Metabolism

Lipid HTO12 is an ionizable lipid used for forming lipid nanoparticles (LNP). It facilitates the delivery of siRNA and mRNA.

The compound 3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] is an SS-cleavable, proton-activated lipid-like substance (SSPalm) that facilitates the delivery of plasmid DNA.

(R,R)-BMS-986397 is a CK1α degrader with a DC50 ranging from 0.1 to 0.5 pM. This compound is applicable in leukemia research.

Dimidazon (BAS 29095) is a mild electron transport inhibitor that targets photosystem II (PSII). It blocks the electron flow from the primary electron acceptor Q to photosystem I within PSII. Dimidazon holds potential for research in photosynthesis regulation and weed control.

1-Stearoyl-sn-glycerol 3-phosphate sodium, a biologically active phospholipid, plays a crucial role in regulating cell motility, proliferation, invasion, survival, and the production of growth factors through interactions with G protein-coupled receptors (GPCR). Synthesized during the formation of membrane phospholipids, this compound typically has a low plasma concentration (approximately 100nM) and originates from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its distinctive structure features stearic acid at the sn-1 position and a hydroxyl group at the sn-2 position.

Xanthosine 5'-monophosphate is produced from inosine monophosphate (IMP) through the catalytic action of inosine monophosphate dehydrogenase (IMPDH).

SHP2-IN-39 (Example 63) is an inhibitor of SHP2, with an IC50 value of 0.007 μM. It is applicable in tumor research.

FR 901537 is a new aromatase inhibitor with antitumor effects.

CA IX-IN-1 (compound 12g) is a potent and highly selective hCA IX inhibitor (IC50: 7 nM) that exhibits antitumour effects.

Calcipotriol Impurity C is the impurity of Calcipotriol. Calcipotriol is a VDR-like receptors ligand.

(R)-2-formamido-4-methylpentanoic acid is a derivative of leucine.

LXR agonist 2 is a potent agonist of the LXR (liver X receptor). LXR agonist 2 stabilises NCOA1 (coactivator), which in turn agonises the LXR.

MDL-100240 inhibits ACE/neprilysin, effective against hypertension-induced heart/vascular changes.

α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM.

Rosiptor (AQX-1125) activates SHIP1, inhibits Akt, and reduces inflammation and allergy in rodents.

C16-18:1 PE is a lipid known for its role in facilitating membrane fusion and enhancing endosomal escape, significantly boosting mRNA delivery efficiency. This compound is utilized in the synthesis of lipid nanoparticles (LNP).

PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.

PTP1B-IN-19, a benzimidazole, selectively inhibits protein tyrosine phosphatase 1B with a Ki of 23.3 μM, potential for type 2 diabetes research.