Biochemicals and Reagents

<p>Gly-Gly-Gly-Gly-Arg-Gly-Asp-Ser-Pro is a peptide used as an activator in research. It can be used to study protein interactions and the effects of ligands on ion channels and receptors. Gly residues are able to form hydrogen bonds, which is why they are often used as spacers in proteins. This peptide has a high purity and CAS number.</p>

<p>Ac-CGGTHPHLPRA-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CGGTHPHLPRA-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CGGTHPHLPRA-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CGGTHPHLPRA-NH2 at the technical inquiry form on this page</p>

<p>H-EGVTVLINEDK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EGVTVLINEDK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EGVTVLINEDK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EGVTVLINEDK-OH at the technical inquiry form on this page</p>

<p>Gly-Leu-Gly is a peptide that has a conformation in which the side chain of the amino acid glycine is attached to the alpha-carbon atom of the amino acid leucine. It is a labile molecule, meaning that it can react with other molecules or break down spontaneously. Gly-Leu-Gly is also called glycylleucine. This peptide has been found to have protonation properties that depend on temperature and kinetic energy. The carbonyl group of this peptide interacts with other molecules by donating or accepting electrons. In addition, this compound can be analyzed using spectrometers and gas chromatographs.</p>

<p>H-FVQGKDWGL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-FVQGKDWGL-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-FVQGKDWGL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-FVQGKDWGL-OH at the technical inquiry form on this page</p>

<p>AR-R 17779 is a selective agonist for α7 nicotinic acetylcholine receptors (nAChRs) (Ki value = 190 nM for rat α7 receptor). This compound has use as a tool to study the function of α7 nicotinic receptors. One such study revealed a role for α7 nicotinic receptors in nicotine-mediated excitatory effects on hippocampal learning and memory. AR-R17779 reduces formation of atherosclerotic plaques and abdominal aortic aneurysms in apolipoprotein E-deficient mice.</p>

<p>H-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2 is a cyclic peptide that contains the sequence of amino acids Arg, Gly, Asp, D, Tyr and Lys. It is a peptide macrocycle that has been shown to be effective against tumor cells. This peptide has been derivatized for targeting purposes and has been shown to be an effective imaging agent for tumor cells in vivo. H-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2 is also biochemically active and can inhibit the growth of cancer cells through multiple mechanisms.</p>

<p>H-LEGFDKADGTLDSQV-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LEGFDKADGTLDSQV-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LEGFDKADGTLDSQV-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LEGFDKADGTLDSQV-OH at the technical inquiry form on this page</p>

<p>Inhibitor of caspases; broad spectrum</p>

<p>Leu-Enkephalin is an endogenous opioid peptide that has been shown to produce analgesia, anti-inflammatory effects, and changes in locomotor activity. Leu-enkephalin binds to the kappa opioid receptor, which is found in high concentrations in the caudate putamen and hippocampal formation. The enkephalins are a family of basic proteins with two amino acids linked by a single amide bond. They are peptide hormones that act as neurotransmitters in the central nervous system and peripheral nervous system. Leu-enkephalin is a drug candidate for treatment of infectious diseases such as HIV and malaria. In addition, leu-enkephalin has been shown to have side effect profiles that are less severe than morphine or methadone.</p>

<p>H-GVYDGREHTV-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GVYDGREHTV-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GVYDGREHTV-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GVYDGREHTV-OH at the technical inquiry form on this page</p>

<p>H-VLENER-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VLENER-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VLENER-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VLENER-OH at the technical inquiry form on this page</p>

<p>Partial agonist of D2 and D3 dopamine receptors; anti-psychotic</p>

<p>Please enquire for more information about C.I.Azoic Diazo Component 45 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A selective antagonist of serotonin 5-HT2B receptors, inhibiting inositol phosphate formation and calcium release. Blocks 5-HT-induced contraction in rat stomach fundus. Reduces fecal output in vivo, upon inhibition of 5-HT2B by RS 127445, demonstrating a potential role for this receptor in colonic motility. Inhibits visceral hypersensitivity induced by restraint stress or colonic inflammation.</p>

<p>Selective partial GABAA receptor antagonist of subtypes  α1, α2, α3, α5 subunits. Non-sedative anxiolytic effects demonstrated in vivo, without compromising motor activity. Anti-nociceptive and anti-inflammatory activities also demonstrated in vivo.</p>

<p>H-NFVDSPIIVDITK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-NFVDSPIIVDITK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-NFVDSPIIVDITK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-NFVDSPIIVDITK-OH at the technical inquiry form on this page</p>

<p>Ac-CEMAFGSFARKRSPRQ-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CEMAFGSFARKRSPRQ-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CEMAFGSFARKRSPRQ-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CEMAFGSFARKRSPRQ-NH2 at the technical inquiry form on this page</p>

<p>H-FIAEQILATL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-FIAEQILATL-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-FIAEQILATL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-FIAEQILATL-OH at the technical inquiry form on this page</p>

<p>H-VLPLATFV-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VLPLATFV-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VLPLATFV-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VLPLATFV-OH at the technical inquiry form on this page</p>

<p>Cyamemazine is a neuroleptic medication, which is a member of the phenothiazine class of compounds. It is synthesized from derivatives of phenothiazine, a group of agents primarily found in pharmaceuticals. The mode of action of cyamemazine involves antagonism at dopamine D2 receptors in the central nervous system. This inhibition of dopamine activity is the principal mechanism through which it exerts its antipsychotic effects. Due to its receptor activity, cyamemazine is used primarily in the management of various psychotic disorders, including schizophrenia and acute psychoses. It also exhibits anxiolytic properties, making it effective in treating anxiety associated with these conditions. By modulating neurotransmitter pathways, cyamemazine helps to alleviate symptoms such as hallucinations, delusions, and agitation, offering therapeutic benefit in complex neuropsychiatric cases. As an atypical antipsychotic, it provides an option for patients who may not respond adequately to other treatments. Although primarily used in a clinical setting, ongoing research continues to investigate potential wider applications and efficacy in treating other mental health issues.</p>

<p>mTOR serine/threonine kinase inhibitor</p>

<p>H-VYLKTNVAL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VYLKTNVAL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VYLKTNVAL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VYLKTNVAL-OH at the technical inquiry form on this page</p>

<p>TPX0131 is a recombinant human anti-IL8 antibody. TPX0131 has been shown to inhibit IL8 induced neutrophil chemotaxis and to block the IL8 receptor. TPX0131 also blocks the activation of NF-κB, a transcription factor involved in inflammation, and inhibits IL8 induced expression of adhesion molecules on endothelial cells. The affinity of TPX0131 for IL8 is low (Kd=1.5 nM) and it has high purity (&gt;98%).</p>

<p>Blocks HER-2 heterodimerization; breast cancer therapy</p>

<p>H-STADGGTTSYAAPVEGR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-STADGGTTSYAAPVEGR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-STADGGTTSYAAPVEGR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-STADGGTTSYAAPVEGR-OH at the technical inquiry form on this page</p>

<p>Potent and selective GSK3-β inhibitor, with IC50 value of 48 nM. Increases Nanog expression and regulates self-renewal in murine embryonic stem cells (ESCs). Induces reprograming of induced pluripotent stem cells (iPSCs) to derive cells from specific lineages.</p>

<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>H-LNDPLCLVHPSS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LNDPLCLVHPSS-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LNDPLCLVHPSS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LNDPLCLVHPSS-OH at the technical inquiry form on this page</p>

<p>Rituximab is a glycosylated monoclonal antibody that binds to the CD20 cell surface protein which is widely expressed on B-cells. Through the binding of rituximab’s Fc portion, the antibody-dependent cellular cytotoxicity pathway (ADCC) and the complement-dependent cytotoxicity (CDC) pathway are initiated, both leading to B-cell lysis (Chisari, 2021). In addition, direct apoptosis can be the result of the inhibition of various B-cell signalling pathways. Rituximab is used in targeted therapy for chronic lymphocytic leukaemia (CLL), non-Hodgkin lymphoma (NHL) and some non-cancer pathologies, such as, multiple sclerosis (Johnson, 2001).</p>

<p>Il-1β is a pro-inflammatory cytokine, which is a type of signaling molecule involved in immune system regulation and inflammation. It is primarily produced by activated macrophages, which are a type of white blood cell that engulfs and digests cellular debris and pathogens. The mode of action of Il-1β involves binding to the interleukin-1 receptor (IL-1R) on target cells, which triggers a cascade of intracellular signaling pathways that lead to the expression of various inflammatory genes.</p>

<p>Tolterodine-D14 is a postoperative drug that belongs to the class of non-selective muscarinic receptor antagonists. It has been evaluated for pharmacokinetic properties in plasma samples from patients undergoing surgery. Tolterodine-D14 undergoes extensive hepatic metabolism, with only about 50% of the drug being excreted unchanged in urine. The elimination half-life of this drug ranges from 2 to 3 hours. Tolterodine-D14 has been shown to be bioequivalent to the reference drug (tolterodine) and can be used as a control level for chromatographic analyses.</p>

<p>Inhibits multiple protein kinases, such as PKC and FLT3</p>

<p>Des-n-Octanoyl-[Ser3]-Ghrelin (Human, 1-14) is a non-Acylated Analog of Ghrelin (Human, 1-14), amino acids 1-14 of the peptide hormone Ghrelin. This peptide does not contain the unique N-octanoyl group which is linked to Ghrelin's third serine residue covalently and which allows Ghrelin to associate with the growth hormone secretagogue receptor (GHS-R). Through interaction with the GHS-R, Ghrelin can exert its various effects on the body such as stimulating appetite, nutrient sensing, meal initiation and the regulation of insulin resistance, diabetes and obesity. Its wider functions are also associated with glucose homeostasis, energy homeostasis, cardio-protective effects, bone metabolism and its potential to be a target for cancer means that it can be used to develop therapies for a whole spectrum of diseases. This molecule is used as a research tool for studying cell biology and pharmacology.</p>

<p>Ac-CKQSKELSLIEHDYYQ-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CKQSKELSLIEHDYYQ-NH2 is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CKQSKELSLIEHDYYQ-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CKQSKELSLIEHDYYQ-NH2 at the technical inquiry form on this page</p>

<p>ÎŽ opioid receptor agonist; anti-nociceptive; anti-depressant</p>

<p>Fmoc-His(Trt)-Wang Resin (100-200 mesh) 1% DVB is a resin for peptide synthesis that contains Fmoc-His(Trt) and 1% DVB. It is used to synthesize peptides with Fmoc chemistry.</p>

<p>BMP7 is a protein that belongs to the TGF-β superfamily. It is a potent inhibitor of bone resorption in vitro and in vivo. BMP7 also has been shown to inhibit the synthesis of collagenase and other proteases by osteoclasts, leading to decreased bone resorption. This protein activates receptors for insulin-like growth factor and activin, which are proteins produced by bone cells (osteoblasts) that regulate bone formation. BMP7 can also be used as a research tool for studying receptor activation, ligand binding, or ion channel function.</p>

<p>Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID), which is a synthetic derivative of salicylic acid. It is primarily sourced through chemical synthesis rather than extraction from natural elements. Diflunisal functions by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which play a crucial role in the biosynthesis of prostaglandins. This inhibition results in reduced production of prostaglandins, compounds involved in inflammation and pain signaling pathways.</p>

<p>H-LLWTLVVLL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LLWTLVVLL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LLWTLVVLL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LLWTLVVLL-OH at the technical inquiry form on this page</p>

<p>Tandospirone is a psychotropic drug that acts as a selective serotonin receptor partial agonist. It is derived from a synthetic source, specifically targeting the 5-HT1A receptors in the brain. Tandospirone modulates serotonergic neurotransmission by binding to these receptors, which are associated with mood regulation. This action results in the anxiolytic and antidepressant effects observed with the drug.</p>

<p>VEGFR2 a tyrosine kinase receptor inhibitor; antineoplastic</p>

<p>H-AQCY-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-AQCY-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-AQCY-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-AQCY-OH at the technical inquiry form on this page</p>

<p>H-AFPEDRSQPGQDCRFRVTQL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-AFPEDRSQPGQDCRFRVTQL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-AFPEDRSQPGQDCRFRVTQL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-AFPEDRSQPGQDCRFRVTQL-OH at the technical inquiry form on this page</p>

<p>A reversible inhibitor of IGF-1R kinase and insulin receptor. Has anti-growth effects in mesenchymal, epithelial and hematopoietic tumor types. Synergistic with other cytotoxic, hormonal and targeted anti-cancer therapy.</p>

<p>H-LLLPHWAK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LLLPHWAK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LLLPHWAK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LLLPHWAK-OH at the technical inquiry form on this page</p>

<p>Calcium channel blocker</p>

<p>H-TSWRCTRVG-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-TSWRCTRVG-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-TSWRCTRVG-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-TSWRCTRVG-OH at the technical inquiry form on this page</p>

<p>Agonist of cannabinoid receptors CB1 and CB2</p>

<p>Baricitinib phosphate is a selective Janus kinase (JAK) inhibitor, which is a synthetic product developed through targeted molecular design. Its mode of action involves the inhibition of JAKs, which are intracellular enzymes that transmit cytokine-mediated signals via the JAK-STAT pathway. By blocking these signals, baricitinib phosphate effectively reduces inflammatory responses.</p>

<p>H-TILDFLK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-TILDFLK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-TILDFLK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-TILDFLK-OH at the technical inquiry form on this page</p>

<p>LOXO-305 is a small molecule inhibitor, which is a synthesized chemical compound designed to selectively target specific enzymes or pathways. Its source is rooted in medicinal chemistry and pharmacological research aimed at elucidating pathways involved in oncogenesis.</p>

<p>A selective inhibitor of glial glycine transporter type 1 (GlyT-1b). It has no considerable affinity for noradrenaline, dopamine, serotonin and GABA receptors. Increases amplitude of electronically evoked NMDA receptor-mediated glutamatergic excitatory postsynaptic current (eEPSCs). This raises glycine levels in spinal cord slides and extends the duration of current at glycinergic synapses.</p>

<p>H-GRAMYAPPIEGNITC-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GRAMYAPPIEGNITC-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GRAMYAPPIEGNITC-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GRAMYAPPIEGNITC-OH at the technical inquiry form on this page</p>

<p>Please enquire for more information about iGRD peptide acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 15(R)-Prostaglandin E1 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Antagonist of nociceptin receptors</p>

<p>C.I. Vat Orange 15 is a polymerization inhibitor that prevents polymerization by reacting with the hydrogen peroxide, which is generated during the chemical reaction. The addition of C.I. Vat Orange 15 to a polymerization system will slow down the reaction and increase the yield of the desired product. This chemical can also be used in organic solvents and a variety of other reactions, such as light resistance and surfactant production. It is not soluble in water and requires an organic solvent for use in coatings or resins, but it does not react with esters or ethers. C.I. Vat Orange 15 has been shown to have high concentrations, but it is not toxic to animals or humans.&gt;&gt;END&gt;&gt;</p>

<p>Please enquire for more information about C.I.Solubilised Sulphur green 3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-GCTASIVLLQAFR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GCTASIVLLQAFR-OH is provided at greater that Flashpure (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GCTASIVLLQAFR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GCTASIVLLQAFR-OH at the technical inquiry form on this page</p>

<p>Sphingosine-1-phosphate receptor modulator</p>

<p>H-LSPLAER-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LSPLAER-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LSPLAER-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LSPLAER-OH at the technical inquiry form on this page</p>

<p>Il-19 is a mouse protein that belongs to the IL-1 family. It has been shown to be an activator of the IL-1 receptor, and is involved in a number of cellular processes such as ion channels, cell biology, and protein interactions. Il-19 is also used as a research tool for studying the function of other proteins.</p>

<p>H-SIQVISNALKVWGLELILFN-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SIQVISNALKVWGLELILFN-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SIQVISNALKVWGLELILFN-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SIQVISNALKVWGLELILFN-OH at the technical inquiry form on this page</p>

<p>H-CGGSYSTTAVVT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CGGSYSTTAVVT-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CGGSYSTTAVVT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CGGSYSTTAVVT-OH at the technical inquiry form on this page</p>

<p>H-LMETGLSSKRYTEEA-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LMETGLSSKRYTEEA-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LMETGLSSKRYTEEA-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LMETGLSSKRYTEEA-OH at the technical inquiry form on this page</p>

<p>Pigment YellOw 75 is a polymerization initiator that has a hydroxyl group and contains functional groups such as an amide, carboxylic acid, or alcohol. The monomers are vinyl acetate, ethylene glycol, and butanediol. Pigment YellOw 75 is used in the production of polyvinyl chloride (PVC). It acts as a radical polymerization initiator by abstracting hydrogen atoms from the vinyl acetate monomer to form radicals that initiate polymerization. This pigment also serves as a particle in radiation-curable coatings. Pigment YellOw 75 is highly reactive and can be used in reactive electrophotography.</p>

<p>Cyclo[Arg-Gly-Asp-D-Phe-Lys(Biotin)] is a peptide macrocycle that is known to bind to integrin and be active against cancer cells. It has been shown to inhibit the growth of cancer cells by inhibiting cell adhesion, which leads to a reduction in the production of biochemicals such as fibronectin. Cyclo[Arg-Gly-Asp-D-Phe-Lys(Biotin)] binds strongly to the integrin receptor on the surface of many types of cancer cells, including those that are resistant to conventional chemotherapy drugs. This peptide macrocycle also inhibits proteolytic cleavage by metalloproteinases and enhances tumor vascularization, making it an attractive candidate for use in cancer treatment.</p>

<p>Acid Orange 154 is a hydroxyalkyl, divalent cyclic compound that is used as a colorant for textiles and paper. This chemical is detected by absorbance at 400 nm and has an anionic charge. Acid Orange 154 has been shown to form benzyl, acidic chlorophenyl, and alkylene derivatives in the presence of metal ions or polymeric stabilizers. Acid Orange 154 can be analyzed using various techniques including gas chromatography and mass spectrometry.</p>

<p>H-EIVCDSLDDYNRRVT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EIVCDSLDDYNRRVT-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EIVCDSLDDYNRRVT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EIVCDSLDDYNRRVT-OH at the technical inquiry form on this page</p>

<p>17:0-20:4 Pi (4,5) P2 is a synthetic phosphoinositide, which is a chemically defined lipid derived from laboratory synthesis. It features a specific acyl chain composition with a heptadecanoic acid (17:0) at the sn-1 position and an arachidonic acid (20:4) at the sn-2 position. This phosphoinositide mimics naturally occurring phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), an essential component of cellular membranes.</p>

<p>H-DYAEVGR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-DYAEVGR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-DYAEVGR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-DYAEVGR-OH at the technical inquiry form on this page</p>

<p>Selectively inhibits α- and ζ-thrombins and elicits procoagulant effects. Reduces platelet deposition in a rat carotid endarterectomy model. Has therapeutic potential as an anti-thrombotic agent in patients with heparin-associated thrombosis.</p>

<p>H-ELDESLQVAER-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-ELDESLQVAER-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-ELDESLQVAER-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-ELDESLQVAER-OH at the technical inquiry form on this page</p>

<p>MLN-3897 is a new small molecule that has potent inhibitory activity against chemokine receptors. MLN-3897 blocks chemotaxis of immune cells and viral replication, and is therefore a potential treatment for autoimmune diseases and other inflammatory diseases. It also inhibits the expression of surface proteins on activated T cells, which may be due to its ability to block leukotriene receptor antagonist activity. This drug is currently in preclinical development, but could potentially be deployed as an anti-inflammatory agent in the future.</p>

<p>SIRT1 activator</p>

<p>Ac-EDIPEVSSIHNGLRC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-EDIPEVSSIHNGLRC-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-EDIPEVSSIHNGLRC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-EDIPEVSSIHNGLRC-NH2 at the technical inquiry form on this page</p>

<p>Iguratimod is a drug that is used to treat autoimmune and inflammatory conditions such as rheumatoid arthritis. This drug works by suppressing the activity of inflammatory cells and cytokines such as interleukin-1 and tumor necrosis factor-alpha (TNF-alpha). By reducing the levels of these cytokines, Iguratimod helps to alleviate inflammation and joint damage associated with conditions like rheumatoid arthritis.</p>

<p>Pigment Yellow 168 is a synthetic organic pigment that is used in paints and varnishes. It is an oil-soluble, reactive dye that can be used as a colorant in plastics. Pigment Yellow 168 has been shown to be stable under UV radiation and light exposure, which makes it ideal for use in outdoor paints.</p>

<p>Naloxone hydrochloride is a competitive antagonist at mu-, delta- and kappa-opioid receptors. Naloxone binding to receptors blocks the effects of opioids such as morphine, heroin, or oxycodone. Naloxone has been shown to be effective in treating acute overdoses of these drugs and reversing the depression of respiratory function that accompanies opioid overdose. It is also used to alleviate withdrawal symptoms and in the treatment of neonatal abstinence syndrome (NAS). NAS is a condition that occurs when infants are exposed to addictive levels of opioids in utero and go through withdrawal after birth.</p>

<p>Prostaglandin F2α receptor agonist</p>

<p>Inhibitor of VEGFR; antineoplastic</p>

<p>Ac-CKEYSQNYRKDYSNTD-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CKEYSQNYRKDYSNTD-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CKEYSQNYRKDYSNTD-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CKEYSQNYRKDYSNTD-NH2 at the technical inquiry form on this page</p>

<p>H-KINMPMSVK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-KINMPMSVK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-KINMPMSVK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-KINMPMSVK-OH at the technical inquiry form on this page</p>

<p>Palmitoyl tetrapeptide 7 trifluoroacetate is an anticancer agent that acts as a protein kinase inhibitor. It has been shown to inhibit the growth of cancer cells and induce apoptosis in human tumors. This peptide analog has been studied extensively for its potential use in cancer therapy due to its ability to suppress the activity of kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and division. Palmitoyl tetrapeptide 7 trifluoroacetate has also been found to be effective against certain strains of influenza virus, such as H1N1, by inhibiting neuraminidase activity. This compound has been isolated from Chinese urine samples and is structurally similar to oseltamivir, a drug used to treat influenza infections.</p>

<p>Dual inhibitor of the adaptor protein 2-associated kinase 1 (AAK1) and BMP2-inducible kinase (BMP2K) with IC50 values of 270 nM and 1 μM, respectively. In a recent study, SGC AAK1 1 stabilised β-catenin, inhibited phosphorylation of the AP2 complex subunit mu protein (AP2M1) and activated Wnt signalling in in vitro experiments._x000D_</p>

<p>H-LGIYDADGDGDFDVDDAK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LGIYDADGDGDFDVDDAK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LGIYDADGDGDFDVDDAK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LGIYDADGDGDFDVDDAK-OH at the technical inquiry form on this page</p>

<p>4,5,6,7-Tetrabromobenzimidazole is a brominated heterocyclic compound, which is synthesized chemically from benzimidazole. Its bromination at the 4, 5, 6, and 7 positions of the benzimidazole ring enhances its reactivity, making it a highly potent inhibitor in various enzymatic processes. This compound is primarily sourced through methods that involve controlled bromination reactions in laboratory settings.</p>

<p>SDZ-62-434 is a reactive drug that binds to the platelet-derived growth factor receptor alpha (PDGFRα), which is over expressed in many cancers. It has been shown to be effective against mouse tumor cells and inhibits the growth of human cancer cells. SDZ-62-434 also has antineoplastic properties and can inhibit tumour cell proliferation. This drug has shown potential as an antitumor agent, and it has been shown to have costimulatory effects on T cells. SDZ-62-434 also binds to T cells and potentiates their response by increasing cytokine production, including tumour necrosis factor alpha (TNFα).</p>

<p>Inhibits actin polymerization</p>

<p>Icatibant is a 10 amino acid peptidomimetic of bradykinin and a selective antagonist to the bradykinin B2 receptor. Icabinant has been used for the treatment of attacks in patients with hereditary angioedema. Recent evidence has shown a link between dysregulated bradykinin‐mediated inflammation and acute respiratory distress syndrome (ARDS), a common complication in COVID-19 patients. Icatibant was proposed to inhibit excessive activation of the bradykinin B2 receptor during the SARS-CoV-2 infection, reducing the risk of ARDS.</p>

<p>PD 168393 is a potent and selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It is synthesized through advanced chemical processes, designed to specifically target and covalently modify the ATP-binding site of EGFR. The mode of action involves the irreversible binding to the cysteine residue in the ATP-binding pocket, leading to the inhibition of EGFR autophosphorylation and subsequent downstream signaling pathways.</p>

<p>Opioid receptor agonist</p>

<p>Z-Gln-Gly-OH is a synthetic dipeptide, which is a modified amino acid sequence commonly used in biochemical applications. It consists of a carbobenzoxy-protected glutamine and a glycine residue. This compound originates from custom organic synthesis, derived through specific chemical protocols to introduce protective groups that block reactive sites on the amino acids. This controlled modification alters the peptide's stability and solubility.The mode of action involves the protection of active sites during complex syntheses, enabling the sequential construction of peptide chains without unintended reactions. This protection is critical in solid-phase peptide synthesis methodologies where precision and specificity of reactions are paramount. The Z-group (benzyloxycarbonyl) ensures the stability of glutamine under various chemical conditions, preventing side reactions that may compromise the integrity of peptide constructs.In research, Z-Gln-Gly-OH finds applications in the design of peptide-based inhibitors, structural studies, and the synthesis of longer chain peptides that mimic biologically relevant structures. The protection strategy allows scientists to develop and manipulate peptides with high fidelity, facilitating advancements in understanding protein functions and interactions in physiological contexts.</p>

<p>H-EAPWEYQK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EAPWEYQK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EAPWEYQK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EAPWEYQK-OH at the technical inquiry form on this page</p>

<p>Monoclonal antibody against PD-1 checkpoint protein</p>

<p>Ac-SYSMEHFRWGKPV-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-SYSMEHFRWGKPV-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-SYSMEHFRWGKPV-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-SYSMEHFRWGKPV-NH2 at the technical inquiry form on this page</p>

<p>Celecoxib is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.<br>Celecoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Anti-microtubular agent; antineoplastic</p>

<p>H-VVVGAVGV-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VVVGAVGV-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VVVGAVGV-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VVVGAVGV-OH at the technical inquiry form on this page</p>

<p>Camstatin is an adjuvant therapy that has been shown to inhibit the activation of protein kinase A (PKA) in cells. It also inhibits phosphorylation of the cAMP-dependent protein kinase, which leads to a potentiation of effects. Camstatin also has a potent inhibitory effect on cellular protein synthesis and phosphate uptake. Camstatin can be used as an inhibitor of the phosphodiesterase enzyme, which is involved in the hydrolysis of intracellular cyclic nucleotides. This prevents the breakdown of cAMP and therefore increases its concentration in the cell and activates PKA.</p>

<p>Vipivotide tetraxetan is a radioactive therapeutic agent, which is a radioligand conjugate composed of a DOTA chelator linked to a targeting moiety. The source of this compound lies in its synthesis, where the DOTA ligand is conjugated to a peptide or small molecule that targets specific cell surface antigens expressed on cancer cells.</p>

<p>Opioid analgesic</p>

<p>Musk active human is a natural substance that belongs to the group of fatty acids. It is found in the musk gland of various animals, including deer, beaver, and otter. Musk active human has been shown to regulate protein glycosylation, which is important for biological function. Musk active human's function in the endoplasmic reticulum is to stabilize proteins and control the process of protein synthesis. A study on an acetylcholine receptor found that it can activate tyrosine kinase, which leads to pathogenic mechanisms. This compound has been expressed in a variety of tissues and seems to play a role in muscle activity. A silico analysis has also shown that this chemical may inhibit the production of sulfoxide through its interaction with enzymes such as cyclooxygenase-2.</p>

<p>H-EARIKEKIE-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EARIKEKIE-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EARIKEKIE-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EARIKEKIE-OH at the technical inquiry form on this page</p>

<p>H-LLVSASQDGK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LLVSASQDGK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LLVSASQDGK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LLVSASQDGK-OH at the technical inquiry form on this page</p>

<p>(2R)-Arimoclomol maleate is an investigational pharmaceutical compound, which is an orally bioavailable small molecule with pharmacological activity primarily targeting cellular protein homeostasis mechanisms. This therapeutic agent is derived from molecular chaperones and operates by selectively enhancing the expression of heat shock proteins (HSPs). The mechanism of action involves the modulation of the heat shock response, wherein (2R)-Arimoclomol maleate amplifies the natural cellular defense pathways against protein misfolding and aggregation.</p>

<p>Inhibitor of glycogen synthase 3 (GSK-3) and cyclin-dependent kinases CDK1, CDK2 and CDK5. Kenpaullone can substitute transcription factor Klf4 in reprogramming of fibroblast to induced pluripotent stem cells when using the method of ectopic expression of transcriptional factors. In an in vitro model for Alzheimer’s disease, kenpaullone decreased production of amyloid beta peptides Aβ40 and Aβ42.</p>

<p>H-SLLSGNTELK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SLLSGNTELK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SLLSGNTELK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SLLSGNTELK-OH at the technical inquiry form on this page</p>

<p>H-FSDISAAK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-FSDISAAK-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-FSDISAAK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-FSDISAAK-OH at the technical inquiry form on this page</p>

<p>Zileuton is an inhibitor of the 5-lipoxygenase enzyme, thus preventing the leukotrienes LTE4, LDT4, LTB4 and LTC4 from being formed. This in turn reduces inflammation, bronchoconstriction and mucus secretion in the airways. As a result, Zileuton can be used in the treatment and management of asthma and allergic rhinitis. Studies have shown that Zileuton has the potential to reverse dementia-related brain damage.</p>

<p>Tris-HCl is the same as Tris base with the addition of HCl. It is used as a buffering agent to prepare buffer solutions.</p>

<p>Peptide H-LASAYGAR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Phox-I2 is an advanced chemical reagent, meticulously synthesized from phosphorus oxychloride, operating through a halogenation mechanism. This reagent is particularly significant in the realm of organic chemistry, where it efficiently converts various substrates through iodine incorporation. Known for its unique ability to facilitate halogen transfer, it ensures precise iodination which is crucial for subsequent synthetic manipulations.</p>

<p>CPI 444 is a monoclonal antibody that binds to the adenosine receptor. It has been shown to inhibit the growth of tumor cells in mice, with an IC50 of 1.3 mg/kg. CPI 444 has also been shown to inhibit the proliferation of tumor cells in vitro by blocking cell cycle progression through G1 phase and arresting cells in G2 phase. This drug is being investigated as a potential treatment for cancer, including urothelial carcinoma and renal cell cancer, as well as other solid tumours. The mechanism of action of CPI 444 is not clear but may be due to its ability to induce death protein-mediated apoptosis or alter the microenvironment by binding to toll-like receptors on immune cells.</p>

<p>H-YRNIEFFTKNSAFPK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-YRNIEFFTKNSAFPK-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-YRNIEFFTKNSAFPK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-YRNIEFFTKNSAFPK-OH at the technical inquiry form on this page</p>