Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(196 products)
- Casein Kinase(138 products)
- DHFR(30 products)
- Decarboxylase(4 products)
- Dehydrogenase(301 products)
- FAAH(64 products)
- FXR(62 products)
- Factor Xa(85 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(226 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(57 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(34 products)
- Hydroxylase(36 products)
- IDO(84 products)
- LDL(7 products)
- Lipase(107 products)
- Lipid(61 products)
- Lipoxygenase(133 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(169 products)
- PED(1 products)
- PKM(17 products)
- PPAR(170 products)
- Phospholipase(86 products)
- ROR(47 products)
- Retinoid Receptor(20 products)
- SGK(10 products)
- Thioredoxin(12 products)
- Transferase(29 products)
- Transporter(44 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9154 products of "Metabolism"
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UGT1A1-IN-1
CAS:UGT1A1-IN-1 (compound 2) acts as a non-competitive inhibitor of UGT1A1, effectively inhibiting the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. This compound binds to the same ligand-binding site on UGT1A1 as bilirubin and additionally functions as a 'turn-on' fluorescent probe substrate for UGT1A1 [1].Formula:C22H19NO3Color and Shape:SolidMolecular weight:345.39DC360
CAS:DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.
Formula:C23H23NO2Color and Shape:SolidMolecular weight:345.434Xanthosine-5'-monophosphate
CAS:Xanthosine 5'-monophosphate is produced from inosine monophosphate (IMP) through the catalytic action of inosine monophosphate dehydrogenase (IMPDH).Formula:C10H13N4O9PColor and Shape:SolidMolecular weight:364.21Z57346765
CAS:Z57346765 is a specific PGK1 inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis.Formula:C17H18N4OPurity:99.85%Color and Shape:SolidMolecular weight:294.35PRL3-CNNM4 interaction-IN-1
CAS:PRL3-CNNM4 interaction-IN-1 (Compound C28d52) is an inhibitor of the PRL3-CNNM4 interaction that also suppresses CNNM inhibition mediated by PRL. This compound exhibits favorable pharmacokinetic and drug metabolism properties.Formula:C8H8O2SColor and Shape:SolidMolecular weight:168.21m-APTA
CAS:m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP). It can be converted into adenine, which is a crucial step in shielding normal cells from the toxicity of nucleobase analogs (NBA). m-APTA holds potential for research in MTAP-deficient cancers.Formula:C16H18N6O3SColor and Shape:SolidMolecular weight:374.418Canosimibe
CAS:Canosimibe is a cholesterol absorption inhibitorFormula:C44H60FN3O10Color and Shape:SolidMolecular weight:809.96LTA4H-IN-3
CAS:LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].Formula:C17H15ClN4O3Color and Shape:SolidMolecular weight:358.78Epoxykynin
CAS:Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].Formula:C19H20BrF3N2O2Color and Shape:SolidMolecular weight:445.27Resolvin E4
CAS:RvE4, a bioactive lipid from eicosapentaenoic acid and synthesized by 15-LO, is anti-inflammatory and boosts efferocytosis in human macrophages.Formula:C20H30O4Color and Shape:SolidMolecular weight:334.454-Acetylphenylboronic acid
CAS:4-Acetylphenylboronic acid acts as an effective inhibitor targeting carbonic anhydrase II (CAII), displaying inhibitory concentrations (IC50) of 246 μM for bovine CAII (bCA II) and 281.40 μM for human CAII (hCA II).Formula:C8H9BO3Color and Shape:SolidMolecular weight:163.97Ro 31-8472
CAS:Ro 31-8472 is an angiotensin-converting enzyme (ACE) inhibitor and an analog of cilazaprilat.Formula:C20H27N3O6Purity:98%Color and Shape:SolidMolecular weight:405.44Nsp12-IN-2
CAS:Nsp12-IN-2 (Compound 8), a triphosphate metabolite of 4'-thiouridine, functions as an inhibitor of SARS-CoV-2 Nsp12. It effectively suppresses the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, halting RNA synthesis and blocking the RNA capping and NMP capping of Nsp9. Nsp12-IN-2 shows potential for research into infections caused by SARS-CoV-2, other coronaviruses, and additional RNA viruses.Formula:C9H12N2Na3O14P3SColor and Shape:SolidMolecular weight:566.15HSD17B13-IN-19
CAS:HSD17B13-IN-19 (compound 16) acts as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values under 0.1 μM and under 1 μM when using estradiol and Leukotriene B3 as substrates, respectively. This compound is crucial in the treatment of nonalcoholic fatty liver diseases (NAFLDs), such as nonalcoholic steatohepatitis (NASH) [1].Formula:C23H23FN2O4SColor and Shape:SolidMolecular weight:442.5LTA4H-IN-2
CAS:LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].Formula:C20H19FN6O2Color and Shape:SolidMolecular weight:394.4CGS 24592
CAS:CGS-24592 is an orally active, selective, and potent inhibitor of neutral endopeptidase 24.11 (NEP), with an IC50 value of 1.6 nmol/L. It reduces the degradation of atrial natriuretic peptide (ANP), thereby increasing plasma ANP concentration and lowering blood pressure. CGS-24592 shows potential for research in cardiovascular diseases such as hypertension and congestive heart failure.Formula:C19H23N2O6PColor and Shape:SolidMolecular weight:406.37Bestatin methyl ester
CAS:Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.Formula:C17H26N2O4Color and Shape:SolidMolecular weight:322.4HSD17B13-IN-17
CAS:HSD17B13-IN-17 (compound 9) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). It demonstrates inhibitory efficacy with IC50 values of ＜0.1 μM for estradiol and ＜1 μM for Leukotriene B3 as substrates. This compound is significant in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formula:C20H16ClFN2O3SColor and Shape:SolidMolecular weight:418.87HSD17B13-IN-28
CAS:HSD17B13-IN-28 (compound 47) is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with an IC50 of < 0.1 μM using estradiol as a substrate. HSD17B13-IN-28 plays an important role in nonalcoholic fatty liver diseases (NAFLDs), including NASH (nonalcoholic steatohepatitis) [1].Formula:C23H16Cl2FN3O3Color and Shape:SolidMolecular weight:472.3YM-355179
CAS:YM-355179 is a novel, selective antagonist of CC chemokine receptor 3 with oral activity.Formula:C33H34FN4O7Purity:98%Color and Shape:SolidMolecular weight:617.64MCTR3
CAS:MCTR3, derived from DHA via maresin 1 in macrophages, hastens tissue healing and reduces inflammation and eicosanoids post-E. coli infection in mice.Formula:C25H37NO5SColor and Shape:SolidMolecular weight:463.637(Z),11(Z)-Nonacosadiene
CAS:7(Z),11(Z)-Nonacosadiene, a female fly pheromone, spurs male courtship; it's a C29 diene made by a female-specific elongase.Formula:C29H56Color and Shape:SolidMolecular weight:404.75PKR-IN-1
CAS:PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).Formula:C9HCl5N4OS2Color and Shape:SolidMolecular weight:422.525HIF-2α-IN-7
CAS:HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.Formula:C18H9F6NO2Color and Shape:SolidMolecular weight:385.26FXIa-IN-8
FXIa-IN-8: potent FXIa blocker (IC50: 14.2 nM), anti-thrombotic, low bleeding/toxicity risk.Color and Shape:SolidPefcalcitol
CAS:Pefcalcitol is a novel antipsoriatic prodrug candidate containing a 16-en-22-oxa-vitamin D3 structure.Formula:C26H34F5NO4Color and Shape:SolidMolecular weight:519.54Lp-PLA2-IN-5
CAS:Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.Formula:C23H18F5N3O4Color and Shape:SolidMolecular weight:495.4Hcyb1
Hcyb1 specifically inhibits PDE2A with 0.57 μM IC50, over 250x selective, and has neuroprotective and antidepressant effects.Formula:C24H20N4OColor and Shape:SolidMolecular weight:380.44MolPort-010-778-422
CAS:MolPort-010-778-422 is a high-affinity inhibitor targeting the ACE2 receptor of the SARS-CoV-2 virus. It demonstrates remarkable antiviral activity with an IC50 of 8.9 nM and holds promise for use in studies related to SARS-CoV-2.Formula:C20H26N2O3S2Color and Shape:SolidMolecular weight:406.56α-Glucosidase-IN-14
α-Glucosidase-IN-14 is a potent inhibitor of α-glucosidase (IC50: 5.22 μM).Formula:C24H27N5O4S2Color and Shape:SolidMolecular weight:513.63FXIa-IN-6
CAS:FXIa-IN-6: Potent, selective FXIa inhibitor (Ki=0.3 nM); strong PK with high oral bioavailability, low clearance preclinically.Formula:C31H29ClF2N4O4Color and Shape:SolidMolecular weight:595.04Vimirogant hydrochloride
Vimirogant (VTP-43742) HCl: Oral, selective RORγt inhibitor (IC50: 17 nM, Ki: 3.5 nM), >1000x selectivity over RORα/β, targets Th17, not Th1/2/Treg.Formula:C27H36ClF3N4O3SColor and Shape:SolidMolecular weight:588.21487AZ-PFKFB3-67 quarterhydrate
AZ-PFKFB3-67 quarterhydrate inhibits PFKFB3 (IC50: 11 nM), PFKFB2 (159 nM), and PFKFB1 (1130 nM).Formula:C26H27N5O4Color and Shape:SolidMolecular weight:460.01hDHODH-IN-10
hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.Formula:C21H15ClF4N2O4Color and Shape:SolidMolecular weight:470.8hMAO-B/MB-COMT-IN-1
Dual hMAO-B/MB-COMT inhibitor, IC50: 2.5 μΜ (hMAO-B), 3.84 μΜ (MB-COMT); potential in Parkinson's research.Formula:C16H19NO3Color and Shape:SolidMolecular weight:273.33Dibutyl phosphate
CAS:Dibutyl phosphate (DBUP) is a metabolite of organophosphate esters (OPEs) found in urine. The presence of dibutyl phosphate is positively correlated with an increased risk of sarcopenia.Formula:C8H19O4PColor and Shape:SolidMolecular weight:210.21GJG057
CAS:GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.Formula:C21H21F5N4O2Purity:99.8%Color and Shape:SolidMolecular weight:456.41CAII-IN-1
CAII-IN-1 (3n) is a selective bovine CA-II inhibitor with 10.3 μM IC50, used in carbonic anhydrase disorder studies.Formula:C19H21FN4SColor and Shape:SolidMolecular weight:356.46IDO1-IN-25
CAS:IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.Formula:C14H8Cl3NO2SColor and Shape:SolidMolecular weight:360.642R,4R-Sacubitril
CAS:2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.Formula:C24H29NO5Purity:98%Color and Shape:SolidMolecular weight:411.49GNTI TFA
CAS:GNTI TFA is a selective kappa opioid receptor antagonist.Formula:C31H31F6N5O7Color and Shape:SolidMolecular weight:699.607-Hydroxy-4-phenylcoumarin
CAS:7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.Formula:C15H10O3Color and Shape:SolidMolecular weight:238.238Squalestatin 3
CAS:Squalestatin 3 is an inhibitor of squalene synthase.Formula:C25H30O13Purity:98%Color and Shape:SolidMolecular weight:538.5β-Glucuronidase/hCAII-IN-1
CAS:β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50Formula:C30H21NO9Color and Shape:SolidMolecular weight:539.49Lunacalcipol
CAS:Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism.Formula:C28H42O4SColor and Shape:SolidMolecular weight:474.7Carbonic anhydrase inhibitor 10
CA inhibitor 10 targets MCF-7 cells, IC50: 11.9 μM; potent h CA IX inhibitor, Ki: 6.2 nM. Anti-cancer research.Formula:C14H17N5O3SColor and Shape:SolidMolecular weight:335.38GT-02216
CAS:GT-02216 is capable of binding allosterically to GCase, thereby enhancing its function. In primary human fibroblasts, it increases GCase activity and decreases Tau accumulation in mutant GBA1 fibroblasts. Additionally, GT-02216 offers protection to hippocampal primary neurons exposed to Tau oligomer in a rat model.Formula:C22H23N5O2Color and Shape:SolidMolecular weight:389.45RXR antagonist 1
RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.Formula:C28H33F3N2O3Color and Shape:SolidMolecular weight:502.57BAY 3389934
CAS:BAY 3389934 is a dual inhibitor of factor IIa (factor IIa) and factor Xa (factor Xa), providing anticoagulant and organ-protective effects. It alleviates coagulopathy and organ dysfunction in baboon models of Staphylococcus aureus sepsis.Formula:C26H30ClN5O7S2Color and Shape:SolidMolecular weight:624.129sEH inhibitor-2
SEH inhibitor-2 is an orally active sEH blocker (IC50=0.9 nM) with predicted 71.2-88.4% absorption, potentially aiding cardiovascular health.Formula:C23H18N4O3Color and Shape:SolidMolecular weight:398.41
