Metabolism

<p>PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP-1B) with an IC50 of 8.2 µM. Additionally, it inhibits α-glucosidase with an IC50 of 120 µM and exhibits competitive inhibition characteristics (Ki=118 µM).</p>

<p>MPO-IN-7 (compound MDC) is a myeloperoxidase inhibitor with IC50 values of 41 μM for α-glucosidase, 25 μM for dipeptidyl peptidase-4, and 4.5 μM for myeloperoxidase. MPO-IN-7 exhibits antioxidant and anti-inflammatory activities in vitro.</p>

<p>Transketolase-IN-5 (compound 6ba) is an inhibitor of transketolase. It exhibits herbicidal activity against Amaranthus retroflexus, Setaria viridis, and Digitaria sanguinalis.</p>

<p>RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.</p>

<p>CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with an IC50 value of 5.8 nM, playing a significant role in cancer research.</p>

<p>BE2647 is a selective inhibitor of the mitochondrial pyruvate carrier (MPC), with an EC50 of 70 nM. It exhibits good metabolic stability in mouse liver microsomes. BE2647 can be utilized in research related to metabolic diseases, metabolic-associated steatotic liver disease (MASLD), or metabolic-associated steatohepatitis (MASH).</p>

<p>α-Glucosidase-IN-65 (compound 5) is a Schiff base derivative of 3,4-dihydroxyphenylacetic acid. It acts as a potent α-glucosidase inhibitor with an IC50 of 12.84 μM.</p>

<p>Fmoc-Cys-Asp10 (TFA) is a non-releasable oligopeptide linker involved in synthesizing releasable oligopeptide linkers. These releasable linkers are used to deliver drugs to fracture-targeting oligopeptides, thereby reducing the healing time of fractured femurs.</p>

<p>α-Glucosidase-IN-46 is a potent inhibitor of α-glucosidase, with an IC50 of 26.0 μM. This compound is applicable in the research of Type 2 diabetes.</p>

<p>LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.</p>

<p>IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.</p>

<p>AChE/BChE-IN-17 (compound 8m) is a potent inhibitor of AChE and BChE, displaying IC50 values of 125.06 nM and 119.68 nM, respectively. Additionally, AChE/BChE-IN-17 inhibits α-glucosidase, with an IC50 of 41050 nM.</p>

<p>MPO-IN-6 (compound ADC) is an electrophilic agent with excellent antioxidant and anti-inflammatory properties. It acts as an inhibitor of myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD), with IC50 values of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 may serve as a potential cardiovascular protective agent.</p>

<p>α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-glucosidase inhibitor with an IC50 of 2.11 μM, demonstrating greater inhibitory potency than the existing α-glucosidase inhibitors Acarbose (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). It exhibits no cytotoxicity on normal human liver cells (LO2) and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research in type 2 diabetes.</p>

<p>LEI110 inhibits PLA2G16 and HRASLS enzymes, Ki 20 nM, selectively targets related thiol hydrolases.</p>

<p>Calcium Channel antagonist 2 is a calcium channel antagonist (IC50=5-20 μM) that can be used to study diseases due to Ca2+ channels like pain and diabetes.</p>

<p>Triornicin is a siderophore and tumor inhibitory factor isolated from Epicoccum purpurascens similar in structure to desferricoprogen.</p>

<p>Deoxyadenosine diphosphate sodium is a diphosphate nucleoside featuring deoxyadenosine as its nucleoside component. It plays a role in the synthesis and repair of DNA. Deoxyadenosine diphosphate sodium acts as an inhibitor of polynucleotide phosphorylase, thereby interfering with the polymerization of ADP and CDP.</p>

<p>Cyperine is a useful organic compound for research related to life sciences. The catalog number is T125020 and the CAS number is 33716-82-4.</p>

<p>Calcium Channel antagonist 3 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM).</p>

<p>α-Amylase/α-Glucosidase-IN-18 (Compound 9g) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 49.17 nM and 10.71 nM, respectively. It is suitable for research related to type 2 diabetes.</p>

<p>L 645164 is an inhibitor of hydroxymethylglutaryl-CoA reductase.</p>

<p>α-Amylase/α-Glucosidase-IN-17 (Compound 3) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 14.61 μM and 25.38 μM, respectively. It exhibits some inhibitory activity against A549 cancer cells and possesses both antitumor and antidiabetic properties.</p>

<p>FTI-2148 diTFA inhibits FT-1 and GGT-1 with IC50s of 1.4 nM and 1.7 μM; a RAS-mimetic compound.</p>

(Z)-7-Dodecen-1-ol counteracts the attractive properties of Z-7-dodecen-1-yl acetate.

ASP8477 is a potent and selective FAAH inhibitor. It increases anandamide levels in the brain when administered orally. In rat models of neuropathic and osteoarthritic pain, ASP8477 demonstrates significant efficacy without causing motor coordination issues. A single oral dose of ASP8477 improves thermal hyperalgesia and cold allodynia in rats with chronic constriction nerve injury. Moreover, ASP8477 restores the decreased muscle pressure threshold in a myalgia model induced by reserpine. Research indicates that ASP8477 possesses analgesic effects effective for alleviating neuropathic and functional pain, making its pharmacological properties suitable for chronic pain treatment.

<p>Largazole is a potent and selective histone deacetylase (HDAC) inhibitor and antiproliferative agent from Symploca.</p>

Creatine Kinase (CPK/CK), Bovine Heart (CK, CPK, Creatine Phosphokinase), is a biological material or organic compound suitable for use in life sciences research.

<p>Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.</p>

<p>Arginase (L-Arginine amidinase) is a key hydrolytic enzyme in the urea cycle, which hydrolyzes L-arginine into urea and L-ornithine.</p>

Benzoyl coenzyme A (sodium) is the sodium salt form of Benzoyl coenzyme A. It is a derivative of coenzyme A (CoA), where the thiol group of CoA is linked to a benzoyl group. This compound serves as a substrate in acyl transfer reactions, playing a role in catalysis. Benzoyl coenzyme A (sodium) is a versatile metabolic intermediate used in studies exploring enzyme substrate specificity, metabolic regulation, and drug metabolism.

Mannose 6-phosphate (M6P) features a type I integral membrane receptor.

<p>2,3-Dehydrosilybin B is a useful organic compound for research related to life sciences and the catalog number is T125883.</p>

<p>Kahalalide A has antimycobacterial activity isolated from the mollusk Elysia rufescens.</p>

<p>BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.</p>

<p>Evinacumab (REGN1500) is a humanized monoclonal antibody targeting ANGPTL3. It is useful for studying cardiovascular diseases.</p>

<p>C22 Galactosylceramide, a CNS sphingolipid, rises in mouse spinal cord on a methionine-restricted diet, found in Alzheimer's hippocampus.</p>

<p>AY 9944 dihydrochloride is a intermediate.</p>

<p>Lipstatin is a potent inhibitor of the pancreas lipase. It is reported to be useful in the treatment and/or prevention of obesity and related diseases.</p>

<p>Acremin F is a useful organic compound for research related to life sciences. The catalog number is T124074 and the CAS number is 863480-61-9.</p>

<p>3-keto Fusidic acid (3-keto FA) is an active metabolite of the antibiotic fusidic acid .13-keto FA is active againstM. tuberculosis(MIC99= 1.25 μM).</p>

<p>Campestanol is a natural plant sterol from Brassica campestris.</p>

<p>Oseltamivir acid methyl ester hydrochloride, a precursor to oseltamivir, is converted by CES1.</p>

<p>BVT-2733 hydrochloride is a potent, selective, and orally active non-steroidal 11β-HSD1 inhibitor. It exhibits stronger inhibition on mouse 11β-HSD1 enzyme (IC50=96 nM) compared to the human 11β-HSD1 enzyme (IC50=3341 nM). BVT-2733 hydrochloride shows potential for research in arthritis and obesity-related diseases.</p>

<p>DJ-53 (compound 68) is an orally active, phenyl-quinoline-based soluble epoxide hydrolase inhibitor.</p>

<p>Hydroxydehydro nifedipine carboxylate is a metabolite of nifedipine .1</p>

<p>SBI993, a SBI-477 analog, confirms MondoA gene action in vivo and lowers muscle TAG and liver fat.</p>

<p>SMS2-IN-1: potent SMS2 inhibitor; IC50: 6.5 nM, Kd: 37 nM; 150x selectivity over SMS1.</p>

<p>OGP, a natural 14-mer serum peptide at μM levels, is crucial for osteogenic response to bone injury.</p>

<p>Ninopterin is an experimental antineoplastic and folic acid analog.</p>

<p>isomer-GAT 107 ((-)GAT 107) is an inactive isomer of (+)GAT 107.</p>

<p>Linoleoyl-L-carnitine, a natural acylcarnitine, rises in mouse liver post high-dose isoniazid (200 mg/kg).</p>

<p>1,3-Diphenethylurea (N,N'-Bis(phenethyl)urea) is a marine derived natural products found in Lissoclinum patella.</p>

<p>5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is an inhibitor of the enzyme phosphodiesterase 10A (PDE10A) with a Ki value of 24 μM. This compound can be employed in research related to schizophrenia.</p>

<p>Purine nucleoside phosphorylase deficiency impairs T cells; it breaks bonds in DNA components, releasing bases and ribose phosphate.</p>

<p>"Cyclohexanoyl CoA (CHCoA) activates CHC in R. palustris, converts to hippuric acid in guinea pig liver."</p>

<p>MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3, with a Ki value of 0.55 μM for ALDH1A3 and 78.2 μM for ALDH1A1. It inhibits retinoic acid biosynthesis and can reduce the viability of glioblastoma cells GSC-83 and GSC-326.</p>

<p>(R)-SCH 42495, less potent enantiomer of NEP inhibitor SCH 42495, has oral antihypertensive action.</p>

<p>Propionylcarnitine (Propionyl carnitine) is a widely used dietary supplement that has been associated with glaucoma and does it ruptu</p>

<p>Corneal metabolism of 12(R)-HETE yields 8(R)-HHxTrE via β-oxidation, losing four carbons from C-1.</p>

<p>Endocrocin is a useful organic compound for research related to life sciences. The catalog number is T124800 and the CAS number is 481-70-9.</p>

<p>(R)-2-Hydroxyoleic acid (R)-2-OHOA, an orally active, R-enantiomer fatty acid, modulates membrane lipids and shows antitumor properties.</p>

<p>Microginin 527, a compound found in Microcystis, is an inhibitor of protein phosphatase, ACE, and leucine aminopeptidase.</p>

<p>N-Trifluoroacetyladriamycin, Valrubicin's metabolite, treats bladder cancer; it's an analog of doxorubicin, infused into the bladder.</p>

<p>UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.</p>

<p>Etodolac acyl glucuronide is an NSAID metabolite formed by UGT1A9, UGT1A10, and UGT2B7 glucuronidation.</p>

<p>SK&amp;F 104976 is a 32-carboxylic acid derivative of lanosterol. It was found to be a potent lanosterol 14 alpha-demethylase (14 alpha DM) inhibitor.</p>

<p>(S)-(+)-ochracin (8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one) is a marine derived natural products found in Helicascus kanaloanus.</p>

<p>Creatine kinase (OcCK) converts creatine and ATP into phosphocreatine and ADP, crucial for ATP/ADP balance during high energy demand.</p>

<p>15-keto Latanoprost, a less potent metabolite and impurity of latanoprost, lowers intraocular pressure in monkeys and constricts pupils in cats.</p>

<p>PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.</p>

<p>Rawsonol is a HMG-CoA reductase inhibitor from the tropical green alga Avrainvillea rawsoni.</p>

<p>MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.</p>

<p>2-Aminoflubendazole, a metabolite of benzimidazoles (BZ), belongs to a class of drugs effective against fungi, protozoa, and helminths.</p>

<p>NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid utilized as an endogenous nitrosation indicator in gas chromatography-thermal energy analysis.</p>

<p>Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1]</p>

<p>PLD is an enzyme in the phospholipase family, found across many life forms, and linked to diseases like diabetes and cancer.</p>

<p>CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4</p>

<p>D-Amino acid oxidase enzyme metabolizes and detoxifies exogenous D-amino acids, regulating D-serine in the brain.</p>

<p>L-Leucine-1-13C (L-Leucine-13C) is a 13C-labeled L-Leucine that significantly enhances the affinity of GLP-4.</p>

<p>6-Methyluracil (Pseudothymine): a Uracil metabolite, indicates acetoacetyl-CoA build-up, has antiradiation effects.</p>

<p>IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO.</p>

<p>N,N-Dimethylglycine hydrochloride (N-Methylsarcosine hydrochloride) is a dietary supplement.</p>

<p>SW157765 is a glucose transporter GLUT8 inhibitor that inhibits the uptake of fluorescent 2-deoxyglucose (2DG) in SW157765-sensitized cells.</p>

<p>ent-Atorvastatin is a selective and competitive inhibitor of HMGCR (HMG-CoA reductase).</p>

<p>D/L-Cysteine is a useful organic compound for research related to life sciences. The catalog number is T125019 and the CAS number is 3374-22-9.</p>

<p>3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol. 3,4-Dehydro Cilostazol is used for pharmacokinetic study[1].</p>

<p>MTIC has anticancer and antitumor activity and can be used to study melanoma.</p>

<p>DiFMUP (6,8-Difluoro-4-methylumbelliferyl phosphate) inhibits protein tyrosine phosphatases (PTPs) and can be used to assay threonine phosphatase activity.</p>

<p>Aspartic acid derivative H-Asp(OtBu)-OtBu HCl, for studying neurological function and non-alcoholic hepatitis.</p>

<p>Ofloxacin-d3 is a deuterated compound of Ofloxacin.</p>

<p>N-Hippuryl-His-Leu hydrate (N-Benzoyl-Gly-His-Leu hydrate) is an ACE substrate and can be used as a model peptide for measuring ACE-I inhibitory activity.</p>

<p>TLK117 is an inhibitor of GSTs that reduces the severity of pulmonary fibrosis and may be used in the study of idiopathic pulmonary fibrosis.</p>

Fmoc-Tyr(tBu)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

<p>Mebeverine alcohol D5 is the deuterium labeled Mebeverine alcohol.</p>

<p>(Rac)-IDO1-IN-5 is a racemic, potent IDO1 inhibitor; selective for apo-IDO1, it crosses the blood-brain barrier.</p>

<p>BMS493 is an inverse agonist of RAR that inhibits retinoic acid-induced differentiation and inhibits the increase in phospholipase A2 activity.</p>

Chenodeoxycholic Acid-d4 is a deuterium-labelled compound of Chenodeoxycholic Acid, which can be used for isotopic tracing. CDCA is a bile acid.

<p>Diisobutyl carbinol is a compound that is used in fragrance materials.</p>

<p>Trandolapril D5 is a deuterated ACE inhibitor used to treat hypertension and CHF.</p>