Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(196 products)
- Casein Kinase(139 products)
- DHFR(30 products)
- Decarboxylase(4 products)
- Dehydrogenase(302 products)
- FAAH(64 products)
- FXR(62 products)
- Factor Xa(87 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(227 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(56 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(34 products)
- Hydroxylase(36 products)
- IDO(84 products)
- LDL(7 products)
- Lipase(107 products)
- Lipid(62 products)
- Lipoxygenase(133 products)
- MAO(85 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(170 products)
- PED(1 products)
- PKM(17 products)
- PPAR(170 products)
- Phospholipase(85 products)
- ROR(47 products)
- Retinoid Receptor(20 products)
- SGK(10 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(43 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9197 products of "Metabolism"
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IRX5010
CAS:IRX5010 (IRX4647F), an analogue of IRX4647, serves as a highly selective RARγ nuclear receptor agonist. It effectively inhibits the growth of EMT-6 triple-negative breast cancer.Formula:C24H26FNO3Color and Shape:SolidMolecular weight:395.466CK1δ-IN-7
CAS:CK1δ-IN-7 (Compound 488) is an inhibitor of casein kinase 1δ (CK1δ).Formula:C23H23N5OColor and Shape:SolidMolecular weight:385.462DDO-3055
CAS:DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Formula:C17H13ClN2O5Color and Shape:SolidMolecular weight:360.749WAY-606344
CAS:WAY-606344 (Compound 97) is an inhibitor of Casein kinase 1δ and shows potential for Alzheimer's disease research.Formula:C14H8ClN3O2Color and Shape:SolidMolecular weight:285.685Glucokinase activator 8
CAS:Glucokinase activator8 is an activator of glucose kinase (glucokinase).Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337α-Amylase-IN-12
CAS:α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor with an IC50 of 0.15 mM, functioning through a mixed inhibition mode. It exhibits an IC50 of 9.40 mM against α-glucosidase. This compound enhances glucose uptake in yeast cells and demonstrates significant anti-glycation activity at high concentrations. α-Amylase-IN-12 is applicable for diabetes research.Formula:C16H11NO4Color and Shape:SolidMolecular weight:281.263Morocromen
CAS:Morocromen is a 2-benzamidobenzoic acid derivative characterized by its ability to enhance coronary activity.Formula:C21H27N3O5Color and Shape:SolidMolecular weight:401.46PHD2-IN-4
CAS:PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.Formula:C21H19N5O3Color and Shape:SolidMolecular weight:389.407SID 24785302
CAS:SID 24785302 is an inhibitor of hexokinase, which can suppress glycolysis, regulate mitochondrial function, and ultimately inhibit the replication of mutant mitochondrial DNA.Formula:C14H12N2O3S2Color and Shape:SolidMolecular weight:320.387SHP2-IN-43
CAS:SHP2-IN-43 (Compound 5) is an SHP2 inhibitor with an IC50 of 98.7 nM. It can be used as a PROTAC target protein ligand in the synthesis of SHP2-D26.Formula:C18H23ClN6OSColor and Shape:SolidMolecular weight:406.93PFM046
CAS:PFM046 is an antagonist of the liver X receptor (LXR), effectively inhibiting the activation of LXRα and LXRβ, with IC50 values of 2.04 μM and 1.58 μM respectively. It reduces the expression of SCD1 and FASN while increasing ABCA1 expression, and demonstrates antitumor activity in mouse models.Formula:C29H42O2Color and Shape:SolidMolecular weight:422.643PDHK-IN-3
PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].Formula:C17H16N2O2Color and Shape:SolidMolecular weight:280.3211-trans Leukotriene E4
CAS:Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.Formula:C23H37NO5SColor and Shape:SolidMolecular weight:439.61BAY R3401
CAS:BAY R3401 is an orally active inhibitor of glycogen phosphorylase, leading to irreversible and non-selective inhibition of liver glycogenolysis. It suppresses glycogen breakdown in hepatocytes with IC50 values of 27.06 μM in HL-7702 cells and 52.83 μM in HepG2 cells. BAY R3401 is applicable for research in type 2 diabetes.Formula:C20H22ClNO4Color and Shape:SolidMolecular weight:375.846CK1δ-IN-10
CAS:CK1δ-IN-10 (Compound 85) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ (CSNKID), with an IC50 value of 0.255 μM.Formula:C17H11F4N5Color and Shape:SolidMolecular weight:361.296Monoamine Oxidase B inhibitor 6
CAS:Monoamine OxidaseB inhibitor 6 (Compound BT5) is a highly selective, reversible, and competitive MAO-B inhibitor capable of crossing the blood-brain barrier, with an IC50 of 0.11 μM. It exhibits antioxidant and neuroprotective properties, making it suitable for research into neurodegenerative diseases.Formula:C15H15N3OSColor and Shape:SolidMolecular weight:285.364ACLY Inhibitor 7
CAS:ACLY Inhibitor 7 is a potent, selective hACLY inhibitor (IC50<1 nM) for metabolic disease and oncology research.Formula:C21H14ClF2NO6SPurity:99.74%Color and Shape:SoildMolecular weight:481.852-Deoxokanshone M
CAS:2-Deoxokanshone M (Nardosinone acid), a degradation product of Nardosinone, exhibits potent vasodilatory activity.Formula:C12H16O2Color and Shape:SolidMolecular weight:192.25AChE/hCA I-IN-1
CAS:AChE/hCA I-IN-1 (Compound L3) is an inhibitor of acetylcholinesterase (AChE) and carbonic anhydrase (CA), effectively inhibiting AChE, hCA I, and hCA II with IC50 values of 302 nM, 265 nM, and 283 nM, respectively.Formula:C13H9BrNNaO4SColor and Shape:SolidMolecular weight:378.174Cephapirin lactone
CAS:Cephapirinlactone is a metabolite of the antibiotic Cephapirin.Formula:C15H13N3O4S2Molecular weight:363.41CA IX-IN-3
CAS:CAIX-IN-3 (Compound 27) is a selective and potent inhibitor of carbonic anhydrase IX (CAIX), with an IC50 of 0.48 nM.Formula:C21H19N5O4S2Color and Shape:SolidMolecular weight:469.537(R)-Acenocoumarol
CAS:(R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) is a short-acting, orally administered anticoagulant that works by inhibiting vitamin K epoxide reductase (vitamin K1 recycling), similar to Warfarin. It demonstrates greater anticoagulant potency in vivo compared to Warfarin. This compound has a single chiral center, resulting in two enantiomeric forms. The (R)-enantiomer has a longer plasma elimination half-life of 6.6 hours, slower plasma clearance of 1.9 L/h, and stronger anticoagulation effects than the (S)-enantiomer.Formula:C19H15NO6Molecular weight:353.33Danifexor
CAS:Danifexor is an agonist of the farnesoid X receptor (Farnesoid X receptor).Formula:C29H20Cl2N2O5Color and Shape:SolidMolecular weight:547.386Diacylglycerol acyltransferase inhibitor-2
CAS:Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.Formula:C21H20FN5O4Color and Shape:SolidMolecular weight:425.41SCO-792
SCO-792: potent, reversible oral enteropeptidase inhibitor, with slow in vitro dissociation and in vivo protein digestion blocking.Formula:C22H22N4O8·xH2OColor and Shape:SolidCS-003 HCl
CAS:CS-003 HCl is a TNRA - triple neurokinin receptor antagonist.Formula:C34H39Cl3N2O6SColor and Shape:SolidMolecular weight:710.1Homodestcardin
CAS:Homodestcardin: cyclic depsipeptide from T. roseum with immunosuppressant properties; inhibits mouse T cell proliferation.Formula:C32H55N5O7Color and Shape:SolidMolecular weight:621.81Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Formula:C30H40Cl2N6O4S2Purity:98%Color and Shape:SolidMolecular weight:683.71Human enteropeptidase-IN-2
Human enteropeptidase-IN-2 is a potent inhibitor of enteropeptidase (enteropeptidase) and can be used in anti-obesity studies.Formula:C20H19F3N4O7Color and Shape:SolidMolecular weight:484.38L 691816
CAS:L 691816 is an effective inhibitor of the 5-LO reaction.Formula:C36H35ClN6OSPurity:98%Color and Shape:SolidMolecular weight:635.22PTP1B-IN-17
PTP1B-IN-17, a benzimidazole derivative, inhibits PTP1B (Ki: 30.2 μM) and may help study type 2 diabetes.Formula:C26H19N3O4SColor and Shape:SolidMolecular weight:469.51C16-18:1 PE
CAS:C16-18:1 PE is a lipid known for its role in facilitating membrane fusion and enhancing endosomal escape, significantly boosting mRNA delivery efficiency. This compound is utilized in the synthesis of lipid nanoparticles (LNP).Formula:C39H78NO7PColor and Shape:SolidMolecular weight:704.015-Carboxy-2′-deoxycytidine
CAS:5-Carboxy-2′-deoxycytidine is a metabolite of Trifluridine.Formula:C10H13N3O6Color and Shape:SolidMolecular weight:271.227Buspirone N-oxide
CAS:Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone. Buspirone is an orally active 5-HT1A receptor agonist and a dopamine D2 (dopamine D2) autoreceptor antagonist. It is an anxiolytic agent used for research in generalized anxiety disorder.Formula:C21H31N5O3Color and Shape:SolidMolecular weight:401.503Tabimorelin hemifumarate
CAS:orally active ghrelin receptor (GHS-R1a) agonistFormula:C32H40N403C4H404Purity:98%Color and Shape:SolidMolecular weight:586.72MAGL-IN-19
CAS:MAGL-IN-19 (compound 7o) is a highly effective and selective inhibitor of MAGL.Formula:C21H26F3N3O3Color and Shape:SolidMolecular weight:425.45(Rac)-8-Hydroxy-efavirenz
CAS:(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1.Formula:C14H9ClF3NO3Color and Shape:SolidMolecular weight:331.674LEQ803
CAS:LEQ803 (N-DesmethylRibociclib) is a metabolite of the CDK4/6 inhibitor Ribociclib, produced through metabolism by CYP3A4. This compound holds potential applications in the field of oncology.Formula:C22H28N8OColor and Shape:SolidMolecular weight:420.511α-Amylase/α-Glucosidase-IN-19
CAS:α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase and α-glucosidase, with an IC50 of 170.7 μM and 60.37 μM, respectively.Formula:C17H14BrClN2OColor and Shape:SolidMolecular weight:377.663KDX1381
CAS:KDX1381 is a bivalent CK2α inhibitor with an IC50 of 17 nM and a KD of 54 nM. It demonstrates antitumor activity in murine 786-O and A375 xenograft models. Furthermore, when combined with a vascular endothelial growth factor receptor (VEGFR) inhibitor or DNA-damaging agents, KDX1381 enhances antitumor effects in mouse hepatocellular carcinoma and glioma models.Formula:C32H32F2N6O4SColor and Shape:SolidMolecular weight:634.70ATX inhibitor 22
ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.Formula:C19H17Cl3F2N2O4SColor and Shape:SolidMolecular weight:513.77HSD17B13-IN-30
CAS:HSD17B13-IN-30 (compound 64) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), exhibiting an IC 50 value of less than 0.1 μM? with estradiol? as substrates. This compound is significantly implicated in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formula:C24H16Cl2F3N3O4Color and Shape:SolidMolecular weight:538.3Falecalcitriol
CAS:Falecalcitriol is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, which is longer duration of action in vivo.Formula:C27H38F6O3Purity:98%Color and Shape:SolidMolecular weight:524.58(2S,4S)-Sacubitril
CAS:(2S,4S)-Sacubitril (Sacubitril Impurity C) is a stereoisomer derived from Sacubitril which is a potent NEP inhibitor.Formula:C24H29NO5Purity:98%Color and Shape:SolidMolecular weight:411.49TNP-470
CAS:TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.Formula:C19H28ClNO6Purity:98%Color and Shape:SolidMolecular weight:401.88Indoluidin E
Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.Formula:C28H30N4O2Color and Shape:SolidMolecular weight:454.56DSM705 hydrochloride
DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.Formula:C19H20ClF3N6OColor and Shape:SolidMolecular weight:440.85Pefcalcitol
CAS:Pefcalcitol is a novel antipsoriatic prodrug candidate containing a 16-en-22-oxa-vitamin D3 structure.Formula:C26H34F5NO4Color and Shape:SolidMolecular weight:519.54SMase-IN-1
CAS:SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase (SMase) inhibitor with an IC50 value of 6.43 µM against Bacillus cereus SMase. It also inhibits eqBuChE with an inhibition rate of 59.50% at a concentration of 50 µM. SMase-IN-1 forms a complex with Cu2+ through bio-metal interactions and can inhibit hemolysis of sheep red blood cells induced by Bacillus cereus.Formula:C8H5ClN2OSColor and Shape:SolidMolecular weight:212.656GW461484A
CAS:GW461484A is a small molecule inhibitor targeting Candida albicans Yck2, exhibiting an IC50 of 0.11 µM. It has a MIC80 of 12.5 µM against C. albicans. GW461484A shows potential for research into fungal diseases, including drug-resistant Candida infections.Formula:C19H14FN3Color and Shape:SolidMolecular weight:303.333Carbonic anhydrase inhibitor 16
CAS:Carbonic anhydrase inhibitor 16 (compound 1) is a CA I/CA II inhibitor with potential antiviral activity, used in virus infection studies.Formula:C14H10N2O4SPurity:99.65%Color and Shape:SolidMolecular weight:302.31GPX4 9i
CAS:GPX4 9i is a ferroptosis inducer that exhibits cytotoxicity towards HT-1080 cells, with an IC50 of 0.007 µM. This cytotoxic effect can be mitigated by the use of the ferroptosis inhibitor, ferrostatin-1.Formula:C29H24N4O3S2Color and Shape:SolidMolecular weight:540.66D-Citrulline
CAS:D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.Formula:C6H13N3O3Color and Shape:SolidMolecular weight:175.19BT-114143
CAS:BT-114143 is a plasminogen activator inhibitor with an IC50 of 8.42 μM. It is applicable in research related to hemorrhagic diseases caused by excessive fibrinolysis, including traumatic bleeding, severe menorrhagia, postpartum hemorrhage, and complications of hemophilia.Formula:C8H11N2O3PColor and Shape:SolidMolecular weight:214.158PDEδ-IN-1
CAS:PDEδ-IN-1 is a ligand for PDEδ and can be utilized in the synthesis of PDEδ autophagic degrader 1.Formula:C18H20N4O3Color and Shape:SolidMolecular weight:340.38HSD17B13-IN-40
CAS:HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formula:C23H14Cl2F3N3O3Color and Shape:SolidMolecular weight:508.28DPM-1003
CAS:DPM-1003 is an allosteric inhibitor of PTP1B, targeting the non-catalytic, disordered C-terminal segment of the PTP1B protein, and has shown beneficial effects in reducing pulmonary inflammation in mice.Formula:C35H57N3O3Color and Shape:SolidMolecular weight:567.845FXR agonist 12
CAS:FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.Formula:C26H44O3Color and Shape:SolidMolecular weight:404.626Mitapivat hydrochloride
CAS:Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Formula:C24H27ClN4O3SColor and Shape:SolidMolecular weight:487.0145-LOX/MAOs-IN-1
CAS:Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.Formula:C18H18N2O2Color and Shape:SolidMolecular weight:294.35Mucidin
CAS:Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.Formula:C16H18O3Molecular weight:258.31ZK159222
CAS:ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.Formula:C32H48O5Purity:98%Color and Shape:SolidMolecular weight:512.72Anticancer agent 78
Anticancer agent 78: anti-aromatase (IC50=0.9 μM), cytotoxic, potential in breast cancer research.Formula:C19H14BrNO4Color and Shape:SolidMolecular weight:400.22MCTR3
CAS:MCTR3, derived from DHA via maresin 1 in macrophages, hastens tissue healing and reduces inflammation and eicosanoids post-E. coli infection in mice.Formula:C25H37NO5SColor and Shape:SolidMolecular weight:463.63Vimirogant hydrochloride
Vimirogant (VTP-43742) HCl: Oral, selective RORγt inhibitor (IC50: 17 nM, Ki: 3.5 nM), >1000x selectivity over RORα/β, targets Th17, not Th1/2/Treg.Formula:C27H36ClF3N4O3SColor and Shape:SolidMolecular weight:588.21487JTZ-951 HCl
CAS:JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).Formula:C17H17ClN4O4Purity:98%Color and Shape:SolidMolecular weight:376.79HIF-2α-IN-5
CAS:HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].Formula:C15H12F4O3S2Color and Shape:SolidMolecular weight:380.38FXIa-IN-6
CAS:FXIa-IN-6: Potent, selective FXIa inhibitor (Ki=0.3 nM); strong PK with high oral bioavailability, low clearance preclinically.Formula:C31H29ClF2N4O4Color and Shape:SolidMolecular weight:595.04PDE4-IN-12
PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).Formula:C34H35NO6Color and Shape:SolidMolecular weight:553.64MeS-IMPY
CAS:[11C]MeS-IMPY exhibits a higher binding affinity for β-amyloid plaques extracted from Alzheimer's disease (AD) brains or AD brain homogenates than IMPY, with Ki values of 7.93 nM and 8.95 nM, respectively. [11C]MeS-IMPY is a potential radioactive ligand for positron emission tomography (PET) imaging of β-amyloid plaques.Formula:C16H17N3SMolecular weight:283.39CYP2C1/CYP2C19-IN-2
CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.Formula:C27H28N2O6SColor and Shape:SolidMolecular weight:508.59GGACK
CAS:GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).Formula:C14H25ClN6O5Molecular weight:392.84HSD17B13-IN-28
CAS:HSD17B13-IN-28 (compound 47) is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with an IC50 of < 0.1 μM using estradiol as a substrate. HSD17B13-IN-28 plays an important role in nonalcoholic fatty liver diseases (NAFLDs), including NASH (nonalcoholic steatohepatitis) [1].Formula:C23H16Cl2FN3O3Color and Shape:SolidMolecular weight:472.3ABD957
CAS:ABD957: covalent ABHD17 depalmitoylases inhibitor, IC50 0.21µM for ABHD17B, blocks N-Ras, halts NRAS-mutant AML cell growth.Formula:C27H36F3N7O5SColor and Shape:SolidMolecular weight:627.683-Oxochenodeoxycholic acid
CAS:3-Oxochenodeoxycholic acid is an endogenous metabolite detectable in feces and may serve as a diagnostic marker for various diseases, including COVID-19.Formula:C24H38O4Color and Shape:SolidMolecular weight:390.556RORγt modulator 5
CAS:RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.Formula:C27H22F5N3O6SColor and Shape:SolidMolecular weight:611.54ZK168281
CAS:ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.Formula:C32H46O5Purity:98%Color and Shape:SolidMolecular weight:510.70Lp-PLA2-IN-10
Lp-PLA2-IN-10, a potent Lp-PLA2 inhibitor, may research neurodegenerative and cardiovascular diseases.Formula:C21H15F5N4O4Color and Shape:SolidMolecular weight:482.36PPI-2458
CAS:PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.Formula:C22H36N2O6Color and Shape:SolidMolecular weight:424.534-(4-Bromophenyl)-4-hydroxypiperidine
CAS:4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.
Formula:C11H14BrNOColor and Shape:SolidMolecular weight:256.139ent-8-iso-15(S)-Prostaglandin F2α
CAS:Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.Formula:C20H34O5Color and Shape:SolidMolecular weight:354.48Mibefradil
CAS:Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).Formula:C29H38FN3O3Purity:98%Color and Shape:SolidMolecular weight:495.63ABHD antagonist 1
CAS:ABHD antagonist 1 is an inhibitor of ABHD6 (α/β-Hydrolase domain containing 6), involved in modulating biochemical pathways affected by ABHD6, thereby influencing cell function and inflammatory responses. This compound is applicable for research in fields such as pain, neurological disorders, inflammatory diseases, autoimmune diseases, metabolic disorders, and cancer.Formula:C19H20BrN3O3SColor and Shape:SolidMolecular weight:450.35Yck2-IN-1
CAS:Yck2-IN-1 (Compound 2a) is an inhibitor of the fungus Candida albicans Yck2. It has an IC50 of approximately 80 nM for Yck2 and an MIC80 of 12.5 µM for C. albicans, demonstrating good metabolic stability [66% remaining in mouse liver microsomes]. In a mouse model with drug-resistant Candida, Yck2-IN-1 significantly reduced fungal load in the kidneys. Yck2-IN-1 shows potential for research in antifungal infection treatments.Formula:C19H11FN4Color and Shape:SolidMolecular weight:314.316PTP1B-IN-21
PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.Formula:C22H22O11Color and Shape:SolidMolecular weight:462.4MAGL-IN-15
CAS:MAGL-IN-15 (Compound 6), a MAGL inhibitor, holds potential for research into diseases and disorders associated with the regulation of endocannabinoid system signaling activities [1].Formula:C16H16F6N4O3Color and Shape:SolidMolecular weight:426.31Sphingomyelin (d18:1/12:0)
CAS:Sphingomyelin (d18:1/12:0) is a polar lipid known for its role in modulating cell signal transduction. It plays a critical role in cell membranes, influencing their fluidity and stability. Additionally, sphingomyelin (d18:1/12:0) is involved in lipid metabolism and has potential in promoting neuronal cell growth. This compound is essential for the functioning and development of the nervous system.Formula:C35H71N2O6PColor and Shape:SolidMolecular weight:646.924-Amino-3-hydroxyphenylalanine
CAS:4-Amino-3-hydroxyphenylalanine (4-AHP) is a photodegradation product of eumelanin. It can be utilized in research focused on the formation of cutaneous melanoma and age-related macular degeneration.Formula:C9H12N2O3Color and Shape:SolidMolecular weight:196.2036′SLN
CAS:6′SLN is a characteristic glycan found on the surface of cancer-related extracellular vesicles (EVs) and serves as the primary form of protein glycosylation within EVs. Additionally, 6′SLN, a derivative of sialic acid, interacts with hemagglutinins (HAs) from both human and avian influenza strains, making it relevant in the study of anti-influenza drugs.Formula:C25H42N2O19Color and Shape:SolidMolecular weight:674.6Lunacalcipol
CAS:Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism.Formula:C28H42O4SColor and Shape:SolidMolecular weight:474.7RXR antagonist 1
RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.Formula:C28H33F3N2O3Color and Shape:SolidMolecular weight:502.57Fmoc-NH-PEG6-alcohol
CAS:Fmoc-NH-PEG6-alcohol, a cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].Formula:C27H37NO8Color and Shape:SolidMolecular weight:503.58hCAVII/IX-IN-1
CAS:hCAVII/IX-IN-1 (compound 4) functions as an inhibitor of hCAVII/IX, exhibiting Ki values of 56.5 nM and 38.2 nM, respectively. It is applicable in the field of cancer research.Formula:C7H7N3O2S2Color and Shape:SolidMolecular weight:229.279sEH inhibitor-1
TCPU (sEH inhibitor-1) is a potent oral human sEH blocker with IC50s of 0.4 nM (human) and 5.3 nM (mouse).
Color and Shape:SolidPAT-347
CAS:PAT-347 is a potent inhibitor of Autotaxin, an enzyme linked to cell survival and diseases like cancer and fibrosis.Formula:C28H21ClF2N2O3SColor and Shape:SolidMolecular weight:538.99α-Glucosidase-IN-63
CAS:α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1]Formula:C16H12FN3O3S2Color and Shape:SolidMolecular weight:377.41Rivaroxaban diol
CAS:Rivaroxabandiol is a metabolite of Rivaroxaban, which is a potent and selective direct inhibitor of coagulation factor Xa (FXa) with an IC50 of 0.7 nM and a Ki of 0.4 nM.Formula:C19H20ClN3O6SColor and Shape:SolidMolecular weight:453.897EC33
CAS:EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].Formula:C4H11NO3S2Color and Shape:SolidMolecular weight:185.27HSD17B13-IN-19
CAS:HSD17B13-IN-19 (compound 16) acts as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values under 0.1 μM and under 1 μM when using estradiol and Leukotriene B3 as substrates, respectively. This compound is crucial in the treatment of nonalcoholic fatty liver diseases (NAFLDs), such as nonalcoholic steatohepatitis (NASH) [1].Formula:C23H23FN2O4SColor and Shape:SolidMolecular weight:442.5EB-0150
EB-0150 inhibits ER α-Glu I/II (IC50: 0.73/0.0337 μM), is an N-substituted valerian with antiviral effects, and has drug discovery potential.Formula:C19H30N6O7Color and Shape:SolidMolecular weight:454.48
