Metabolismo

<p>Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin.</p>

<p>H-4-Nitro-Phe-OEt . HCl is an alanine derivative.</p>

<p>Lysine monohydrate is a bioactive chemical.</p>

<p>Migalastat hydrochloride (GR181413A) 是一种可口服且具有有效和竞争性的 α-galactosidase A 抑制剂，可促进α-半乳糖苷酶A向溶酶体的运输，可用于研究法布里病。</p>

<p>Ketogestin is a progestational steroid and an inhibitor of enzyme 11β-hydroxysteroid dehydrogenase, and a weak negative modulator of GABAA receptors.</p>

<p>H-Tyr-Phe-OH, an orally active peptide, inhibits angiotensin-converting enzyme ACE inhibitory activity and can be used as a biomarker for thyroid nodules.</p>

<p>2-Hydroxypalmitic acid is a useful organic compound for research related to life sciences. The catalog number is T124257 and the CAS number is 764-67-0.</p>

<p>PF-05085727 inhibits PDE2A &gt;4,000-fold selectivity over PDE1 and PDE3-11.</p>

<p>Enalapril D5 maleate is deuterium labeled Enalapril, which is an angiotensin converting enzyme (ACE) inhibitor.</p>

<p>Glycyltyrosine, a dipeptide composed of tyrosine and glycine, is an incomplete breakdown product of protein catabolism or protein digestion.</p>

<p>L-Leucine-1-13C (L-Leucine-13C) is a 13C-labeled L-Leucine that significantly enhances the affinity of GLP-4.</p>

<p>Fmoc-Lys(Tfa)-OH is a peptide, a lysine derivative with an Fmoc protective group on the α-amino group, widely used in biochemical experiments.</p>

<p>MPO-IN-1 is an orally active myeloperoxidase (MPO) inhibitor that inhibits MPO and thyroid peroxidase (TPO), useful for studying inflammation.</p>

<p>(R)-Leucic acid is an metabolite of amino acid.</p>

<p>β-Methyl L-aspartate hydrochloride (L-Aspartic acid β-methyl ester hydrochloride) is an aspartic acid derivative commonly used to synthesize various compounds</p>

<p>11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid capable of being found in Saccharomyces cerevisiae (KD115).</p>

<p>Pre-vitamin D3 decanoate, a derivative of vitamin D3, can be transformed into the active form of vitamin D in the body. Initially, it is converted to 25-hydroxyvitamin D3 in the liver and then to 1,25-dihydroxyvitamin D3 in the kidneys. During preparation, vitamin D3 might react with triglycerides in the formulation, forming ester compounds that impact the stability and bioavailability of vitamin D3. This compound is utilized in the study of diseases related to vitamin D, including osteoporosis, autoimmune diseases, and certain cancers.</p>

<p>Pyridoxamine 5′-phosphate, the active form of vitamin B6 phosphorylated, acts as a central metabolite, potent antioxidant, and enzyme substrate by serving as</p>

<p>3α-Aminocholestane (5α-Cholestan-3α-amine) is a SHIP1 inhibitor, (IC50 : 2.5 μM), which can be used for research and immune-related diseases.</p>

<p>VX-548 is a potassium salt of L-aspartic acid that boosts nitrogen oxides, enhances phagocytosis, aids fish survival, and may stimulate antibiotics.</p>

<p>2-Methylbutyrylcarnitine, a fatty acid metabolite from pyruvate pathway, indicates metabolic diseases, found in blood and urine.</p>

<p>Ofloxacin-d3 is a deuterated compound of Ofloxacin.</p>

<p>Albendazole sulfone is a metabolite of albendazole with antiparasitic and anthelmintic activity, exhibiting cytotoxicity HuH-7</p>

VitaminA-d6 is a deuterated compound of VitaminA. VitaminA has a CAS number of 68-26-8.

<p>Gemcabene calcium reduces LDL-C, cuts triglycerides, increases HDL-C, and has anti-inflammatory effects, lowering CRP.</p>

<p>Boc-Glu-OBzl, a peptide precursor, aids in synthesizing inhibitors for human caspases and HRV 3C protease.</p>

<p>MeTC7 is a VDR antagonist with antitumor activity that inhibits PD-L1 and may inhibit the growth of xenografts and transgenic tumors in vivo.</p>

<p>Oxadiazon is a protoporphyrinogen oxidase (PPO) inhibitor and herbicide that suppresses photosynthesis at the chloroplast level.</p>

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IFN-α. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human IFN-α. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IFN-α, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human IFN-α. You can calculate the concentration of Human IFN-α in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human VEGF-A. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human VEGF-A. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human VEGF-A, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human VEGF-A. You can calculate the concentration of Human VEGF-A in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-6. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse IL-6. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse IL-6. You can calculate the concentration of Mouse IL-6 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to TGF-β1. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for TGF-β1. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain TGF-β1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of TGF-β1. You can calculate the concentration of TGF-β1 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse GROα/CXCL1. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse GROα/CXCL1. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse GROα/CXCL1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse GROα/CXCL1. You can calculate the concentration of Mouse GROα/CXCL1 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-6. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human IL-6. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human IL-6. You can calculate the concentration of Human IL-6 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse TNF-α. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse TNF-α. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse TNF-α, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse TNF-α. You can calculate the concentration of Mouse TNF-α in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IFN-γ. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse IFN-γ. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IFN-γ, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse IFN-γ. You can calculate the concentration of Mouse IFN-γ in the samples by comparing the OD of the samples to the standard curve.

<p>2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide present in DNA.</p>

<p>Tuftsin 3TFA is a tetrapeptide. It is a macrophage/microglial activator.</p>

<p>AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).</p>

<p>Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696.</p>

<p>Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) is used clinically to treat diseases caused by vitamin K deficiency and as a vitamin K supplement.</p>

<p>TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).</p>

<p>Tebufenpyrad (Comanche) (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant</p>

<p>Hyaluronic acid sodium (Sodium Hyaluronate) is an anionic, nonsulfated glycosaminoglycan distributed throughout connective, epithelial, and neural tissues.</p>

<p>Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.</p>

<p>Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that</p>

<p>Nequinate is an anticoccidial agent, preventing coccidiosis .</p>

<p>JNJ-42165279 selectively inactivates FAAH without notably affecting other enzymes, ion channels, receptors, or CYPs/hERG at 10 μM.</p>

<p>Fmoc-1,6-diaminohexane has the potential for Alzheimer's disease and cancer treatment.Fmoc-1,6-diaminohexane is an analog of Osw-1.</p>

<p>Nepicastat (SYN117) is a potent, BBB-permeable, selective DBH inhibitor with IC50s of 8.5/9 nM in bovine/human.</p>

<p>AGI-5198 (IDH-C35) is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).</p>

<p>MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.</p>

<p>Cetilistat (ATL-962) is a drug for obesity and type 2 diabetes, blocking pancreatic lipase. Developed by Alizyme.</p>

<p>BI-0115 inhibits LOX-1, preventing oxLDL uptake by triggering receptor inhibition and dimer formation.</p>

<p>HIF-2a translation inhibitor is a compound used as a molecular building block.</p>

<p>Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects.</p>

<p>Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.</p>

<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>

<p>Febuxostat (TEI 6720) sodium, a potent XO inhibitor with a Ki of 0.6 nM, may help in gout and hyperuricemia.</p>

<p>Lanthanum(III) chloride blocks divalent cation channels, useful for biochemical research.</p>

<p>Neomangiferin combats fatty liver in rats and inhibits an enzyme linked to bone loss.</p>

<p>2-Hydroxy-3-methylbutanoic acid ((±)-2-Hydroxyisopentanoic Acid) is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia.</p>

<p>CP-609754 shows selective inhibition of farnesyltransferase.</p>

<p>Indoximod (NLG-8189) is a methylated tryptophan that inhibits IDO to boost T cell function by preventing tryptophan depletion.</p>

<p>Edoxaban (DU-176b) HCl: Oral, selective Factor Xa inhibitor, Ki 0.561 nM; prevents thromboembolic disease.</p>

<p>SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)</p>

<p>ABT-639 is a potent and selective T-type calcium channel blocker.</p>

<p>HNHA is an inhibitor of HDAC.</p>

<p>Synthetic fatty acid TTA has β-sulfur, resists β-oxidation, and activates PPARs, especially PPARα.</p>

<p>CVT-2738 (RS-94287) is a metabolite of Ranolazine. Ranolazine is a partial fatty acid oxidation (pFOX) inhibitor and anti-anginal drug.</p>

<p>Milrinone Lactate is a positive inotropic cardiotonic compound. Milrinone Lactate has vasodilator properties, inhibiting cAMP phosphodiesterase type 3 activity in the myocardium and vascular smooth muscle.</p>

<p>Galloflavin is a lactate dehydrogenase inhibitor. Galloflavin inhibits both human LDH isoforms (type A and type B).Cost-effective and quality-assured.</p>

<p>PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.</p>

<p>Telotristat, active metabolite of LX1606, is an oral tryptophan hydroxylase inhibitor with potential antiserotonergic effects.</p>

<p>TTA-A2: T-type calcium channel blocker; anticonvulsant targeting Cav3.1, Cav3.2; IC50 of 89/92 nM; potential for treating neurological conditions.</p>

<p>Liquiritin (Liquiritigenin-4'-O-glucoside) (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.</p>

<p>Perfluorooctanoic acid (PFOA) (PFOA) is a persistent and widespread industry-made chemical.</p>

<p>ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM)</p>

<p>SN 6 (SN6) is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)</p>

<p>Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).</p>

<p>RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)</p>

<p>3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone. It is always be detected as a indicator of furazolidone residues in vivo.</p>

<p>Fatostatin inhibits SREBP-1/2 by binding to SCAP, blocking their ER-Golgi transport.</p>

<p>RP-64477 is the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor.</p>

<p>2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the lactation period.</p>

<p>AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for</p>

<p>"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."</p>

<p>PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.</p>

<p>RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.</p>

<p>PHGDH inactive is inactive against PHGDH and serves as a negative control for NCT-502 and NCT-503 [1].</p>

<p>6-Phosphogluconic acid competitively inhibits PGI with Ki: 0.048 mM for glucose 6-P, 0.042 mM for fructose 6-P.</p>

<p>Enterostatin, human, mouse, rat acetate is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase.</p>

<p>CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).</p>

<p>FPH2 (BRD-9424) (BRD-9424) is a small molecule promoting differentiation of iPS-derived hepatocytes.</p>

<p>ATP disodium salt hydrate (Adenosine disodium triphosphate) is a nucleoside triphosphate used in cells as a coenzyme.</p>

<p>RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).</p>

<p>(±)-Haloxyfop (Haloxyfop Acid) is a herbicide.</p>

<p>Eliglustat (Genz 99067) is an oral inhibitor of glucosylceramide synthase which is used in the therapy of type 1 Gaucher disease.</p>

<p>Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.</p>

<p>Polmacoxib, a first-class NSAID, dual inhibitor of CA and COX-2, may hinder colorectal cancer growth in mice.</p>

<p>PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.</p>