Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(41 products)
- Aminopeptidase(67 products)
- CETP(18 products)
- Carbonic Anhydrase(177 products)
- Casein Kinase(130 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(267 products)
- FAAH(63 products)
- FXR(58 products)
- Factor Xa(80 products)
- Fatty Acid Synthase(32 products)
- Ferroptosis(215 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(53 products)
- HIF/HIF Prolyl-Hydroxylase(142 products)
- HMG-CoA Reductase(32 products)
- Hydroxylase(30 products)
- IDO(82 products)
- LDL(8 products)
- Lipase(96 products)
- Lipid(59 products)
- Lipoxygenase(124 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(36 products)
- P450(6 products)
- PAI-1(25 products)
- PDE(165 products)
- PED(1 products)
- PKM(15 products)
- PPAR(164 products)
- Phospholipase(82 products)
- ROR(42 products)
- Retinoid Receptor(29 products)
- SGK(11 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(42 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 8597 products of "Metabolism"
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CK1δ-IN-3
CAS:<p>CK1δ-IN-3 (compound 376) is a CK1δ (casein kinase 1δ) inhibitor that can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Formula:C24H19N3O2SPurity:99.27%Color and Shape:SolidMolecular weight:413.49RORγt modulator 5
CAS:<p>RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.</p>Formula:C27H22F5N3O6SColor and Shape:SolidMolecular weight:611.54HIV-1 inhibitor-40
<p>HIV-1 inhibitor-40 (4ab) is a potent NNRTI (EC50: 1.9 nM), non-toxic in vivo, and a sensitive CYP inhibitor.</p>Formula:C25H18N6O2Color and Shape:SolidMolecular weight:434.45NNC 55-0396
CAS:<p>NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.</p>Formula:C30H40Cl2FN3O2Purity:99.00%Color and Shape:SolidMolecular weight:564.56Sitamaquine hydrochloride
CAS:<p>Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.</p>Formula:C21H35Cl2N3OColor and Shape:SolidMolecular weight:416.43GSK 366
CAS:<p>GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).</p>Formula:C17H16ClN3O4Purity:98%Color and Shape:SolidMolecular weight:361.78D-2-Phosphoglyceric acid
CAS:<p>D-2-Phosphoglyceric acid is a crucial metabolic intermediate known for its role in enhancing cellular energy metabolism and regulating biosynthesis. It plays a key role in both glycolysis and photosynthesis, which are essential for cellular energy supply. Additionally, D-2-Phosphoglyceric acid serves as a biomarker for monitoring metabolic states in various organisms.</p>Formula:C3H7O7PColor and Shape:SolidMolecular weight:186.06hCA VB-IN-1
<p>hCA VB-IN-1 (compound 15) is a potent and selective inhibitor of hCA VB (carbonic anhydrase) with a KI of 515.7 nM [1].</p>Formula:C9H13N3O4SColor and Shape:SolidMolecular weight:259.28WR 199507 trihydrobromide
CAS:<p>WR 199507 trihydrobromide is a primary aminoquinoline metabolite that induces the formation of methemoglobin in canine erythrocyte lysates.</p>Formula:C15H24Br3N3O2Color and Shape:SolidMolecular weight:518.08α-Hydroxy alprazolam
CAS:<p>α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.</p>Formula:C17H13ClN4OColor and Shape:SolidMolecular weight:324.76Desmonomethylpromazine
CAS:<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>Formula:C16H18N2SColor and Shape:SolidMolecular weight:270.39PDE5-IN-8
CAS:<p>PDE5-IN-8 (compound 2) is an inhibitor of PDEs.</p>Formula:C22H20ClN3O2Color and Shape:SolidMolecular weight:393.87Glucosylceramide synthase-IN-3
<p>Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.</p>Formula:C21H20FN3O3Color and Shape:SolidMolecular weight:381.4Anticancer agent 142
CAS:<p>Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].</p>Formula:C13H14BrF2N2O7PS2Purity:98%Color and Shape:SolidMolecular weight:523.26PAT-347
CAS:<p>PAT-347 is a potent inhibitor of Autotaxin, an enzyme linked to cell survival and diseases like cancer and fibrosis.</p>Formula:C28H21ClF2N2O3SColor and Shape:SolidMolecular weight:538.99GPX4-IN-15
CAS:<p>GPX4-IN-15 (Compound C1) is an inhibitor of GPX4, demonstrating an inhibition rate of 19.8% at a concentration of 1 μM. This compound effectively inhibits the proliferation of cancer cell lines MDA-MB-468, BT-549, and MDA-MB-231, with IC50 values of 0.86 μM, 0.96 μM, and 0.48 μM respectively.</p>Formula:C17H15Cl2NO4Color and Shape:SolidMolecular weight:368.21Monoamine oxidase/Aromatase-IN-1
<p>Compound 2q: Dual MAO/aromatase inhibitor; IC50: 39 nM (MAO-B), 31 nM (aromatase). Useful in neurological/breast cancer research.</p>Formula:C19H19N3O3SColor and Shape:SolidMolecular weight:369.44sEH inhibitor-2
<p>SEH inhibitor-2 is an orally active sEH blocker (IC50=0.9 nM) with predicted 71.2-88.4% absorption, potentially aiding cardiovascular health.</p>Formula:C23H18N4O3Color and Shape:SolidMolecular weight:398.41Asimicin
CAS:<p>Asimicin is a effective complex I inhibitor.</p>Formula:C37H66O7Purity:98%Color and Shape:SolidMolecular weight:622.92DLCI-1
CAS:<p>DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6), significantly reducing self-administered nicotine doses in both male and female mice.</p>Formula:C12H14N2SColor and Shape:SolidMolecular weight:218.322,4-Dihydroxybutanoic acid
CAS:<p>2,4-Dihydroxybutanoic acid is typically not found in extracts of normal human urine and is present only in trace amounts in newborns, while cases of succinic semialdehyde dehydrogenase deficiency consistently exhibit elevated levels of this metabolite.</p>Formula:C4H8O4Color and Shape:SolidMolecular weight:120.104-Hexen-3-one
CAS:<p>4-Hexen-3-one inhibits the growth of H. pylori in the ATCC 43526 strain and TDR strain. Additionally, this compound suppresses urease activity.</p>Formula:C6H10OColor and Shape:SolidMolecular weight:98.14PDHK-IN-5
<p>PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.</p>Formula:C30H31N5O2Color and Shape:SolidMolecular weight:493.6NADH-IN-2
CAS:<p>NADH-IN-2 (compound 8) is a Type II NADH dehydrogenase inhibitor.</p>Formula:C16H16N2Color and Shape:SolidMolecular weight:236.31Complex III-IN-2
<p>Complex III-IN-2 inhibits complex III, with antifungal EC50: 29.31 mg/L vs R. solani, 29.98 mg/L vs S. sclerotiorum.</p>Formula:C15H21ClN2O2SColor and Shape:SolidMolecular weight:328.867-APB hydrochloride
CAS:<p>7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.</p>Formula:C11H14ClNOColor and Shape:SolidMolecular weight:211.688PKR-IN-1
CAS:<p>PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).</p>Formula:C9HCl5N4OS2Color and Shape:SolidMolecular weight:422.525Casein kinase 1δ-IN-19
CAS:<p>Casein kinase1δ-IN-19 (compound 492) is a potent inhibitor of casein kinase 1δ. It is utilized in research related to neurodegenerative disorders, such as Alzheimer's disease.</p>Formula:C21H19N5O3Color and Shape:SolidMolecular weight:389.407ERAP1 modulator-2
CAS:<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Formula:C22H25F3N2O4SColor and Shape:SolidMolecular weight:470.505Dopaminechrome
CAS:<p>Dopaminechrome (DACHR) is an oxidation product of dopamine that promotes the generation of H2O2 at mitochondrial complex I in the brain in a concentration- and respiration-dependent manner. It possesses neurotoxic properties and can be utilized in Parkinson's disease research.</p>Formula:C8H7NO2Color and Shape:SolidMolecular weight:149.147PDE4B-IN-3
<p>PDE4B-IN-3 is a potent inhibitor of PDE4B (IC50: 0.94 μM) and exhibits anti-inflammatory effects.</p>Formula:C30H35N3O4S2Color and Shape:SolidMolecular weight:565.75Cgs 25155
CAS:<p>Cgs 25155 is an orally active inhibitor of NEP 24.11.</p>Formula:C25H34N2O6SPurity:98%Color and Shape:SolidMolecular weight:490.61Dioctanoylphosphatidic acid sodium
CAS:<p>Dioctanoylphosphatidic acid sodium serves as a modulator of phagocyte respiratory bursts, a precursor to diacylglycerol and lyso-phosphatidic acid, and influences the phosphorylation of the mammalian target of rapamycin (mTOR). Additionally, it enhances the viability of gallbladder cancer cells inhibited by histone deacetylase inhibitors (HDACI). This compound is derived from glycerophospholipids through the action of phospholipase D.</p>Formula:C19H36NaO8PColor and Shape:SolidMolecular weight:446.45Mitapivat hydrochloride
CAS:<p>Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.</p>Formula:C24H27ClN4O3SColor and Shape:SolidMolecular weight:487.014CIT-ALD
CAS:<p>CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.</p>Formula:C18H14FNO2Molecular weight:295.31Etamicastat
CAS:<p>Etamicastat can be used in the research of cardiovascular diseases.</p>Formula:C14H15F2N3OSPurity:98%Color and Shape:SolidMolecular weight:311.35Rosiptor acetate
CAS:<p>Rosiptor (AQX-1125) activates SHIP1, inhibits Akt, and reduces inflammation and allergy in rodents.</p>Formula:C22H39NO4Purity:98%Color and Shape:Solid PowderMolecular weight:381.55Z21090
CAS:<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Formula:C12H14ClN3O3Color and Shape:SolidMolecular weight:283.71BLT-4
CAS:<p>BLT-4 is a specific and reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the SR-BI-mediated transfer of lipids between high-density lipoprotein (HDL) and cells.</p>Formula:C18H16N2O2Color and Shape:SolidMolecular weight:292.332ICMT-IN-55
CAS:<p>ICMT-IN-55 (compound 31) acts as an ICMT inhibitor, exhibiting an IC50 value of 90 nM [1].</p>Formula:C22H26F3NO2Color and Shape:SolidMolecular weight:393.44ACLY-IN-1
CAS:<p>ACLY-IN-1 (compound 55) is a potent ACLY inhibitor with an IC50 of 8.3 nM, and it can be utilized in hyperlipidemia research.</p>Formula:C20H12BrClF2N2O4SColor and Shape:SolidMolecular weight:529.74GlcCer (d18:1/18:0)
CAS:<p>GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a sphingolipid with potential applications in research on Parkinson's disease and Lewy body dementia.</p>Formula:C42H81NO8Color and Shape:SolidMolecular weight:728.094BMS-341400 mesylate
CAS:<p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>Formula:C24H26ClN9O5SColor and Shape:SolidMolecular weight:588.039EB-0156
<p>EB-0156: potent ER α-glucosidase inhibitor, IC50 of 0.0479/ <0.001 μM, N-substituted valerian, broad-spectrum antiviral potential.</p>Formula:C21H32N6O7Color and Shape:SolidMolecular weight:480.51L-Afegostat
CAS:<p>L-Afegostat (5-epi-Isofagomine), an iminosugar, inhibits glycosidase and β-Glucosidase (K i 30 μM), aids in carbohydrate synthesis.</p>Formula:C6H13NO3Color and Shape:SolidMolecular weight:147.17(+)-Potassium Ds-threo-isocitrate monobasic
CAS:<p>(+)-Potassium Ds-threo-isocitrate monobasic is a bioactive compound known for its role in enhancing cellular metabolism and regulating energy production. This substance is also utilized in researching metabolic pathways and the regulation of enzyme activities. Widely applied in biochemical research, (+)-Potassium Ds-threo-isocitrate monobasic is studied for its potential functions in cellular processes and disease mechanisms.</p>Formula:C6H7KO7Color and Shape:SolidMolecular weight:230.21Gcase activator 2
CAS:<p>Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.</p>Formula:C21H24N4O2Purity:99.51% - 99.76%Color and Shape:SolidMolecular weight:364.44hCAII-IN-4
CAS:<p>hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.</p>Formula:C31H23NO9Color and Shape:SolidMolecular weight:553.52TAK-915
CAS:<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Formula:C19H18F4N4O5Purity:98%Color and Shape:SolidMolecular weight:458.36BPU17
CAS:<p>BPU17 interacts with PHB1 and disrupts the PHB1-PHB2 interaction, causing slight mitochondrial dysfunction. This damage hinders transcription dependent on SRF/CArG-box, thereby inhibiting epithelial-mesenchymal transition (EMT) in retinal pigment epithelial cells (RPEs). BPU17 has demonstrated anti-fibrotic activity in vivo. It holds potential as a research agent for anti-angiogenic age-related macular degeneration (nAMD).</p>Formula:C12H13ClN2O2Color and Shape:SolidMolecular weight:252.70IDO antagonist-1
CAS:<p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>Formula:C39H53N7O5Color and Shape:SolidMolecular weight:699.88PF-06795071
CAS:<p>PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).</p>Formula:C18H17F4N3O3Purity:98%Color and Shape:SolidMolecular weight:399.34Pyrocatechol sulfate
CAS:<p>Pyrocatechol sulfate, a phenolic metabolite found in human plasma, is associated with the intake of specific foods such as berries and the state of the gut microbiome. It serves as a potential urinary biomarker for kidney function, dialysis clearance rates, whole grain consumption, and regular coffee intake. Additionally, in conjunction with other phenolic sulfates, pyrocatechol sulfate plays a role in regulating various biological functions, including those related to brain health and the rhythmic beating of cardiac cells.</p>Formula:C6H6O5SColor and Shape:SolidMolecular weight:190.17EC33
CAS:<p>EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].</p>Formula:C4H11NO3S2Color and Shape:SolidMolecular weight:185.27Nampt-IN-13
CAS:<p>Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).</p>Formula:C24H30N6O2Color and Shape:SolidMolecular weight:434.53DC371739
CAS:<p>DC371739 is an effective oral PCSK9 inhibitor that decreases both PCSK9 and ANGPTL3 mRNA expression. It also reduces PCSK9 protein expression while enhancing that of LDLR. Given its properties, DC371739 has potential applications in the study of hyperlipidemia.</p>Formula:C29H30N2O4Color and Shape:SolidMolecular weight:470.56FTI-2153 TFA
<p>FTI-2153 TFA inhibits farnesyltransferase with high selectivity (IC50: 1.4 nM), over 3000x more than Rap1A processing.</p>Formula:C27H31F3N4O5SColor and Shape:SolidMolecular weight:580.62Fmoc-NH-PEG6-alcohol
CAS:<p>Fmoc-NH-PEG6-alcohol, a cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].</p>Formula:C27H37NO8Color and Shape:SolidMolecular weight:503.58Perfluorohexane sulfonamide
CAS:<p>Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.</p>Formula:C6H2F13NO2SColor and Shape:SolidMolecular weight:399.133-Benzylidenecamphor
CAS:<p>3-Benzylidenecamphor, a UV absorber, is noted for its excellent photostability and antioxidant activity. It is extensively utilized in sunscreen products to shield the skin from UV damage. Additionally, 3-Benzylidenecamphor is used in cosmetics to enhance product shelf life and safety.</p>Formula:C17H20OColor and Shape:SolidMolecular weight:240.34CK2 inhibitor 3
<p>CK2 inhibitor 3: potent CK2 blocker, IC50 of 280 nM, suppresses tumor cell growth, highly selective among 320 kinases.</p>Formula:C13H9BrN4O3SColor and Shape:SolidMolecular weight:381.29-cis-β-Carotene
CAS:<p>9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal.</p>Formula:C40H56Purity:98%Color and Shape:SolidMolecular weight:536.87LRAT-IN-1
CAS:<p>LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.</p>Formula:C27H47N5O5S2Color and Shape:SolidMolecular weight:585.82Magnesium ionophore III
CAS:<p>Magnesium ionophore III (ETH 4030) is an ion carrier that regulates intracellular magnesium ion concentrations. It enhances cellular functions and metabolic activities by increasing the permeability of cell membranes to magnesium ions. Additionally, Magnesium ionophore III is utilized in research to explore the significance of magnesium ions in biological processes and their impact on cellular physiology.</p>Formula:C30H58N4O4Color and Shape:SolidMolecular weight:538.81OMDM169
CAS:<p>OMDM169: potent/selective MAGL inhibitor, raises 2-AG, analgesic via cannabinoid receptors, IC50: 0.13-0.41μM in rat/COS-7, inactive at CB1/CB2.</p>Formula:C25H45NO5Purity:98%Color and Shape:SolidMolecular weight:439.63Sphingomyelin (d18:1/12:0)
CAS:<p>Sphingomyelin (d18:1/12:0) is a polar lipid known for its role in modulating cell signal transduction. It plays a critical role in cell membranes, influencing their fluidity and stability. Additionally, sphingomyelin (d18:1/12:0) is involved in lipid metabolism and has potential in promoting neuronal cell growth. This compound is essential for the functioning and development of the nervous system.</p>Formula:C35H71N2O6PColor and Shape:SolidMolecular weight:646.9220-HEDE
CAS:<p>20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.</p>Formula:C20H36O3Purity:98%Color and Shape:SolidMolecular weight:324.50Aripiprazole N,N-Dioxide
CAS:<p>AripiprazoleN,N-Dioxide is a metabolite of the atypical antipsychotic drug aripiprazole, formed through its oxidation.</p>Formula:C23H27Cl2N3O4Molecular weight:480.38GGACK
CAS:<p>GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).</p>Formula:C14H25ClN6O5Molecular weight:392.84Carbonic anhydrase inhibitor 19
CAS:<p>Carbonic anhydrase inhibitor19 (compound 26a) targets glaucoma-associated isozymes hCA II and hCA XII, with inhibition constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound is effective in reducing intraocular pressure.</p>Formula:C23H25N3O6S2Molecular weight:503.59Casein kinase 1δ-IN-26
CAS:<p>Casein kinase1δ-IN-26 (compound 505) is a potent inhibitor of casein kinase 1δ. This compound is applicable in research related to neurodegenerative disorders such as Alzheimer’s disease.</p>Formula:C16H13N3O4SColor and Shape:SolidMolecular weight:343.357α-Glucosidase-IN-43
CAS:<p>α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor with an IC50 of 4.32 μM, demonstrating acute blood-glucose-lowering properties. It is safe and effective in vivo, showing no toxicity to normal fibroblasts in mice and can ameliorate diabetes induced by streptozotocin in rats. α-Glucosidase-IN-43 is applicable for research on postprandial hyperglycemia in diabetic patients.</p>Formula:C27H31N3O4Molecular weight:461.55Vimirogant
CAS:<p>Vimirogant is a RORγ inhibitor (Ki: <100 nM).</p>Formula:C27H35F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:552.65α-Amylase/α-Glucosidase-IN-7
CAS:<p>α-Amylase/α-Glucosidase-IN-7 (Compound 3f) serves as a competitive inhibitor for the enzymes α-glucosidase and α-amylase, exhibiting IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, it effectively inhibits AChE and BChE, with IC50 values of 9.25 µM and 10.06 µM, respectively. This compound is useful in research related to diabetes and Alzheimer's [1].</p>Formula:C15H9Cl2FN2OSColor and Shape:SolidMolecular weight:355.21LXRα agonist 1
CAS:<p>LXRα agonist 1 (Compound 40) is a selective activator of LXRα, with an EC50 of 42 nM, and also demonstrates some activation effects on LXRβ, with an EC50 of 266 nM. It promotes target gene transcription by stabilizing the ligand-binding domain (LBD) of LXRα. When combined with the Raf inhibitor Sorafenib, LXRα agonist 1 shows significant antitumor activity in liver cancer cells. This compound is applicable in research focused on lipotoxicity-related cancers.</p>Formula:C28H27N3O2Color and Shape:SolidMolecular weight:437.533DC360
CAS:<p>DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.</p>Formula:C23H23NO2Color and Shape:SolidMolecular weight:345.434CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Formula:C27H27F9N2O4Color and Shape:SolidMolecular weight:614.5Bestatin methyl ester
CAS:<p>Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.</p>Formula:C17H26N2O4Color and Shape:SolidMolecular weight:322.4CGS 24592
CAS:<p>CGS-24592 is an orally active, selective, and potent inhibitor of neutral endopeptidase 24.11 (NEP), with an IC50 value of 1.6 nmol/L. It reduces the degradation of atrial natriuretic peptide (ANP), thereby increasing plasma ANP concentration and lowering blood pressure. CGS-24592 shows potential for research in cardiovascular diseases such as hypertension and congestive heart failure.</p>Formula:C19H23N2O6PColor and Shape:SolidMolecular weight:406.37LTA4H-IN-2
CAS:<p>LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].</p>Formula:C20H19FN6O2Color and Shape:SolidMolecular weight:394.4Glucosylceramide synthase-IN-4
CAS:<p>Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].</p>Formula:C22H18F5N3O3Color and Shape:SolidMolecular weight:467.39α-Glucosidase-IN-63
CAS:<p>α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1]</p>Formula:C16H12FN3O3S2Color and Shape:SolidMolecular weight:377.41ABCB1-IN-4
CAS:<p>ABCB1-IN-4 (Compound C6z) is an orally active inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.63 μM and 0.14 μM, respectively. It holds potential for diabetes research.</p>Formula:C16H14N4SColor and Shape:SolidMolecular weight:294.374FXR/CES2 modulator 1
CAS:<p>Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.</p>Formula:C27H21Cl2NO5Color and Shape:SolidMolecular weight:510.36Ranosidenib
CAS:<p>Ranolisib is an isocitrate dehydrogenase (IDH) inhibitor known for its antitumor activity.</p>Formula:C15H16F9N5OColor and Shape:SolidMolecular weight:453.31Nampt-IN-14
CAS:<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Formula:C33H35N7O2Color and Shape:SolidMolecular weight:561.68Inosine 5′-diphosphate sodium
CAS:<p>Inosine 5'-diphosphate sodium, a purine ribonucleoside diphosphate with inosine as its nucleobase, plays a role in intracellular energy metabolism and signal transduction processes.</p>Formula:C10H13N4Na3O12P2Color and Shape:SolidMolecular weight:512.15Lp-PLA2-IN-6
CAS:<p>Lp-PLA2-IN-6: Potent tetracyclic inhibitor of rhLp-PLA2, with pIC50 of 10.0, and potential in neurodegenerative research.</p>Formula:C25H21F5N4O3Color and Shape:SolidMolecular weight:520.45NSC 828467
<p>NSC 828467 is one of the top five CA-IX inhibitors with significant in vitro anticancer activity (IC50: 27.2 nM).</p>Formula:C21H19N9O2SColor and Shape:SolidMolecular weight:461.52-Amino-5-methyl-5-hexenoic acid
CAS:<p>2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) acts as a methionine analog, competing with methionine and thereby hindering cell growth. This compound inhibits protein synthesis in Salmonella typhimurium TA1535 and Escherichia coli K-12 without affecting the synthesis of DNA or RNA.</p>Formula:C7H13NO2Color and Shape:SolidMolecular weight:143.184Sekikaic Acid
CAS:<p>Sekikaic acid, a phenolic lichen metabolite in H. obscurata, has antioxidant and antiviral properties, inhibiting MLL1-CBP.</p>Formula:C22H26O8Color and Shape:SolidMolecular weight:418.449(S)-HETE
CAS:<p>9(S)-HETE is an enantiomer of (±)9-HETE, not an enzymatic product, and doesn't promote cell adhesion like 12(S)-HETE. Identified by chiral HPLC.</p>Formula:C20H32O3Color and Shape:SolidMolecular weight:320.47Casein Kinase II Inhibitor IV Hydrochloride
CAS:<p>Casein Kinase II Inhibitor IV HCl promotes keratinocyte differentiation, potential for skin disorder therapy.</p>Formula:C24H24ClN5O3Purity:98%Color and Shape:SolidMolecular weight:465.93Turoctocog alfa
CAS:<p>Turoctocog alfa: recombinant FVIII from CHO cells for hemophilia A study.</p>Color and Shape:SolidPD-224378
CAS:<p>PD-224378 is the lactam form of glycamine (β-isomer), produced through a Maillard reaction between pregabalin and lactose.</p>Formula:C20H35NO11Color and Shape:SolidMolecular weight:465.492Casein kinase 1δ-IN-18
CAS:<p>Casein kinase1δ-IN-18 (compound 660) is an inhibitor of casein kinase 1δ (CK1δ), which can be utilized for research in neurodegenerative diseases.</p>Formula:C16H12ClN3O2S2Color and Shape:SolidMolecular weight:377.868RORγt inverse agonist 34
CAS:<p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>Formula:C31H37N3O3SColor and Shape:SolidMolecular weight:531.709Clopidogrel-β-D-glucuronide
CAS:<p>Clopidogrel-β-D-glucuronide is a metabolite of Clopidogrel. It directly interacts with the CYP2C8 enzyme and strongly inhibits the hepatic enzyme CYP2C8.</p>Formula:C21H22ClNO8SColor and Shape:SolidMolecular weight:483.919Myxothiazol
CAS:<p>Myxothiazol blocks mitochondrial complex III and triggers SESN2, a gene important for stress response.</p>Formula:C25H33N3O3S2Color and Shape:SolidMolecular weight:487.68hCAVII/IX-IN-1
CAS:<p>hCAVII/IX-IN-1 (compound 4) functions as an inhibitor of hCAVII/IX, exhibiting Ki values of 56.5 nM and 38.2 nM, respectively. It is applicable in the field of cancer research.</p>Formula:C7H7N3O2S2Color and Shape:SolidMolecular weight:229.279
