Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(196 products)
- Casein Kinase(139 products)
- DHFR(30 products)
- Decarboxylase(4 products)
- Dehydrogenase(302 products)
- FAAH(64 products)
- FXR(62 products)
- Factor Xa(87 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(227 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(56 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(34 products)
- Hydroxylase(36 products)
- IDO(84 products)
- LDL(7 products)
- Lipase(107 products)
- Lipid(62 products)
- Lipoxygenase(133 products)
- MAO(85 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(170 products)
- PED(1 products)
- PKM(17 products)
- PPAR(170 products)
- Phospholipase(85 products)
- ROR(47 products)
- Retinoid Receptor(18 products)
- SGK(10 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(43 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9195 products of "Metabolism"
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m-APTA
CAS:m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP). It can be converted into adenine, which is a crucial step in shielding normal cells from the toxicity of nucleobase analogs (NBA). m-APTA holds potential for research in MTAP-deficient cancers.Formula:C16H18N6O3SColor and Shape:SolidMolecular weight:374.418Tabimorelin hemifumarate
CAS:orally active ghrelin receptor (GHS-R1a) agonistFormula:C32H40N403C4H404Purity:98%Color and Shape:SolidMolecular weight:586.72CGS 24592
CAS:CGS-24592 is an orally active, selective, and potent inhibitor of neutral endopeptidase 24.11 (NEP), with an IC50 value of 1.6 nmol/L. It reduces the degradation of atrial natriuretic peptide (ANP), thereby increasing plasma ANP concentration and lowering blood pressure. CGS-24592 shows potential for research in cardiovascular diseases such as hypertension and congestive heart failure.Formula:C19H23N2O6PColor and Shape:SolidMolecular weight:406.37Epoxykynin
CAS:Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].Formula:C19H20BrF3N2O2Color and Shape:SolidMolecular weight:445.27Enpp-1-IN-12
ENPP1-IN-12 is a potent, oral ENPP1 inhibitor with a Ki of 41 nM and anti-tumor properties.Formula:C17H19N5O3SColor and Shape:SolidMolecular weight:373.43(E)-10-Hydroxynortriptyline maleate
CAS:(E)-10-Hydroxy Nortriptyline maleate, a derivative of antidepressant Nortriptyline, eases depression symptoms.Formula:C23H25NO5Purity:98%Color and Shape:SolidMolecular weight:395.455EB-0176
EB-0176: A valerian derivative; broad-spectrum antiviral; potent ER α-glucosidase I/II inhibitor; IC50s: 0.6439/0.0011 μM.Formula:C23H33N5O7Color and Shape:SolidMolecular weight:491.54FABP1-IN-1
CAS:FABP1-IN-1 (44) is a selective FABP1 inhibitor with an IC50 value of 4.46 μM. It is applicable in research related to alcoholic fatty liver disease.Formula:C30H25NO5Molecular weight:479.5211-trans Leukotriene E4
CAS:Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.Formula:C23H37NO5SColor and Shape:SolidMolecular weight:439.61IMR687
CAS:IMR687: a PDE9 inhibitor that could improve memory in Alzheimer's by slowing cGMP hydrolysis.Formula:C21H26N6O2Purity:98%Color and Shape:SolidMolecular weight:394.47HSD17B13-IN-30
CAS:HSD17B13-IN-30 (compound 64) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), exhibiting an IC 50 value of less than 0.1 μM? with estradiol? as substrates. This compound is significantly implicated in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formula:C24H16Cl2F3N3O4Color and Shape:SolidMolecular weight:538.3AXKO-0046
AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.Formula:C25H33N3Color and Shape:SolidMolecular weight:375.55RXR antagonist 2
RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.Formula:C29H35F3N2O3Color and Shape:SolidMolecular weight:516.6DEL-I25
CAS:DEL-I25 is an effective activator of GPX4 that protects cells from ferroptosis (iron-dependent cell death).Formula:C21H23N5O3Color and Shape:SolidMolecular weight:393.44Lp(a)-IN-5
CAS:Lp(a)-IN-5 (Compound A) is an orally active inhibitor of lipoprotein (a) [Lp(a)]. It effectively inhibits the assembly of Apo(a) and ApoB proteins, with an IC50 value of 0.41 nM. Lp(a)-IN-5 shows potential for research into diseases associated with elevated plasma Lp(a) levels, such as cardiovascular diseases.Formula:C43H56N4O7Color and Shape:SolidMolecular weight:740.927(S)-Dexfadrostat
CAS:(S)-Dexfadrostat ((S)-Fadrozole), an aromatase inhibitor, exhibits an IC 50 of 4.6 nM in in vitro assays using human placental microsomes. It is applicable for research on estrogen-dependent breast cancer, gynecomastia, and systemic lupus erythematosus.Formula:C14H13N3Color and Shape:SolidMolecular weight:223.27ACLY-IN-1
CAS:ACLY-IN-1 (compound 55) is a potent ACLY inhibitor with an IC50 of 8.3 nM, and it can be utilized in hyperlipidemia research.Formula:C20H12BrClF2N2O4SColor and Shape:SolidMolecular weight:529.74IDX375
CAS:IDX375 is a non-nucleoside inhibitor that selectively targets the HCV NS5B enzyme. It shows promising selectivity for genotypes 1a and 1b. The structure and binding sites of IDX375 have been confirmed through X-ray co-crystallization studies.Formula:C24H37N4O6PSColor and Shape:SolidMolecular weight:540.61IDH1 Inhibitor 1
CAS:Oral, brain-penetrant mutant IDH1 inhibitor targeting R132H/C with IC50: 0.021/0.045μM; 2.52μM for IDH1WT.Formula:C20H18F4N6O2Purity:98%Color and Shape:SolidMolecular weight:450.39RORγt modulator 5
CAS:RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.Formula:C27H22F5N3O6SColor and Shape:SolidMolecular weight:611.54Desmonomethylpromazine
CAS:Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.Formula:C16H18N2SColor and Shape:SolidMolecular weight:270.39PTP1B-IN-19
PTP1B-IN-19, a benzimidazole, selectively inhibits protein tyrosine phosphatase 1B with a Ki of 23.3 μM, potential for type 2 diabetes research.Formula:C26H19N3O4SColor and Shape:SolidMolecular weight:469.51Keto lovastatin
CAS:Keto lovastatin is an impurity of lovastatin with antibacterial properties. Lovastatin is a cell-permeable HMG-CoA reductase (HMG-CoA reductase) inhibitor used to reduce cholesterol levels.Formula:C24H34O6Color and Shape:SolidMolecular weight:418.523PSI-7410
CAS:PSI-7410 is a metabolite of PSI-7851. PSI-7851 acts as an inhibitor of the HCV non-structural protein 5B (NS5B) and exhibits antiviral properties.Formula:C10H15FN2O11P2Color and Shape:SolidMolecular weight:420.179GKA50 quarterhydrate
GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.Formula:C26H30N2O7Color and Shape:SolidMolecular weight:469.01ALOX15-IN-1
ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.Formula:C24H31N3O5SColor and Shape:SolidMolecular weight:473.59PNPLA3 modifier 1
CAS:PNPLA3 Modifier 1 (Compound 10), a modifier of patatin-like phospholipase domain-containing protein 3 (pnpla3), exhibits a geometric mean EC50 of 4.9 nM.Formula:C16H19ClF2N2O4SColor and Shape:SolidMolecular weight:408.85Carbonic anhydrase inhibitor 19
CAS:Carbonic anhydrase inhibitor19 (compound 26a) targets glaucoma-associated isozymes hCA II and hCA XII, with inhibition constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound is effective in reducing intraocular pressure.Formula:C23H25N3O6S2Molecular weight:503.59Casein kinase 1δ-IN-18
CAS:Casein kinase1δ-IN-18 (compound 660) is an inhibitor of casein kinase 1δ (CK1δ), which can be utilized for research in neurodegenerative diseases.Formula:C16H12ClN3O2S2Color and Shape:SolidMolecular weight:377.868α-Glucosidase-IN-19
Alpha-Glucosidase-IN-19 (Compound 6B) is an orally active alpha-glucosidase inhibitor (IC50: 3.63 μM) with antidiabetic effects.Formula:C31H25NOSColor and Shape:SolidMolecular weight:459.6ZK168281
CAS:ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.Formula:C32H46O5Purity:98%Color and Shape:SolidMolecular weight:510.70Clopidogrel-β-D-glucuronide
CAS:Clopidogrel-β-D-glucuronide is a metabolite of Clopidogrel. It directly interacts with the CYP2C8 enzyme and strongly inhibits the hepatic enzyme CYP2C8.Formula:C21H22ClNO8SColor and Shape:SolidMolecular weight:483.919ASB14780
ASB14780 is a 4-phenoxy derivative and an inhibitor of cytoplasmic phospholipase cPLA2α (IC50: 20 nM).Color and Shape:SolidLipid 12T-O14
CAS:Lipid 12T-O14 is a lipid nanoparticle that facilitates the delivery of local mRNA vaccines and systemic mRNA agents.Formula:C37H66N2O2SColor and Shape:SolidMolecular weight:603.00Osunprotafib hydrochloride
CAS:Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active, selective inhibitor targeting the active sites of PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM). It shows 6-8 times weaker activity towards PTPN9 and no detectable activity against SHP-1 or SHP-2. This compound enhances the sensitivity of human cancer cell lines to IFNγ. By boosting JAK-STAT signaling and reducing T cell dysfunction, Osunprotafib hydrochloride exhibits potent antitumor immunity.Formula:C17H25ClFN3O4SColor and Shape:SolidMolecular weight:421.92IDO1-IN-13
IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.Formula:C20H16BrN5O2SColor and Shape:SolidMolecular weight:470.34CYP11B1-IN-2
CYP11B1-IN-2 selectively inhibits human and rat CYP11B1 (IC50: 9/25 nM) orally to research cortisol-related diseases.Color and Shape:SolidZK159222
CAS:ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.Formula:C32H48O5Purity:98%Color and Shape:SolidMolecular weight:512.72CAII-IN-1
CAII-IN-1 (3n) is a selective bovine CA-II inhibitor with 10.3 μM IC50, used in carbonic anhydrase disorder studies.Formula:C19H21FN4SColor and Shape:SolidMolecular weight:356.46Fusarisetin A
CAS:Fusarisetin A, a pentacyclic fungal metabolite, is an acinar morphogenesis inhibitor .Formula:C22H31NO5Color and Shape:SolidMolecular weight:389.49(Rac)-OSMI-1
(Rac)-OSMI-1, a racemate, inhibits OGT (IC50: 2.7 μM) affecting O-GlcNAcylation without changing surface glycans.Formula:C28H25N3O6S2Color and Shape:SolidMolecular weight:563.64Etoricoxib N1'-oxide
CAS:EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.Formula:C18H15ClN2O3SColor and Shape:SolidMolecular weight:374.841Implitapide
CAS:Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).Formula:C35H37N3O2Purity:98%Color and Shape:SolidMolecular weight:531.69Tacrolimus anhydrous 8-epimer
CAS:Tacrolimus anhydrous 8-epimer, an immunosuppressive l-pipecolic acid macrolide, blocks T cell growth by hindering IL-2.Formula:C44H69NO12Color and Shape:SolidMolecular weight:804.02FAAH/MAGL-IN-3
FAAH/MAGL-IN-3 irreversibly inhibits FAAH (IC50: 179 nM) & MAGL (IC50: 759 nM) with low PAMPA permeability.Formula:C21H25N3O6SColor and Shape:SolidMolecular weight:447.5FXR/HSD17B13 modulator 1
CAS:FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).Formula:C26H19Cl2NO4Color and Shape:SolidMolecular weight:480.339GK420
CAS:GK420 (AVX420) is a potent inhibitor of cytoplasmic phospholipase A2α (cPLA2α), with an XI(50) value of 0.0016. It effectively inhibits the release of arachidonic acid, with an EC50 of 0.09 μM. GK420 plays a significant role in cancer research.Formula:C20H25NO5SColor and Shape:SolidMolecular weight:391.481AD011
AD011, a cACE/NEP inhibitor derived from lenopril-tryptophan, may offer strong anti-hypertensive, cardioprotective benefits.Formula:C27H33N3O5Color and Shape:SolidMolecular weight:479.57LRAT-IN-1
CAS:LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.Formula:C27H47N5O5S2Color and Shape:SolidMolecular weight:585.82hDHODH-IN-10
hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.Formula:C21H15ClF4N2O4Color and Shape:SolidMolecular weight:470.8OSI-413 free base
CAS:OSI-413 (free base) (CP 373413) is the primary metabolite of Erlotinib. Erlotinib (CP-358774) acts as a direct EGFR tyrosine kinase inhibitor with an IC50 of 2 nM against human EGFR.Formula:C21H21N3O4Color and Shape:SolidMolecular weight:379.409Hcyb1
Hcyb1 specifically inhibits PDE2A with 0.57 μM IC50, over 250x selective, and has neuroprotective and antidepressant effects.Formula:C24H20N4OColor and Shape:SolidMolecular weight:380.44Lp-PLA2-IN-5
CAS:Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.Formula:C23H18F5N3O4Color and Shape:SolidMolecular weight:495.4Magnesium ionophore III
CAS:Magnesium ionophore III (ETH 4030) is an ion carrier that regulates intracellular magnesium ion concentrations. It enhances cellular functions and metabolic activities by increasing the permeability of cell membranes to magnesium ions. Additionally, Magnesium ionophore III is utilized in research to explore the significance of magnesium ions in biological processes and their impact on cellular physiology.Formula:C30H58N4O4Color and Shape:SolidMolecular weight:538.81CK2-IN-3
CK2-IN-3: potent, selective CK2 inhibitor; Kd=12 nM, IC50: 1.51 μM (CK2α), 7.64 μM (CK2α'). For cancer research.Formula:C22H26N4O7Color and Shape:SolidMolecular weight:458.46Mutant IDH1-IN-3
CAS:Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor targeting the mutant isocitrate dehydrogenase 1 (IDH1), with an IC50 of 13 nM for R132HIDH1. It effectively suppresses the production of D-2-hydroxyglutarate (2HG) in cells and is applicable for research in oncology.Formula:C22H30N4OColor and Shape:SolidMolecular weight:366.5MolPort-010-778-422
CAS:MolPort-010-778-422 is a high-affinity inhibitor targeting the ACE2 receptor of the SARS-CoV-2 virus. It demonstrates remarkable antiviral activity with an IC50 of 8.9 nM and holds promise for use in studies related to SARS-CoV-2.Formula:C20H26N2O3S2Color and Shape:SolidMolecular weight:406.56PKR-IN-1
CAS:PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).Formula:C9HCl5N4OS2Color and Shape:SolidMolecular weight:422.5253,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol]
CAS:The compound 3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] is an SS-cleavable, proton-activated lipid-like substance (SSPalm) that facilitates the delivery of plasmid DNA.Formula:C12H28N2O2S2Color and Shape:SolidMolecular weight:296.493Lipid HTO12
CAS:Lipid HTO12 is an ionizable lipid used for forming lipid nanoparticles (LNP). It facilitates the delivery of siRNA and mRNA.Formula:C41H83NO4Color and Shape:SolidMolecular weight:654.102COTC
CAS:COTC is an anticancer bacterial metabolite; inhibits glyoxalase with GSH, halts HeLa cell growth, and fights tumor in Ehrlich murine model.Formula:C11H14O6Color and Shape:SolidMolecular weight:242.23Lipid 11
CAS:Lipid 11 (Compound Lipid 1) is a cationic lipid designed for nucleic acid delivery. It forms lipid nanoparticles (LNPs) through electrostatic interactions with nucleic acids, such as ceDNA. By using its cationic amine groups, Lipid 11 complexes with negatively charged nucleic acids, enabling cellular uptake and release of the nucleic acid cargo. Lipid 11 shows potential for use in the development of gene therapy drug delivery systems.Formula:C43H85NO4Color and Shape:SolidMolecular weight:680.14CK1δ-IN-10
CAS:CK1δ-IN-10 (Compound 85) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ (CSNKID), with an IC50 value of 0.255 μM.Formula:C17H11F4N5Color and Shape:SolidMolecular weight:361.296PF-06795071
CAS:PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).Formula:C18H17F4N3O3Purity:98%Color and Shape:SolidMolecular weight:399.34BRD2879
CAS:BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM).Formula:C30H38FN3O5SPurity:98%Color and Shape:SolidMolecular weight:571.70Casein kinase 1δ-IN-30
CAS:Casein kinase1δ-IN-30 (Compound 581) is an inhibitor of casein kinase 1δ (CK1δ). It can be utilized in research related to neurodegenerative diseases.Formula:C18H15BrN6O2SColor and Shape:SolidMolecular weight:459.32hCAI/II/XII-IN-1
CAS:hCAI/II/XII-IN-1 (compound 7) is an inhibitor of human carbonic anhydrases hCAI, hCAII, and hCAXII, with Ki values of 78.5 nM, 9.1 nM, 605 nM, 7.7 nM, and 3.7 nM.Formula:C12H12N2O2SColor and Shape:SolidMolecular weight:248.301RO5101576
CAS:RO5101576 is a potent antagonist of LTB4 receptor.Formula:C36H38O8SPurity:98%Color and Shape:SolidMolecular weight:630.75AD015
CAS:AD015 is a dual inhibitor of angiotensin-converting enzyme (ACE) and neprilysin (NEP), effectively inhibiting NEP, nACE, and cACE with IC50 values of 0.009, 0.019, and 0.0008 μM, respectively.Formula:C23H26N2O4SColor and Shape:SolidMolecular weight:426.53Carbonic anhydrase inhibitor 9
Carbonic anhydrase inhibitor 9 targets hCA II and IX with Ki of 56.4 and 56.9 nM respectively; shows antiproliferative activity.Formula:C22H20BrN5O4SColor and Shape:SolidMolecular weight:530.39PF-07202954
CAS:PF-07202954 is a DGAT2 inhibitor with a long half-life. reduce the triglyceride content in the liver of rats fed with a Western diet, NASH.Formula:C22H23FN6O3Purity:98.99%Color and Shape:SolidMolecular weight:438.452R,4R-Sacubitril
CAS:2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.Formula:C24H29NO5Purity:98%Color and Shape:SolidMolecular weight:411.49TQ05310
CAS:TQ05310 is an orally active inhibitor of mutant IDH2, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutations. This compound suppresses the production of 2-hydroxyglutarate (2-HG) by inhibiting the enzymatic activity of mutant IDH2, and induces differentiation in cells expressing IDH2-R140Q and IDH2-R172K. TQ05310 is utilized in research on acute myeloid leukemia.Formula:C19H17F6N7OColor and Shape:SolidMolecular weight:473.38GSK2945 hydrochloride
GSK2945 HCl is a specific Rev-erbα antagonist, EC50: 21.5 μM (mouse), 20.8 μM (human), increases cholesterol 7α-hydroxylase.Formula:C20H19Cl3N2O2SColor and Shape:SolidMolecular weight:457.8APOL1-IN-3
CAS:APOL1-IN-3 is an APOL1 inhibitor used for kidney disease research.Formula:C16H19F3N4O2SColor and Shape:SolidMolecular weight:388.41BT-114143
CAS:BT-114143 is a plasminogen activator inhibitor with an IC50 of 8.42 μM. It is applicable in research related to hemorrhagic diseases caused by excessive fibrinolysis, including traumatic bleeding, severe menorrhagia, postpartum hemorrhage, and complications of hemophilia.Formula:C8H11N2O3PColor and Shape:SolidMolecular weight:214.15820-HEDE
CAS:20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.Formula:C20H36O3Purity:98%Color and Shape:SolidMolecular weight:324.503β,7β-Dihydroxy-5-cholestenoic acid
CAS:3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid whose levels are elevated in Niemann-Pick Type C and B diseases, leading to toxicity in ocular motor neurons. It is synthesized by the enzymatic action of hydroxysteroid 11-β dehydrogenase 1 from 3β-hydroxy-7-oxocholest-5-en-(25R)26-enoic acid (3βH,7O-CA).Formula:C27H44O4Color and Shape:SolidMolecular weight:432.64CK1δ-IN-3
CAS:CK1δ-IN-3 (compound 376) is a CK1δ (casein kinase 1δ) inhibitor that can be used to study neurodegenerative diseases such as Alzheimer's disease.Formula:C24H19N3O2SPurity:99.27%Color and Shape:SolidMolecular weight:413.49BAY R3401
CAS:BAY R3401 is an orally active inhibitor of glycogen phosphorylase, leading to irreversible and non-selective inhibition of liver glycogenolysis. It suppresses glycogen breakdown in hepatocytes with IC50 values of 27.06 μM in HL-7702 cells and 52.83 μM in HepG2 cells. BAY R3401 is applicable for research in type 2 diabetes.Formula:C20H22ClNO4Color and Shape:SolidMolecular weight:375.84611-Mercaptoundecanoate-NHS
CAS:11-Mercaptoundecanoate-NHS is a lipid utilized in the synthesis of Linkers.Formula:C15H25NO4SColor and Shape:SolidMolecular weight:315.428Nonsteroidal aromatase inhibitor 1
Compound 13h, a nonsteroidal aromatase inhibitor, has a potent IC50 of 0.09 nM against CYP19A1, showing promise for breast cancer research.Formula:C22H16N4O2Color and Shape:SolidMolecular weight:368.393-Benzylidenecamphor
CAS:3-Benzylidenecamphor, a UV absorber, is noted for its excellent photostability and antioxidant activity. It is extensively utilized in sunscreen products to shield the skin from UV damage. Additionally, 3-Benzylidenecamphor is used in cosmetics to enhance product shelf life and safety.Formula:C17H20OColor and Shape:SolidMolecular weight:240.34BPU17
CAS:BPU17 interacts with PHB1 and disrupts the PHB1-PHB2 interaction, causing slight mitochondrial dysfunction. This damage hinders transcription dependent on SRF/CArG-box, thereby inhibiting epithelial-mesenchymal transition (EMT) in retinal pigment epithelial cells (RPEs). BPU17 has demonstrated anti-fibrotic activity in vivo. It holds potential as a research agent for anti-angiogenic age-related macular degeneration (nAMD).Formula:C12H13ClN2O2Color and Shape:SolidMolecular weight:252.70L-Sepiapterin
CAS:L-Sepiapterin aids in making BH4, a coenzyme essential for eNOS, enhancing artery function and angiogenesis, while suppressing ovarian cancer cell growth.Formula:C9H11N5O3Color and Shape:SolidMolecular weight:237.22LDHA-IN-5
CAS:LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primaryFormula:C27H22FN7O6S3Color and Shape:SolidMolecular weight:655.7CB30865
CAS:CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Formula:C26H22BrN5O2Purity:99.04%Color and Shape:SolidMolecular weight:516.39PTP1B-IN-3 diammonium
PTP1B-IN-3 diammonium, an oral enzyme inhibitor, has potent antidiabetic and anticancer effects, with a 120 nM IC50.Formula:C12H13BrF2N3O3PColor and Shape:SolidMolecular weight:396.12SAR114137
CAS:SAR114137 is a highly effective pharmaceutical compound characterized by potent bioactivity. It exhibits variations in its amorphous content during the physical processing of crystalline active pharmaceutical ingredients (APIs). The amorphous API content of SAR114137 significantly decreases when subjected to various jet milling techniques. Additionally, SAR114137 demonstrates good chemical stability in drug formulations.Formula:C17H24F2N4O2Color and Shape:SolidMolecular weight:354.39Ro 23-9358
CAS:Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.Formula:C30H51NO6Color and Shape:SolidMolecular weight:521.729α-Amylase/α-Glucosidase-IN-19
CAS:α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase and α-glucosidase, with an IC50 of 170.7 μM and 60.37 μM, respectively.Formula:C17H14BrClN2OColor and Shape:SolidMolecular weight:377.663EpoY
CAS:EpoY (SD-142) is an irreversible inhibitor of the primary brain microtubule-associated tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and small vasohibin-binding protein (SVBP). By inhibiting TCP with an IC50 value of approximately 500 nM, EpoY effectively reduces the levels of detyrosinated α-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition results in significant differentiation defects and is linked to potential issues related to cancer and cardiomyopathy.Formula:C15H17NO7Color and Shape:SolidMolecular weight:323.304-Acetylphenylboronic acid
CAS:4-Acetylphenylboronic acid acts as an effective inhibitor targeting carbonic anhydrase II (CAII), displaying inhibitory concentrations (IC50) of 246 μM for bovine CAII (bCA II) and 281.40 μM for human CAII (hCA II).Formula:C8H9BO3Color and Shape:SolidMolecular weight:163.97BAR-2227
CAS:BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.Formula:C24H17Cl2NO4Color and Shape:SolidMolecular weight:454.30MRS4458
CAS:MRS4458 is an effective inhibitor of the P2Y14 Receptor.Formula:C24H20F3N5O3SPurity:98%Color and Shape:SolidMolecular weight:515.51Glucosylceramide synthase-IN-3
Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.Formula:C21H20FN3O3Color and Shape:SolidMolecular weight:381.4OMDM169
CAS:OMDM169: potent/selective MAGL inhibitor, raises 2-AG, analgesic via cannabinoid receptors, IC50: 0.13-0.41μM in rat/COS-7, inactive at CB1/CB2.Formula:C25H45NO5Purity:98%Color and Shape:SolidMolecular weight:439.63DDO-3733
CAS:DDO-3733 is a conformational activator of Protein Phosphatase 5 (PP5) that functions independently of TRP, facilitating the dephosphorylation of downstream substrates.Formula:C10H6F2N2OSColor and Shape:SolidMolecular weight:240.23Oxythiamine diphosphate ammonium
Oxythiamin diphosphate ammonium is a potent inhibitor of transketolase (TK).Color and Shape:Solid7-Hydroxy-4-phenylcoumarin
CAS:7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.Formula:C15H10O3Color and Shape:SolidMolecular weight:238.238
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