Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(196 products)
- Casein Kinase(138 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(301 products)
- FAAH(64 products)
- FXR(62 products)
- Factor Xa(85 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(226 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(57 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(34 products)
- Hydroxylase(36 products)
- IDO(84 products)
- LDL(7 products)
- Lipase(107 products)
- Lipid(61 products)
- Lipoxygenase(133 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(169 products)
- PED(1 products)
- PKM(17 products)
- PPAR(170 products)
- Phospholipase(86 products)
- ROR(47 products)
- Retinoid Receptor(21 products)
- SGK(10 products)
- Thioredoxin(12 products)
- Transferase(29 products)
- Transporter(44 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9162 products of "Metabolism"
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E234G HYPE-IN-1
CAS:Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].Formula:C14H9N5O2Color and Shape:SolidMolecular weight:279.25ABCB1-IN-4
CAS:ABCB1-IN-4 (Compound C6z) is an orally active inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.63 μM and 0.14 μM, respectively. It holds potential for diabetes research.Formula:C16H14N4SColor and Shape:SolidMolecular weight:294.374α-Glucosidase-IN-63
CAS:α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1]Formula:C16H12FN3O3S2Color and Shape:SolidMolecular weight:377.41Nampt activator-4
CAS:Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].Formula:C26H22F3N7OSColor and Shape:SolidMolecular weight:537.56ABHD antagonist 1
CAS:ABHD antagonist 1 is an inhibitor of ABHD6 (α/β-Hydrolase domain containing 6), involved in modulating biochemical pathways affected by ABHD6, thereby influencing cell function and inflammatory responses. This compound is applicable for research in fields such as pain, neurological disorders, inflammatory diseases, autoimmune diseases, metabolic disorders, and cancer.Formula:C19H20BrN3O3SColor and Shape:SolidMolecular weight:450.35UGT1A1-IN-1
CAS:UGT1A1-IN-1 (compound 2) acts as a non-competitive inhibitor of UGT1A1, effectively inhibiting the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. This compound binds to the same ligand-binding site on UGT1A1 as bilirubin and additionally functions as a 'turn-on' fluorescent probe substrate for UGT1A1 [1].Formula:C22H19NO3Color and Shape:SolidMolecular weight:345.39LTA4H-IN-3
CAS:LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].Formula:C17H15ClN4O3Color and Shape:SolidMolecular weight:358.78Epoxykynin
CAS:Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].Formula:C19H20BrF3N2O2Color and Shape:SolidMolecular weight:445.274-Acetylphenylboronic acid
CAS:4-Acetylphenylboronic acid acts as an effective inhibitor targeting carbonic anhydrase II (CAII), displaying inhibitory concentrations (IC50) of 246 μM for bovine CAII (bCA II) and 281.40 μM for human CAII (hCA II).Formula:C8H9BO3Color and Shape:SolidMolecular weight:163.97Antidiabetic agent 5
CAS:Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].Formula:C17H15N3O4SColor and Shape:SolidMolecular weight:357.38Z21090
CAS:Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].Formula:C12H14ClN3O3Color and Shape:SolidMolecular weight:283.71Vimirogant
CAS:Vimirogant is a RORγ inhibitor (Ki: <100 nM).Formula:C27H35F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:552.65Carbonic anhydrase inhibitor 17
CAS:Carbonic anhydrase inhibitor 17 (compound 7c) is a pyrazine-based sulfonamide that acts as a carbonic anhydrase II inhibitor, with an IC50 value of 0.63 nM.Formula:C18H15ClN4O3S2Molecular weight:434.92PKR Inhibitor, negative control
CAS:The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.Formula:C15H8Cl3NO2Molecular weight:340.59GGACK
CAS:GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).Formula:C14H25ClN6O5Molecular weight:392.84L 668411
CAS:L 668411, the 2,3-ditritiated methyl ester of L 659699, inhibits HMG-CoA synthase.Formula:C19H30O5Purity:98%Color and Shape:SolidMolecular weight:338.4420-HEDE
CAS:20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.Formula:C20H36O3Purity:98%Color and Shape:SolidMolecular weight:324.50PNPLA3 modifier 1
CAS:PNPLA3 Modifier 1 (Compound 10), a modifier of patatin-like phospholipase domain-containing protein 3 (pnpla3), exhibits a geometric mean EC50 of 4.9 nM.Formula:C16H19ClF2N2O4SColor and Shape:SolidMolecular weight:408.85IDX375
CAS:IDX375 is a non-nucleoside inhibitor that selectively targets the HCV NS5B enzyme. It shows promising selectivity for genotypes 1a and 1b. The structure and binding sites of IDX375 have been confirmed through X-ray co-crystallization studies.Formula:C24H37N4O6PSColor and Shape:SolidMolecular weight:540.61(S)-Dexfadrostat
CAS:(S)-Dexfadrostat ((S)-Fadrozole), an aromatase inhibitor, exhibits an IC 50 of 4.6 nM in in vitro assays using human placental microsomes. It is applicable for research on estrogen-dependent breast cancer, gynecomastia, and systemic lupus erythematosus.Formula:C14H13N3Color and Shape:SolidMolecular weight:223.27Sphingomyelin (d18:1/12:0)
CAS:Sphingomyelin (d18:1/12:0) is a polar lipid known for its role in modulating cell signal transduction. It plays a critical role in cell membranes, influencing their fluidity and stability. Additionally, sphingomyelin (d18:1/12:0) is involved in lipid metabolism and has potential in promoting neuronal cell growth. This compound is essential for the functioning and development of the nervous system.Formula:C35H71N2O6PColor and Shape:SolidMolecular weight:646.92MAGL-IN-19
CAS:MAGL-IN-19 (compound 7o) is a highly effective and selective inhibitor of MAGL.Formula:C21H26F3N3O3Color and Shape:SolidMolecular weight:425.45Dioctanoylphosphatidic acid sodium
CAS:Dioctanoylphosphatidic acid sodium serves as a modulator of phagocyte respiratory bursts, a precursor to diacylglycerol and lyso-phosphatidic acid, and influences the phosphorylation of the mammalian target of rapamycin (mTOR). Additionally, it enhances the viability of gallbladder cancer cells inhibited by histone deacetylase inhibitors (HDACI). This compound is derived from glycerophospholipids through the action of phospholipase D.Formula:C19H36NaO8PColor and Shape:SolidMolecular weight:446.452,4-Dihydroxybutanoic acid
CAS:2,4-Dihydroxybutanoic acid is typically not found in extracts of normal human urine and is present only in trace amounts in newborns, while cases of succinic semialdehyde dehydrogenase deficiency consistently exhibit elevated levels of this metabolite.Formula:C4H8O4Color and Shape:SolidMolecular weight:120.109-cis-β-Carotene
CAS:9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal.Formula:C40H56Purity:98%Color and Shape:SolidMolecular weight:536.87(S)-CPP sodium
CAS:(S)-CPP sodium serves as an inhibitor of the branched-chain α-keto acid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, (S)-CPP (IC50 of 6.3 μM) inhibits BDK, which activates the complex, leading to a significant reduction in the levels of leucine/isoleucine and valine in the plasma of wild-type mice.Formula:C9H8ClNaO2Color and Shape:SolidMolecular weight:206.60OMDM169
CAS:OMDM169: potent/selective MAGL inhibitor, raises 2-AG, analgesic via cannabinoid receptors, IC50: 0.13-0.41μM in rat/COS-7, inactive at CB1/CB2.Formula:C25H45NO5Purity:98%Color and Shape:SolidMolecular weight:439.63GC-IN-2
CAS:GC-IN-2 (Compound 25) is an effective and selective non-sugar-based glucocerebrosidase inhibitor with an IC50 value of 6.46 μM. It is utilized in research related to Gaucher's disease.Formula:C19H16N2O3SColor and Shape:SolidMolecular weight:352.413β,7β-Dihydroxy-5-cholestenoic acid
CAS:3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid whose levels are elevated in Niemann-Pick Type C and B diseases, leading to toxicity in ocular motor neurons. It is synthesized by the enzymatic action of hydroxysteroid 11-β dehydrogenase 1 from 3β-hydroxy-7-oxocholest-5-en-(25R)26-enoic acid (3βH,7O-CA).Formula:C27H44O4Color and Shape:SolidMolecular weight:432.641,2-Dipentadecanoyl-rac-glycerol
CAS:1,2-Dipentadecanoyl-rac-glycerol (DG(15:0/15:0/0:0)) is a compound referenced in studies examining the effect of insulin on the content of 1,2-diacylglycerol in rat hearts. Insulin is observed to increase the amount of 1,2-diacylglycerol containing specific fatty acid compositions in the heart, which may be linked to cardiac contractility.Formula:C33H64O5Color and Shape:SolidMolecular weight:540.86RO5101576
CAS:RO5101576 is a potent antagonist of LTB4 receptor.Formula:C36H38O8SPurity:98%Color and Shape:SolidMolecular weight:630.75hCAIX-IN-20
CAS:hCAIX-IN-20 (compound APBS-5m) is a potent inhibitor of carbonic anhydrase IX (hCA IX), with a Ki of 2.7 nM, playing a significant role in cancer research.Formula:C19H13Cl2N5O4S2Molecular weight:510.373-Oxochenodeoxycholic acid
CAS:3-Oxochenodeoxycholic acid is an endogenous metabolite detectable in feces and may serve as a diagnostic marker for various diseases, including COVID-19.Formula:C24H38O4Color and Shape:SolidMolecular weight:390.556HSD17B13-IN-32
CAS:HSD17B13-IN-32 (Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤0.1 μM for estradiol. It can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].Formula:C23H15Cl2N5O3Color and Shape:SolidMolecular weight:480.3OH-α-PVP TFA
CAS:OH-α-PVP (OH-α-Pyrrolidinovalerophenone) TFA is a metabolite of α-pyrrolidinovalerophenone, which is a synthetic cathinone stimulant.Formula:C17H24F3NO3Molecular weight:347.37Carbonic anhydrase inhibitor 28
Carbonic anhydrase inhibitor28 (Compound 11) serves as an inhibitor for the Pseudomonas aeruginosa carbonic anhydrase. It exhibits antibacterial activity, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 0.5 and 1 μg/mL, respectively, against P. aeruginosa. Carbonic anhydrase inhibitor28 is utilized in research focused on anti-infection applications.Formula:C24H24FN5O7SColor and Shape:SolidMolecular weight:545.54(±)14(15)-DiHETE
CAS:(±)14(15)-DiHETE is an oxidized lipid and a metabolite of Eicosapentaenoic Acid, which is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA).Formula:C20H32O4Color and Shape:SolidMolecular weight:336.47FXIa-IN-10
FXIa-IN-10 is a potent, orally bioavailable inhibitor of Activator XI (FXIa) (Ki: 0.17 nM).Formula:C23H18Cl2F3N9O2Color and Shape:SolidMolecular weight:580.35Phocaecholic Acid
CAS:Phocaecholic acid, a bile acid, has been identified in the bile of ducks (A. platyrhynchos).Formula:C24H40O5Color and Shape:SolidMolecular weight:408.57SHP2-IN-39
CAS:SHP2-IN-39 (Example 63) is an inhibitor of SHP2, with an IC50 value of 0.007 μM. It is applicable in tumor research.Formula:C17H20Cl2N6OSColor and Shape:SolidMolecular weight:427.35Tauro-ω-muricholic acid sodium
Tauro-ω-muricholic acid sodium (TωMCA sodium) is an analogue of tauro-α-muricholic acid, a bile acid of hepatic origin.Formula:C26H44NNaO7SColor and Shape:SolidMolecular weight:537.68Casein kinase 1δ-IN-26
CAS:Casein kinase1δ-IN-26 (compound 505) is a potent inhibitor of casein kinase 1δ. This compound is applicable in research related to neurodegenerative disorders such as Alzheimer’s disease.
Formula:C16H13N3O4SColor and Shape:SolidMolecular weight:343.357Zolpyridine
CAS:Zolpyridine is a degradation product of Zolpidem tartrate.Formula:C14H14N2OColor and Shape:SolidMolecular weight:226.272-Deoxokanshone M
CAS:2-Deoxokanshone M (Nardosinone acid), a degradation product of Nardosinone, exhibits potent vasodilatory activity.Formula:C12H16O2Color and Shape:SolidMolecular weight:192.25HSD17B13-IN-44
CAS:HSD17B13-IN-44 (Compound 23) functions as an inhibitor targeting hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of < 0.1 μM against estradiol. This compound is applicable in the study of liver diseases or metabolic disorders [1].Formula:C18H14FNO5S2Color and Shape:SolidMolecular weight:407.44(R)-Acenocoumarol
CAS:(R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) is a short-acting, orally administered anticoagulant that works by inhibiting vitamin K epoxide reductase (vitamin K1 recycling), similar to Warfarin. It demonstrates greater anticoagulant potency in vivo compared to Warfarin. This compound has a single chiral center, resulting in two enantiomeric forms. The (R)-enantiomer has a longer plasma elimination half-life of 6.6 hours, slower plasma clearance of 1.9 L/h, and stronger anticoagulation effects than the (S)-enantiomer.Formula:C19H15NO6Molecular weight:353.33SCO-792
SCO-792: potent, reversible oral enteropeptidase inhibitor, with slow in vitro dissociation and in vivo protein digestion blocking.Formula:C22H22N4O8·xH2OColor and Shape:SolidAZ-PFKFB3-67 quarterhydrate
AZ-PFKFB3-67 quarterhydrate inhibits PFKFB3 (IC50: 11 nM), PFKFB2 (159 nM), and PFKFB1 (1130 nM).Formula:C26H27N5O4Color and Shape:SolidMolecular weight:460.01TKL-IN-2
CAS:TKL-IN-2 (Compound 7m) is a TKL inhibitor with an IC50 of 0.11 mg/L against SvTKL. It exhibits excellent herbicidal activity against Digitaria sanguinalis and Amaranthus retroflexus, while being safe for corn, wheat, soybean, and cotton. TKL-IN-2 is suitable for research in weed control in crop fields.Formula:C23H17ClF3N3OColor and Shape:SolidMolecular weight:443.85(6S)-CP-470711
CAS:(6S)-CP-470711 (Compound 8) acts as an inhibitor of sorbitol dehydrogenase (SDH) in both humans and rats, exhibiting inhibitory concentrations (IC50) of 19 nM and 27 nM, respectively. Additionally, (6S)-CP-470711 has been shown to ameliorate diabetes in rats induced by Streptozotocin.Formula:C18H26N6O2Color and Shape:SolidMolecular weight:358.44
