Metabolism

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse MyoD. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse MyoD. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse MyoD, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse MyoD in the samples is then determined by comparing the OD of the samples to the standard curve.

NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.

Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.

LY 195448 (4-(3-(2-Hydroxy-2-phenyl)ethylamino-3-methylbutyl)benzamide) shows antitumor activity in a mouse tumor model, blocking cells in the mid-stage.

Chlormethiazole hydrochloride is an anticonvulsant and sedative. It also has neuroprotective.

Cefadroxil (BL-S 578) is a Cephalosporin Antibacterial. The chemical classification of cefadroxil anhydrous is Cephalosporins.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Pig CD163. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Pig CD163. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Pig CD163, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Pig CD163 in the samples is then determined by comparing the OD of the samples to the standard curve.

Opevesostat (ODM-208) is an inhibitor of lyase (CYP11A1) (the enzyme cleavage cholesterol side chain).

JW 642 inhibits MAGL in mouse, rat, human brains (IC50: 7.6, 14, 3.7 nM).

Denagliptin is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor for the treatment of endocrine Ü metabolic diseases and can be used in the study of

ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].

Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.

trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).

3-Methylindolin-2-one (3-Methyloxindole) is a reactant for O-acetylation reactions, enantioselective α-amination reactions and for aldol reactions.

N-(1-Adamantyl)acetamide is used as intermediates for synthesis of amantadine hydrochloride.

Miglustat (NB-DNJ), derived from deoxynojirimycin, inhibits glucosylceramide synthase to manage Gaucher disease Type I.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Simian APOC3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Simian APOC3. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Simian APOC3, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Simian APOC3 in the samples is then determined by comparing the OD of the samples to the standard curve.

SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.