Metabolism

<p>Crotonyl-CoA tetrasodium is the tetrasodium salt form of Crotonyl-CoA. It serves as an intermediate in butyrate fermentation and in the metabolism of lysine and tryptophan. This compound plays a crucial role in the metabolism of fatty acids and amino acids.</p>

<p>α-Glucosidase-IN-73 (compound 16b), an α-Glucosidase inhibitor, exhibits an IC 50 value of 0.158 μM and possesses the ability to activate PPAR γ. This compound is applicable in studies focusing on anti-diabetic and anti-inflammatory treatments.</p>

<p>Lantanose A is a bioactive chemical from Lantana cumara roots.</p>

<p>Adriamycin Aglycone, also known as Doxorubicinone, is an oncolytic agent. It is a metabolite of Doxorubicin which binds to the DNA minor-groove.</p>

<p>DPP IV/hCA II-IN-1: strong DPP IV &amp; CA inhibitor, IC50=0.049μM (DPP IV), Ki=0.0361-3.034μM (CA II-IV).</p>

<p>Calcitriol D6: deuterated Calcitriol, active vitamin D hormone, D3 metabolite, activates vitamin D receptor.</p>

<p>(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.</p>

<p>Pomonic acid, a triterpenoid, inhibits cholesterol ester build-up and ACAT activity.</p>

<p>CE(20:5(5Z,8Z,11Z,14Z,17Z) is an endogenous metabolite.</p>

<p>XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.</p>

<p>m-Tyramine has effects on the adrenergic and dopaminergic receptor.m-Tyramine is an endogenous trace amine neuromodulator.</p>

<p>ADP-specific glucokinase, expressed in thermophilic archaea, is an ADP-specific enzyme that catalyzes the conversion of glucose to glucose-6-phosphate, thereby facilitating glycolysis. This enzyme can activate T cells and enhance the phagocytic activity of macrophages. It is used in research related to metabolic disorders, neurological diseases, and tumors.</p>

<p>m-PEG8-DSPE is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>(S)-Salsolidine is a MAO inhibitor with Ki 63μM; its R enantiomer is more effective, Ki 26μM.</p>

<p>IONIS PTP1BRx (ISIS 404173) acts as an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). This compound exhibits anti-diabetic properties, making it suitable for research into insulin resistance related to obesity and type 2 diabetes.</p>

<p>Trimetazidine-N-oxide, main active metabolite of Trimetazidine, blocks 3-ketoyl CoA thiolase (IC50: 75nM) and has multiple protective properties.</p>

<p>CAY10434, a potent CYP4A hydroxylase inhibitor, has an IC50 of 8.8 nM and boosts angiotensin II contraction, Emax 6764 mg.</p>

<p>Anti bacterial agent 237 (compound Ru-8) acts as a potent antibacterial agent against Staphylococcus aureus, exhibiting minimum inhibitory concentrations (MICs) ranging from 0.78 to 1.56 μg/mL. It works by disrupting bacterial cell membranes, altering their permeability, and inducing the production of reactive oxygen species, which leads to bacterial cell death without promoting resistance. Additionally, Anti bacterial agent 237 demonstrates low hemolytic toxicity towards rabbit erythrocytes and Raw 264.7 cells. It has shown significant antibacterial activity in models of skin wound infections in mice and larval infections by the greater wax moth, effectively combating Staphylococcus aureus infections.</p>

<p>Imperatoxin A TFA, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, acts as an activator of Ca2+-release channels/ryanodine receptors (RyRs). It facilitates the influx of Ca2+ from the sarcoplasmic reticulum into the cell.</p>

<p>A unique collection of xnum metabolic pathway-related bioactive small molecule compounds for high-throughput, high-content screening.</p>