Metabolism

N-Desmethyl Clomipramine hydrochloride is a primary plasma N-desmethyl Clomipramine metabolite .

<p>Fmoc-Lys(Tfa)-OH is a peptide, a lysine derivative with an Fmoc protective group on the α-amino group, widely used in biochemical experiments.</p>

<p>HTS01037 is an inhibitor of fatty acid-binding. HTS01037 is a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki: 0.67 μM).</p>

<p>Muramic acid is a prevalent constituent found in the cell walls of Gram-positive bacteria, serving as a distinguishing marker for such bacteria[1].</p>

<p>UDP-xylose, natural from Cryptococcus laurentii, aids in synthesizing glycoproteins and polysaccharides.</p>

<p>Fmoc-Lys(Z)-OH is a lysine derivative with an Fmoc protecting group, widely used in biochemical experiments and drug synthesis research.</p>

<p>Phenylpropiolic acid is an endogenous metabolite.</p>

<p>Compound 9h is a potent Glo-I inhibitor with IC50 of 1.28 μM, showing promise as an anticancer agent.</p>

<p>Metoprolol acid is a urinary metoprolol metabolite and doesn't work pharmacologically.</p>

TPC2-A1-N is a TPC2 small molecule agonist that can be used to detect different functions of TPC2 channels in intact cells.

<p>Trandolapril D5 is a deuterated ACE inhibitor used to treat hypertension and CHF.</p>

<p>Myristoyl Ethanolamide is an endogenous cannabinoid analog belonging to the fatty acyl ethanolamine famil，has physiological activity in the nervous system.</p>

<p>Nucleoside Derivatives - Other modified nucleosides; Drugs and Inhibitors; Ribavirin related compound A; metabolite of Ribavirin</p>

N-Desmethyl imatinib D8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.

<p>α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of the substrate.</p>

<p>Hexanoyl glycine, an acylated amino acid, serves as a urinary biomarker for metabolic disorders, radiation exposure, and cancer detection.</p>

<p>Glycerophosphoric acid is one of the main components of teichoic acid in bacterial cell walls and is a common emulsifier.</p>

<p>Fmoc-Tyr(tBu)-OH is a protected amino acid for solid-phase peptide synthesis, enabling Leu-EnkephalinAmide formation and versatile amino acid derivatives.</p>

<p>Fmoc-Met-OH (Fmoc-L-Met-OH) is an fmoc-based programmed synthesis of methionine derivatives.</p>

<p>NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.</p>

<p>Hemicellulase is a glycoside hydrolase enzyme key in degrading plant fibers and carbon cycling.</p>

<p>Nagilactone B is extracted from the root bark of Podocarpus nagi and it also is a liver X receptor (LXR) agonist.</p>

<p>H-DL-Gly-OBzl HCl is a glycine derivative.</p>

<p>D-Arginine is inactive form, inhibitor of EC 4.1.1.19 (arginine decarboxylase), toxicity to microorganisms, and acts as a regulator of microbial subpopulation.</p>

<p>H-Asp(OtBu)-OH (L-Aspartic acid 4-tert-butyl ester) is an aspartic acid derivative that can be used for the synthesis of short peptides.</p>

<p>Fmoc-L-aspartic acid (Fmoc-Asp-OH) is an aspartic acid derivative.</p>

<p>N-Palmitoyl-L-glutamine is a glutamine derivative, with low activity as a substrate for the enzyme PmAcy, which synthesizes n -acyl amino acids.</p>

<p>Mebeverine alcohol is a metabolite of Mebeverine.</p>

<p>Zymosterol—a cholesterol precursor, vital for biosynthesis, mainly in cell membranes.</p>

<p>Clodinafop-propargyl is used to control grass weeds in cereals postemergence, targeting species like Avena and Lolium.</p>

<p>Fmoc-Chg-OH (Fmoc-l-cyclohexylglycine) is a glycine derivative containing an Fmoc protecting group and can be used in peptide synthesis and drug design.</p>

<p>Fmoc-Lys(Alloc)-OH is a lysine derivative containing Fmoc protecting group, which can be used for peptide synthesis and drug design.</p>

<p>Fmoc-Aib-OH (Fmoc-alpha-methylalanine) is an alanine acid derivative, which can be used for peptide synthesis and biopharmaceutical design.</p>

<p>Enrofloxacin monohydrochloride, an antibiotic, has MIC 90 of 0.312 μg/mL for M. bovis and inhibits vaccinia virus.</p>

<p>Fmoc-Cha-OH (Fmoc-L-cyclohexylalanine) is an alanine derivative containing an Fmoc protecting group, which can be used for peptide synthesis and drug design.</p>

Hydroxylamine hydrochloride(Hydroxylammonium chloride) is a selective and potent monoamine oxidase (MAO) inhibitor with inhibitory effects on platelet aggregation.

<p>Lomitapide Mesylate (BMS-201038 mesylate) is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.</p>

<p>Ascr#2 (asc-C6-MK) is a glycoside analog in Cryptobacterium hidradii that promotes dauer formation and can be used to detect population density.</p>

<p>1,3,5-Triisopropylbenzene is commonly used in fuels, lubricants, and micellar expanders, a potential retinoid X nuclear receptor alpha (RXRα) agonist.</p>

Acetazolamide D3 is a deuterium-labeled Acetazolamide. Acetazolamide is a potent carbonic anhydrase inhibitor.

<p>Lysine monohydrate is a bioactive chemical.</p>

<p>Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.</p>

<p>Maltose phosphorylase (MP) is a dimeric enzyme that catalyzes the conversion of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose.</p>

<p>NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of inhibitor of Eya2(Eya2 ED and MBP-Eya2 FL with IC50s of 3 μM and 6.9 μM ).</p>

<p>Compound 9j inhibits Glyoxalase I with 1.13 μM IC50, showing anticancer potential and low toxicity.</p>

<p>Glycyltyrosine, a dipeptide composed of tyrosine and glycine, is an incomplete breakdown product of protein catabolism or protein digestion.</p>

<p>3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol. 3,4-Dehydro Cilostazol is used for pharmacokinetic study[1].</p>

<p>Cyhalofop, a new aryloxyphenoxypropionate herbicide in India, controls various grass weeds in rice.</p>

<p>Sodium 3-methyl-2-oxobutanoate is the precursor of pantothenic acid in Escherichia coli.</p>

<p>Debrisoquine is an antihypertensive drug similar to guanethidine.</p>

1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril is recognized for its enzyme inhibitory properties within biological organisms. It is employed as a potential anti-cancer agent in compound development. Additionally, it plays a role in the modulation of cellular signaling pathways, making it useful for cellular biology research. This compound is considered effective in exerting biological activity under specific conditions.

<p>Fmoc-Dab(Boc)-OH is a chemical intermediate used for chemical synthesis.</p>

<p>21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.</p>

<p>PG 34 is a structural analogue of OSMI-1 and a weak inhibitor of O-GlcNAc translocase (OGT) with an IC50 value of 68 μM.</p>

<p>2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos), a fucosyltransferase inhibitor, inhibits salivary acidification in an inflammatory mode</p>

Acetaminophen metabolite 3-hydroxy-acetaminophen is an antioxidant and a non-toxic microsomal metabolite of acetaminophen, suitable for metabolic studies.

<p>PKUMDL-WQ-2201 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with Anti-tumor Activity, it binds to site II.</p>

<p>Pravastatin lactone, a non-enzymatic stomach derivative of pravastatin, inhibits HMG-CoA reductase and stems from mevastatin.</p>

Methyl acetyl-L-cysteinate (N-Acetyl-L-cysteine methyl ester) is a cysteine derivative that is used in biosynthesis and is associated with body metabolism and

<p>N'-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N'-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N'-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2<br>1.Hecht, S.S.Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesChem. Res. Toxicol.11(6)559-603(1998) 2.Yuan, J.-M., Knezevich, A.D., Wang, R., et al.Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersCarcinogenesis32(9)1366-1371(2011)</p>

<p>MCPA（Krezone） is a highly effective phenoxy herbicide. Use of MCPA would have impacts on nearby water and soil resources.</p>

Glycyl-L-phenylalanine (Gly-L-Phe) is a dipeptide peptide transport in tracheal epithelial cells degraded in mucosal fluids skin aging and moisturizing.

<p>Atrial natriuretic factor (1-28) (human, porcine) TFA exhibits antihypertensive activity by promoting sodium and urine excretion. It inhibits the release of adrenocorticotropic hormone (ACTH) and β-endorphin by suppressing pro-opiomelanocortin (POMC) expression. Additionally, it elevates cGMP levels in RMIC cells, with an IC50 of 1.2 nM.</p>

<p>Gemcabene calcium reduces LDL-C, cuts triglycerides, increases HDL-C, and has anti-inflammatory effects, lowering CRP.</p>

<p>Fmoc-Ile-OH (Fmoc-L-isoleucine) is an Fmoc-modified isoleucine with a strong affinity for peptides and proteins and can be used to synthesize other active</p>

<p>1,10-Diiododecane: Crosslinks polygalacturonic acid, alkylates bis-cryptophanes, produces decane at 20°C.</p>

<p>Viaminate, a derivative of retinoic acid, is utilized in the treatment of severe acne and other keratinization disorders.</p>

<p>Z-Asn-OH (N-Cbz-L-asparagine) is a glycine derivative mainly used in peptide synthesis.Cbz-Asn-OH prevents unwanted reactions.</p>

<p>HFI-142 is a inhibitor to aminopeptidase N; inhibit leukotriene A4 biosynthesis in red blood cells; inhibit dditional aminopeptidases.</p>

<p>2-Amino-3-mercaptopropanoic acid hydrochloride hydrate is a cysteine derivative, widely used in biochemical experiments and drug synthesis research.</p>

<p>Boc-Ile-OH is a useful organic compound for research related to life sciences. The catalog number is T65714 and the CAS number is 13139-16-7.</p>

ALDH3A1-IN-1 (Compound 18) is a potent inhibitor of ALDH3A1 with IC50 of 1.61 μM, outperforms DEAB in prostate cancer cells.

<p>alpha-Amyl cinnamaldehyde is a common additive in the perfume and cosmetic industry as an aroma substance.</p>

<p>LAS17 is a GSTP1 inhibitor with antitumor activity and inhibits breast cancer cell growth.</p>

<p>Malondialdehyde tetrabutylammonium serves as a biomarker with antioxidant properties, and is extensively used in both the food and cosmetics industries primarily for monitoring and assessing product stability and safety. It acts as an indicator of lipid peroxidation, aiding in the evaluation of oxidative stress levels. Additionally, this compound has significant implications for indicating cellular damage and is investigated as a potential biomarker for various diseases.</p>

<p>Ochratoxin α (Ochratoxin alpha) is a degradation product of Ochratoxin A, used for studying Ochratoxin A degradation.</p>

<p>MPO-IN-1 is an orally active myeloperoxidase (MPO) inhibitor that inhibits MPO and thyroid peroxidase (TPO), useful for studying inflammation.</p>

<p>Autotaxin modulator 1 is a new modulator of Autotaxin.</p>

<p>D-Gluconic acid (D-Gluco-hexonic acid) is a carboxylic acid that has antiseptic and chelating properties through oxidation.</p>

<p>2-Bromoacetamide (α-Bromoacetamide) is a class of disinfection by-products that exhibit developmental toxicity in animals.</p>

<p>PF-05085727 inhibits PDE2A &gt;4,000-fold selectivity over PDE1 and PDE3-11.</p>

LEI-401 is a NAPE-PLD inhibitor.LEI-401 reduces the level of n-acyl ethanolamines in the brain of free-ranging mice and modulates their emotional behaviour.

<p>Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).</p>

<p>BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.</p>

<p>SDH-IN-1 (compound 4i) is an SDH (succinate dehydrogenase) inhibitor (IC50 = 4.53 μM) with antifungal activity against S. sclerotiorum fungicidal purposes.</p>

<p>N-Hippuryl-His-Leu hydrate (N-Benzoyl-Gly-His-Leu hydrate) is an ACE substrate and can be used as a model peptide for measuring ACE-I inhibitory activity.</p>

<p>Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.</p>

<p>(9Z,12E)-Tetradecadien-1-yl acetate is the main component of the pheromone of insects Plodia Interpunctella and Ephestia Kuehniella, and cereal pests.</p>

<p>Glycerophosphoinositol lysine fights dandruff, inflammation, aging, and reduces UVB-induced PGE in NHEK cells.</p>

Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.

4-Hydroxyphenyl Carvedilol D5 is the deuterium labeled 4-Hydroxyphenyl Carvedilol.

<p>Gemcitabine triphosphate (dFdCTP), a cell metabolite, aids tumor imaging and measures drug uptake/retention.</p>

<p>2-Thiophenecarboxaldehyde is an endogenous metabolite.</p>

Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin.

<p>Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase with anti-inflammatory activities.</p>

<p>Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl) compound inhibits coagulation factor Xa, useful for thrombotic conditions study.</p>

<p>β-Methyl L-aspartate hydrochloride (L-Aspartic acid β-methyl ester hydrochloride) is an aspartic acid derivative commonly used to synthesize various compounds</p>

<p>H-Glu(OMe)-OH is a glutamate derivative that is utilized in synthesizing various compounds and is related to immune and metabolic processes in the body.</p>

<p>Ternidazole hydrochloride (Ternidazole HCl) is a 5-nitroimidazole antibiotic with antimicrobial antioxidant and antiprotozoal activity.</p>