Metabolism

<p>Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.</p>

<p>EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage</p>

<p>4,5-Dimethylthiazole exhibits inhibitory against mitochondrial respiration in liver cells and can be used in biochemical experiments and drug synthesis.</p>

<p>Asundexian (BAY-2433334) is a potent and orally active inhibitor of the coagulation factor FXIa that directly and reversibly binds to the active site of FXIa,</p>

<p>N-(2-hydroxyethyl)-oxamic acid stems from Metronidazole reduction, occurring chemically or via gut bacteria; it's an effective antibiotic.</p>

<p>Bacterial α-Amylase is an enzyme that catalyzes the hydrolysis reaction of starch into smaller sugar molecules such as maltose and glucose.</p>

<p>LDHA-IN-3 is a potent selenobenzene-based LDHA inhibitor with a 145.2 nM IC50, useful in cancer research.</p>

<p>N-acetyl Leukotriene E4 is an endogenous metabolite of Leukotriene E4, less active than Leukotriene E4, causing constriction of the airways.</p>

<p>DSPE-PEG1000-THRPPMWSPVWP is a PEG compound composed of DSPE and the transferrin receptor (TfR) peptide. The THRPPMWSPVWP peptide binds to TfR and is subsequently internalized into cells expressing TfR.</p>

<p>9(R)-HODE cholesteryl ester, from atherosclerotic lesions, may form enzymatically or by lipid peroxidation; used as a chiral analysis standard.</p>

<p>Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.</p>

<p>Ser-Ala-alloresact acetate is a sperm-activating peptide (SAP) that is released by marine invertebrate eggs and plays an important role in fertilization.</p>

<p>Calcium 2-oxoglutarate is an intermediate in the production of GTP or ATP in the Krebs cycle. It is a reversible inhibitor of tyrosinase (IC50: 15 mM).</p>

<p>Ruthenoleuton is a 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 3.49 μM and a Ki of 0.80 μM. It possesses antioxidant properties and is applicable in research on inflammatory diseases.</p>

<p>Cho-Arg is a cholesterol-based cationic lipid that complexes with DNA, aids transfection, and is cytotoxic at 88.5 μg/ml IC50.</p>

<p>SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.</p>

<p>DKI5, a LOX-1 inhibitor with 22.5 μM IC50, may exhibit anti-inflammatory, antioxidant, and anti-lipid peroxidation effects in vitro.</p>

<p>Boc-IEGR-AMC: fluorogenic substrate for factor Xa and Halocynthia roretzi acrosin.</p>

<p>18:0,18:1 PS sodium, a lipid found in synaptic vesicles and cholesterol, serves a role in metabolic research [1].</p>

<p>γ-Acetylenic GABA hydrochloride is a GABA transaminase inhibitor.</p>

<p>ICMT-IN-35 (compound 10n), an ICMT inhibitor with an IC50 value of 0.8 μM, is a FTPA-triazole derivative.</p>

<p>AV22-149 (compound 22) is an inhibitor of Carbonic Anhydrase .</p>

<p>Galactosylhydroxylysine, a bone collagen breakdown product, is released during bone resorption and excreted in urine.</p>

<p>MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>

<p>Boc-L-aspartic acid 4-benzyl ester (Boc-Asp(OBzl)-OH) is an aspartic acid derivative.</p>

<p>Penicitide A: marine metabolite, moderately cytotoxic to A. brassicae, HepG2 cells.</p>

<p>Adefovir diphosphate 2TEA,a metabolite of Adefovir, an oral reverse transcriptase inhibitor with antiviral activity against herpes, hepatitis B, and HIV.</p>

<p>Resveratrol-3-O-sulfate reduces IL-1α/β, IL-6, TNF-α in LPS-stimulated U-937 cells, inhibits Caco-2 cell growth, induces apoptosis, and binds mitoNEET.</p>

<p>BSO-07 is a ROS/JNK activator that exhibits potent anti-cancer properties, demonstrated by an IC50 of 24.81 μM in human breast cancer (BC) cells. The mechanism of action for BSO-07 involves JNK activation and the promotion of increased ROS levels, which lead to the induction of apoptosis (Apoptosis) and tumorigenic apoptosis. This includes enhanced expression of apoptosis-related proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, along with a reduction in the levels of anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL, and Survivin). BSO-07 holds promise for research in the field of breast cancer.</p>

<p>hBChE-IN-3 (compound 30) serves as both an activator of carbonic anhydrase (CA) and an inhibitor of cholinesterase (ChE), exhibiting IC50 values of 7.4 nM for AchE and 1.9 nM for BchE. This compound is utilized in the research of neurodegenerative and psychiatric disorders.</p>

<p>CAIX/CAXII-IN-3 (compound 11) serves as an inhibitor for CAIX/CAXII, exhibiting an IC50 value of less than 65 nM. Additionally, this compound effectively inhibits the proliferation of human melanoma cells.</p>

<p>β-Glucosidase is a glucoside bond hydrolase involved in glucose metabolism and can be used to study diseases caused by abnormal glucose metabolism.</p>

<p>Chaetosemin J, antifungal, inhibits Botrytis, Alternaria, Magnaporthe, Gibberella; MIC 12.5-25 μM.</p>

<p>Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .</p>

<p>IDO-IN-15 is an IDO1 inhibitor ( IC 50 &lt; 0.51 nM).</p>

<p>Dios-Arg, a steroid cationic lipid, binds DNA for transfection, but is cytotoxic to H1299/HeLa cells at 83.5/74.1 μg/ml IC50s.</p>

<p>hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide with potential as a dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2.</p>

<p>Ilexsaponin B2 is a natural product for research related to life sciences. The catalog number is TJS0502 and the CAS number is 108906-69-0.</p>

<p>12-Hydroxynevirapine, major Nevirapine metabolite; non-toxic but liver/skin SULTs convert it to reactive 12-Sulphoxy-nevirapine.</p>

<p>WXC-25 is an α-glucosidase inhibitor with an IC50 value of 2.02 μM.</p>

<p>Motapizone (NAT 05-239), a PDE3 inhibitor, moderates LPS-induced cytokine release and blocks platelet aggregation by boosting cAMP.</p>

<p>3-Hydroxyanisole has inhibitory activity against MAO-A (IC50 = 24 ± 2.8 μM) and can be used to study neurological and psychiatric diseases.</p>

<p>PDE11A4-IN-1 (compound 23b) is a potent, selective inhibitor of PDE11A4, demonstrating an IC50 of 12 nM and exhibiting high selectivity against PDE1, PDE2,</p>

<p>N-Lactylvaline is an endogenous metabolite detectable in patients with intermediate maple syrup urine disease.</p>

<p>1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.</p>

<p>γ-glutamyltransferase (GGT) is an enzyme located on the outer surface of the cell membrane. It maintains physiological concentrations of intracellular glutathione and cellular defense against oxidative stress by cleaving extracellular glutathione and increasing the availability of amino acids. γ-glutamyltransferase can be utilized as a biomaterial or organic compound in life science-related research.</p>

<p>2,5-Anhydro-D-glucitol-1,6-diphosphate mildly stimulates yeast Pyruvate Kinase; it's an analogue of a potent activator.</p>

<p>SX29 is a non-competitive α-glucosidase inhibitor with oral activity, exhibiting an IC50 of 2.12 μM. It possesses hypoglycemic properties; oral administration of SX29 reduces blood glucose levels and enhances glucose tolerance in diabetic mice.</p>

<p>α-Glucosidase-IN-74, a nicotinamide-thiazole derivative, functions as an α-glucosidase (α-glucosidase) inhibitor. It demonstrates antidiabetic activity by reducing blood glucose and triglyceride levels in Streptozotocin-induced diabetic animals.</p>

<p>7-Hydroxymethotrexate, major Methotrexate metabolite, inhibits dihydrofolate reductase and DNA synthesis by blocking folic acid conversion.</p>