Metabolism

<p>(1S)-Calcitriol, a natural 1α,25(OH)2D3 metabolite, regulates VDR actions like keratinocyte growth inhibition.</p>

<p>(+)-Menthofuran is a useful organic compound for research related to life sciences and the catalog number is T125544.</p>

<p>Carbonic anhydrase inhibitor31 is an mtCA2 inhibitor (Ki: 5.2 nM) that can be used in antituberculosis research.</p>

<p>D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP), belonging to the CAZy glycoside hydrolase family GH112, plays a pivotal role in</p>

<p>Desoxycarbadox, derived from Carbadox, is a quinoxaline-di-N-oxide antibiotic compound.</p>

<p>IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.</p>

<p>MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>

<p>Prunetin 5-O-β-D-glucopyranoside, an isoflavone obtained from Potentilla astracanica extracts, is a potent uncompetitive inhibitor of α-glucosidase (IC 50 = 56.</p>

<p>Promothiocin A is an antibiotic.</p>

<p>D-Ribofuranose 1-phosphate is used to synthesize 5-fluorouracil via uridine phosphorylase.</p>

<p>BPP is a fluorescent microviscosity probe used to image natural HOBr in living cells and zebrafish.</p>

<p>Impurity C of Calcitriol is an impurity of Calcitriol.Impurity C of Calcitriol is used in the synthesis of vitamin D3.</p>

<p>Chaetosemin J, antifungal, inhibits Botrytis, Alternaria, Magnaporthe, Gibberella; MIC 12.5-25 μM.</p>

<p>Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .</p>

<p>Malonyl CoA: needed for fat creation, stops fat breakdown, reversibly inhibits CPT1 in mitochondria.</p>

<p>α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aided</p>

<p>ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.</p>

<p>5-Formylcytosine (5FC) is a rare mammalian DNA base aiding in demethylation, altering helix structure, and affecting RNA polymerase II activity.</p>

<p>Cyclosporin A-Derivative 3 is a derivative of Cyclosporin A with calcineurin inhibition [1] .</p>

<p>DSPE-PEG1000-R8 is a PEG compound composed of DSPE and the cell-penetrating peptide (R8). It is applicable for drug delivery.</p>