Metabolism

<p>α-Glucosidase-IN-44 (compound IT4) is an α-glucosidase inhibitor with an IC50 value of 2.35 μM. This compound is orally active and has the ability to reduce fasting blood glucose levels in diabetic mice.</p>

<p>Xanthine oxidase-IN-13 (Compound 10) is a selective inhibitor of xanthine oxidase, with an IC50 of 149.56 μM for bovine xanthine oxidase. It is utilized in the study of inflammatory arthritis.</p>

<p>HexokinaseIIVDACbinding domain peptide (Hxk2VBD peptide) is a cell-permeable peptide derived from the hexokinase II VDAC binding domain. This peptide inhibits the mitochondrial localization of hexokinase 2 (HXK2) and also suppresses neurotrophic factor-induced axon growth.</p>

<p>α-Amylase/α-Glucosidase-IN-14 is an orally bioactive inhibitor of α-amylase and α-glucosidase, with IC50 values of 45.53 μM and 27.73 μM, respectively.</p>

<p>α-Amylase/α-Glucosidase-IN-9 (compound 5h) is a dual inhibitor of α-amylase (IC50= 16.4 μM) and α-glucosidase (IC50= 31.6 μM).</p>

<p>α-Amylase/α-Glucosidase-IN-15 (compound 6C) is an orally active inhibitor of α-glucosidase (α-Glucosidase) and α-amylase (α-amylase), with IC50 values of 21 μM and 61 μM, respectively.</p>

<p>α-Glucosidase-IN-50 (compound 8) acts as an inhibitor of α-Glucosidase.</p>

<p>Fmoc-Cys-Asp10 (TFA) is a non-releasable oligopeptide linker involved in synthesizing releasable oligopeptide linkers. These releasable linkers are used to deliver drugs to fracture-targeting oligopeptides, thereby reducing the healing time of fractured femurs.</p>

<p>IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.</p>

<p>AChE/BChE-IN-17 (compound 8m) is a potent inhibitor of AChE and BChE, displaying IC50 values of 125.06 nM and 119.68 nM, respectively. Additionally, AChE/BChE-IN-17 inhibits α-glucosidase, with an IC50 of 41050 nM.</p>

<p>α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is an isoxazoline-indigo hybrid with notable antidiabetic properties. It acts as a competitive inhibitor of the key digestive enzymes α-amylase (IC50 = 30.39 μM) and α-glucosidase (IC50 = 65.1 μM). Additionally, it does not penetrate the blood-brain barrier.</p>

<p>MPO-IN-6 (compound ADC) is an electrophilic agent with excellent antioxidant and anti-inflammatory properties. It acts as an inhibitor of myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD), with IC50 values of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 may serve as a potential cardiovascular protective agent.</p>

<p>SGK1-IN-3 hydrochloride (compound 3a) is an efficacious, orally bioavailable SGK1 inhibitor. The serine/threonine kinase SGK1 acts as an activator of the β-catenin pathway and strongly stimulates cartilage degradation, being upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride holds potential for osteoarthritis research.</p>

<p>CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.</p>

<p>Nattokinase is a serine protease derived from nattō, oral， fibrinolytic/anticoagulant properties. It degrades fibrin, fibrinolytic substrates, and PAI-1.</p>

<p>Creatine-d3 is an isotopically labeled version of creatine. Creatine is an endogenous amino acid metabolite that plays a crucial role in cellular energy, particularly within muscles and the brain.</p>

<p>Triornicin is a siderophore and tumor inhibitory factor isolated from Epicoccum purpurascens similar in structure to desferricoprogen.</p>

<p>Deoxyadenosine diphosphate sodium is a diphosphate nucleoside featuring deoxyadenosine as its nucleoside component. It plays a role in the synthesis and repair of DNA. Deoxyadenosine diphosphate sodium acts as an inhibitor of polynucleotide phosphorylase, thereby interfering with the polymerization of ADP and CDP.</p>

<p>Cyperine is a useful organic compound for research related to life sciences. The catalog number is T125020 and the CAS number is 33716-82-4.</p>

<p>L 645164 is an inhibitor of hydroxymethylglutaryl-CoA reductase.</p>

<p>FTI-2148 diTFA inhibits FT-1 and GGT-1 with IC50s of 1.4 nM and 1.7 μM; a RAS-mimetic compound.</p>

<p>DF-461 is an inhibitor of squalene synthase.</p>

<p>L-Proline-15N is an isotopically labeled amino acid suitable for metabolic research, aiding in the exploration of amino acid metabolism pathways and mechanisms.</p>

<p>Phytosterols found in algae have anti-cancer activity and are used in the study of cardiovascular diseases and cancer.</p>

<p>ERAP1-IN-3 (compound 13) is a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1), with a pIC50 value of 8.6. ERAP1-IN-3 shows potential for research in cancer immunotherapy and autoimmune disease studies.</p>

<p>AZD-3199, a β2 adrenergic receptor agonist, is used potentially for the treatment of asthma and chronic obstructive.</p>

<p>Fluazuron is an insect growth regulator.</p>

<p>2,3-Dehydrosilybin B is a useful organic compound for research related to life sciences and the catalog number is T125883.</p>

<p>Kahalalide A has antimycobacterial activity isolated from the mollusk Elysia rufescens.</p>

<p>SLC7A11-IN-3 (Compound 42711_11) acts as an inhibitor of SLC7A11.</p>

<p>Folitixorin calcium is an antineoplastic enhancing agent.</p>

<p>Acanthifolicin, an okadaic acid derivative, has been shown top inhibit protein phosphatase 1 with an IC50= 20 nM (similar to that of okadaic acid at 19 nM).</p>

<p>4,8-Dioxa-3H-perfluorononanoic acid, a type of per- and polyfluoroalkyl substance (PFAS), exhibits affinity for the human pregnane X receptor (hPXR) and demonstrates potential agonistic activity.</p>

<p>LY 135114 is a metabolite of LY 195448, which is a phenethanolamine with anti-tumour activity.</p>

<p>Osmanthuside H is a useful organic compound for research related to life sciences. The catalog number is T125796 and the CAS number is 149155-70-4.</p>

<p>isomer-GAT 107 ((-)GAT 107) is an inactive isomer of (+)GAT 107.</p>

<p>5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is an inhibitor of the enzyme phosphodiesterase 10A (PDE10A) with a Ki value of 24 μM. This compound can be employed in research related to schizophrenia.</p>

<p>Dactylocyclines A: novel antibiotic from Dactylosporangium, effective against tetracycline-resistant microbes.</p>

<p>Alitame hydrate is a non-nutritive sweetener that is 2000 times sweeter than sucrose. It is formed from aspartic acid, alanine &amp;amp; an amide.</p>

<p>14,15-LTD4, an eoxin synthesized by eosinophils, mast cells, and nasal polyps, has modest contractile activity but can increase vascular permeability.</p>

<p>4-Hydroxybenzoicacid-d4 is a deuterated form of 4-Hydroxybenzoicacid, which is a phenolic derivative of benzoic acid. It is effective in inhibiting most Gram-positive bacteria and some Gram-negative bacteria with an IC50 of 160 μg/mL.</p>

<p>Purpactin A is a useful organic compound for research related to life sciences. The catalog number is T126026 and the CAS number is 133806-59-4.</p>

<p>Etodolac acyl glucuronide is an NSAID metabolite formed by UGT1A9, UGT1A10, and UGT2B7 glucuronidation.</p>

<p>Edoxaban impurity 6 is a byproduct of the anticoagulant Edoxaban, a potent oral factor Xa inhibitor with Kis of 0.561 nM. Used to prevent stroke.</p>

<p>Acrihellin is a cardioactive steroid, a cardiotonic drug.</p>

<p>Aspergillomarasmine A is a polyamine acid naturally produced by the mold Aspergillus Versicolor.</p>

<p>2,3-Indolobetulonic acid is pentacyclic triterpenoid derivative of betulonic acid and an inhibitor of α-glucosidase (IC50= 1.8 μM).1</p>

<p>Reduced haloperidol, an active metabolite of haloperidol, binds dopamine D2/sigma-1 receptors and inhibits neurotransmitter reuptake.</p>

<p>2'',3''-Di-O-acetyl-5''-deoxy-5-fuluro-D-cytidine is a derivative of capecitabine.</p>

<p>Imidazole-d4 is an isotope-labeled variant of imidazole, which is a heterocyclic aromatic compound. Imidazole molecules serve as inhibitors for acetylcholinesterase (AChEI) and xanthine oxidase (XO) and have been utilized as corrosion inhibitors. They display a range of biological activities, including antifungal, antitubercular, anti-inflammatory, antioxidant, and analgesic properties. Imidazole inhibits platelet microsomes from converting endoperoxides (PGG2 and PGH2) into thromboxane A2. Additionally, imidazole derivatives show inhibitory effects on the SARS-CoV-2 3CLpro enzyme, offering potential for research in Alzheimer’s disease, gout, COVID-19, and thrombotic disorders.</p>