Metabolism

<p>β-Tetralone (2-Tetralone) is a vital drug synthesis precursor with complex pharmacological properties in combating neurological disorders. Cost-effective and quality-assured.</p>

<p>Manoyl oxide is a proposed intermediate in the biosynthesis of forskolin and other medically important labdane-type terpenoids.</p>

<p>Mersalyl is an organic mercurial diuretic.</p>

<p>Metrizamide is a nonionic radiopaque contrast agent.</p>

<p>Diadenosine pentaphosphate pentasodium, an endogenous purine from platelets and various cells, has vasoactive properties.</p>

<p>Anti bacterial agent 237 (compound Ru-8) acts as a potent antibacterial agent against Staphylococcus aureus, exhibiting minimum inhibitory concentrations (MICs) ranging from 0.78 to 1.56 μg/mL. It works by disrupting bacterial cell membranes, altering their permeability, and inducing the production of reactive oxygen species, which leads to bacterial cell death without promoting resistance. Additionally, Anti bacterial agent 237 demonstrates low hemolytic toxicity towards rabbit erythrocytes and Raw 264.7 cells. It has shown significant antibacterial activity in models of skin wound infections in mice and larval infections by the greater wax moth, effectively combating Staphylococcus aureus infections.</p>

<p>DSPE-PEG5000-APRPG is a PEG compound composed of DSPE and the APRPG peptide, utilized for drug delivery.</p>

<p>11(R)-HETE aids in oocyte maturation in sea urchins and tentacle regeneration in hydras; it is also made by aspirin-influenced COX-2 and arachidonic acid.</p>

<p>DSPE-PEG5000-KAA is a PEG compound composed of DSPE and the CKAAKNK (KAA) peptide. The CKAAKNK peptide specifically targets the tumor vasculature of RIP-Tag2 transgenic mice. DSPE-PEG5000-KAA can be utilized for drug delivery purposes.</p>

<p>O-Demethyl Lenvatinib, a Lenvatinib metabolite, is an oral TKI targeting VEGFR, FGFR, PDGFR, KIT &amp; RET with potent antitumor effects.</p>

<p>ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.</p>

<p>Pestalotin, a fungal derivative, promotes rice seedling growth and sugar release, has antifungal properties, and is cytotoxic to certain cells.</p>

<p>CAXII-IN-2 (compound 3j) is a highly effective inhibitor of CAXII. It demonstrates inhibitory activity against CA IX and CAXII, with Ki values of 27.4 nM and 4.0 nM, respectively.</p>

<p>Dansylphenylalanine is a typical fluorescent analyte.</p>

<p>(Rac)-BMS-816336 is a racemic 11β-HSD1 inhibitor; IC50: 10 nM (human), 68 nM (mouse), metabolically stable.</p>

<p>Isodihydroauroglaucin is a useful organic compound for research related to life sciences. The catalog number is T124274 and the CAS number is 74886-31-0.</p>

<p>Diacetinase, a member of the esterase family, catalyzes the hydrolysis of glyceryl diacetate (Diacetin). It is utilized in the measurement of lipase activity.</p>

<p>Yokonoside is a biochemical.</p>

<p>Clopidogrel Related Compound A is a useful organic compound for research related to life sciences.</p>

<p>α-Glucosidase-IN-87 (Compound 11c) is an orally active inhibitor of α-glucosidase with an IC50 of 119.7 μM. It exhibits hypoglycemic properties and is applicable in research on metabolic diseases such as diabetes.</p>

<p>IETP2 targets low-density lipoprotein receptor-related protein 1 (LRP1) with a KD of 738 nM, making it useful for delivering drugs and imaging agents across the blood-labyrinth barrier (BLB).</p>

<p>DSPE-PEG5000-R9 is a PEG compound composed of DSPE and the polyarginine-9 peptide (R9) peptide, applicable for drug delivery.</p>

<p>DSPE-PEG1000-CCK8 is a PEG compound composed of DSPE and Cholecystokinin-8 (CCK8). Cholecystokinin-8 exhibits peptide activity that regulates gallbladder contraction and the functions of the digestive system. DSPE-PEG1000-CCK8 can be utilized for drug delivery.</p>

<p>Calcitriol Derivatives is an analog of vitamin D3.</p>

<p>Dihydrozeatin riboside is a cytokinin that can be isolated from Phaseolus vulgaris L.</p>

<p>Ozolinone, an etozoline metabolite, is a loop diuretic treating hypertension and edema.</p>

<p>CD13-IN-1 (Compound 5f) is a CD13 inhibitor with an IC50 value of 1.71 μM. It effectively suppresses the proliferation of various tumor cells, demonstrating antitumor activity.</p>

<p>AH078 (compound 37) is a selective PROTAC degrader targeting CK1δ and CK1ε with low selectivity for CK1α. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1δ/CK1ε ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.</p>

<p>ROC-0929 (13a) is a selective sPLA2 inhibitor with IC50 of 80 nM, targeting hGX and blocking ERK1/2, p-38 phosphorylation for inflammation research.</p>

<p>Glycyllysine is a dipeptide. It can be used to study the interactions of the lysine side chain with copper in Glycyl-L-lysine-copper(II) complex.</p>

<p>DSPE-PEG1000-ANG is a PEG compound composed of DSPE and a dual-targeting ligand (Angiopep-2, ANG). ANG demonstrates high LRP1 binding efficiency and has been utilized for targeting glioma delivery. DSPE-PEG1000-ANG is suitable for drug delivery applications.</p>

<p>PKM2 inhibitor G is a inhibitor of pyruvate kinase.</p>

<p>Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human.</p>

<p>Myoregulin (MLN peptide), a regulin family member, modulates muscle performance through intracellular calcium handling.</p>

<p>N-Desbutyl Dronedarone-d7 HCl is the deuterium-labelled isomer of N-Desbutyl Dronedarone HCl, used for isotope tracing. N-Desbutyl Dronedarone is a metabolite of the antiarrhythmic drug Dronedarone.</p>

<p>Isoglycycoumarin, a flavonoid derived from the roots of Glycyrrhiza uralensis, serves as a highly selective probe for human cytochrome P450 2A6.</p>

<p>hCA IX-IN-1 inhibits hCA I/II/IX/XII with Ki of 331.4/28.4/9.4/17.8 nM, has anticancer properties.</p>

<p>SDUY816 is an orally active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. It exhibits analgesic properties and demonstrates good safety and pharmacokinetic profiles, having an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral, 10 mg/kg). SDUY816 is applicable for research in the field of neuropathic pain disorders.</p>

<p>hCA/VEGFR-2-IN-4 (compound 15b), an indolinylbenzenesulfonamide, serves as a potential dual inhibitor targeting cancer-related human carbonic anhydrases hCA IX/</p>

<p>CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological</p>

<p>Ethyl gentisate acts as a dual regulator of cell differentiation, promoting osteoblast differentiation while inhibiting osteoclast differentiation.</p>

<p>Tanshinone IIA anhydride: irreversible inhibitor for human CE1 (Ki=1.9 nM) and hiCE (Ki=1.4 nM).</p>

<p>hCYP3A4-IN-1 (compound C6) is a potent, orally active inhibitor of hCYP3A4, exhibiting IC50 values of 43.93 nM in human liver microsomes (HLMs) and 153.00 nM in</p>

<p>Tyrosylalanine (H-Tyr-Ala-OH), a dipeptide comprising L-tyrosine and L-alanine, is referenced in studies [1] [2].</p>

<p>Muvalaplin tetrahydrochloride (LY3473329) is an orally active lipoprotein (a)Lp(a) agent currently under investigation. Research on the oral formulation of Muvalaplin tetrahydrochloride is ongoing.</p>

<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>

<p>Phosmet oxon is a toxic byproduct of phosmet, an organophosphate insecticide for apple trees and various crops, targeting moths, aphids, mites, and flies.</p>

<p>4β-hydroxy Cholesterol is a useful organic compound for research related to life sciences. The catalog number is T21530 and the CAS number is 17320-10-4.</p>

<p>Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary</p>

<p>Hydroorotic acid（Dihydroorotic acid） is an endogenous metabolite，a potential biomarker for diabetic nephropathy and adrenal pheochromocytoma.</p>