Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(196 products)
- Casein Kinase(138 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(302 products)
- FAAH(65 products)
- FXR(62 products)
- Factor Xa(87 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(227 products)
- GR(3 products)
- GSNOR(4 products)
- Glucokinase(57 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(34 products)
- Hydroxylase(36 products)
- IDO(84 products)
- LDL(8 products)
- Lipase(106 products)
- Lipid(61 products)
- Lipoxygenase(134 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(169 products)
- PED(1 products)
- PKM(17 products)
- PPAR(170 products)
- Phospholipase(85 products)
- ROR(47 products)
- Retinoid Receptor(24 products)
- SGK(10 products)
- Thioredoxin(12 products)
- Transferase(29 products)
- Transporter(45 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9217 products of "Metabolism"
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hCAIX/XII-IN-15
CAS:hCAIX/XII-IN-15 (Compound 17β) is an inhibitor of hCA IX and hCA XII, exhibiting Ki values of 0.42 and 4.37 μM, respectively. It demonstrates a pro-apoptotic effect in multiple myeloma cells.Formula:C17H18O4SColor and Shape:SolidMolecular weight:318.387sEH inhibitor-2
SEH inhibitor-2 is an orally active sEH blocker (IC50=0.9 nM) with predicted 71.2-88.4% absorption, potentially aiding cardiovascular health.Formula:C23H18N4O3Color and Shape:SolidMolecular weight:398.41Tabimorelin hemifumarate
CAS:orally active ghrelin receptor (GHS-R1a) agonistFormula:C32H40N403C4H404Purity:98%Color and Shape:SolidMolecular weight:586.72Keto lovastatin
CAS:Keto lovastatin is an impurity of lovastatin with antibacterial properties. Lovastatin is a cell-permeable HMG-CoA reductase (HMG-CoA reductase) inhibitor used to reduce cholesterol levels.Formula:C24H34O6Color and Shape:SolidMolecular weight:418.523ALOX15-IN-1
ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.Formula:C24H31N3O5SColor and Shape:SolidMolecular weight:473.59TQ05310
CAS:TQ05310 is an orally active inhibitor of mutant IDH2, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutations. This compound suppresses the production of 2-hydroxyglutarate (2-HG) by inhibiting the enzymatic activity of mutant IDH2, and induces differentiation in cells expressing IDH2-R140Q and IDH2-R172K. TQ05310 is utilized in research on acute myeloid leukemia.Formula:C19H17F6N7OColor and Shape:SolidMolecular weight:473.38Rostratin B
CAS:Rostratin B, a cytotoxic disulfide, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an IC50 value of 1.9 μg/mL.Formula:C18H20N2O6S2Color and Shape:SolidMolecular weight:424.49sEH inhibitor-4
Compound B15: potent sEH inhibitor (0.03 nm), reduces inflammation & pain.Formula:C27H28Cl2N4O3Color and Shape:SolidMolecular weight:527.44α-Glucosidase-IN-12
α-Glucosidase-IN-12 is a potent inhibitor of α-glucosidase (IC50: 10.20 μM).Formula:C25H30N4O4S2Color and Shape:SolidMolecular weight:514.66PPI-2458
CAS:PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.Formula:C22H36N2O6Color and Shape:SolidMolecular weight:424.53Mitapivat hydrochloride
CAS:Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Formula:C24H27ClN4O3SColor and Shape:SolidMolecular weight:487.014RORγt inverse agonist 29
RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.Formula:C25H24N2O5SColor and Shape:SolidMolecular weight:464.53CYP2C1/CYP2C19-IN-2
CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.Formula:C27H28N2O6SColor and Shape:SolidMolecular weight:508.59Carbonic anhydrase inhibitor 5
Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.Formula:C24H20ClN3O3SColor and Shape:SolidMolecular weight:465.95Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Formula:C30H40Cl2N6O4S2Purity:98%Color and Shape:SolidMolecular weight:683.717-Hydroxyrisperidone
CAS:7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone. Risperidone acts as a 5-HT2 receptor blocker, an inhibitor of P-glycoprotein (P-Glycoprotein), and an antagonist of the dopamine D2 receptor.Formula:C23H27FN4O3Color and Shape:SolidMolecular weight:426.484BMS-214662 mesylate
CAS:BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.Formula:C26H27N5O5S3Color and Shape:SolidMolecular weight:585.718Enpp-1-IN-7
Enpp-1-IN-7: potent enpp-1 inhibitor, broad specificity, potential in cancer/infectious disease research. (WO2021203772A1)Formula:C18H19N7O4SColor and Shape:SolidMolecular weight:429.45PTP1B-IN-21
PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.Formula:C22H22O11Color and Shape:SolidMolecular weight:462.4α-Glucosidase-IN-18
α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM.Formula:C23H19NO2SColor and Shape:SolidMolecular weight:373.47SCP1-IN-1
CAS:SCP1-IN-1 (SH T-62) is a potent inhibitor of SCP1, promoting REST degradation and potentially aiding glioblastoma research.Formula:C20H19F3N2O7S2Purity:99.53%Color and Shape:SoildMolecular weight:520.5Ref: TM-T60077
1mg49.00€5mg104.00€10mg169.00€25mg311.00€50mg472.00€100mg707.00€1mL*10mM (DMSO)119.00€Nonsteroidal aromatase inhibitor 1
Compound 13h, a nonsteroidal aromatase inhibitor, has a potent IC50 of 0.09 nM against CYP19A1, showing promise for breast cancer research.Formula:C22H16N4O2Color and Shape:SolidMolecular weight:368.39α-Amylase-IN-10
CAS:α-Amylase-IN-10 (Compound 15n) is an inhibitor of α-Amylase, with an IC50 of 5.00 µM. This compound is applicable for research in type 2 diabetes.Formula:C21H15ClN2O4SColor and Shape:SolidMolecular weight:426.873Turoctocog alfa
CAS:Turoctocog alfa: recombinant FVIII from CHO cells for hemophilia A study.Color and Shape:Solidtrans-Doxercalciferol
CAS:trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is an activator of the Vitamin D receptor and prevents renal disease.Formula:C28H44O2Purity:98%Color and Shape:SolidMolecular weight:412.65Tacrolimus anhydrous 8-epimer
CAS:Tacrolimus anhydrous 8-epimer, an immunosuppressive l-pipecolic acid macrolide, blocks T cell growth by hindering IL-2.Formula:C44H69NO12Color and Shape:SolidMolecular weight:804.02Alkannin
CAS:Alkannin: potent, tumor-specific PKM2 inhibitor; non-inhibitory to PKM1/PKL; potential anticancer agent.Formula:C16H16O5Color and Shape:SolidMolecular weight:288.3BLT-4
CAS:BLT-4 is a specific and reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the SR-BI-mediated transfer of lipids between high-density lipoprotein (HDL) and cells.Formula:C18H16N2O2Color and Shape:SolidMolecular weight:292.3327-APB hydrochloride
CAS:7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.Formula:C11H14ClNOColor and Shape:SolidMolecular weight:211.688Rosiptor acetate
CAS:Rosiptor (AQX-1125) activates SHIP1, inhibits Akt, and reduces inflammation and allergy in rodents.Formula:C22H39NO4Purity:98%Color and Shape:Solid PowderMolecular weight:381.55AD012
AD012, a dual cACE/NEP inhibitor, leverages lenopril-tryptophan for potential anti-hypertensive and cardioprotective benefits.Formula:C25H32N2O6Color and Shape:SolidMolecular weight:456.53(E)-10-Hydroxynortriptyline maleate
CAS:(E)-10-Hydroxy Nortriptyline maleate, a derivative of antidepressant Nortriptyline, eases depression symptoms.Formula:C23H25NO5Purity:98%Color and Shape:SolidMolecular weight:395.455RXR antagonist 2
RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.Formula:C29H35F3N2O3Color and Shape:SolidMolecular weight:516.6Complex III-IN-2
Complex III-IN-2 inhibits complex III, with antifungal EC50: 29.31 mg/L vs R. solani, 29.98 mg/L vs S. sclerotiorum.Formula:C15H21ClN2O2SColor and Shape:SolidMolecular weight:328.86Canosimibe
CAS:Canosimibe is a cholesterol absorption inhibitorFormula:C44H60FN3O10Color and Shape:SolidMolecular weight:809.96GSK2945 hydrochloride
GSK2945 HCl is a specific Rev-erbα antagonist, EC50: 21.5 μM (mouse), 20.8 μM (human), increases cholesterol 7α-hydroxylase.Formula:C20H19Cl3N2O2SColor and Shape:SolidMolecular weight:457.8NSC 828467
NSC 828467 is one of the top five CA-IX inhibitors with significant in vitro anticancer activity (IC50: 27.2 nM).Formula:C21H19N9O2SColor and Shape:SolidMolecular weight:461.5PHGDH-IN-2
PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.Formula:C22H20N4O3SColor and Shape:SolidMolecular weight:420.48Lp-PLA2-IN-6
CAS:Lp-PLA2-IN-6: Potent tetracyclic inhibitor of rhLp-PLA2, with pIC50 of 10.0, and potential in neurodegenerative research.Formula:C25H21F5N4O3Color and Shape:SolidMolecular weight:520.45ATX inhibitor 12
Oral ATX inhibitor 12 (IC50: 1.72 nM) at 60 mg/kg prevents lung damage in C57Bl/6J mice.
Formula:C30H34FN5O2Color and Shape:SolidMolecular weight:515.62Squalestatin 3
CAS:Squalestatin 3 is an inhibitor of squalene synthase.Formula:C25H30O13Purity:98%Color and Shape:SolidMolecular weight:538.5AChE/PDE4-IN-1
AChE/PDE4-IN-1, compound 12c, dual inhibitor; IC50: 0.28μM for AChE, 1.88μM for PDE4D, may reduce Alzheimer's neuroinflammation.Formula:C23H28N2O3Color and Shape:SolidMolecular weight:380.48Glucosylceramide synthase-IN-3
Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.Formula:C21H20FN3O3Color and Shape:SolidMolecular weight:381.4Miaosporone A
Miaosporone A: angucyclic quinone, cytotoxic to MCF-7, NCI-H187, Vero cells; anti-TB and anti-malaria with IC50 of 2.4 μM, 2.5 μM.Formula:C19H18O5Color and Shape:SolidMolecular weight:326.34WR 199507 trihydrobromide
CAS:WR 199507 trihydrobromide is a primary aminoquinoline metabolite that induces the formation of methemoglobin in canine erythrocyte lysates.Formula:C15H24Br3N3O2Color and Shape:SolidMolecular weight:518.08AXKO-0046
AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.Formula:C25H33N3Color and Shape:SolidMolecular weight:375.55Lp(a)-IN-5
CAS:Lp(a)-IN-5 (Compound A) is an orally active inhibitor of lipoprotein (a) [Lp(a)]. It effectively inhibits the assembly of Apo(a) and ApoB proteins, with an IC50 value of 0.41 nM. Lp(a)-IN-5 shows potential for research into diseases associated with elevated plasma Lp(a) levels, such as cardiovascular diseases.Formula:C43H56N4O7Color and Shape:SolidMolecular weight:740.927TMX-4113
TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1].Formula:C12H12N4O2S2Color and Shape:SolidMolecular weight:308.38ROR1-IN-1
CAS:ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.Formula:C33H27N5O3Molecular weight:541.60α-Amylase-IN-7
CAS:α-Amylase-IN-7 (Compound 6e) is an inhibitor of α-Amylase, with an IC50 of 40 μM, indicating its potency. This compound shows potential as an anti-diabetic medication.Formula:C18H15ClN6O2SMolecular weight:414.87
