Metabolism

<p>NAD Synthetase is responsible for the final step in the synthesis of Nicotinamide Adenine Dinucleotide (NAD). The enzyme sourced from Escherichia coli exhibits Km values of 200 μM for NAD, 11 μM for ATP, and 0.65 μM for ammonia. Conversely, NAD Synthetase derived from yeast demonstrates Km values of 170 μM for NAD, 190 μM for ATP, and 64 μM for ammonia. This enzyme is applicable in enzymatic assays for ATP, ammonia, urea, or creatinine and can also be used in enzymatic recycling methods. Additionally, NAD Synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative disorders.</p>

<p>Alterporriol B is a biochemical.</p>

<p>ATP dipotassium is key for energy storage, metabolism, cellular processes, and as a signaling molecule for immunity and inflammation.</p>

<p>2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.</p>

<p>hCYP3A4-IN-1 (compound C6) is a potent, orally active inhibitor of hCYP3A4, exhibiting IC50 values of 43.93 nM in human liver microsomes (HLMs) and 153.00 nM in</p>

<p>D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP), belonging to the CAZy glycoside hydrolase family GH112, plays a pivotal role in</p>

<p>Sorbifolin is a flavone glucoside from Pterogyne nitens with myeloperoxidase inhibition (IC50: 19.2 nM) and radical scavenging effects.</p>

<p>AH078 (compound 37) is a selective PROTAC degrader targeting CK1δ and CK1ε with low selectivity for CK1α. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1δ/CK1ε ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.</p>

<p>24, 25-Dihydroxy VD3 is closely related to 1,25-dihydroxy vitamin D3, the active form of vitamin D3.</p>

<p>PR280 is a potent inhibitor of dihydroceramide desaturase 1 (Des1) with an IC50 of 700 nM. It forms hydrogen bonds with amino acid residues of Des1, while its cyclopropenone group may coordinate with the iron center, stabilizing its binding at Des1's active site. This inhibits the ceramide biosynthesis pathway, preventing dihydroceramide (dhCer) from converting into ceramide. PR280 can be used in research related to sphingolipid metabolism disorders, including cancer and metabolic diseases.</p>

<p>Folcysteine, a cysteine derivative, may fight tumors, aids in DNA synthesis, repair, methylation, and acts as a folate cofactor.</p>

<p>DSPE-PEG1000-TAT is a PEG compound composed of DSPE and the cell-penetrating peptide (TAT) peptide. It can be utilized for drug delivery.</p>

<p>Tpp-CAQK, a specially engineered mitochondrial compound, has been shown to improve phagocytosis of myelin debris by macrophages, reduce mitochondrial dysfunction and pro-inflammatory features, and enhance tissue repair and functional recovery in mice after spinal cord injury.</p>

<p>LY 295427 is a bioactive chemical.</p>

<p>IONIS PTP1BRx (ISIS 404173) sodium, an antisense inhibitor of protein tyrene phosphatase 1B (PTP-1B), exhibits antidiabetic properties. This compound is utilzed in researching insulin resistance and type 2 diabetes mellitus associated with obesity.</p>

<p>Zaragozic acid D(2) inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.</p>

<p>Maurocalcine TFA acts as an agonist for ryanodine receptor (RyR) channels 1, 2, and 3, demonstrating cell-penetrating capabilities. It induces binding of [3H]ryanodine to RyR1 with an EC50 of 2558 nM and exhibits an apparent affinity of 14 nM for RyR2. This compound is applicable for in vivo cell tracking or other cellular imaging techniques.</p>

<p>DSPE-PEG2000-KAA is a PEG compound composed of DSPE and the CKAAKNK (KAA) peptide. The CKAAKNK peptide specifically binds to the tumor vasculature of RIP-Tag2 transgenic mice. DSPE-PEG2000-KAA can be used for drug delivery.</p>

<p>Epoxide hydrolase, an enzyme responsible for catalyzing the reaction of epoxides with water to convert epoxy groups into diols, plays a crucial role in the metabolism of environmental pollutants and lipids. It is instrumental in detoxification, inflammatory responses, and regulating the health of the cardiovascular system. Additionally, Epoxide hydrolase is used in asymmetric catalytic reactions, such as the asymmetric ring-opening of epoxides, which are important for the synthesis of chiral pharmaceutical molecules.</p>

<p>Calcitetrol is the hormonally active form of vitamin D with three hydroxyl groups.</p>