Metabolism

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PL in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Caldaret HCl is an intracellular Ca2+ modulator that regulates calcium homeostasis at the sarcoplasmic reticulum and cell membrane, and can be used to study acute myocardial infarction and heart failure.</p>

<p>MDCG sodium (N-methyl-N-dithiocarboxyglucamine sodium) is a metal chelator that promotes biliary excretion of Cd.</p>

<p>T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.</p>

<p>Pargyline hydrochloride (Pargylamine hydrochloride) is an irreversible monoamine oxidase(MAO) inhibitor with antihypertensive properties.</p>

<p>GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).</p>

<p>Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential</p>

<p>GW 7647 is an effective and highly selective PPARα agonist. GW 7647 can reduce the production of nitric oxide in macrophages. Cost-effective and quality-assured.</p>

<p>Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent protein tyrosine phosphatase inhibitor.</p>

<p>Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.</p>

<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>

<p>Oxiconazole nitrate (Ro 13-8996) is an antifungal imidazole inhibiting fungal growth by blocking ergosterol synthesis, disrupting cell membranes.</p>

<p>6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.</p>

<p>CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.</p>

<p>JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM).</p>

<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>

<p>Hi 76-0079: HSL inhibitor, IC50=184 nM; potential for obesity and diabetes research.</p>

<p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>

<p>ML390 exerts its potent differentiation effect on multiple leukemia models.</p>

<p>Clorgyline hydrochloride (Clorgiline hydrochloride), a white powder, is served as monoamine oxidase inhibitor.</p>

<p>Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.</p>

<p>Acipimox (K-9321), a niacin derivative, treats hyperlipidemia in type 2 diabetics.</p>

<p>Amylase (Diastase) is any one of a group of enzymes which catalyses the breakdown of starch into maltose.</p>

<p>3-Pyridinemethanol (Roniacol) is an alcohol analog of nicotinic acid which is a peripheral vasodilator that causes flushing and may decrease blood pressure.</p>

<p>Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility.</p>

<p>Pramiracetam, an advanced nootropic from piracetam, enhances cognitive function post-brain trauma and treats cerebrovascular disorders.</p>

<p>1-Aminohydantoin HCl, a metabolite of furantoin, binds to proteins, releases in acid, and is detectable in meat/milk for drug residue tests.</p>

<p>Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes.</p>

<p>Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).</p>

<p>Anhydrosimvastatin (Dehydro simvastatin) is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor.</p>

<p>Hyaluronic acid sodium (MW 20 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>4-(Aminomethyl)benzoic acid (PAMBA), an antifibrinolytic, is an unnatural amino acid derivative.</p>

<p>N-Carbethoxy-4-piperidone is an aminopyrimidine derivative, compositions containing them and there served as pharmaceuticals.</p>

<p>Carbadox, an antibacterial for swine dysentery and growth promotion, is banned in the UK due to carcinogen and mutagen risks.</p>

<p>OGT inhibitor 4a is an O-linked n-acetylglucosaminyltransferase (OGT) inhibitor with anticancer activity for the study of autoimmune and neurological disorders.</p>

<p>Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.</p>

<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>

<p>Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling</p>

<p>DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.</p>

<p>Osocimab (BAY 1213790) is a strong FXIa inhibitor, Ki 2.4 nM, EC50 0.2 nM, and reduces thrombosis in research.</p>

<p>ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist.</p>

<p>Ca2+ channel agonist 1 activates N-type Ca2+ channels and inhibits Cdk2 (EC50: 14.23 μM/3.34 μM) for motor nerve issues.</p>

<p>Hyaluronic acid sodium (MW 40 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>Bis(4-cyanophenyl)methanol (4, 4'-Dicyanobenzhydrol) is a metabolite of Letrozole.</p>

<p>4-Desmethoxy Omeprazole, active Omeprazole metabolite, is a PPI that inhibits CYP2C19 (Ki: 2-6μM).</p>

<p>Diphenyl phosphate (Phenyl hydrogen phosphate) is capable of gender-specific inhibition of growth and energy metabolism in zebrafish.</p>

<p>Ezetimibe inhibits NPC1L1, activates Nrf2, and reduces cholesterol absorption; ent-Ezetimibe is its RRS-enantiomer.</p>

<p>Liarozole dihydrochloride inhibits CYP450, estrogen, androgen synthesis; an oral drug for prostate cancer/skin disorders.</p>