Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(196 products)
- Casein Kinase(138 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(301 products)
- FAAH(64 products)
- FXR(62 products)
- Factor Xa(85 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(226 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(57 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(34 products)
- Hydroxylase(36 products)
- IDO(84 products)
- LDL(7 products)
- Lipase(107 products)
- Lipid(61 products)
- Lipoxygenase(133 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(169 products)
- PED(1 products)
- PKM(17 products)
- PPAR(170 products)
- Phospholipase(86 products)
- ROR(47 products)
- Retinoid Receptor(21 products)
- SGK(10 products)
- Thioredoxin(12 products)
- Transferase(29 products)
- Transporter(44 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9162 products of "Metabolism"
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Casein kinase 1δ-IN-26
CAS:Casein kinase1δ-IN-26 (compound 505) is a potent inhibitor of casein kinase 1δ. This compound is applicable in research related to neurodegenerative disorders such as Alzheimer’s disease.
Formula:C16H13N3O4SColor and Shape:SolidMolecular weight:343.357RORγt inverse agonist 34
CAS:RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.Formula:C31H37N3O3SColor and Shape:SolidMolecular weight:531.709Carboxylesterase-IN-4
CAS:Carboxylesterase-IN-4 (compound 3e) is a potent inhibitor of carboxylesterase, with an IC50 of 1.58 nM. It is utilized in research related to cholesterolemia.Formula:C19H19O7PColor and Shape:SolidMolecular weight:390.32RORγt/DHODH-IN-1
CAS:RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significantFormula:C24H26ClF6N3O3SColor and Shape:SolidMolecular weight:585.99SHP2-IN-43
CAS:SHP2-IN-43 (Compound 5) is an SHP2 inhibitor with an IC50 of 98.7 nM. It can be used as a PROTAC target protein ligand in the synthesis of SHP2-D26.Formula:C18H23ClN6OSColor and Shape:SolidMolecular weight:406.93α-Glucosidase-IN-19
Alpha-Glucosidase-IN-19 (Compound 6B) is an orally active alpha-glucosidase inhibitor (IC50: 3.63 μM) with antidiabetic effects.Formula:C31H25NOSColor and Shape:SolidMolecular weight:459.6Clopidogrel-β-D-glucuronide
CAS:Clopidogrel-β-D-glucuronide is a metabolite of Clopidogrel. It directly interacts with the CYP2C8 enzyme and strongly inhibits the hepatic enzyme CYP2C8.Formula:C21H22ClNO8SColor and Shape:SolidMolecular weight:483.919Desmonomethylpromazine
CAS:Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.Formula:C16H18N2SColor and Shape:SolidMolecular weight:270.39CHI3L1-IN-2
CAS:CHI3L1-IN-2 (Compound 36), a potent inhibitor of CHI3L1 (YKL-40), effectively blocks the interaction between CHI3L1 and heparan sulfate (CHI3L1:HSIII), demonstrating an IC 50 of 26 nM [1].Formula:C26H37ClN4Molecular weight:441.05MGAT2-IN-1
CAS:MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).Formula:C27H21ClF5N7O3SColor and Shape:SolidMolecular weight:654.01Rostratin B
CAS:Rostratin B, a cytotoxic disulfide, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an IC50 value of 1.9 μg/mL.Formula:C18H20N2O6S2Color and Shape:SolidMolecular weight:424.49AChE/PDE4-IN-1
AChE/PDE4-IN-1, compound 12c, dual inhibitor; IC50: 0.28μM for AChE, 1.88μM for PDE4D, may reduce Alzheimer's neuroinflammation.Formula:C23H28N2O3Color and Shape:SolidMolecular weight:380.48Zolpyridine
CAS:Zolpyridine is a degradation product of Zolpidem tartrate.Formula:C14H14N2OColor and Shape:SolidMolecular weight:226.27hCAII-IN-5
CAS:hCAII-IN-5 (compound 12h) is a potent, selective inhibitor of human carbonic anhydrase II (hCA II) with an inhibition constant (IC50) of 4.55 µM [1].Formula:C29H18N2O7Color and Shape:SolidMolecular weight:506.46CYP121A1-IN-1
CYP121A1-IN-1: Strong inhibitor for CYP121A1, hinders Mycobacterium tuberculosis growth (MIC 90 ~6.25 μM), reduces mycocyclosin synthesis.Formula:C22H20N4OColor and Shape:SolidMolecular weight:356.42Pyripyropene A
CAS:Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM).Formula:C31H37NO10Purity:98%Color and Shape:SolidMolecular weight:583.63BMS-986339
CAS:BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.Formula:C35H41F4N3O4Color and Shape:SolidMolecular weight:643.71α-Glucosidase-IN-12
α-Glucosidase-IN-12 is a potent inhibitor of α-glucosidase (IC50: 10.20 μM).Formula:C25H30N4O4S2Color and Shape:SolidMolecular weight:514.66EGFR/VEGFR2-IN-2
EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.Formula:C24H15FO3Color and Shape:SolidMolecular weight:370.37PPI-2458
CAS:PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.Formula:C22H36N2O6Color and Shape:SolidMolecular weight:424.53hCA VB-IN-1
hCA VB-IN-1 (compound 15) is a potent and selective inhibitor of hCA VB (carbonic anhydrase) with a KI of 515.7 nM [1].Formula:C9H13N3O4SColor and Shape:SolidMolecular weight:259.28FXIa-IN-9
CAS:FXIa-IN-9, a potent FXIa inhibitor (K i : human 0.17 nM, rabbit 0.5 nM), forms hydrogen bonds and has anticoagulant properties.Formula:C23H18Cl2F3N9O2Color and Shape:SolidMolecular weight:580.35Ceftolozane TFA
CAS:Ceftolozane TFA is a cephalosporin class antibiotic (antibiotic) designed to inhibit Gram-negative bacterial infections. Additionally, it can be utilized in the synthesis of novel antibiotics (antibiotic) that are more efficacious and safer.Formula:C25H31F3N12O10S2Color and Shape:SolidMolecular weight:780.71Raloxifene N-Oxide
CAS:Raloxifene N-Oxide is a Raloxifene oxidative degradation product.Formula:C28H27NO5SPurity:98%Color and Shape:SolidMolecular weight:489.58Miaosporone A
Miaosporone A: angucyclic quinone, cytotoxic to MCF-7, NCI-H187, Vero cells; anti-TB and anti-malaria with IC50 of 2.4 μM, 2.5 μM.Formula:C19H18O5Color and Shape:SolidMolecular weight:326.34Monoamine oxidase/Aromatase-IN-1
Compound 2q: Dual MAO/aromatase inhibitor; IC50: 39 nM (MAO-B), 31 nM (aromatase). Useful in neurological/breast cancer research.Formula:C19H19N3O3SColor and Shape:SolidMolecular weight:369.44COTC
CAS:COTC is an anticancer bacterial metabolite; inhibits glyoxalase with GSH, halts HeLa cell growth, and fights tumor in Ehrlich murine model.Formula:C11H14O6Color and Shape:SolidMolecular weight:242.23L-690330 hydrate
L-690330 hydrate inhibits IMPase; Ki: 0.30 μM (human), 0.42 μM (bovine cortex); 0.27 μM (recom. human), 0.19 μM (bovine).Formula:C8H14O9P2Color and Shape:SolidMolecular weight:316.14Carbonic anhydrase inhibitor 9
Carbonic anhydrase inhibitor 9 targets hCA II and IX with Ki of 56.4 and 56.9 nM respectively; shows antiproliferative activity.Formula:C22H20BrN5O4SColor and Shape:SolidMolecular weight:530.39Mitapivat hydrochloride
CAS:Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Formula:C24H27ClN4O3SColor and Shape:SolidMolecular weight:487.014L-Sepiapterin
CAS:L-Sepiapterin aids in making BH4, a coenzyme essential for eNOS, enhancing artery function and angiogenesis, while suppressing ovarian cancer cell growth.Formula:C9H11N5O3Color and Shape:SolidMolecular weight:237.22Methyl dotriacontanoate
CAS:Methyl dotriacontanoate (C32:0 FAME; Lacceric acid methyl ester) is a naturally occurring fatty acid methyl ester found in the cuticular wax of P. abies needles. It is also present in sediment samples from the Suwannee River in Florida and Lake Kivu in the East African Rift.Formula:C33H66O2Molecular weight:494.88FAAH/MAGL-IN-2
CAS:FAAH/MAGL-IN-2: potent, reversible, oral FAAH & MAGL inhibitor, IC50: 11/36 nM, may research neuropathic pain, no locomotion issue.Formula:C15H13Cl2N3O3SColor and Shape:SolidMolecular weight:386.25PDHK-IN-5
PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.Formula:C30H31N5O2Color and Shape:SolidMolecular weight:493.6RORγt inverse agonist 29
RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.Formula:C25H24N2O5SColor and Shape:SolidMolecular weight:464.53P053
CAS:P053: potent, selective CerS1 inhibitor, IC50 = 0.5µM, curbs muscle fat oxidation, affects body fat.Formula:C18H21Cl2NO2Purity:98%Color and Shape:SolidMolecular weight:354.27Myxothiazol
CAS:Myxothiazol blocks mitochondrial complex III and triggers SESN2, a gene important for stress response.Formula:C25H33N3O3S2Color and Shape:SolidMolecular weight:487.68PDE4-IN-12
PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).Formula:C34H35NO6Color and Shape:SolidMolecular weight:553.64PKM2-IN-9
CAS:PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.Formula:C24H22N4O2Color and Shape:SolidMolecular weight:398.457Carbonic anhydrase inhibitor 4
CA inhibitor 4, photoprobe; targets hCA I-XIV; Ki: 640-1166 nM.Formula:C21H18N2O4SColor and Shape:SolidMolecular weight:394.442-Deoxokanshone M
CAS:2-Deoxokanshone M (Nardosinone acid), a degradation product of Nardosinone, exhibits potent vasodilatory activity.Formula:C12H16O2Color and Shape:SolidMolecular weight:192.25Darlifarnib
CAS:Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.Formula:C29H20N6OColor and Shape:SolidMolecular weight:468.509L 671776
CAS:L 671776 is an inositol monophosphatase inhibitor.Formula:C23H32O5Purity:98%Color and Shape:SolidMolecular weight:388.5Enpp-1-IN-11
Enpp-1-IN-11 inhibits ENPP1 with a 45 nM Ki, is plasma stable, and has low clearance in human/mouse livers, potentially aiding cancer research.Formula:C15H15N5O3SColor and Shape:SolidMolecular weight:345.38(±)-HIP-B
CAS:(±)-HIP-B is an excitatory amino acid transporter blocker.Formula:C6H8N2O4Purity:98%Color and Shape:SolidMolecular weight:172.14TMX-4116
CAS:TMX-4116 is a CK1α degrader targeting multiple cell lines with DC50s below 200 nM, used in multiple myeloma research and protein degradation strategy studies.Formula:C17H19N5O4SColor and Shape:SolidMolecular weight:389.43CYP2C1/CYP2C19-IN-2
CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.Formula:C27H28N2O6SColor and Shape:SolidMolecular weight:508.59NAZ2329
CAS:NAZ2329: Cell-permeable, targets R5 RPTPs, inhibits hPTPRZ1 (IC50=7.5 μM) & hPTPRG (IC50=4.8 μM), hampers glioblastoma growth, affects stem cell traits.Formula:C21H18F3NO4S3Color and Shape:SoildMolecular weight:501.56ABD957
CAS:ABD957: covalent ABHD17 depalmitoylases inhibitor, IC50 0.21µM for ABHD17B, blocks N-Ras, halts NRAS-mutant AML cell growth.Formula:C27H36F3N7O5SColor and Shape:SolidMolecular weight:627.68Carbonic anhydrase inhibitor 5
Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.Formula:C24H20ClN3O3SColor and Shape:SolidMolecular weight:465.95
