Metabolism

<p>Endogenous metabolite in urine, 1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine, linked to obesity research.</p>

<p>Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro [1] .</p>

<p>5-(3-Hydroxyphenyl)-5-phenylhydantoin is a bioactive chemical.</p>

<p>Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).</p>

<p>MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>

<p>ω-Tbo-IT1, a peptide toxin extracted from the venom of Tibellus oblongus, functions as an inhibitor of insect calcium channels [1].</p>

<p>2-(Isopentylamino)naphthalene-1,4-dione: a vitamin K analog inhibiting spasms and seizures in mice with various ED50 values.</p>

<p>Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease.</p>

<p>Motapizone (NAT 05-239), a PDE3 inhibitor, moderates LPS-induced cytokine release and blocks platelet aggregation by boosting cAMP.</p>

<p>12-Hydroxynevirapine, major Nevirapine metabolite; non-toxic but liver/skin SULTs convert it to reactive 12-Sulphoxy-nevirapine.</p>

<p>GLUT inhibitor-1: oral, targets GLUT1/3 (IC50: 242/179 nM), for cancer/autoimmune research.</p>

<p>Reduced haloperidol, an active metabolite of haloperidol, binds dopamine D2/sigma-1 receptors and inhibits neurotransmitter reuptake.</p>

<p>Sphingomyelin phosphodiesterase, a hydrolase, converts sphingomyelin into phosphocholine and ceramide, affecting cellular processes and cholesterol metabolism.</p>

<p>Arachidonoyl-L-carnitine chloride is an endogenous metabolite and acylcarnitine widely used in biochemical experiments and studies of metabolic disorders.</p>

<p>ND-011992: Quinazoline inhibitor of E. coli respiratory enzymes; IC50s: 0.12-2.47 μM; potential tuberculosis research.</p>

<p>(R)-ICMT-IN-3 (compound ent 2-27) functions as a potent inhibitor of ICMT, exhibiting an IC50 value of 0.01 μM [1].</p>

<p>2'',3''-Di-O-acetyl-5''-deoxy-5-fuluro-D-cytidine is a derivative of capecitabine.</p>

<p>Xanthine Oxidase-IN-9 (also known as Icarisids E or Compound 2) effectively inhibits xanthine oxidase (XOD) with an IC50 value of 31.81 μM [1].</p>

<p>Imidazole-d4 is an isotope-labeled variant of imidazole, which is a heterocyclic aromatic compound. Imidazole molecules serve as inhibitors for acetylcholinesterase (AChEI) and xanthine oxidase (XO) and have been utilized as corrosion inhibitors. They display a range of biological activities, including antifungal, antitubercular, anti-inflammatory, antioxidant, and analgesic properties. Imidazole inhibits platelet microsomes from converting endoperoxides (PGG2 and PGH2) into thromboxane A2. Additionally, imidazole derivatives show inhibitory effects on the SARS-CoV-2 3CLpro enzyme, offering potential for research in Alzheimer’s disease, gout, COVID-19, and thrombotic disorders.</p>

<p>Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .</p>

<p>Captopril EP Impurity E, an ACE inhibitor with antihypertensive properties, has an IC50 of 0.025 μM.</p>

<p>Norimatinib mesylate, N-Desmethyl imatinib metabolite, inhibits v-Abl, c-Kit, PDGFR.</p>

<p>GlcNAc kinase (EcNagK), ATP-dependent, phosphorylates C-6 hydroxyl on GlcNAc, producing GlcNAc-6-P.</p>

<p>α-Amylase/α-Glucosidase-IN-14 is an orally bioactive inhibitor of α-amylase and α-glucosidase, with IC50 values of 45.53 μM and 27.73 μM, respectively.</p>

<p>Bendroflumethiazide (Naturetin) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)</p>

<p>NADP+ is the oxidized cofactor form of NADPH, vital for cell survival, redox balance, and signaling; synthesized from NAD+ and ATP.</p>

<p>MEY-003, an Autotaxin (ATX) inhibitor, exhibits EC50 values of 460 nM for hATX-β and 1.09 μM for hATX-ɣ (analysis with LPC18:1), demonstrating its potency</p>

<p>Compound 21, an orally active and selective RARα antagonist, exhibits a potent inhibition of the retinoic acid receptor α with an IC50 of 4.6 nM [1].</p>

<p>Viridicatin is a natural product for research related to life sciences. The catalog number is T38335 and the CAS number is 129-24-8.</p>

<p>Compound 14, a &lt;1 μM 5-lipoxygenase inhibitor, researches inflammation, cancer, stroke, Alzheimer's.</p>

<p>Octachlorodibenzo-p-dioxin (OCDD) is an environmental contaminant with no acute toxicity when administered. In rats, the systemic elimination half-life of Octachlorodibenzo-p-dioxin (50 μg/kg intravenously or 50-5000 μg/kg orally) is 3-5 months. It can accumulate and concentrate in the liver and adipose tissue after low-dose, repeated exposure. Repeated dosing of Octachlorodibenzo-p-dioxin leads to increased activity of 7-ethoxyresorufin-O-deethylase (7-EROD) and elevated total cytochrome P-450 levels.</p>

<p>(Iso)-Dehydroemetine (Dehydroisoemetine, (+/-)-) is a compound with antispasmolytic effect on smooth muscle.</p>

<p>Meproscillarin is a glycoside with high bioavailability (about 70%) and an elimination independent of renal function.</p>

<p>(S,S)-GSK321 is a (S,S)-enantiomer of GSK321 [1] .</p>

<p>PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.</p>

<p>Complement factor I, a serine protease, attenuates complement activity both in the fluid phase and on cell surfaces, working alongside cofactors such as factor</p>

<p>HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1</p>

<p>Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.</p>

<p>PDE4-IN-3, a new oral drug, potently blocks PDE4 enzyme with 4.2 nM IC50.</p>

<p>(S)-3,4-Dihydroxybutyric acid (Li hydrate) is a urinary metabolite; higher in SSADH deficiency cases.</p>

<p>ACAT-IN-4 hydrochloride is a potent ACAT inhibitor and blocks NF-κB transcription.</p>

<p>DCG04: a mannose-6-phosphate receptor ligand, fluorescent cysteine cathepsin probe for endolysosomal targeting.</p>

<p>2'-Rhamnoechinacoside is a naturally occurring compound sourced from Cistanche tubulosa.</p>

<p>(Rac)-sn-Glycerol 3-phosphate sodium, an a-site substrate analogue, inhibits indole reactions with E(A-A).</p>

<p>Compound 6T, designated as Carbonic anhydrase inhibitor26, acts as an inhibitor of Carbonic Anhydrase II (Carbonic AnhydraseII), exhibiting an IC50 value of 9.10 ± 0.26 μM.</p>

<p>11-trans LTC4 is a C-11 isomer of LTC4, forms slowly on storage, is less common but similarly potent in contractions, pKis: 6.42 (LTC4), 6.58 (11-trans).</p>

<p>Fluticasone dimer impurity: a dimer of Fluticasone Propionate, a potent corticosteroid.</p>

<p>9-PAHPA, a fatty acid ester of hydroxy fatty acid (FAHFA), belongs to a recently identified family of endogenous lipids known for their antidiabetic and anti-</p>

<p>Cytoglobosin C, a derivative of cytochalasan, demonstrates significant cytotoxic effects on SGC-7901 and A549 cell lines, with an inhibitory concentration (IC50</p>

<p>Milpocitide, a (293-333)-peptide fragment of the human low-density lipoprotein receptor (LDLR), specifically corresponds to the EGF-like domain 1 [1].</p>