Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(41 products)
- Aminopeptidase(67 products)
- CETP(18 products)
- Carbonic Anhydrase(177 products)
- Casein Kinase(130 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(267 products)
- FAAH(63 products)
- FXR(58 products)
- Factor Xa(80 products)
- Fatty Acid Synthase(32 products)
- Ferroptosis(215 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(53 products)
- HIF/HIF Prolyl-Hydroxylase(142 products)
- HMG-CoA Reductase(32 products)
- Hydroxylase(30 products)
- IDO(82 products)
- LDL(8 products)
- Lipase(96 products)
- Lipid(59 products)
- Lipoxygenase(124 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(36 products)
- P450(6 products)
- PAI-1(25 products)
- PDE(165 products)
- PED(1 products)
- PKM(15 products)
- PPAR(164 products)
- Phospholipase(82 products)
- ROR(42 products)
- Retinoid Receptor(29 products)
- SGK(11 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(42 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 8597 products of "Metabolism"
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Nonsteroidal aromatase inhibitor 1
<p>Compound 13h, a nonsteroidal aromatase inhibitor, has a potent IC50 of 0.09 nM against CYP19A1, showing promise for breast cancer research.</p>Formula:C22H16N4O2Color and Shape:SolidMolecular weight:368.39AD015
CAS:<p>AD015 is a dual inhibitor of angiotensin-converting enzyme (ACE) and neprilysin (NEP), effectively inhibiting NEP, nACE, and cACE with IC50 values of 0.009, 0.019, and 0.0008 μM, respectively.</p>Formula:C23H26N2O4SColor and Shape:SolidMolecular weight:426.53DH376
CAS:<p>DH376 inhibits DAGLα in a time and dose dependent manner in mouse brain. DH376 shows picomolar activity.</p>Formula:C31H28F2N4O3Color and Shape:SolidMolecular weight:542.58α-Amylase/α-Glucosidase-IN-19
CAS:<p>α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase and α-glucosidase, with an IC50 of 170.7 μM and 60.37 μM, respectively.</p>Formula:C17H14BrClN2OColor and Shape:SolidMolecular weight:377.663DDO-3733
CAS:<p>DDO-3733 is a conformational activator of Protein Phosphatase 5 (PP5) that functions independently of TRP, facilitating the dephosphorylation of downstream substrates.</p>Formula:C10H6F2N2OSColor and Shape:SolidMolecular weight:240.23D-Citrulline
CAS:<p>D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.</p>Formula:C6H13N3O3Color and Shape:SolidMolecular weight:175.195-LOX/MAOs-IN-1
CAS:<p>Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.</p>Formula:C18H18N2O2Color and Shape:SolidMolecular weight:294.356′SLN
CAS:<p>6′SLN is a characteristic glycan found on the surface of cancer-related extracellular vesicles (EVs) and serves as the primary form of protein glycosylation within EVs. Additionally, 6′SLN, a derivative of sialic acid, interacts with hemagglutinins (HAs) from both human and avian influenza strains, making it relevant in the study of anti-influenza drugs.</p>Formula:C25H42N2O19Color and Shape:SolidMolecular weight:674.6SGK1-IN-3
<p>SGK1-IN-3: Potent oral inhibitor of SGK1, may target osteoarthritis.</p>Formula:C23H20Cl2N6O3SColor and Shape:SolidMolecular weight:531.41IDO1-IN-25
CAS:<p>IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.</p>Formula:C14H8Cl3NO2SColor and Shape:SolidMolecular weight:360.64RWJ 22108
CAS:<p>RWJ 22108 is a bronchial-selective calcium channel (calcium channel) blocker that exhibits an IC50 of 5.7 nM in dog bronchial smooth muscle calcium-dependent contractions.</p>Formula:C27H30ClFN2O4SColor and Shape:SolidMolecular weight:533.06Retezorogant
CAS:<p>Retezorogant is a retinoic acid receptor-related orphan receptor gamma (RORγ) antagonist.</p>Formula:C23H33ClN2O3Color and Shape:SolidMolecular weight:420.97(-)-Mesembrine
CAS:<p>Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4).</p>Formula:C17H23NO3Color and Shape:SolidMolecular weight:289.37Urobilin hydrochloride
CAS:<p>Urobilin hydrochloride, a metabolic byproduct of Hemoglobin, is excreted through urine and feces in various mammals. It also serves as an indicator of human waste contamination.</p>Formula:C33H43ClN4O6Color and Shape:SolidMolecular weight:627.17α-Glucosylrutin
CAS:<p>α-Glucosylrutin is an effective antioxidant known for its activity in scavenging free radicals. Due to its high epidermal bioavailability, it is commonly utilized in studies related to skin aging.</p>Formula:C33H40O21Color and Shape:SolidMolecular weight:772.66MK-3168 (12C)
CAS:<p>MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.</p>Formula:C21H21ClN4OSColor and Shape:SolidMolecular weight:412.94NTPDase-IN-3
CAS:<p>NTPDase-IN-3 inhibits NTPDase1/2/3/8 (IC50: 0.21/1.07/0.38/0.05 μM), useful for cancer and thrombosis research.</p>Formula:C22H24ClN3OS2Color and Shape:SolidMolecular weight:446.03SelB-1
CAS:<p>SelB-1 acts as a dual inhibitor of Topoisomerase I/II (TopoisomeraseI/II), exhibiting anticancer activity suitable for research on prostate and colon cancers. Additionally, SelB-1 can induce the expression of autophagy (autophagy) genes and lipid peroxidation while reducing GSH levels.</p>Formula:C32H24O5Color and Shape:SolidMolecular weight:488.53h15-LOX-2 inhibitor 3
CAS:<p>Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.</p>Formula:C22H13N5O3Color and Shape:SolidMolecular weight:395.37MAGL-IN-18
CAS:<p>MAGL-IN-18 (compound 118) serves as a highly potent inhibitor of Monoacylglycerol lipase (MAGL), demonstrating an IC 50 value of 0.03nM.</p>Formula:C23H28F3N7OColor and Shape:SolidMolecular weight:475.51Diacylglycerol acyltransferase inhibitor-2
CAS:<p>Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.</p>Formula:C21H20FN5O4Color and Shape:SolidMolecular weight:425.41PTP1B-IN-21
<p>PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.</p>Formula:C22H22O11Color and Shape:SolidMolecular weight:462.4ent-8-iso-15(S)-Prostaglandin F2α
CAS:<p>Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.</p>Formula:C20H34O5Color and Shape:SolidMolecular weight:354.48Enpp-1-IN-7
<p>Enpp-1-IN-7: potent enpp-1 inhibitor, broad specificity, potential in cancer/infectious disease research. (WO2021203772A1)</p>Formula:C18H19N7O4SColor and Shape:SolidMolecular weight:429.45Lp-PLA2-IN-10
<p>Lp-PLA2-IN-10, a potent Lp-PLA2 inhibitor, may research neurodegenerative and cardiovascular diseases.</p>Formula:C21H15F5N4O4Color and Shape:SolidMolecular weight:482.36RORγt modulator 5
CAS:<p>RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.</p>Formula:C27H22F5N3O6SColor and Shape:SolidMolecular weight:611.54Carbonic anhydrase inhibitor 5
<p>Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.</p>Formula:C24H20ClN3O3SColor and Shape:SolidMolecular weight:465.95NAZ2329
CAS:<p>NAZ2329: Cell-permeable, targets R5 RPTPs, inhibits hPTPRZ1 (IC50=7.5 μM) & hPTPRG (IC50=4.8 μM), hampers glioblastoma growth, affects stem cell traits.</p>Formula:C21H18F3NO4S3Color and Shape:SoildMolecular weight:501.56CYP2C1/CYP2C19-IN-2
<p>CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Formula:C27H28N2O6SColor and Shape:SolidMolecular weight:508.59PDE4-IN-12
<p>PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).</p>Formula:C34H35NO6Color and Shape:SolidMolecular weight:553.64RORγt inverse agonist 29
<p>RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.</p>Formula:C25H24N2O5SColor and Shape:SolidMolecular weight:464.53Carbonic anhydrase inhibitor 9
<p>Carbonic anhydrase inhibitor 9 targets hCA II and IX with Ki of 56.4 and 56.9 nM respectively; shows antiproliferative activity.</p>Formula:C22H20BrN5O4SColor and Shape:SolidMolecular weight:530.39FXIa-IN-9
CAS:<p>FXIa-IN-9, a potent FXIa inhibitor (K i : human 0.17 nM, rabbit 0.5 nM), forms hydrogen bonds and has anticoagulant properties.</p>Formula:C23H18Cl2F3N9O2Color and Shape:SolidMolecular weight:580.35PPI-2458
CAS:<p>PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.</p>Formula:C22H36N2O6Color and Shape:SolidMolecular weight:424.53α-Glucosidase-IN-12
<p>α-Glucosidase-IN-12 is a potent inhibitor of α-glucosidase (IC50: 10.20 μM).</p>Formula:C25H30N4O4S2Color and Shape:SolidMolecular weight:514.66α-Glucosidase-IN-19
<p>Alpha-Glucosidase-IN-19 (Compound 6B) is an orally active alpha-glucosidase inhibitor (IC50: 3.63 μM) with antidiabetic effects.</p>Formula:C31H25NOSColor and Shape:SolidMolecular weight:459.6RORγt/DHODH-IN-1
CAS:<p>RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant</p>Formula:C24H26ClF6N3O3SColor and Shape:SolidMolecular weight:585.99Indoluidin E
<p>Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.</p>Formula:C28H30N4O2Color and Shape:SolidMolecular weight:454.56Tabimorelin hemifumarate
CAS:<p>orally active ghrelin receptor (GHS-R1a) agonist</p>Formula:C32H40N403C4H404Purity:98%Color and Shape:SolidMolecular weight:586.72PDHK-IN-3
<p>PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].</p>Formula:C17H16N2O2Color and Shape:SolidMolecular weight:280.32PDHK-IN-4
<p>PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.</p>Formula:C24H25N5O3Color and Shape:SolidMolecular weight:431.49RORγt inhibitor 2
CAS:<p>RORγt Inhibitor 2, a potent inhibitor of RORγt, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are</p>Formula:C31H33F5N2O7SColor and Shape:SolidMolecular weight:672.66PTP1B-IN-18
<p>PTP1B-IN-18 is an orally active, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 35.2 μM).PTP1B-IN-18 can be used to study type 2 diabetes.</p>Formula:C26H19N3O4SColor and Shape:SolidMolecular weight:469.51α-Glucosidase-IN-14
<p>α-Glucosidase-IN-14 is a potent inhibitor of α-glucosidase (IC50: 5.22 μM).</p>Formula:C24H27N5O4S2Color and Shape:SolidMolecular weight:513.63MGAT2-IN-1
CAS:<p>MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).</p>Formula:C27H21ClF5N7O3SColor and Shape:SolidMolecular weight:654.01FXIa-IN-8
<p>FXIa-IN-8: potent FXIa blocker (IC50: 14.2 nM), anti-thrombotic, low bleeding/toxicity risk.</p>Color and Shape:SolidFAAH/MAGL-IN-1
<p>FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.</p>Formula:C15H9Cl2N3O3Color and Shape:SolidMolecular weight:350.16PLAP-IN-1
CAS:<p>PLAP-IN-1: Potent, selective inhibitor of PLAP, IC50 of 32 nM; doesn't notably inhibit TNAP.</p>Formula:C25H21Cl2N3O5Color and Shape:SoildMolecular weight:514.36PKR-IN-1
CAS:<p>PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).</p>Formula:C9HCl5N4OS2Color and Shape:SolidMolecular weight:422.525Lp-PLA2-IN-5
CAS:<p>Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.</p>Formula:C23H18F5N3O4Color and Shape:SolidMolecular weight:495.4Hcyb1
<p>Hcyb1 specifically inhibits PDE2A with 0.57 μM IC50, over 250x selective, and has neuroprotective and antidepressant effects.</p>Formula:C24H20N4OColor and Shape:SolidMolecular weight:380.44hDHODH-IN-10
<p>hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.</p>Formula:C21H15ClF4N2O4Color and Shape:SolidMolecular weight:470.8hMAO-B/MB-COMT-IN-1
<p>Dual hMAO-B/MB-COMT inhibitor, IC50: 2.5 μΜ (hMAO-B), 3.84 μΜ (MB-COMT); potential in Parkinson's research.</p>Formula:C16H19NO3Color and Shape:SolidMolecular weight:273.33CAII-IN-2
<p>CAII-IN-2 (3g): potent, selective CA-II inhibitor; IC50-12.1 μM for bovine CA-II; valuable in CA-related disorder research.</p>Formula:C18H19BrN4SColor and Shape:SolidMolecular weight:403.34S-15176
CAS:<p>S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). It effectively suppresses mitochondrial swelling induced by tert-butyl hydroperoxide, with an IC50 value of 45.7 μM. S-15176 prevents the opening of PTP, thus averting the dissipation of mitochondrial membrane potential and the oxidation of NAD(P)H, while enhancing mitochondrial calcium loading capacity. It holds potential for research into ischemia-reperfusion injury.</p>Formula:C31H48N2O4SColor and Shape:SolidMolecular weight:544.79QGC583
CAS:<p>QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.</p>Formula:C13H20NO5PColor and Shape:SolidMolecular weight:301.28DGAT2-IN-3
CAS:<p>DGAT2-IN-3 (compound 9) is an inhibitor of DGAT2 with an IC50 value of 0.4 nM. It is utilized in research related to fatty liver disease, diabetes, and cardiovascular diseases.</p>Formula:C21H20F4N4O5SColor and Shape:SolidMolecular weight:516.47A-800141
CAS:<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>Formula:C24H30N2O4SColor and Shape:SolidMolecular weight:442.571BAR-2227
CAS:<p>BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.</p>Formula:C24H17Cl2NO4Color and Shape:SolidMolecular weight:454.30(rel)-Mirogabalin
CAS:<p>(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.</p>Formula:C12H19NO2Color and Shape:SolidMolecular weight:209.28Complex III-IN-1
<p>Complex III-IN-1 inhibits complex III, has antifungal properties, and an EC50 of 18.53 mg/L against S. sclerotiorum.</p>Formula:C14H20ClNO2S2Color and Shape:SolidMolecular weight:333.9β-Glucuronidase/hCAII-IN-1
CAS:<p>β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50</p>Formula:C30H21NO9Color and Shape:SolidMolecular weight:539.49Lunacalcipol
CAS:<p>Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism.</p>Formula:C28H42O4SColor and Shape:SolidMolecular weight:474.7RXR antagonist 1
<p>RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.</p>Formula:C28H33F3N2O3Color and Shape:SolidMolecular weight:502.57hCAVII/IX-IN-1
CAS:<p>hCAVII/IX-IN-1 (compound 4) functions as an inhibitor of hCAVII/IX, exhibiting Ki values of 56.5 nM and 38.2 nM, respectively. It is applicable in the field of cancer research.</p>Formula:C7H7N3O2S2Color and Shape:SolidMolecular weight:229.279sEH inhibitor-1
<p>TCPU (sEH inhibitor-1) is a potent oral human sEH blocker with IC50s of 0.4 nM (human) and 5.3 nM (mouse).</p>Color and Shape:SolidPTP1B-IN-16
<p>PTP1B-IN-16: selective benzimidazole inhibitor of PTP1B, Ki: 12.6 μM, potential for type 2 diabetes research.</p>Formula:C26H18ClN3O4SColor and Shape:SolidMolecular weight:503.96Yck2-IN-1
CAS:<p>Yck2-IN-1 (Compound 2a) is an inhibitor of the fungus Candida albicans Yck2. It has an IC50 of approximately 80 nM for Yck2 and an MIC80 of 12.5 µM for C. albicans, demonstrating good metabolic stability [66% remaining in mouse liver microsomes]. In a mouse model with drug-resistant Candida, Yck2-IN-1 significantly reduced fungal load in the kidneys. Yck2-IN-1 shows potential for research in antifungal infection treatments.</p>Formula:C19H11FN4Color and Shape:SolidMolecular weight:314.316AD011
<p>AD011, a cACE/NEP inhibitor derived from lenopril-tryptophan, may offer strong anti-hypertensive, cardioprotective benefits.</p>Formula:C27H33N3O5Color and Shape:SolidMolecular weight:479.57Rivaroxaban diol
CAS:<p>Rivaroxabandiol is a metabolite of Rivaroxaban, which is a potent and selective direct inhibitor of coagulation factor Xa (FXa) with an IC50 of 0.7 nM and a Ki of 0.4 nM.</p>Formula:C19H20ClN3O6SColor and Shape:SolidMolecular weight:453.897Casein kinase 1δ-IN-17
CAS:<p>Casein kinase1δ-IN-17 (compound 753) is an inhibitor of casein kinase 1δ (CK1δ). It is applicable in research related to neurodegenerative diseases.</p>Formula:C14H14N4SColor and Shape:SolidMolecular weight:270.353PPARδ agonist 11
CAS:<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Formula:C19H15F3N2O3S2Color and Shape:SolidMolecular weight:440.46BAY 74-4113
CAS:<p>BAY 74-4113 is a DGAT1 inhibitor with an IC50 of 72 nM. It is utilized in research related to obesity.</p>Formula:C26H20F2N2O3SColor and Shape:SolidMolecular weight:478.51RORγ-IN-2
CAS:<p>RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.</p>Formula:C28H32F3N5O4S2Color and Shape:SolidMolecular weight:623.71EB-0150
<p>EB-0150 inhibits ER α-Glu I/II (IC50: 0.73/0.0337 μM), is an N-substituted valerian with antiviral effects, and has drug discovery potential.</p>Formula:C19H30N6O7Color and Shape:SolidMolecular weight:454.48EB-0176
<p>EB-0176: A valerian derivative; broad-spectrum antiviral; potent ER α-glucosidase I/II inhibitor; IC50s: 0.6439/0.0011 μM.</p>Formula:C23H33N5O7Color and Shape:SolidMolecular weight:491.54CAII-IN-3
<p>CAII-IN-3, a thiosemicarbazone, potently inhibits CA-II with an IC50 of 13.4 μM.</p>Formula:C18H18F2N4SColor and Shape:SolidMolecular weight:360.42FTI-2153 TFA
<p>FTI-2153 TFA inhibits farnesyltransferase with high selectivity (IC50: 1.4 nM), over 3000x more than Rap1A processing.</p>Formula:C27H31F3N4O5SColor and Shape:SolidMolecular weight:580.62IDO2-IN-1
CAS:<p>IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.</p>Formula:C21H21BrN10O3Color and Shape:SolidMolecular weight:541.36ASB14780
<p>ASB14780 is a 4-phenoxy derivative and an inhibitor of cytoplasmic phospholipase cPLA2α (IC50: 20 nM).</p>Color and Shape:SolidArphamenine A
CAS:<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Formula:C16H24N4O3Color and Shape:SolidMolecular weight:320.387PDE4B-IN-3
<p>PDE4B-IN-3 is a potent inhibitor of PDE4B (IC50: 0.94 μM) and exhibits anti-inflammatory effects.</p>Formula:C30H35N3O4S2Color and Shape:SolidMolecular weight:565.75L 731735
CAS:<p>L 731735 is a farnesyltransferase inhibitor.</p>Formula:C19H40N4O4SPurity:98%Color and Shape:SolidMolecular weight:420.61CB30865
CAS:<p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>Formula:C26H22BrN5O2Purity:99.04%Color and Shape:SolidMolecular weight:516.39IDH1 Inhibitor 1
CAS:<p>Oral, brain-penetrant mutant IDH1 inhibitor targeting R132H/C with IC50: 0.021/0.045μM; 2.52μM for IDH1WT.</p>Formula:C20H18F4N6O2Purity:98%Color and Shape:SolidMolecular weight:450.39Oxythiamine diphosphate ammonium
<p>Oxythiamin diphosphate ammonium is a potent inhibitor of transketolase (TK).</p>Color and Shape:SolidRo 23-9358
CAS:<p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>Formula:C30H51NO6Color and Shape:SolidMolecular weight:521.729PTP1B-IN-3 diammonium
<p>PTP1B-IN-3 diammonium, an oral enzyme inhibitor, has potent antidiabetic and anticancer effects, with a 120 nM IC50.</p>Formula:C12H13BrF2N3O3PColor and Shape:SolidMolecular weight:396.12OSI-413 free base
CAS:<p>OSI-413 (free base) (CP 373413) is the primary metabolite of Erlotinib. Erlotinib (CP-358774) acts as a direct EGFR tyrosine kinase inhibitor with an IC50 of 2 nM against human EGFR.</p>Formula:C21H21N3O4Color and Shape:SolidMolecular weight:379.409FXR/HSD17B13 modulator 1
CAS:<p>FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).</p>Formula:C26H19Cl2NO4Color and Shape:SolidMolecular weight:480.339Casein kinase 1δ-IN-16
CAS:<p>Casein kinase1δ-IN-16 (compound 506) is an inhibitor of casein kinase 1δ (CK1δ). This compound is applicable in research related to neurodegenerative diseases.</p>Formula:C17H12N4S2Color and Shape:SolidMolecular weight:336.434sEH inhibitor-4
<p>Compound B15: potent sEH inhibitor (0.03 nm), reduces inflammation & pain.</p>Formula:C27H28Cl2N4O3Color and Shape:SolidMolecular weight:527.44PHGDH-IN-2
<p>PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.</p>Formula:C22H20N4O3SColor and Shape:SolidMolecular weight:420.48Ketomethylenebestatin
CAS:<p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>Formula:C17H25NO4Purity:98%Color and Shape:SolidMolecular weight:307.38Oxoprolintane
CAS:<p>Oxoprolintane is a metabolite of the psychoactive compound Prolintane. It exhibits activity in modulating the central nervous system and may serve as a potential neuroprotective agent. Oxoprolintane shows promise for research in the field of neurological disorders.</p>Formula:C15H21NOColor and Shape:SolidMolecular weight:231.333BRD2879
CAS:<p>BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM).</p>Formula:C30H38FN3O5SPurity:98%Color and Shape:SolidMolecular weight:571.70BAY 3389934
CAS:<p>BAY 3389934 is a dual inhibitor of factor IIa (factor IIa) and factor Xa (factor Xa), providing anticoagulant and organ-protective effects. It alleviates coagulopathy and organ dysfunction in baboon models of Staphylococcus aureus sepsis.</p>Formula:C26H30ClN5O7S2Color and Shape:SolidMolecular weight:624.129Carbonic anhydrase inhibitor 2
CAS:<p>Compound 7c inhibits carbonic anhydrase II, lowering intraocular pressure in glaucomatous rabbits.</p>Formula:C12H16N4O6SColor and Shape:SolidMolecular weight:344.34HIF-2α-IN-7
CAS:<p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>Formula:C18H9F6NO2Color and Shape:SolidMolecular weight:385.26NTPDase-IN-2
CAS:<p>NTPDase-IN-2 inhibits h-NTPDase-2/-8 (IC50: 0.04, 2.27 µM), non-competitive for h-NTPDase-1/-2 (Km: 74 µM); useful in cancer, immune, bacterial research.</p>Formula:C24H20FN3OS2Color and Shape:SolidMolecular weight:449.56GJG057
CAS:<p>GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.</p>Formula:C21H21F5N4O2Purity:99.8%Color and Shape:SolidMolecular weight:456.41CAII-IN-1
<p>CAII-IN-1 (3n) is a selective bovine CA-II inhibitor with 10.3 μM IC50, used in carbonic anhydrase disorder studies.</p>Formula:C19H21FN4SColor and Shape:SolidMolecular weight:356.46hMAO-B/MB-COMT-IN-2
<p>Dual inhibitor hMAO-B/MB-COMT-IN-2 targets hMAO-B (IC50: 4.27μM) & MB-COMT (IC50: 2.69μM), aids in neurodegenerative research.</p>Formula:C17H18N2O3Color and Shape:SolidMolecular weight:298.342R,4R-Sacubitril
CAS:<p>2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.</p>Formula:C24H29NO5Purity:98%Color and Shape:SolidMolecular weight:411.497-Hydroxy-4-phenylcoumarin
CAS:<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Formula:C15H10O3Color and Shape:SolidMolecular weight:238.238CYP1B1-IN-2
<p>CYP1B1-IN-2 (compound 9j) is a highly potent and selective inhibitor of CYP1B1, a cytochrome P450 enzyme. It exhibits an IC50 value of 0.52 nM [1].</p>Formula:C20H11F3O2Color and Shape:SolidMolecular weight:340.3Squalestatin 3
CAS:<p>Squalestatin 3 is an inhibitor of squalene synthase.</p>Formula:C25H30O13Purity:98%Color and Shape:SolidMolecular weight:538.5hCAII-IN-3
<p>hCAII-IN-3 inhibits key hCA isoforms with Ki: hCA I (403.8 nM), hCA II (5.1 nM), hCA IX (10.2 nM), hCA XII (5.2 nM); shows anticancer potential.</p>Formula:C17H21N3O3SColor and Shape:SolidMolecular weight:347.43Mitochondrial-IN-1
CAS:<p>Mitochondrial-IN (C458) is a potent inhibitor of mitochondrial complex I. It offers significant protection against Aβ toxicity, exhibits favorable pharmacokinetic properties, and has minimal off-target effects.</p>Formula:C22H30N2OColor and Shape:SolidMolecular weight:338.494-(4-Bromophenyl)-4-hydroxypiperidine
CAS:<p>4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.</p>Formula:C11H14BrNOColor and Shape:SolidMolecular weight:256.139ZK824859 hydrochloride
<p>ZK824859 hydrochloride: oral uPA inhibitor with IC50 of 79 nM (uPA), 1580 nM (tPA), 1330 nM (fibrin).</p>Formula:C23H23ClF2N2O4Color and Shape:SolidMolecular weight:464.89hCAIX/XII-IN-15
CAS:<p>hCAIX/XII-IN-15 (Compound 17β) is an inhibitor of hCA IX and hCA XII, exhibiting Ki values of 0.42 and 4.37 μM, respectively. It demonstrates a pro-apoptotic effect in multiple myeloma cells.</p>Formula:C17H18O4SColor and Shape:SolidMolecular weight:318.387ZK168281
CAS:<p>ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.</p>Formula:C32H46O5Purity:98%Color and Shape:SolidMolecular weight:510.70HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Formula:C17H16N6O4Color and Shape:SolidMolecular weight:368.35Etiocholanolone glucuronide
CAS:<p>Etiocholanolone glucuronide (Etio-G) is a metabolite of Etiocholanolone, produced through the catalysis by UDP glucuronosyltransferase in the liver. Etiocholanolone glucuronide shows potential for research in metabolic-related diseases.</p>Formula:C25H38O8Color and Shape:SolidMolecular weight:466.564Enpp-1-IN-12
<p>ENPP1-IN-12 is a potent, oral ENPP1 inhibitor with a Ki of 41 nM and anti-tumor properties.</p>Formula:C17H19N5O3SColor and Shape:SolidMolecular weight:373.43HIF-2α-IN-5
CAS:<p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].</p>Formula:C15H12F4O3S2Color and Shape:SolidMolecular weight:380.38JTZ-951 HCl
CAS:<p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>Formula:C17H17ClN4O4Purity:98%Color and Shape:SolidMolecular weight:376.79GK420
CAS:<p>GK420 (AVX420) is a potent inhibitor of cytoplasmic phospholipase A2α (cPLA2α), with an XI(50) value of 0.0016. It effectively inhibits the release of arachidonic acid, with an EC50 of 0.09 μM. GK420 plays a significant role in cancer research.</p>Formula:C20H25NO5SColor and Shape:SolidMolecular weight:391.481Implitapide
CAS:<p>Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).</p>Formula:C35H37N3O2Purity:98%Color and Shape:SolidMolecular weight:531.69Etoricoxib N1'-oxide
CAS:<p>EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.</p>Formula:C18H15ClN2O3SColor and Shape:SolidMolecular weight:374.841ZK159222
CAS:<p>ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.</p>Formula:C32H48O5Purity:98%Color and Shape:SolidMolecular weight:512.72TS010
<p>TS010 is a highly potent inhibitor of GLO-I, with an IC50 value of 0.57 μM. It holds significant promise for advancements in cancer research [1].</p>Formula:C16H12N4O4SColor and Shape:SolidMolecular weight:356.36Porphobilinogen
CAS:<p>Porphobilinogen act as a phytotoxin, a metabotoxin, and a neurotoxin.</p>Formula:C10H14N2O4Purity:98%Color and Shape:SolidMolecular weight:226.23FXR agonist 12
CAS:<p>FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.</p>Formula:C26H44O3Color and Shape:SolidMolecular weight:404.626FTI 276 TFA
CAS:<p>FTI 276 TFA targets plasmodium falciparum & humans, inhibits PFT with IC50s: 0.9 nM (parasite) & 0.5 nM (human).</p>Formula:C23H28F3N3O5S2Color and Shape:SolidMolecular weight:547.61JPHM-2-167
CAS:<p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>Formula:C30H28N6O2Color and Shape:SolidMolecular weight:504.582Calcium 2-hydroxypropanoate pentahydrate
CAS:<p>Calcium 2-hydroxypropanoate (pentahydrate) acts as an activator of the hydroxyl-carboxylic acid receptor 1 (HCAR1) and serves as an epigenetic regulator that induces lysine residue lactylation. This compound, a glycolysis end product, bridges the gap between glycolysis and oxidative phosphorylation and functions as a tumor metabolite with immunoprotective effects of lactate in antitumor immunity.</p>Formula:C3H5O3CaH2OColor and Shape:SolidMolecular weight:154.147ACLY Inhibitor 7
CAS:<p>ACLY Inhibitor 7 is a potent, selective hACLY inhibitor (IC50<1 nM) for metabolic disease and oncology research.</p>Formula:C21H14ClF2NO6SPurity:99.74%Color and Shape:SoildMolecular weight:481.85Monoamine Oxidase B inhibitor 6
CAS:<p>Monoamine OxidaseB inhibitor 6 (Compound BT5) is a highly selective, reversible, and competitive MAO-B inhibitor capable of crossing the blood-brain barrier, with an IC50 of 0.11 μM. It exhibits antioxidant and neuroprotective properties, making it suitable for research into neurodegenerative diseases.</p>Formula:C15H15N3OSColor and Shape:SolidMolecular weight:285.364CK1δ-IN-10
CAS:<p>CK1δ-IN-10 (Compound 85) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ (CSNKID), with an IC50 value of 0.255 μM.</p>Formula:C17H11F4N5Color and Shape:SolidMolecular weight:361.296BAY R3401
CAS:<p>BAY R3401 is an orally active inhibitor of glycogen phosphorylase, leading to irreversible and non-selective inhibition of liver glycogenolysis. It suppresses glycogen breakdown in hepatocytes with IC50 values of 27.06 μM in HL-7702 cells and 52.83 μM in HepG2 cells. BAY R3401 is applicable for research in type 2 diabetes.</p>Formula:C20H22ClNO4Color and Shape:SolidMolecular weight:375.846P5SA-2
CAS:<p>P5SA-2 is a selective allosteric activator of PPP5C, functioning by modulating the structure of the PPP5C phosphatase domain. At a concentration of 100 μM, it can enhance PPP5C activity by 3.2-fold, with an apparent affinity constant of 7.8 μM. P5SA-2 is applicable in research related to cancer and Alzheimer's disease.</p>Formula:C17H15ClN2O3Color and Shape:SolidMolecular weight:330.766SGK1-IN-6
CAS:<p>SGK1-IN-6 (compound 12f) is an SGK1 inhibitor with an IC50 value of 0.39 μM. In PC3 xenograft models using BALB/c nude mice, SGK1-IN-6 effectively hinders tumor growth without causing any observable toxicity.</p>Formula:C30H30F3N5O4Color and Shape:SolidMolecular weight:581.586IDO1 ligand-1
CAS:<p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>Formula:C29H34FN3O2Color and Shape:SolidMolecular weight:475.598(Rac)-8-Hydroxy-efavirenz
CAS:<p>(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1.</p>Formula:C14H9ClF3NO3Color and Shape:SolidMolecular weight:331.674BMS-185354
CAS:<p>BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM, offering potential for cancer research.</p>Formula:C26H27NO3Color and Shape:SolidMolecular weight:401.497Desmonomethylpromazine
CAS:<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>Formula:C16H18N2SColor and Shape:SolidMolecular weight:270.39Propofol sulfate sodium
CAS:<p>Propofolsulfate (sodium) is a metabolite of Propofol.</p>Formula:C12H17NaO4SColor and Shape:SolidMolecular weight:280.316Beloranib
CAS:<p>Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.</p>Formula:C29H41NO6Purity:98%Color and Shape:SolidMolecular weight:499.64FR 901537
CAS:<p>FR 901537 is a new aromatase inhibitor with antitumor effects.</p>Formula:C23H29N3O6S2Purity:98%Color and Shape:SolidMolecular weight:507.6211-trans Leukotriene E4
CAS:<p>Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.</p>Formula:C23H37NO5SColor and Shape:SolidMolecular weight:439.61ATUX-8385
CAS:<p>ATUX-8385 is a potent activator of PP2A. It binds to the PR65 subunit and holds promise for research into cancer and chronic diseases, including Alzheimer's disease and chronic obstructive pulmonary disease (COPD).</p>Formula:C24H20F5N3O4SColor and Shape:SolidMolecular weight:541.49Lufironil
CAS:<p>Lufironil (HOE 077) is an inhibitor of prolyl 4-hydroxylase, designed for investigating chronic liver conditions such as alcoholic hepatitis and cirrhosis.</p>Formula:C13H19N3O4Color and Shape:SolidMolecular weight:281.31L 671776
CAS:<p>L 671776 is an inositol monophosphatase inhibitor.</p>Formula:C23H32O5Purity:98%Color and Shape:SolidMolecular weight:388.5hCAI/II/XII-IN-1
CAS:<p>hCAI/II/XII-IN-1 (compound 7) is an inhibitor of human carbonic anhydrases hCAI, hCAII, and hCAXII, with Ki values of 78.5 nM, 9.1 nM, 605 nM, 7.7 nM, and 3.7 nM.</p>Formula:C12H12N2O2SColor and Shape:SolidMolecular weight:248.301AChE/PDE4-IN-1
<p>AChE/PDE4-IN-1, compound 12c, dual inhibitor; IC50: 0.28μM for AChE, 1.88μM for PDE4D, may reduce Alzheimer's neuroinflammation.</p>Formula:C23H28N2O3Color and Shape:SolidMolecular weight:380.484-Hydroxyclonidine
CAS:<p>4-Hydroxyclonidine is a metabolite of Clonidine. It is equally effective as Clonidine in displacing labeled Clonidine from antibodies.</p>Formula:C9H9Cl2N3OColor and Shape:SolidMolecular weight:246.093DPM-1003
CAS:<p>DPM-1003 is an allosteric inhibitor of PTP1B, targeting the non-catalytic, disordered C-terminal segment of the PTP1B protein, and has shown beneficial effects in reducing pulmonary inflammation in mice.</p>Formula:C35H57N3O3Color and Shape:SolidMolecular weight:567.845AZ513
CAS:<p>AZ513 is a reversible FAAH inhibitor, exhibiting an IC50 of 551 nM for human FAAH and 27 nM for rat FAAH. It inhibits the hydrolysis of arachidonoyl ethanolamide in HEK293 cells transfected with human FAAH, with an IC50 of 360 nM.</p>Formula:C14H9Cl2N3OColor and Shape:SolidMolecular weight:306.147Docosapentaenoic acid (22n-3) sodium
CAS:<p>Docosapentaenoic acid (22n-3) sodium is a component of phospholipids. It exhibits inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 17 μg/mL and 22 μg/mL, respectively. Additionally, Docosapentaenoic acid 22n-3 sodium enhances cell viability and has mild anti-inflammatory effects.</p>Formula:C22H34NaO2Color and Shape:SolidMolecular weight:353.494JTT-553
CAS:<p>JTT-553 is a DGAT1 inhibitor with an IC50 of 2.38 nM. It effectively reduces plasma levels of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and liver triglycerides (TG). JTT-553 enhances insulin-dependent glucose absorption and glucose intolerance in the adipose tissue of diet-induced obese (DIO) mice. In KK-Ay mice, it lowers TNF-α mRNA levels and elevates GLUT4 mRNA levels in adipose tissue. By contributing to weight loss, JTT-553 improves insulin resistance in adipose tissue and overall glucose metabolism. This compound is useful for research on obesity and type 2 diabetes mellitus (T2DM).</p>Formula:C25H27F3N4O3Color and Shape:SolidMolecular weight:488.50LEQ803
CAS:<p>LEQ803 (N-DesmethylRibociclib) is a metabolite of the CDK4/6 inhibitor Ribociclib, produced through metabolism by CYP3A4. This compound holds potential applications in the field of oncology.</p>Formula:C22H28N8OColor and Shape:SolidMolecular weight:420.511CA IX-IN-3
CAS:<p>CAIX-IN-3 (Compound 27) is a selective and potent inhibitor of carbonic anhydrase IX (CAIX), with an IC50 of 0.48 nM.</p>Formula:C21H19N5O4S2Color and Shape:SolidMolecular weight:469.537L-739750
CAS:<p>L-739,750 is an inhibitor (FTI) of peptidomimetic farnesyltransferase.</p>Formula:C23H39N3O6S2Purity:98%Color and Shape:SolidMolecular weight:517.7GSK2945 hydrochloride
<p>GSK2945 HCl is a specific Rev-erbα antagonist, EC50: 21.5 μM (mouse), 20.8 μM (human), increases cholesterol 7α-hydroxylase.</p>Formula:C20H19Cl3N2O2SColor and Shape:SolidMolecular weight:457.8RORγt inhibitor 4
CAS:<p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>Formula:C22H16Cl2F3NO4SColor and Shape:SolidMolecular weight:518.333CK1δ-IN-6
CAS:<p>CK1δ-IN-6 (Compound 303) is an inhibitor of Casein kinase 1δ, with potential applications in Alzheimer's disease research.</p>Formula:C23H17N3O4Color and Shape:SolidMolecular weight:399.399α-Glucosidase-IN-15
<p>α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM.</p>Formula:C24H24N2SColor and Shape:SolidMolecular weight:372.53SID 24785302
CAS:<p>SID 24785302 is an inhibitor of hexokinase, which can suppress glycolysis, regulate mitochondrial function, and ultimately inhibit the replication of mutant mitochondrial DNA.</p>Formula:C14H12N2O3S2Color and Shape:SolidMolecular weight:320.387PHD2-IN-4
CAS:<p>PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.</p>Formula:C21H19N5O3Color and Shape:SolidMolecular weight:389.407Morocromen
CAS:<p>Morocromen is a 2-benzamidobenzoic acid derivative characterized by its ability to enhance coronary activity.</p>Formula:C21H27N3O5Color and Shape:SolidMolecular weight:401.46α-Amylase-IN-12
CAS:<p>α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor with an IC50 of 0.15 mM, functioning through a mixed inhibition mode. It exhibits an IC50 of 9.40 mM against α-glucosidase. This compound enhances glucose uptake in yeast cells and demonstrates significant anti-glycation activity at high concentrations. α-Amylase-IN-12 is applicable for diabetes research.</p>Formula:C16H11NO4Color and Shape:SolidMolecular weight:281.263FTI-2148
CAS:<p>FTI-2148 blocks RAS-related FT-1 & GGT-1; IC50: 1.4 nM & 1.7 μM.</p>Formula:C24H28N4O3SPurity:98%Color and Shape:SolidMolecular weight:452.57Glucokinase activator 8
CAS:<p>Glucokinase activator8 is an activator of glucose kinase (glucokinase).</p>Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337Danifexor
CAS:<p>Danifexor is an agonist of the farnesoid X receptor (Farnesoid X receptor).</p>Formula:C29H20Cl2N2O5Color and Shape:SolidMolecular weight:547.386VHR-IN-1
CAS:<p>VHR-IN-1 (Compound SA1) is an effective and selective VHR phosphatase inhibitor with an IC50 of 18 nM. It hinders the proliferation of cervical cancer cells, demonstrating antitumor activity.</p>Formula:C28H22ClN3O5S3Color and Shape:SolidMolecular weight:612.139ZSH-2208
CAS:<p>ZSH-2208 is a retinoic acid A analogue that inhibits tumour cell proliferation and survival through RARγ-TNFAIP3 and retinoid receptors.</p>Formula:C20H18O3SPurity:99.81%Color and Shape:SolidMolecular weight:338.42Casein kinase 1δ-IN-23
CAS:<p>Casein kinase1δ-IN-23 (compound 423) is an effective inhibitor of casein kinase1δ. It is applicable in research related to neurodegenerative diseases such as Alzheimer's disease.</p>Formula:C19H15N3O3SColor and Shape:SolidMolecular weight:365.406Salacinol
CAS:<p>Salacinol is a naturally occurring alpha-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata.</p>Formula:C9H18O9S2Color and Shape:SolidMolecular weight:334.37WAY-606344
CAS:<p>WAY-606344 (Compound 97) is an inhibitor of Casein kinase 1δ and shows potential for Alzheimer's disease research.</p>Formula:C14H8ClN3O2Color and Shape:SolidMolecular weight:285.685DDO-3055
CAS:<p>DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.</p>Formula:C17H13ClN2O5Color and Shape:SolidMolecular weight:360.749CK1δ-IN-7
CAS:<p>CK1δ-IN-7 (Compound 488) is an inhibitor of casein kinase 1δ (CK1δ).</p>Formula:C23H23N5OColor and Shape:SolidMolecular weight:385.462IRX5010
CAS:<p>IRX5010 (IRX4647F), an analogue of IRX4647, serves as a highly selective RARγ nuclear receptor agonist. It effectively inhibits the growth of EMT-6 triple-negative breast cancer.</p>Formula:C24H26FNO3Color and Shape:SolidMolecular weight:395.466Casein kinase 1δ-IN-28
CAS:<p>Casein kinase1δ-IN-28 (Compound 4) is an inhibitor of CK1ε, with an IC50 of 0.0146 μM. The human liver microsome metabolism rate for Casein kinase1δ-IN-28 is 52%.</p>Formula:C23H23FN6Color and Shape:SolidMolecular weight:402.467Casein kinase 1δ-IN-30
CAS:<p>Casein kinase1δ-IN-30 (Compound 581) is an inhibitor of casein kinase 1δ (CK1δ). It can be utilized in research related to neurodegenerative diseases.</p>Formula:C18H15BrN6O2SColor and Shape:SolidMolecular weight:459.32FXIa-6f
CAS:<p>FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species</p>Formula:C31H29ClF2N4O4Color and Shape:SolidMolecular weight:595.04CK1δ-IN-5
CAS:<p>CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.</p>Formula:C22H21N5Color and Shape:SolidMolecular weight:355.436Lp(a)-IN-7
CAS:<p>Lp(a)-IN-7 (example 1) is an inhibitor of lipoprotein (a) [Lp(a)] formation, exhibiting an IC50 of 2.51 nM in media containing apolipoprotein B (apoB) and apolipoprotein (a). This compound is applicable in cardiovascular disease research.</p>Formula:C20H30Cl2N2O4Color and Shape:SolidMolecular weight:433.369ATX inhibitor 22
<p>ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.</p>Formula:C19H17Cl3F2N2O4SColor and Shape:SolidMolecular weight:513.77α-Glucosidase-IN-17
CAS:<p>α-Glucosidase-IN-17 (Compound 12B) is a potent and orally active inhibitor of α-glucosidase, demonstrating antidiabetic activity with an inhibitory</p>Formula:C30H27NO2SColor and Shape:SolidMolecular weight:465.61IMR687
CAS:<p>IMR687: a PDE9 inhibitor that could improve memory in Alzheimer's by slowing cGMP hydrolysis.</p>Formula:C21H26N6O2Purity:98%Color and Shape:SolidMolecular weight:394.47Lapaquistat
CAS:<p>Lapaquistat: active TAK-475 metabolite; reduces cholesterol synthesis and statin myotoxicity.</p>Formula:C31H39ClN2O8Purity:98%Color and Shape:SolidMolecular weight:603.1L-690330 hydrate
<p>L-690330 hydrate inhibits IMPase; Ki: 0.30 μM (human), 0.42 μM (bovine cortex); 0.27 μM (recom. human), 0.19 μM (bovine).</p>Formula:C8H14O9P2Color and Shape:SolidMolecular weight:316.14ATX inhibitor 12
<p>Oral ATX inhibitor 12 (IC50: 1.72 nM) at 60 mg/kg prevents lung damage in C57Bl/6J mice.</p>Formula:C30H34FN5O2Color and Shape:SolidMolecular weight:515.62Homodestcardin
CAS:<p>Homodestcardin: cyclic depsipeptide from T. roseum with immunosuppressant properties; inhibits mouse T cell proliferation.</p>Formula:C32H55N5O7Color and Shape:SolidMolecular weight:621.81Falecalcitriol
CAS:<p>Falecalcitriol is an analog of calcitriol. It has a higher potency both in vivo and in vitro systems, which is longer duration of action in vivo.</p>Formula:C27H38F6O3Purity:98%Color and Shape:SolidMolecular weight:524.58PSI-7410
CAS:<p>PSI-7410 is a metabolite of PSI-7851. PSI-7851 acts as an inhibitor of the HCV non-structural protein 5B (NS5B) and exhibits antiviral properties.</p>Formula:C10H15FN2O11P2Color and Shape:SolidMolecular weight:420.179LDHA-IN-5
CAS:<p>LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary</p>Formula:C27H22FN7O6S3Color and Shape:SolidMolecular weight:655.7Glucokinase activator 7
CAS:<p>Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].</p>Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337Cilazaprilat
CAS:<p>Cilazaprilat is the active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.</p>Formula:C20H27N3O5Color and Shape:SolidMolecular weight:389.45Lp(a)-IN-5
CAS:<p>Lp(a)-IN-5 (Compound A) is an orally active inhibitor of lipoprotein (a) [Lp(a)]. It effectively inhibits the assembly of Apo(a) and ApoB proteins, with an IC50 value of 0.41 nM. Lp(a)-IN-5 shows potential for research into diseases associated with elevated plasma Lp(a) levels, such as cardiovascular diseases.</p>Formula:C43H56N4O7Color and Shape:SolidMolecular weight:740.927AXKO-0046
<p>AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.</p>Formula:C25H33N3Color and Shape:SolidMolecular weight:375.55P053
CAS:<p>P053: potent, selective CerS1 inhibitor, IC50 = 0.5µM, curbs muscle fat oxidation, affects body fat.</p>Formula:C18H21Cl2NO2Purity:98%Color and Shape:SolidMolecular weight:354.27(2S,4S)-Sacubitril
CAS:<p>(2S,4S)-Sacubitril (Sacubitril Impurity C) is a stereoisomer derived from Sacubitril which is a potent NEP inhibitor.</p>Formula:C24H29NO5Purity:98%Color and Shape:SolidMolecular weight:411.49PENAO
CAS:<p>PENAO is a potent mitochondrial toxin for tumor cells. It deactivates the mitochondria of tumor cells by targeting the adenine nucleotide translocase in the cell membrane.</p>Formula:C13H19AsN2O5SColor and Shape:SolidMolecular weight:390.29SMase-IN-1
CAS:<p>SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase (SMase) inhibitor with an IC50 value of 6.43 µM against Bacillus cereus SMase. It also inhibits eqBuChE with an inhibition rate of 59.50% at a concentration of 50 µM. SMase-IN-1 forms a complex with Cu2+ through bio-metal interactions and can inhibit hemolysis of sheep red blood cells induced by Bacillus cereus.</p>Formula:C8H5ClN2OSColor and Shape:SolidMolecular weight:212.6568-Hydroxychlorpromazine
CAS:<p>8-Hydroxychlorpromazine is a metabolite of Chlorpromazine that can enhance the hyperglycemic response following glucose loading, suggesting a possible synergistic role in Chlorpromazine-induced glucose metabolism disorders. It holds potential for research into metabolic diseases.</p>Formula:C17H19ClN2OSColor and Shape:SolidMolecular weight:334.864PDE4-IN-6
<p>PDE4-IN-6: Potent PDE4 inhibitor, IC50 - 0.125μM (B), 0.43μM (D), anti-inflammatory, for arthritis research.</p>Formula:C25H20FNO5SColor and Shape:SolidMolecular weight:465.49MDL-100240
CAS:<p>MDL-100240 inhibits ACE/neprilysin, effective against hypertension-induced heart/vascular changes.</p>Formula:C26H28N2O5SPurity:98%Color and Shape:SolidMolecular weight:480.58
