Metabolism

M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite that can be extracted from Streptomyces albus.

Benzoyl coenzyme A (sodium) is the sodium salt form of Benzoyl coenzyme A. It is a derivative of coenzyme A (CoA), where the thiol group of CoA is linked to a benzoyl group. This compound serves as a substrate in acyl transfer reactions, playing a role in catalysis. Benzoyl coenzyme A (sodium) is a versatile metabolic intermediate used in studies exploring enzyme substrate specificity, metabolic regulation, and drug metabolism.

Arginase (L-Arginine amidinase) is a key hydrolytic enzyme in the urea cycle, which hydrolyzes L-arginine into urea and L-ornithine.

1-Palmitoyl-d9-2-palmitoyl-sn-glycero-3-PE serves as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PE (1,2-DPPE) using GC- or LC-MS. 1,2-DPPE, a prevalent PE (phospholipid), contains C16:0 fatty acids at the sn-1 and sn-2 positions and is essential in the inner plasma membrane leaflet. This compound forms a condensed lipid monolayer with cholesterol through tight hydrogen bonding between 1,2-DPPE headgroups, enhancing membrane fluidity to support transport and signaling.

Aspartate Aminotransferase, Human is a biocatalyst and serves as a pivotal enzyme in new biotechnology. Enzyme engineering aims to improve the reaction kinetics, substrate specificity, and activity under extreme conditions (such as low or high pH). By introducing stimuli-responsive modifications to these enzymes, the dynamic regulation of activity can also be achieved.

Creatine Kinase (CPK/CK), Bovine Heart (CK, CPK, Creatine Phosphokinase), is a biological material or organic compound suitable for use in life sciences research.

ASP8477 is a potent and selective FAAH inhibitor. It increases anandamide levels in the brain when administered orally. In rat models of neuropathic and osteoarthritic pain, ASP8477 demonstrates significant efficacy without causing motor coordination issues. A single oral dose of ASP8477 improves thermal hyperalgesia and cold allodynia in rats with chronic constriction nerve injury. Moreover, ASP8477 restores the decreased muscle pressure threshold in a myalgia model induced by reserpine. Research indicates that ASP8477 possesses analgesic effects effective for alleviating neuropathic and functional pain, making its pharmacological properties suitable for chronic pain treatment.

PAF C-18:1: a cell-produced phospholipid for inflammation, weaker in neutrophil chemotaxis, equal for eosinophil migration, and used in PAF receptor studies.

4,8-Dioxa-3H-perfluorononanoic acid, a type of per- and polyfluoroalkyl substance (PFAS), exhibits affinity for the human pregnane X receptor (hPXR) and demonstrates potential agonistic activity.

Phenylpyruvate tautomerase catalyzes the interconversion between the enol and keto isomers of phenylpyruvate and (para-hydroxyphenyl)pyruvate.

Osmanthuside H is a useful organic compound for research related to life sciences. The catalog number is T125796 and the CAS number is 149155-70-4.

WZB117-PPG is an inhibitor of glucose transporter 1 (GLUT1) with anticancer properties. Under visible light irradiation, this compound demonstrates significant photolytic efficiency and cytotoxicity toward cancer cells.

Compound Fr13694, with CAS No. 137-00-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13694 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

α-Amylase-IN-4 (Compd 10y) exhibits the highest level of amylase inhibition, demonstrating an IC50 value of 17.83 ± 0.14 μg/mL [1].

UK140 is an inhibitor of the urokinase-type plasminogen activator (uPA), with Ki values of 0.20 µM for human uPA (huPA) and 2.79 µM for mouse uPA (muPA). UK140 is applicable in studies related to tumor metastasis.

Crelosidenib is a potent and selective mutant IDH inhibitor for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutases.

RORγ inverse agonist 1 has anti-inflammatory activity and can be used to treat rheumatism and psoriasis.

Spiromesifen is a useful miticide and insecticide in plant breeding. It is particuarly useful against spider mites and whiteflies in vitro.

Ac-SDKP acetate: ACE inhibitor, regulates stem cell growth, anti-inflammatory, antifibrotic.

Control peptide, scrambled version of gp91 ds-tat NADPH oxidase inhibitor, lacks 2 N-terminal amino acids.

ALT-100 (HumanIgG1) is a human-derived IgG1 monoclonal antibody that targets NAMPT. For its isotype control, please refer to HumanIgG1kappa, Isotype Control.

HSD17B13-IN-71 (Compound 149), an effective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), displays potent activity with an IC 50 value of ≤ 0.1 μM against estradiol. This compound is applicable in the study of various disorders including liver diseases, metabolic diseases, and cardiovascular conditions such as NAFLD or NASH, in addition to drug-induced liver injury (DILI) [1].

(2R,3R)-2,3,4-Trihydroxybutanoic acid, also known as erythorbic acid, is a naturally occurring organic acid found in various bodily fluids including aqueous humor, urine, plasma, cerebrospinal fluid, and synovial fluid. It is prevalent in both healthy adults and children and is produced through the oxidation of GlcNAc.

3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats.

Rapaglutin A is a glucose transporter (GLUT) inhibitor. It acts as a pan-GLUT inhibitor for the class I isomers GLUT1, GLUT3, and GLUT4, with an IC50 of 12 nM. Additionally, Rapaglutin A inhibits the proliferation of A549 cells.

Glucoiberin potassium is an active compound.

Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity.

Corynecin IV is a metabolite similar to chloramphenicol, originally isolated from corynebacteria.

Acifluorfen-sodium is a herbicide.

PDE2A-IN-1 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC 50 value of 1.3 nM.

9-O-Acetylneuraminic acid, an endogenous metabolite, binds to lectins and effectively inhibits hemagglutination .

308-R-C4-PEG3-C1-Boc is an SGK3 ligand-linker conjugate, utilized in the synthesis of PROTAC SGK3 degrader-2.

Compound PDK0420, with CAS No. 99-05-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0420 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

RORγ agonist2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. It significantly inhibits tumor growth in an MC38 tumor mouse model with the same genetic background.

Methylspinazarin, a Streptomyces naphthoquinone, selectively inhibits COMT (IC50=0.8μg/ml), lowers blood pressure in hypertensive rats at 50mg/kg.

CAII/CAXII-IN-1 (compound 8d) is an inhibitor of CAII and CAXII, with IC50 values of 0.38 µM for CAII and 0.61 µM for CAXII.

THP1 Lipid is an ionizable lipid utilized in the synthesis of lipid nanoparticles (LNPs) for mRNA delivery to muscle tissue, exhibiting extremely low toxicity. In tdTomato transgenic mice, it facilitates the editing of specific genes in liver tissue. Additionally, THP1 Lipid is employed in vaccine delivery and studies involving CRISPR/Cas9-mediated gene editing.

8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin.

DSPE-PEG3400-CSTSMLKAC is a PEG compound composed of DSPE and CSTSMLKAC. CSTSMLKAC is capable of mediating phage selective homing to ischemic cardiac tissue. DSPE-PEG3400-CSTSMLKAC can be utilized for drug delivery.

PROTACsEH degrader-2 is a PROTAC degrader that targets soluble epoxide hydrolase (sEH), with pIC50 values of 8.37 (human sEH-H) and 7.12 (mouse sEH-H). It is applicable for research into inflammation and neuroinflammation-related diseases, such as Alzheimer's disease.

Ro 3-7410 is an active hydroxy metabolite of bufuralol.

CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.

VH-N412 is a carrier-modified neurotrophin (NT) known for its excellent ability to penetrate the blood-brain barrier. This compound actively binds to both low-density lipoprotein receptor (LDLR) and neurotropin receptor 1 (NTSR-1), acting as an inducer of pharmacologically induced hypothermia (PIH). Additionally, VH-N412 exhibits anticonvulsant and neuroprotective properties, making it a valuable agent for research in neurological disorders such as epilepsy.

Ferroleuton is a selective competitive inhibitor of 5-lipoxygenase with an IC50 of 0.21 μM. It demonstrates antioxidant properties, clearing 86% of DPPH at 50 μM and exhibiting activities in ABTS (EC50 = 19.42 μM) and FRAP (EC50 = 3.32 μM) assays.

Enkephalin-met, des-tyr(1)- ccauses retrograde amnesia in rats.

5β-Dihydrocortisone is a sterol metabolite of cortisone produced by 5β-reductase (AKR1D1) in the liver, existing as a mixture of isomers.

cisVH 298 is a negative control for VH 298. Exhibits no detectable binding of VHL.

hDHODH-IN-17 (Compound 10) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH), with an IC50 value of 0.188 μM. It fits well with the hDHODH active site and interacts effectively with amino acid residues. hDHODH-IN-17 is a potential broad-spectrum antiviral drug.

3-Methoxy-4-hydroxyphenylglycol (HMPG), a metabolite of norepinephrine degradation in the brain, serves as an indicator of central nervous system noradrenergic activity and is useful for research on depression, chronic schizophrenia, and other conditions [1].