Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(195 products)
- Casein Kinase(137 products)
- DHFR(34 products)
- Decarboxylase(4 products)
- Dehydrogenase(302 products)
- FAAH(66 products)
- FXR(62 products)
- Factor Xa(87 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(226 products)
- GR(3 products)
- GSNOR(4 products)
- Glucokinase(57 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(33 products)
- Hydroxylase(35 products)
- IDO(84 products)
- LDL(8 products)
- Lipase(107 products)
- Lipid(61 products)
- Lipoxygenase(134 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(167 products)
- PED(1 products)
- PKM(17 products)
- PPAR(169 products)
- Phospholipase(83 products)
- ROR(47 products)
- Retinoid Receptor(28 products)
- SGK(11 products)
- Thioredoxin(12 products)
- Transferase(29 products)
- Transporter(46 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9274 products of "Metabolism"
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Docosapentaenoic acid (22n-3) sodium
CAS:Docosapentaenoic acid (22n-3) sodium is a component of phospholipids. It exhibits inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 17 μg/mL and 22 μg/mL, respectively. Additionally, Docosapentaenoic acid 22n-3 sodium enhances cell viability and has mild anti-inflammatory effects.Formula:C22H34NaO2Color and Shape:SolidMolecular weight:353.494NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Formula:C17H21N5O3SColor and Shape:SolidMolecular weight:375.45Antidiabetic agent 5
CAS:Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].Formula:C17H15N3O4SColor and Shape:SolidMolecular weight:357.38Tacrolimus anhydrous 8-epimer
CAS:Tacrolimus anhydrous 8-epimer, an immunosuppressive l-pipecolic acid macrolide, blocks T cell growth by hindering IL-2.Formula:C44H69NO12Color and Shape:SolidMolecular weight:804.02Raloxifene N-Oxide
CAS:Raloxifene N-Oxide is a Raloxifene oxidative degradation product.Formula:C28H27NO5SPurity:98%Color and Shape:SolidMolecular weight:489.58Miaosporone A
Miaosporone A: angucyclic quinone, cytotoxic to MCF-7, NCI-H187, Vero cells; anti-TB and anti-malaria with IC50 of 2.4 μM, 2.5 μM.Formula:C19H18O5Color and Shape:SolidMolecular weight:326.349(Z),12(E)-Octadecadienoic Acid
CAS:9(Z),12(E)-Octadecadienoic Acid (C18:2(9E,12Z); C18:2 n-6), an isomer of linoleic acid, is a type of ω-6 polyunsaturated fatty acid containing a trans double bond at the C9 position. It is identified as a minor component in milk fat and partially hydrogenated vegetable oils. The concentration of 9(Z),12(E)-Octadecadienoic Acid in rabbit meat increases following supplementation with heated sunflower seed oil, α-tocopherol acetate, and zinc.Formula:C18H32O2Molecular weight:280.45Myxothiazol
CAS:Myxothiazol blocks mitochondrial complex III and triggers SESN2, a gene important for stress response.Formula:C25H33N3O3S2Color and Shape:SolidMolecular weight:487.68UGT1A1-IN-1
CAS:UGT1A1-IN-1 (compound 2) acts as a non-competitive inhibitor of UGT1A1, effectively inhibiting the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. This compound binds to the same ligand-binding site on UGT1A1 as bilirubin and additionally functions as a 'turn-on' fluorescent probe substrate for UGT1A1 [1].Formula:C22H19NO3Color and Shape:SolidMolecular weight:345.39Glucosylceramide synthase-IN-4
CAS:Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].Formula:C22H18F5N3O3Color and Shape:SolidMolecular weight:467.39Irafamdastat
CAS:Irafamdastat (BMS-986368) [Example 74] is an inhibitor of FAAH and MAGL, with IC50 values of ≤ 100 nM for human FAAH and 100 nM-1 μM for human MAGL. It exhibits anticonvulsant properties.Formula:C20H21F3N4O4Color and Shape:SolidMolecular weight:438.40Canosimibe
CAS:Canosimibe is a cholesterol absorption inhibitorFormula:C44H60FN3O10Color and Shape:SolidMolecular weight:809.96E234G HYPE-IN-1
CAS:Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].Formula:C14H9N5O2Color and Shape:SolidMolecular weight:279.25(R)-Acenocoumarol
CAS:(R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) is a short-acting, orally administered anticoagulant that works by inhibiting vitamin K epoxide reductase (vitamin K1 recycling), similar to Warfarin. It demonstrates greater anticoagulant potency in vivo compared to Warfarin. This compound has a single chiral center, resulting in two enantiomeric forms. The (R)-enantiomer has a longer plasma elimination half-life of 6.6 hours, slower plasma clearance of 1.9 L/h, and stronger anticoagulation effects than the (S)-enantiomer.Formula:C19H15NO6Molecular weight:353.33DLCI-1
CAS:DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6), significantly reducing self-administered nicotine doses in both male and female mice.Formula:C12H14N2SColor and Shape:SolidMolecular weight:218.32NTPDase-IN-1
NTPDase-IN-1 selectively inhibits NTPDases 1, 2, 8 with IC50 of 0.05, 0.23, 0.54 μM. Non-competitive, K m 21 μM, used in cancer, immune, infection research.Formula:C18H25N3OS2Color and Shape:SolidMolecular weight:363.54Mirivadelgat
CAS:Mirivadelgat is an activator of aldehyde dehydrogenase 2 (aldehyde dehydrogenase2). It is anticipated to be useful in research related to interstitial lung disease, pulmonary arterial hypertension, and cancer.Formula:C30H34FN3O5Molecular weight:535.607(S)-Ibuprofen acyl-β-D-glucuronide
CAS:(S)-Ibuprofen acyl-β-D-glucuronide ((S)-Ibuprofen glucuronide) serves as a crucial analytical tool in examining the metabolic pathways and pharmacokinetic profile of S-ibuprofen, a widely used non-steroidal anti-inflammatory drug. This compound is specifically an acylglucuronic acid metabolite of S-ibuprofen, synthesized primarily in the liver [1].Formula:C19H26O8Molecular weight:382.4Complex III-IN-2
Complex III-IN-2 inhibits complex III, with antifungal EC50: 29.31 mg/L vs R. solani, 29.98 mg/L vs S. sclerotiorum.Formula:C15H21ClN2O2SColor and Shape:SolidMolecular weight:328.86PTP1B-IN-19
PTP1B-IN-19, a benzimidazole, selectively inhibits protein tyrosine phosphatase 1B with a Ki of 23.3 μM, potential for type 2 diabetes research.Formula:C26H19N3O4SColor and Shape:SolidMolecular weight:469.51GPX4 9i
CAS:GPX4 9i is a ferroptosis inducer that exhibits cytotoxicity towards HT-1080 cells, with an IC50 of 0.007 µM. This cytotoxic effect can be mitigated by the use of the ferroptosis inhibitor, ferrostatin-1.Formula:C29H24N4O3S2Molecular weight:540.66Sekikaic Acid
CAS:Sekikaic acid, a phenolic lichen metabolite in H. obscurata, has antioxidant and antiviral properties, inhibiting MLL1-CBP.Formula:C22H26O8Color and Shape:SolidMolecular weight:418.44HIV-1 inhibitor-40
HIV-1 inhibitor-40 (4ab) is a potent NNRTI (EC50: 1.9 nM), non-toxic in vivo, and a sensitive CYP inhibitor.Formula:C25H18N6O2Color and Shape:SolidMolecular weight:434.45AD012
AD012, a dual cACE/NEP inhibitor, leverages lenopril-tryptophan for potential anti-hypertensive and cardioprotective benefits.Formula:C25H32N2O6Color and Shape:SolidMolecular weight:456.53RO5101576
CAS:RO5101576 is a potent antagonist of LTB4 receptor.Formula:C36H38O8SPurity:98%Color and Shape:SolidMolecular weight:630.75PDE4B/7A-IN-2
CAS:5-HT1A/5-HT7 antagonist; 5-HT1A Ki=8 nM, 5-HT7 Ki=451 nM; PDE4B IC50=80.4 μM, PDE7A IC50=151.3 μM; stronger than escitalopram.Formula:C25H35N3O2Color and Shape:SolidMolecular weight:409.56Imipramine Blue chloride
Imipramine Blue chloride is an effective anti-invasive agent capable of inhibiting glioma invasion. It suppresses the production of reactive oxygen species (reactive oxygen species) mediated by NADPH oxidase.Formula:C40H51ClN4Color and Shape:SolidMolecular weight:623.31Rostratin A
CAS:Rostratin A, a disulfide from Exserohilum rostratum, is cytotoxic to HCT-116 cells with an IC50 of 8.5 μg/mL.Formula:C18H24N2O6S2Color and Shape:SolidMolecular weight:428.52Calcipotriol Impurity C
CAS:Calcipotriol Impurity C is the impurity of Calcipotriol. Calcipotriol is a VDR-like receptors ligand.Formula:C27H40O3Purity:98%Color and Shape:SolidMolecular weight:412.614ATUX-1215
CAS:ATUX-1215, a protein phosphatase 2A (PP2A) activator, diminishes the phosphorylation of ERK, p38, JNK, and Akt, as well as decreases the secretion of IL-12p70,Formula:C27H24F5NO4SColor and Shape:SolidMolecular weight:553.54LXRβ agonist-3
CAS:LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM).Formula:C30H33N3O6SColor and Shape:SolidMolecular weight:563.66Etamicastat
CAS:Etamicastat can be used in the research of cardiovascular diseases.Formula:C14H15F2N3OSPurity:98%Color and Shape:SolidMolecular weight:311.35Emopamil
CAS:Emopamil, a calcium channel inhibitor, reduces neuronal damage caused by ischemia.Formula:C23H30N2Color and Shape:SolidMolecular weight:334.5KY-455
CAS:KY-455 is a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. It demonstrates inhibition of ACAT in rabbit intestines, liver, macrophages, and adrenal glands with IC50 values of 0.4, 0.9, 2.9, and 4.1 μmol/L, respectively.Formula:C20H32N2OColor and Shape:SolidMolecular weight:316.48EpoY
CAS:EpoY (SD-142) is an irreversible inhibitor of the primary brain microtubule-associated tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and small vasohibin-binding protein (SVBP). By inhibiting TCP with an IC50 value of approximately 500 nM, EpoY effectively reduces the levels of detyrosinated α-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition results in significant differentiation defects and is linked to potential issues related to cancer and cardiomyopathy.Formula:C15H17NO7Color and Shape:SolidMolecular weight:323.30Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Formula:C30H40Cl2N6O4S2Purity:98%Color and Shape:SolidMolecular weight:683.71ABT-046
CAS:ABT-046 is an orally active, selective, and highly efficient Diacylglycerol Acyltransferase 1 (DGAT-1) inhibitor that can be used in metabolic disease research.Formula:C20H22N4O2Purity:98.13%Color and Shape:SolidMolecular weight:350.41Retezorogant
CAS:Retezorogant is a retinoic acid receptor-related orphan receptor gamma (RORγ) antagonist.Formula:C23H33ClN2O3Color and Shape:SolidMolecular weight:420.97CA IX-IN-1
CA IX-IN-1 (compound 12g) is a potent and highly selective hCA IX inhibitor (IC50: 7 nM) that exhibits antitumour effects.Formula:C16H22N4O8SColor and Shape:SolidMolecular weight:430.43PENAO
CAS:<p>PENAO is a potent mitochondrial toxin for tumor cells. It deactivates the mitochondria of tumor cells by targeting the adenine nucleotide translocase in the cell membrane.</p>Formula:C13H19AsN2O5SColor and Shape:SolidMolecular weight:390.29JTE-151
CAS:JTE-151, a RORγ inhibitor, suppresses the overactive immune response by inhibiting RORγ, which is linked to the activation of Th17 cells. This action positions JTE-151 as a potential candidate for autoimmune disease research [1].Formula:C28H37ClN2O4Molecular weight:501.06NADH-IN-2
CAS:NADH-IN-2 (compound 8) is a Type II NADH dehydrogenase inhibitor.Formula:C16H16N2Color and Shape:SolidMolecular weight:236.31Carbonic anhydrase inhibitor 16
CAS:Carbonic anhydrase inhibitor 16 (compound 1) is a CA I/CA II inhibitor with potential antiviral activity, used in virus infection studies.Formula:C14H10N2O4SPurity:99.65%Color and Shape:SolidMolecular weight:302.31Carbonic anhydrase inhibitor 19
CAS:Carbonic anhydrase inhibitor19 (compound 26a) targets glaucoma-associated isozymes hCA II and hCA XII, with inhibition constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound is effective in reducing intraocular pressure.Formula:C23H25N3O6S2Molecular weight:503.59α-Glucosidase-IN-43
CAS:α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor with an IC50 of 4.32 μM, demonstrating acute blood-glucose-lowering properties. It is safe and effective in vivo, showing no toxicity to normal fibroblasts in mice and can ameliorate diabetes induced by streptozotocin in rats. α-Glucosidase-IN-43 is applicable for research on postprandial hyperglycemia in diabetic patients.Formula:C27H31N3O4Molecular weight:461.55Carbonic anhydrase inhibitor 17
CAS:Carbonic anhydrase inhibitor 17 (compound 7c) is a pyrazine-based sulfonamide that acts as a carbonic anhydrase II inhibitor, with an IC50 value of 0.63 nM.Formula:C18H15ClN4O3S2Molecular weight:434.92DS44470011
CAS:DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.Formula:C21H19N3O4Color and Shape:SolidMolecular weight:377.39α-Amylase/α-Glucosidase-IN-7
CAS:α-Amylase/α-Glucosidase-IN-7 (Compound 3f) serves as a competitive inhibitor for the enzymes α-glucosidase and α-amylase, exhibiting IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, it effectively inhibits AChE and BChE, with IC50 values of 9.25 µM and 10.06 µM, respectively. This compound is useful in research related to diabetes and Alzheimer's [1].Formula:C15H9Cl2FN2OSColor and Shape:SolidMolecular weight:355.21LXRα agonist 1
CAS:LXRα agonist 1 (Compound 40) is a selective activator of LXRα, with an EC50 of 42 nM, and also demonstrates some activation effects on LXRβ, with an EC50 of 266 nM. It promotes target gene transcription by stabilizing the ligand-binding domain (LBD) of LXRα. When combined with the Raf inhibitor Sorafenib, LXRα agonist 1 shows significant antitumor activity in liver cancer cells. This compound is applicable in research focused on lipotoxicity-related cancers.Formula:C28H27N3O2Color and Shape:SolidMolecular weight:437.533DEL-I25
CAS:DEL-I25 is an effective activator of GPX4 that protects cells from ferroptosis (iron-dependent cell death).Formula:C21H23N5O3Color and Shape:SolidMolecular weight:393.44
