabolism

<p>Archangelicin is a useful organic compound for research related to life sciences. The catalog number is T125179 and the CAS number is 2607-56-9.</p>

<p>FP-biotin: organophosphorus toxicant for biomarker discovery, targets FAAH, ABHD6, MAG-lipase in plasma via avidin-bead purification.</p>

<p>Endogenous metabolite in urine, 1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine, linked to obesity research.</p>

<p>Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro [1] .</p>

<p>5-(3-Hydroxyphenyl)-5-phenylhydantoin is a bioactive chemical.</p>

<p>JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA).</p>

<p>MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>

<p>GOase, a type II copper enzyme from fungus, oxidizes alcohols to aldehydes and reduces O2 to H2O2.</p>

<p>Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease.</p>

<p>Motapizone (NAT 05-239), a PDE3 inhibitor, moderates LPS-induced cytokine release and blocks platelet aggregation by boosting cAMP.</p>

<p>12-Hydroxynevirapine, major Nevirapine metabolite; non-toxic but liver/skin SULTs convert it to reactive 12-Sulphoxy-nevirapine.</p>

<p>Carboxylesterase-IN-1, a pesticide inhibits carboxylesterase at 50 μg/mL, akin to triphenyl phosphate.</p>

<p>Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside (pNP-G7) is a substrate for α-amylase, used to measure α-amylase activity.</p>

<p>Phosphodiesterase II (PDE2) breaks down cAMP and cGMP, important in cellular regulation and widespread in tissues for biochemical research.</p>

<p>Previtamin D3 is an intermediate in the production of cholecalciferol (vitamin D3).</p>

<p>HPA-IN-1: potent human pancreatic α-amylase inhibitor; IC50: 12.0 μM for HPA, 410.4 μM for α-glucosidase.</p>

<p>Uricase catalyzes uric acid to allantoin in many mammals' peroxisomes, used in biochemistry.</p>

<p>ND-011992: Quinazoline inhibitor of E. coli respiratory enzymes; IC50s: 0.12-2.47 μM; potential tuberculosis research.</p>

<p>α-Glucosidase-IN-78 (Compound 12m) is a reversible competitive inhibitor of α-glucosidase (α-glucosidase) with an IC50 of 6.0 μM. Due to its blood sugar-lowering properties, α-Glucosidase-IN-78 is applicable in diabetes research.</p>

<p>RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.</p>

<p>Xanthine Oxidase-IN-9 (also known as Icarisids E or Compound 2) effectively inhibits xanthine oxidase (XOD) with an IC50 value of 31.81 μM [1].</p>

<p>CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with an IC50 value of 5.8 nM, playing a significant role in cancer research.</p>

<p>Captopril EP Impurity E, an ACE inhibitor with antihypertensive properties, has an IC50 of 0.025 μM.</p>

<p>GlcNAc kinase (EcNagK), ATP-dependent, phosphorylates C-6 hydroxyl on GlcNAc, producing GlcNAc-6-P.</p>

<p>ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.</p>

<p>4-Hydroxy Atorvastatin calcium salt is metabolised by cytochrome P450 CYP3A4 and has antimicrobial and anti-microbial activity.</p>

<p>α-Glucosidase-IN-83 (compound I-1) is a potent inhibitor of α-glucosidase, demonstrating an IC50 of 1.49 μg/mL. This compound effectively reduces blood glucose levels in vivo.</p>

<p>α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-glucosidase inhibitor with an IC50 of 2.11 μM, demonstrating greater inhibitory potency than the existing α-glucosidase inhibitors Acarbose (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). It exhibits no cytotoxicity on normal human liver cells (LO2) and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research in type 2 diabetes.</p>

<p>MAGL-IN-21 (Compound (S)-6) is a selective inhibitor of monoacylglycerol lipase (MAGL) with an IC50 of 1.59 nM.</p>

<p>LysoFos Glycerol 14 is a useful organic compound for research related to life sciences. The catalog number is TF0117 and the CAS number is 326495-21-0.</p>

<p>Viridicatin is a natural product for research related to life sciences. The catalog number is T38335 and the CAS number is 129-24-8.</p>

<p>Compound 14, a &lt;1 μM 5-lipoxygenase inhibitor, researches inflammation, cancer, stroke, Alzheimer's.</p>

<p>(S,S)-GSK321 is a (S,S)-enantiomer of GSK321 [1] .</p>

<p>DMPG sodium is a phospholipid analog commonly used in the preparation of artificial lipid bilayers to mimic the structure and function of biological membranes.</p>

<p>Anti-ANGPTL4 Antibody is a humanized antibody targeting ANGPTL4.</p>

<p>LL P880 beta is a fungal metabolite.</p>

<p>Alfacalcidol-D6 is a deuterated Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication.</p>

<p>3,5,6,7,8,4′-hexamethoxyflavone is a natural product for research related to life sciences. The catalog number is TN7114 and the CAS number is 34170-18-8.</p>

<p>Guignardone J, a secondary metabolite, is isolated from the endophytic fungus Phyllosticta capitalensis [1].</p>

<p>Alpha-1,3-N-Acetylgalactosaminyltransferase (Pm1138) (EC 2.4.1.40(Pm1138)), also known as the ABO system transferase, exhibits glycosyl transferase activity [1</p>

<p>Milpocitide, a (293-333)-peptide fragment of the human low-density lipoprotein receptor (LDLR), specifically corresponds to the EGF-like domain 1 [1].</p>

<p>N-Methyl pemetrexed, an impurity found in Pemetrexed, serves as an antifolate cytotoxic agent utilized in cancer research [1].</p>

<p>Formate dehydrogenase, found in all life forms, converts formate to CO2 and is categorized by metal content for research.</p>

<p>DMPS-Na is an arsenicolytic agent with toxicity that can be used to study cell membranes.</p>

<p>DG013A (formate) is a tripeptide-mimicking inhibitor of hypophosphorous acid. It exhibits IC50 values of 33 nM for ERAP1 and 11 nM for ERAP2. This compound can be utilized in research related to autoimmune diseases and cancer.</p>

<p>AP39 boosts mitochondrial H2S with triphenylphosphonium and dithiolethione; AP219 lacks H2S-donating part.</p>

<p>A 58365 B: ACE inhibitor from Streptomyces chromofuscus; treats heart failure &amp; hypertension.</p>

<p>C2 L-threo Ceramide is a sphingolipid that modulates cholesterol in cells and affects IL-4, cell cycle, and leukemia cell growth.</p>

<p>Calcitriol D6: deuterated Calcitriol, active vitamin D hormone, D3 metabolite, activates vitamin D receptor.</p>

<p>Iso-C15:0 3-OH is a fatty acid that can be isolated from the PLRT strain. PLRT is a rod-shaped, Gram-negative, chemolithoheterotrophic, obligately aerobic bacterium, obtained from the feces of the mollusk Aplysia punctata.</p>

<p>Bicyclic UK18 is a competitive inhibitor of human urokinase-type plasminogen activator (uPA) with a Ki value of 53 nM.</p>

<p>α-D-Glucose-1-phosphate disodium hydrate serves multiple roles in medical and biochemical applications, including as a precursor in the synthesis of glucuronic</p>

<p>Mycestericin G, a sphingosine-like fungal metabolite, demonstrates immunosuppressive activity [1].</p>

<p>Pegevongitide acts as an agonist of the angiopoietin-1 receptor.</p>

<p>D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP), belonging to the CAZy glycoside hydrolase family GH112, plays a pivotal role in</p>

<p>RORγt inhibitor 1 is a RORγt allosteric inhibitor with an IC 50 value of 1 nM.</p>

<p>R 80123 is a highly selective inhibitor of phosphodiesterase,is the Z-isomer of R 79595</p>

<p>Omfiloctocog alfa (SCT-800) is a recombinant FVIII for Hemophilia A research.</p>

<p>β-N-Acetylhexosaminidase is an exoglycosidase that catalyzes the hydrolysis of terminal non-reducing β-N-acetylgalactosamine and glucosamine residues in</p>

<p>DPPE-mPEG, a PEG-modified lipid, minimizes nonspecific protein adsorption and extends circulation time in vivo [1].</p>

<p>Pyrocholecalciferol, a vitamin D analogue, is produced through the photochemical transformation of 7-dehydrocholesterol (7-DHC) [1] [2].</p>

<p>LgtA is a glycosyltransferase that adds N-acetylglucosamine to lactose and N-acetyllactosamine.</p>

<p>Canadensolide is an antifungal metabolite of Penicillium canadense .</p>

<p>Spaglumic acid acetate (Isospaglumic acid acetate) is a neuropeptide found in millimolar concentrations in brain.</p>

<p>Cirsiliol 4′-glucoside, a compound extracted from Ruellia tuberosa L., acts as a free radical scavenger and demonstrates potential anti-diabetic activity [1].</p>

<p>2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol is a triglyceride.</p>

<p>Deschloro Cetirizine Dihydrochloride: a Cetirizine impurity, second-gen antihistamine, and metabolite of hydroxyzine.</p>

<p>Neohydroxyaspergillic acid, a fungal product from A. sclerotiorum, combats various bacteria and fungi with MICs ranging from 125-700 μg/ml.</p>

<p>Nepetalactone is found in the plant Nepeta parnassica and has high mosquito repellency properties.</p>

<p>substrate of IMP dehydrogenase (IMPDH)</p>

<p>2',5,6',7-Tetrahydroxyflavone is a useful organic compound for research related to life sciences.</p>

<p>N-Stearoylsphingomyelin (N-Stearoyl-D-sphingomyelin), a sphingolipid, inhibits Phospholipase Cδ1 (PLCδ1) [1].</p>

<p>ARC19499, an aptamer, inhibits TFPI to aid clotting through the extrinsic pathway, enhancing thrombin in hemophilia.</p>

<p>Acremin F is a useful organic compound for research related to life sciences. The catalog number is T124074 and the CAS number is 863480-61-9.</p>

<p>Myxochelin A from A. disciformis fights Gram-positive bacteria, inhibits 5-LO with IC50 of 1.9 μM, and is cytotoxic to colon cancer cells.</p>

<p>isomer-CM 352 is a metalase inhibitor that can be used to slow brain damage.</p>

<p>Casein Kinase Substrates 3 is a substrate of casein kinase.</p>

D-γ-Glutamyl-D-glutamic acid is a linear polymer with repeating D-glutamic acid units, useful in studies of microbial cell walls and immunological recognition.

<p>alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (Hp3/4FT) can be found in Helicobacter pylori .</p>

<p>Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule.</p>

<p>Estriol 3-β-D-glucuronide is a metabolite of estriol .</p>

<p>Sphingomyelins, 2-15% of organ phospholipids, are prevalent in brain and nerve sheaths, regulate cholesterol, and turn into ceramides by hydrolysis.</p>

<p>PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of</p>

<p>Deaminocozymase also known as Nicotinamide-hypoxanthine dinucleotide, is a biochemical.</p>

<p>Glucose 1-dehydrogenase, an enzyme, transforms glucose and NAD(P) into NAD(P)H and gluconic acid.</p>

<p>Suberylglycine is an acyl glycine that is a normally minor metabolite of fatty acid.</p>

<p>ScHEX1, a glycolytic hexokinase, is blocked by n-acetylglucosamine, detaching from the mitochondrial membrane and activating NLRP3 inflammasome.</p>

<p>ACTH (18-39), or Corticotropin-like Peptide, boosts insulin, amylase, and protein secretion dose-dependently.</p>

<p>Perfluorobutane is a gas that is colorless.</p>

<p>Cholesteryl arachidonate is a human endogenous metabolite.</p>

<p>Sucunamostat (SCO-792) hydrochloride is an orally active, reversible inhibitor of enteropeptidase, displaying inhibition constants (IC50) of 4.6 nM for rat</p>

<p>CgtB enzyme, needed for GM1-like LOS SIAL, catalyzes galactose addition in biochemical studies.</p>

<p>2-NP-AHD, derived from AHD/nitrofuran metabolite, indicates illegal nitrofuran use.</p>

<p>trans-Hydroxy Glimepiride, an active sulfonylurea glimepiride metabolite, is primarily synthesized in the liver by CYP2C9.</p>

<p>Saccharopine hydrochloride, from lysine degradation, disrupts mitochondria and hinders development.</p>

<p>1,3-Diphenethylurea (N,N'-Bis(phenethyl)urea) is a marine derived natural products found in Lissoclinum patella.</p>

<p>11-epi-Chaetomugilin I, from Chaetomium globosum, has cytotoxic effects against P388, HL-60, L1210 leukemia, and KB carcinoma cells.</p>

<p>"Cyclohexanoyl CoA (CHCoA) activates CHC in R. palustris, converts to hippuric acid in guinea pig liver."</p>

<p>D-Fructose-13C6 can be used as an internal standard for the quantification of D-fructose by GC- or LC-MS.</p>

<p>Eremofortin A, a metabolite, can be isolated from Penicillium roqueforti cultures [1].</p>