Metabolism

<p>NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.</p>

<p>DSPE-PEG2000-NYZL1 is a PEG compound composed of DSPE and NYZL1. NYZL1 has the ability to specifically bind to bladder cancer tissues and cells. DSPE-PEG2000-NYZL1 is suitable for drug delivery applications.</p>

<p>Resveratrol-3-O-sulfate reduces IL-1α/β, IL-6, TNF-α in LPS-stimulated U-937 cells, inhibits Caco-2 cell growth, induces apoptosis, and binds mitoNEET.</p>

N-Acetyl-Ser-Asp-Lys-Pro (TFA), a bone marrow tetrapeptide, is a specific ACE substrate for angiotensin conversion.

<p>EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage</p>

<p>Pyrocholecalciferol, a vitamin D analogue, is produced through the photochemical transformation of 7-dehydrocholesterol (7-DHC) [1] [2].</p>

<p>Daclatasvir Impurity B, a noted impurity of the antiviral agent Daclatasvir, acts as a potent inhibitor of the HCV NS5A protein [1].</p>

<p>CAIX/CAXII-IN-4 (Compound 7h) is an inhibitor of carbonic anhydrase (CA) that binds to CAIX, CA XII, and CAII with Ki values of 1.324 μM, 0.435 μM, and 3.035 μM, respectively. This compound exhibits broad-spectrum anti-tumor activity and inhibits the proliferation of central nervous system tumor cells U251, with a GI50 of 0.361 μM.</p>

<p>substrate of IMP dehydrogenase (IMPDH)</p>

<p>C24 3'-sulfo Galactosylceramide is a key myelin sulfatide, high in leukodystrophy patients, non-immunogenic compared to C24:1 variant.</p>

<p>Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.</p>

<p>A unique collection of xnum metabolic pathway-related bioactive small molecule compounds for high-throughput, high-content screening.</p>

<p>CP-610431 inhibits ACC1/ACC2 (nonselective) with ~50 nM IC50, potentially aiding metabolic syndrome research.</p>

<p>2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine is a histamine metabolite.</p>

<p>Arylsulfatase, a type I sulfatase enzyme found in both prokaryotes and eukaryotes, is frequently utilized in biochemical research [1].</p>

<p>Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers.</p>

<p>Lagunamycin is used as a novel 5-lipoxygenase inhibitor.</p>

<p>Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule.</p>

<p>Ophiobolin A: Fungal metabolite, phytotoxin, inhibits calmodulin-activated phosphodiesterase (IC50: 9μM), with antimicrobial and anticancer properties.</p>

<p>PGK is an enzyme that catalyzes phosphate transfer between 1,3-BPG and ADP, vital in glycolysis and gluconeogenesis.</p>

<p>ABC34, an inactive JJH260 control, poorly inhibits AIG1 enzyme at IC50 &gt;25 μM; potently blocks off-target hydrolases ABHD6 and PPT1.</p>

<p>3-Oxo-7-hydroxychol-4-enoic acid, a body metabolite, may signal bad liver disease prognosis.</p>

<p>DSPE-PEG1000-pPB is a PEG compound consisting of DSPE and a cyclic oligopeptide (pPB). The pPB component exhibits a strong binding affinity to PDGFRβ, which is overexpressed in activated hepatic stellate cells (HSC). DSPE-PEG1000-pPB is applicable for drug delivery.</p>

<p>Asundexian (BAY-2433334) is a potent and orally active inhibitor of the coagulation factor FXIa that directly and reversibly binds to the active site of FXIa,</p>

<p>Bacterial α-Amylase is an enzyme that catalyzes the hydrolysis reaction of starch into smaller sugar molecules such as maltose and glucose.</p>

<p>Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.</p>

<p>LDHA-IN-3 is a potent selenobenzene-based LDHA inhibitor with a 145.2 nM IC50, useful in cancer research.</p>

<p>N-acetyl Leukotriene E4 is an endogenous metabolite of Leukotriene E4, less active than Leukotriene E4, causing constriction of the airways.</p>

<p>Alphostatin is an alkaline phosphatase inhibitor isolated from Bacillus megaterium.</p>

<p>Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.</p>

<p>Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.</p>

<p>Ser-Ala-alloresact acetate is a sperm-activating peptide (SAP) that is released by marine invertebrate eggs and plays an important role in fertilization.</p>

<p>(±)14-HDHA is an oxidized metabolite of DHA and can be further oxidized to the 14-oxoDHA, 14-HDoHE inhibits LPS-induced IL-6 mRNA expression.</p>

<p>PKR activator 4 (example 7A), a potent activator of pyruvate kinase R (PKR), holds promise for blood disorder research [1].</p>

CE(20:5(5Z,8Z,11Z,14Z,17Z) is an endogenous metabolite.

<p>SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.</p>

<p>m-Tyramine has effects on the adrenergic and dopaminergic receptor.m-Tyramine is an endogenous trace amine neuromodulator.</p>

<p>α-Glucosidase-IN-85 (Compound 8D1) functions as an inhibitor of α-Glucosidase, with an IC50 of 5.43 μM. This compound is useful for research related to type 2 diabetes.</p>

<p>m-PEG8-DSPE is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>γ-Acetylenic GABA hydrochloride is a GABA transaminase inhibitor.</p>

Ppack trifluoroacetate: Peptide, inhibits thrombin, prevents clotting (Ki: 0.24 nM), used in anticoagulation & thrombin research.

<p>CstII (ST8Sia VI), an alpha-2,8-sialyltransferase, catalyzes α2,8 oligo/polysialic acid chain elongation. Used in biochemical research.</p>

<p>Palitantin is a useful organic compound for research related to life sciences. The catalog number is T125757 and the CAS number is 15265-28-8.</p>

Leuhistin is an aminopeptidases N inhibitor isolated from Bacillus laterosporus BMI156-14F1.

<p>2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.</p>

<p>Tibenelast is a cioactive chemical.</p>

<p>Alterporriol B is a biochemical.</p>

<p>AM6701 is a novel highly potent inhibitor of human alpha/beta hydrolase domain 6 (habhd6)</p>

<p>BSO-07 is a ROS/JNK activator that exhibits potent anti-cancer properties, demonstrated by an IC50 of 24.81 μM in human breast cancer (BC) cells. The mechanism of action for BSO-07 involves JNK activation and the promotion of increased ROS levels, which lead to the induction of apoptosis (Apoptosis) and tumorigenic apoptosis. This includes enhanced expression of apoptosis-related proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, along with a reduction in the levels of anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL, and Survivin). BSO-07 holds promise for research in the field of breast cancer.</p>

<p>hBChE-IN-3 (compound 30) serves as both an activator of carbonic anhydrase (CA) and an inhibitor of cholinesterase (ChE), exhibiting IC50 values of 7.4 nM for AchE and 1.9 nM for BchE. This compound is utilized in the research of neurodegenerative and psychiatric disorders.</p>