Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(196 products)
- Casein Kinase(139 products)
- DHFR(30 products)
- Decarboxylase(4 products)
- Dehydrogenase(302 products)
- FAAH(64 products)
- FXR(62 products)
- Factor Xa(87 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(227 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(56 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(34 products)
- Hydroxylase(36 products)
- IDO(84 products)
- LDL(7 products)
- Lipase(107 products)
- Lipid(62 products)
- Lipoxygenase(133 products)
- MAO(85 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(170 products)
- PED(1 products)
- PKM(17 products)
- PPAR(170 products)
- Phospholipase(85 products)
- ROR(47 products)
- Retinoid Receptor(20 products)
- SGK(10 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(43 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9197 products of "Metabolism"
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RORγ-IN-2
CAS:RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.
Formula:C28H32F3N5O4S2Color and Shape:SolidMolecular weight:623.71Norfluoxetine
CAS:Norfluoxetine, the active metabolite of the antidepressant Fluoxetine, acts as a selective inhibitor for serotonin uptake.Formula:C16H16F3NOColor and Shape:SolidMolecular weight:295.30GSK 366
CAS:GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).Formula:C17H16ClN3O4Purity:98%Color and Shape:SolidMolecular weight:361.78Arphamenine A
CAS:Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).Formula:C16H24N4O3Color and Shape:SolidMolecular weight:320.387L 731735
CAS:L 731735 is a farnesyltransferase inhibitor.Formula:C19H40N4O4SPurity:98%Color and Shape:SolidMolecular weight:420.61Oxythiamine diphosphate ammonium
Oxythiamin diphosphate ammonium is a potent inhibitor of transketolase (TK).Color and Shape:SolidPTP1B-IN-3 diammonium
PTP1B-IN-3 diammonium, an oral enzyme inhibitor, has potent antidiabetic and anticancer effects, with a 120 nM IC50.Formula:C12H13BrF2N3O3PColor and Shape:SolidMolecular weight:396.12Osunprotafib hydrochloride
CAS:Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active, selective inhibitor targeting the active sites of PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM). It shows 6-8 times weaker activity towards PTPN9 and no detectable activity against SHP-1 or SHP-2. This compound enhances the sensitivity of human cancer cell lines to IFNγ. By boosting JAK-STAT signaling and reducing T cell dysfunction, Osunprotafib hydrochloride exhibits potent antitumor immunity.Formula:C17H25ClFN3O4SColor and Shape:SolidMolecular weight:421.92HSD17B13-IN-19
CAS:HSD17B13-IN-19 (compound 16) acts as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values under 0.1 μM and under 1 μM when using estradiol and Leukotriene B3 as substrates, respectively. This compound is crucial in the treatment of nonalcoholic fatty liver diseases (NAFLDs), such as nonalcoholic steatohepatitis (NASH) [1].Formula:C23H23FN2O4SColor and Shape:SolidMolecular weight:442.5BRD2879
CAS:BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM).Formula:C30H38FN3O5SPurity:98%Color and Shape:SolidMolecular weight:571.70Nsp12-IN-2
CAS:Nsp12-IN-2 (Compound 8), a triphosphate metabolite of 4'-thiouridine, functions as an inhibitor of SARS-CoV-2 Nsp12. It effectively suppresses the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, halting RNA synthesis and blocking the RNA capping and NMP capping of Nsp9. Nsp12-IN-2 shows potential for research into infections caused by SARS-CoV-2, other coronaviruses, and additional RNA viruses.Formula:C9H12N2Na3O14P3SColor and Shape:SolidMolecular weight:566.15hCAII-IN-4
CAS:hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.Formula:C31H23NO9Color and Shape:SolidMolecular weight:553.52Irafamdastat
CAS:Irafamdastat (BMS-986368) [Example 74] is an inhibitor of FAAH and MAGL, with IC50 values of ≤ 100 nM for human FAAH and 100 nM-1 μM for human MAGL. It exhibits anticonvulsant properties.Formula:C20H21F3N4O4Color and Shape:SolidMolecular weight:438.40DX-9065A HCl hydrate
CAS:DX-9065a: Competitive fXa/prothrombinase inhibitor; blocks proinflammatory events; Ki ~10-20 nM.Formula:C26H39ClN4O8Purity:98%Color and Shape:SolidMolecular weight:571.06PD-224378
CAS:PD-224378 is the lactam form of glycamine (β-isomer), produced through a Maillard reaction between pregabalin and lactose.Formula:C20H35NO11Color and Shape:SolidMolecular weight:465.492DC360
CAS:DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.
Formula:C23H23NO2Color and Shape:SolidMolecular weight:345.4344-MDM
CAS:4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.Formula:C14H14OColor and Shape:SolidMolecular weight:198.26CP 524515
CAS:CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.
Formula:C27H27F9N2O4Color and Shape:SolidMolecular weight:614.57-APB hydrochloride
CAS:7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.Formula:C11H14ClNOColor and Shape:SolidMolecular weight:211.688FTI 276 TFA
CAS:FTI 276 TFA targets plasmodium falciparum & humans, inhibits PFT with IC50s: 0.9 nM (parasite) & 0.5 nM (human).Formula:C23H28F3N3O5S2Color and Shape:SolidMolecular weight:547.61
