Metabolism

<p>2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a type of polychlorinated dibenzofuran (PCDF). It induces the expression of aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-o-deethylase (EROD) genes in H-4-II-E rat hepatoma cells, with EC50 values of 0.687 and 0.575 nM, respectively.</p>

<p>RMC-3943 is a potent SHP2 allosteric inhibitor with an IC50 of 2.19 nM.</p>

<p>Cysteinylglycine acetate (Cys-Gly Acetate) is an acetate salt of Cysteinylglycine.</p>

<p>Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM.</p>

<p>O-Demethyl Lenvatinib, a Lenvatinib metabolite, is an oral TKI targeting VEGFR, FGFR, PDGFR, KIT &amp; RET with potent antitumor effects.</p>

<p>Acetoacetic acid(3-oxobutanoic acid) is a oxidative stress inducer, gluconeogenesis, and can be used as an indicator of in ketoacidosis.</p>

<p>Wild-type human myoregulin (wt hMLN) is a microprotein that inhibits the sarcoplasmic reticulum Ca²⁺ pump (SERCA), playing a crucial role in the regulation of</p>

<p>Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.</p>

<p>Compound 4d, known as hCA XII-IN-6, is a potent inhibitor of human carbonic anhydrase XII (hCA XII) with a Ki value of 84.2 nM and exhibits anti-proliferative</p>

<p>α-Glucosidase-IN-26 (Compound 7i), with an IC50 value of 4.63 µM, functions as an α-glucosidase inhibitor and is utilized in research related to type 2 diabetes</p>

<p>A unique collection of xnum metabolic pathway-related bioactive small molecule compounds for high-throughput, high-content screening.</p>

D-Pro-Phe-Arg-Chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, is significant in the regulation of thrombosis and inflammation

<p>Ser-Ala-alloresact acetate is a sperm-activating peptide (SAP) that is released by marine invertebrate eggs and plays an important role in fertilization.</p>

<p>Amidases, belonging to the nitrilase superfamily, catalyze amide hydrolysis to yield carboxylic acid and ammonia.</p>

<p>IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].</p>

<p>BSO-07 is a ROS/JNK activator that exhibits potent anti-cancer properties, demonstrated by an IC50 of 24.81 μM in human breast cancer (BC) cells. The mechanism of action for BSO-07 involves JNK activation and the promotion of increased ROS levels, which lead to the induction of apoptosis (Apoptosis) and tumorigenic apoptosis. This includes enhanced expression of apoptosis-related proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, along with a reduction in the levels of anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL, and Survivin). BSO-07 holds promise for research in the field of breast cancer.</p>

<p>Xanthine oxidase-IN-16 is an effective orally active inhibitor of xanthine oxidase (XO), demonstrating significant therapeutic efficacy in rats with hyperuricemia and an IC50 of 102 nM.</p>

<p>HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.</p>

<p>Calciseptine, a neurotoxin isolated from the Black Mamba (Dendroaspis p.</p>

<p>Alanine aminotransferase (ALT), a pyridoxal-dependent enzyme, catalyzes the reversible interconversion of L-alanine and 2-oxoglutarate into pyruvate and L-</p>

<p>SF2312 ammonium is the ammonium salt of SF2312, a phosphonate antibiotic and enolase inhibitor derived from the actinomycete Micromonospora and active under</p>

<p>PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2</p>

<p>Glucocerebrosidase (Glucosylceramidase; GBA), a lysosomal enzyme, catalyzes the hydrolysis of the β-glucosidic linkage in glucocerebroside (GC) to yield glucose</p>

<p>Stevisaliosides D (Compound 5), extracted from the roots of Stevia serrata, exhibits inhibition of PTP1B with an IC50 of 31.8 μM and has applications in</p>

<p>Forrestiacid J is an inhibitor of ATP-citrate lyase (ACL), exhibiting an IC50 value of 2.6 μM [1].</p>

<p>hBChE-IN-4 (compound 40) serves as an effective activator for hCA and an inhibitor for BChE. It demonstrates affinity for various hCA subtypes with affinity constants (KA) of 266 nM for hCA I, 76.9 nM for hCA II, 918 nM for hCA IV, 893 nM for hCA VB, and 98.0 nM for hCA VII. Inhibition concentrations (IC50) for eeAChE and eqBChE are recorded at 72.1 nM and 4.2 nM, respectively. hBChE-IN-4 is non-cytotoxic and has demonstrated potential cognitive enhancement effects. It holds potential for research in neurodegenerative and other neuropsychiatric disorders.</p>

<p>Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers.</p>

<p>Netupitant N-oxide is a highly selective antagonist of NK1 receptor, is Netupitant metabolite.</p>

<p>Forrestiacid K, a terpenoid derived from Pseudotsuga forrestii, functions as an inhibitor of ATP-citrate lyase (ACL) [1].</p>

<p>Ribulose: key in pentose metabolism, aids L-ribose isomerase study, yeast engineering, and chiral compound research.</p>

<p>HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in</p>

<p>γ-Glu-Gly TFA, a γ-glutamyl dipeptide, is a human lipid metabolite with a structure resembling GABA (γ-aminobutyric acid).</p>

<p>PROTACMAGLdegrader-1 is an orally active PROTAC agent that simultaneously targets both monoacylglycerol lipase (MAGL) and the E3 ubiquitin ligase MDM2. It functions by degrading MAGL and inhibiting the interaction between MDM2 and p53. Additionally, PROTACMAGLdegrader-1 has partial blood-brain barrier (BBB) penetration and can induce apoptosis in glioblastoma stem cells (GSC).</p>

<p>Compound 3e (hCAIX/XII-IN-7) is a potent inhibitor of human carbonic anhydrase (hCA) isozymes IX and XII, displaying inhibitory constants (Kis) of 503.7 nM for</p>

<p>Glutathione Peroxidase (GSH-Px; EC 1.11.1.9), a member of the peroxidase family, catalyzes the oxidation of reduced glutathione (GSH) to oxidized glutathione (</p>

<p>Micafungin metabolite M1 is an active metabolite of Micafungin, generated through metabolism by arylsulfatase, and exhibits antifungal activity. It can be utilized in research on deep fungal infections caused by Candida species (Candidiasis) and Aspergillus species (Aspergillosis).</p>

<p>(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.</p>

<p>SP4f, an activator of PPAR-γ, exhibits an EC50 value of 826 nM in HK-2 cells.</p>

<p>RabbitFactor Xa is produced from purified Rabbit Factor X through activation by Russells' Viper Venom, followed by the removal of the venom.</p>

<p>6-hydroxy Chlorzoxazone, a chlorzoxazone metabolite, is formed in the liver via CYP2E1.</p>

<p>Isbufylline can exert significant anti-inflammatory actions, in addition to its bronchodilator activity.</p>

<p>Compound 5f (Antioxidant agent-13) is an antioxidant that demonstrates inhibition of DPPH and FRAP with half maximal inhibitory concentrations (IC50s) of 80.33</p>

<p>Carbonic anhydrase, a zinc enzyme in all life forms, converts CO2 to bicarbonate; studied for cancer, glaucoma, obesity, epilepsy.</p>

<p>α-Glucosidase-IN-40 (compound 5) serves as a noncompetitive inhibitor of the α-glucosidase enzyme, exhibiting an inhibitory concentration (IC50) of 24.62 μM [1</p>

<p>Alpha-Pyrone exhibits inhibitory activity against tyrosinase, carbonic anhydrase 1, and carbonic anhydrase 9</p>

<p>MAGL-IN-9, also referred to as compound 16, is a reversible inhibitor of monoacylglycerol lipase (MAGL) with a potent IC50 value of 2.7 nM [1].</p>

<p>Atorvastatin Epoxy Tetrahydrofuran: an impurity from Atorvastatin oxidation; it's an oral HMG-CoA reductase inhibitor.</p>

<p>Orotidine 5′-monophosphate, a pyrimidine ribonucleoside, functions as an endogenous metabolite in human, E.</p>

<p>α-Glucosidase-IN-38 (Compound 11j) is a potent α-glucosidase inhibitor, demonstrating an IC50 of 12.44±0.38 μM, and is significant in the context of Diabetes</p>

<p>Eurestobart is a humanized IgG1κ (IgG1 kappa) monoclonal antibody that specifically targets the enzyme ectonucleoside triphosphate diphosphohydrolase (ENTPDase</p>