Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(196 products)
- Casein Kinase(138 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(302 products)
- FAAH(64 products)
- FXR(62 products)
- Factor Xa(85 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(226 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(57 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(34 products)
- Hydroxylase(36 products)
- IDO(84 products)
- LDL(7 products)
- Lipase(107 products)
- Lipid(61 products)
- Lipoxygenase(134 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(169 products)
- PED(1 products)
- PKM(17 products)
- PPAR(170 products)
- Phospholipase(86 products)
- ROR(47 products)
- Retinoid Receptor(22 products)
- SGK(10 products)
- Thioredoxin(12 products)
- Transferase(29 products)
- Transporter(45 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9185 products of "Metabolism"
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BAY 3389934
CAS:BAY 3389934 is a dual inhibitor of factor IIa (factor IIa) and factor Xa (factor Xa), providing anticoagulant and organ-protective effects. It alleviates coagulopathy and organ dysfunction in baboon models of Staphylococcus aureus sepsis.Formula:C26H30ClN5O7S2Color and Shape:SolidMolecular weight:624.129FXIa-6f
CAS:FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical speciesFormula:C31H29ClF2N4O4Color and Shape:SolidMolecular weight:595.04α-Glucosidase-IN-17
CAS:α-Glucosidase-IN-17 (Compound 12B) is a potent and orally active inhibitor of α-glucosidase, demonstrating antidiabetic activity with an inhibitoryFormula:C30H27NO2SColor and Shape:SolidMolecular weight:465.61RMGPa-IN-1
CAS:RMGPa-IN-1 (Compound 10C) is an inhibitor of rabbit muscle glycogen phosphorylase a (RMGPa), exhibiting an IC50 value of 82.5 μM. This compound holds potential for research in diabetes.Formula:C33H54O4Color and Shape:SolidMolecular weight:514.779PENAO
CAS:PENAO is a potent mitochondrial toxin for tumor cells. It deactivates the mitochondria of tumor cells by targeting the adenine nucleotide translocase in the cell membrane.Formula:C13H19AsN2O5SColor and Shape:SolidMolecular weight:390.29Beloranib
CAS:Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.Formula:C29H41NO6Purity:98%Color and Shape:SolidMolecular weight:499.64SHP2 IN-1
CAS:SHP2 IN-1 is an allergic SHP2 (PTPN11) inhibitor(IC50 : 3 nM).Formula:C18H22Cl2N6OSPurity:98%Color and Shape:SolidMolecular weight:441.38Lp(a)-IN-7
CAS:Lp(a)-IN-7 (example 1) is an inhibitor of lipoprotein (a) [Lp(a)] formation, exhibiting an IC50 of 2.51 nM in media containing apolipoprotein B (apoB) and apolipoprotein (a). This compound is applicable in cardiovascular disease research.Formula:C20H30Cl2N2O4Color and Shape:SolidMolecular weight:433.369(±)-HIP-B
CAS:(±)-HIP-B is an excitatory amino acid transporter blocker.Formula:C6H8N2O4Purity:98%Color and Shape:SolidMolecular weight:172.14L 671776
CAS:L 671776 is an inositol monophosphatase inhibitor.Formula:C23H32O5Purity:98%Color and Shape:SolidMolecular weight:388.5Carbonic anhydrase inhibitor 4
CA inhibitor 4, photoprobe; targets hCA I-XIV; Ki: 640-1166 nM.Formula:C21H18N2O4SColor and Shape:SolidMolecular weight:394.44MAFP
CAS:MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.Formula:C21H36FO2PColor and Shape:SolidMolecular weight:370.48P053
CAS:P053: potent, selective CerS1 inhibitor, IC50 = 0.5µM, curbs muscle fat oxidation, affects body fat.
Formula:C18H21Cl2NO2Purity:98%Color and Shape:SolidMolecular weight:354.27PDHK-IN-5
PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.Formula:C30H31N5O2Color and Shape:SolidMolecular weight:493.6DS44470011
CAS:DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.Formula:C21H19N3O4Color and Shape:SolidMolecular weight:377.39L-690330 hydrate
L-690330 hydrate inhibits IMPase; Ki: 0.30 μM (human), 0.42 μM (bovine cortex); 0.27 μM (recom. human), 0.19 μM (bovine).Formula:C8H14O9P2Color and Shape:SolidMolecular weight:316.14Monoamine oxidase/Aromatase-IN-1
Compound 2q: Dual MAO/aromatase inhibitor; IC50: 39 nM (MAO-B), 31 nM (aromatase). Useful in neurological/breast cancer research.Formula:C19H19N3O3SColor and Shape:SolidMolecular weight:369.44ATX inhibitor 12
Oral ATX inhibitor 12 (IC50: 1.72 nM) at 60 mg/kg prevents lung damage in C57Bl/6J mice.
Formula:C30H34FN5O2Color and Shape:SolidMolecular weight:515.62HIF-1α-IN-5
HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.Formula:C16H15N3O2Color and Shape:SolidMolecular weight:281.31GPX4-IN-15
CAS:GPX4-IN-15 (Compound C1) is an inhibitor of GPX4, demonstrating an inhibition rate of 19.8% at a concentration of 1 μM. This compound effectively inhibits the proliferation of cancer cell lines MDA-MB-468, BT-549, and MDA-MB-231, with IC50 values of 0.86 μM, 0.96 μM, and 0.48 μM respectively.Formula:C17H15Cl2NO4Color and Shape:SolidMolecular weight:368.21LTA4H-IN-3
CAS:LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].Formula:C17H15ClN4O3Color and Shape:SolidMolecular weight:358.78WR 199507 trihydrobromide
CAS:WR 199507 trihydrobromide is a primary aminoquinoline metabolite that induces the formation of methemoglobin in canine erythrocyte lysates.Formula:C15H24Br3N3O2Color and Shape:SolidMolecular weight:518.08Perfluorohexane sulfonamide
CAS:Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.Formula:C6H2F13NO2SColor and Shape:SolidMolecular weight:399.13KY-455
CAS:KY-455 is a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. It demonstrates inhibition of ACAT in rabbit intestines, liver, macrophages, and adrenal glands with IC50 values of 0.4, 0.9, 2.9, and 4.1 μmol/L, respectively.Formula:C20H32N2OColor and Shape:SolidMolecular weight:316.48FXR agonist 9
CAS:FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.Formula:C28H30N2O5Color and Shape:SolidMolecular weight:474.55MAGL-IN-20
MAGL-IN-20 (compound ±34) is a reversible inhibitor of monoacylglycerol lipase (MAGL). It exhibits significant antiproliferative activity against a range of cancer cell lines, including H460, HT29, CT-26, Huh7, and HCCLM-3.Formula:C23H24N2OColor and Shape:SolidMolecular weight:344.45LU 2443
CAS:LU 2443 is an orally active antiepileptic agent that is extensively absorbed, with up to 18% remaining unabsorbed in rats. The active half-life in plasma is 13.17 hours.Formula:C9H8N2S2Color and Shape:SolidMolecular weight:208.3FTI 276 TFA
CAS:FTI 276 TFA targets plasmodium falciparum & humans, inhibits PFT with IC50s: 0.9 nM (parasite) & 0.5 nM (human).Formula:C23H28F3N3O5S2Color and Shape:SolidMolecular weight:547.61Antidiabetic agent 5
CAS:Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].Formula:C17H15N3O4SColor and Shape:SolidMolecular weight:357.38Porphobilinogen
CAS:Porphobilinogen act as a phytotoxin, a metabotoxin, and a neurotoxin.Formula:C10H14N2O4Purity:98%Color and Shape:SolidMolecular weight:226.23TS010
TS010 is a highly potent inhibitor of GLO-I, with an IC50 value of 0.57 μM. It holds significant promise for advancements in cancer research [1].Formula:C16H12N4O4SColor and Shape:SolidMolecular weight:356.36Diacylglycerol acyltransferase inhibitor-2
CAS:Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.Formula:C21H20FN5O4Color and Shape:SolidMolecular weight:425.41MAGL-IN-18
CAS:MAGL-IN-18 (compound 118) serves as a highly potent inhibitor of Monoacylglycerol lipase (MAGL), demonstrating an IC 50 value of 0.03nM.Formula:C23H28F3N7OColor and Shape:SolidMolecular weight:475.51h15-LOX-2 inhibitor 3
CAS:Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.Formula:C22H13N5O3Color and Shape:SolidMolecular weight:395.37SelB-1
CAS:SelB-1 acts as a dual inhibitor of Topoisomerase I/II (TopoisomeraseI/II), exhibiting anticancer activity suitable for research on prostate and colon cancers. Additionally, SelB-1 can induce the expression of autophagy (autophagy) genes and lipid peroxidation while reducing GSH levels.Formula:C32H24O5Color and Shape:SolidMolecular weight:488.53DX-9065A HCl hydrate
CAS:DX-9065a: Competitive fXa/prothrombinase inhibitor; blocks proinflammatory events; Ki ~10-20 nM.Formula:C26H39ClN4O8Purity:98%Color and Shape:SolidMolecular weight:571.06MK-3168 (12C)
CAS:MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.Formula:C21H21ClN4OSColor and Shape:SolidMolecular weight:412.94Urobilin hydrochloride
CAS:Urobilin hydrochloride, a metabolic byproduct of Hemoglobin, is excreted through urine and feces in various mammals. It also serves as an indicator of human waste contamination.Formula:C33H43ClN4O6Color and Shape:SolidMolecular weight:627.17RWJ 22108
CAS:RWJ 22108 is a bronchial-selective calcium channel (calcium channel) blocker that exhibits an IC50 of 5.7 nM in dog bronchial smooth muscle calcium-dependent contractions.Formula:C27H30ClFN2O4SColor and Shape:SolidMolecular weight:533.06IDO1-IN-25
CAS:IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.Formula:C14H8Cl3NO2SColor and Shape:SolidMolecular weight:360.646′SLN
CAS:6′SLN is a characteristic glycan found on the surface of cancer-related extracellular vesicles (EVs) and serves as the primary form of protein glycosylation within EVs. Additionally, 6′SLN, a derivative of sialic acid, interacts with hemagglutinins (HAs) from both human and avian influenza strains, making it relevant in the study of anti-influenza drugs.Formula:C25H42N2O19Color and Shape:SolidMolecular weight:674.65-LOX/MAOs-IN-1
CAS:Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.Formula:C18H18N2O2Color and Shape:SolidMolecular weight:294.35D-Citrulline
CAS:D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.Formula:C6H13N3O3Color and Shape:SolidMolecular weight:175.19DDO-3733
CAS:DDO-3733 is a conformational activator of Protein Phosphatase 5 (PP5) that functions independently of TRP, facilitating the dephosphorylation of downstream substrates.Formula:C10H6F2N2OSColor and Shape:SolidMolecular weight:240.23Etiocholanolone glucuronide
CAS:Etiocholanolone glucuronide (Etio-G) is a metabolite of Etiocholanolone, produced through the catalysis by UDP glucuronosyltransferase in the liver. Etiocholanolone glucuronide shows potential for research in metabolic-related diseases.Formula:C25H38O8Color and Shape:SolidMolecular weight:466.564GlcCer (d18:1/18:0)
CAS:GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a sphingolipid with potential applications in research on Parkinson's disease and Lewy body dementia.Formula:C42H81NO8Color and Shape:SolidMolecular weight:728.094α-Amylase/α-Glucosidase-IN-19
CAS:α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase and α-glucosidase, with an IC50 of 170.7 μM and 60.37 μM, respectively.Formula:C17H14BrClN2OColor and Shape:SolidMolecular weight:377.663Dihydrokainic acid
CAS:EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptakeFormula:C10H17NO4Purity:98%Color and Shape:SolidMolecular weight:215.25Mitochondrial-IN-1
CAS:Mitochondrial-IN (C458) is a potent inhibitor of mitochondrial complex I. It offers significant protection against Aβ toxicity, exhibits favorable pharmacokinetic properties, and has minimal off-target effects.Formula:C22H30N2OColor and Shape:SolidMolecular weight:338.49hCAII-IN-4
CAS:hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.Formula:C31H23NO9Color and Shape:SolidMolecular weight:553.52
