c-Kit
c-Kit inhibitors are compounds that block the activity of the Stem Cell Factor Receptor (c-Kit), a tyrosine kinase that plays a pivotal role in cell survival, proliferation, and differentiation, particularly in hematopoietic cells. Mutations in c-Kit are linked to various cancers, including gastrointestinal stromal tumors (GIST) and leukemia. At CymitQuimica, we provide c-Kit inhibitors to support your research in oncology, hematology, and stem cell biology.
Found 101 products of "c-Kit"
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Lenvatinib
CAS:<p>Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.</p>Formula:C21H19ClN4O4Purity:98.46% - 99.69%Color and Shape:SolidMolecular weight:426.85Pazopanib
CAS:<p>Pazopanib (GW786034) is an inhibitor of protein tyrosine kinases that inhibits VEGFR1/2/3. Pazopanib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C21H23N7O2SPurity:98.78% - 99.85%Color and Shape:White PowderMolecular weight:437.52Imatinib Mesylate
CAS:<p>Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR,</p>Formula:C29H31N7O·CH4SO3Purity:98% - >99.99%Color and Shape:White Crystalline PowderMolecular weight:589.71JI6
CAS:<p>JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor.</p>Formula:C19H17N3O4SPurity:98.51%Color and Shape:SoildMolecular weight:383.42N-Desmethyl imatinib
CAS:<p>N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.</p>Formula:C28H29N7OPurity:98.60%Color and Shape:Off-White To Pale-Yellow SolidMolecular weight:479.58Amuvatinib hydrochloride
CAS:<p>Amuvatinib HCl (MP470 HCl) is a multi-targeted oral tyrosine kinase inhibitor and hinders RAD51-mediated DNA repair, exhibiting anticancer properties.</p>Formula:C23H22ClN5O3SPurity:98%Color and Shape:SolidMolecular weight:483.97M4205
CAS:<p>M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17.</p>Formula:C29H32N8OPurity:99.07%Color and Shape:SolidMolecular weight:508.62Multi-kinase-IN-5
<p>Multi-kinase-IN-5 (compound 15c) is a multi-kinase inhibitory agent that shows significant inhibition against a range of protein kinases including RET, KIT,</p>Formula:C19H15N5O2SColor and Shape:SolidMolecular weight:377.42KG5
CAS:<p>KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).</p>Formula:C20H16F3N7OSPurity:98.32%Color and Shape:SolidMolecular weight:459.45c-Kit-IN-6
<p>C-Kit-IN-6 (Compound 101) is an inhibitor of c-Kit, demonstrating IC50 values ranging from 100 nM to 1 μM.</p>Formula:C25H28FN5O5Color and Shape:SolidMolecular weight:497.52Motesanib Diphosphate
CAS:<p>Motesanib Diphosphate (AMG 706) is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic</p>Formula:C22H23N5O·2H3PO4Purity:99.69%Color and Shape:SolidMolecular weight:569.44c-Kit/CD117 Protein, Human, Recombinant (His)
<p>c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Purity:99.4%Color and Shape:Lyophilized PowderMolecular weight:56.7 kDa (predicted); 86 kDa (reducing condition, due to glycosylation)Anti-C-Kit Antibody (6X205)
<p>Anti-C-Kit Antibody (6X205) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (6X205) can be used in ELISA.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody (3B930)
<p>Anti-C-Kit Antibody (3B930) is a Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody (3B930) can be used in WB,ELISA,IP.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody-PE (1R766)
<p>Anti-C-Kit Antibody-PE (1R766) is a PE-conjugated Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody-PE (1R766) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody-APC (8E724)
<p>Anti-C-Kit Antibody-APC (8E724) is a APC-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-APC (8E724) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody (2T761)
<p>Anti-C-Kit Antibody (2T761) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (2T761) can be used in ELISA(Det).</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody (9Y519)
<p>Anti-C-Kit Antibody (9Y519) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (9Y519) can be used in ELISA.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody-FITC (7P530)
<p>Anti-C-Kit Antibody-FITC (7P530) is a FITC-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-FITC (7P530) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-CD117 Antibody (9H202)
<p>Anti-CD117 Antibody (9H202) is an antibody targeting CD117. Anti-CD117 Antibody (9H202) can be used in ELISA, IHC, FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody (8E724)
<p>Anti-C-Kit Antibody (8E724) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (8E724) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody-PE (8E724)
<p>Anti-C-Kit Antibody-PE (8E724) is a PE-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-PE (8E724) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody (3F840)
<p>Anti-C-Kit Antibody (3F840) is a Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody (3F840) can be used in ELISA,IHC-P.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody-HRP (2T761)
<p>Anti-C-Kit Antibody-HRP (2T761) is a HRP-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-HRP (2T761) can be used in ELISA.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody (1R766)
<p>Anti-C-Kit Antibody (1R766) is a Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody (1R766) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody-FITC (8E724)
<p>Anti-C-Kit Antibody-FITC (8E724) is a FITC-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-FITC (8E724) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody (7P530)
<p>Anti-C-Kit Antibody (7P530) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (7P530) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody-APC (1R766)
<p>Anti-C-Kit Antibody-APC (1R766) is a APC-conjugated Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody-APC (1R766) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody-PE (7P530)
<p>Anti-C-Kit Antibody-PE (7P530) is a PE-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-PE (7P530) can be used in FCM.</p>Color and Shape:Odour LiquidAnti-C-Kit Antibody (3N57)
<p>Anti-C-Kit Antibody (3N57) is a Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody (3N57) can be used in ELISA(Cap).</p>Color and Shape:Odour Liquidc-Kit/CD117 Protein, Human, Recombinant (hFc)
<p>c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>Purity:97.1%Color and Shape:Lyophilized PowderMolecular weight:82 kDa (predicted); 93-115 kDa (reducing conditions)c-Kit/CD117 Protein, Human, Recombinant (aa 540-972, His & GST)
<p>c-Kit Protein, Human, Recombinant (aa 540-972, His & GST) is expressed in Baculovirus insect cells with His and GST tag.</p>Color and Shape:Lyophilized PowderMolecular weight:76.8 kDa (predicted); 68 kDa (reducing conditions)PLX647
CAS:<p>PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).</p>Formula:C21H17F3N4Purity:99.38%Color and Shape:SolidMolecular weight:382.38c-Kit/CD117 Protein, Mouse, Recombinant (hFc)
<p>c-Kit Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>Color and Shape:Lyophilized PowderMolecular weight:82.5 kDa (predicted); 100-110 kDa (reducing condition, due to glycosylation)Telatinib mesylate
CAS:<p>Telatinib mesylate is a potent, orally active inhibitor of VEGFR2 (IC50: 6 nM), VEGFR3 (IC50: 4 nM), PDGFα (IC50: 15 nM) and c-Kit (IC50: 1 nM).</p>Formula:C21H20ClN5O6SColor and Shape:SolidMolecular weight:505.93c-Kit/CD117 Protein, Mouse, Recombinant (His)
<p>c-Kit Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Purity:98.2%Color and Shape:Lyophilized PowderMolecular weight:57 kDa (predicted); 70-80 kDa (reducing condition, due to glycosylation)c-Kit/CD117 Protein, Human, Recombinant (aa 50-190, His)
<p>c-Kit Protein, Human, Recombinant (aa 50-190, His) is expressed in E.</p>Color and Shape:Lyophilized PowderMolecular weight:17.9 kDa (predicted); 18 kDa (reducing conditions)c-Kit/CD117 Protein, Mouse, Recombinant (His)
<p>The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.</p>Color and Shape:Lyophilized PowderMolecular weight:56.63 kDa (predicted). Due to glycosylation, the protein migrates to 75-100 kDa based on Tris-Bis PAGE result.c-Kit/CD117 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
<p>The c-kit proto-oncogen (CD117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.</p>Color and Shape:Lyophilized PowderMolecular weight:56.69 kDa (predicted). Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.AST 487
CAS:<p>AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.</p>Formula:C26H30F3N7O2Purity:98.17% - 99.56%Color and Shape:SolidMolecular weight:529.56ISCK03
CAS:<p>ISCK03 is a selective SCF/c-Kit inhibitor.</p>Formula:C19H21N3O2SPurity:98.39%Color and Shape:SolidMolecular weight:355.45JNJ-38158471
CAS:<p>JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor, inhibits closely related tyrosine kinases such as Ret and Kit .</p>Formula:C15H17ClN6O3Purity:97.08%Color and Shape:SolidMolecular weight:364.79OSI-930
CAS:<p>OSI-930 is an oral c-Kit/VEGFR-2 inhibitor targeting tumor growth and angiogenesis.</p>Formula:C22H16F3N3O2SPurity:99.67%Color and Shape:SolidMolecular weight:443.44Masitinib
CAS:<p>Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.</p>Formula:C28H30N6OSPurity:97.56% - >99.99%Color and Shape:SolidMolecular weight:498.64Toceranib Phosphate
CAS:<p>Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family.</p>Formula:C22H28FN4O6PPurity:98.56%Color and Shape:SolidMolecular weight:494.45BLU-263
CAS:<p>BLU-263 is an investigational, potent, and selective oral small molecule inhibitor of KIT with sub-nanomolar potency against D816V-mutant KIT.</p>Formula:C27H29FN10OPurity:99.01% - 99.67%Color and Shape:SolidMolecular weight:528.58Ripretinib
CAS:<p>Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.</p>Formula:C24H21BrFN5O2Purity:99.07% - 99.38%Color and Shape:SolidMolecular weight:510.36SU14813
CAS:<p>SU14813: inhibits multiple kinases (VEGFR2, VEGFR1, PDGFRβ, KIT) with IC50s of 50, 2, 4, 15 nM; antiangiogenic and antitumor.</p>Formula:C23H27FN4O4Purity:98.13%Color and Shape:SolidMolecular weight:442.48Avapritinib
CAS:<p>Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases.Cost-effective and quality-assured.</p>Formula:C26H27FN10Purity:96.59% - 99.7%Color and Shape:SolidMolecular weight:498.56Multi-kinase inhibitor 1
CAS:<p>Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.</p>Formula:C20H17F3N4O3Purity:99.34%Color and Shape:SolidMolecular weight:418.37Ki20227
CAS:<p>Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).</p>Formula:C24H24N4O5SPurity:98.97% - 99.88%Color and Shape:SolidMolecular weight:480.54Flumatinib
CAS:<p>Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.</p>Formula:C29H29F3N8OPurity:99.39% - 99.95%Color and Shape:SolidMolecular weight:562.59AZD2932
CAS:<p>AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.</p>Formula:C24H25N5O4Purity:97.71% - 98.37%Color and Shape:SolidMolecular weight:447.49AZD3229 Tosylate
CAS:<p>AZD3229 Tosylate is a highly potent inhibitor targeting mutant forms of the pan-KIT enzyme, with a primary application in the treatment of gastrointestinal</p>Formula:C31H34FN7O6SColor and Shape:SolidMolecular weight:651.71Midostaurin
CAS:<p>PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.</p>Formula:C35H30N4O4Purity:97.61% - >99.99%Color and Shape:SolidMolecular weight:570.64Dovitinib lactate
CAS:<p>Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).</p>Formula:C24H27FN6O4Purity:99.54% - 99.77%Color and Shape:SolidMolecular weight:482.51Tandutinib
CAS:<p>Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3</p>Formula:C31H42N6O4Purity:99.45% - ≥98%Color and Shape:White SolidMolecular weight:562.7Vimseltinib
CAS:<p>Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).</p>Formula:C23H25N7O2Purity:99.05% - 99.57%Color and Shape:SolidMolecular weight:431.49SKLB4771
CAS:<p>SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.</p>Formula:C25H27N7O3S2Purity:98% - >99.99%Color and Shape:SolidMolecular weight:537.66AZD3229
CAS:<p>AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.</p>Formula:C24H26FN7O3Purity:98.83%Color and Shape:SolidMolecular weight:479.51c-Kit-IN-1
CAS:<p>c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).</p>Formula:C26H21F2N5O3Purity:98.72% - 98.73%Color and Shape:SolidMolecular weight:489.47Imatinib
CAS:<p>Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit</p>Formula:C29H31N7OPurity:99.42% - 99.94%Color and Shape:Off White PowderMolecular weight:493.6Telatinib
CAS:<p>Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, 15 nM.</p>Formula:C20H16ClN5O3Purity:97.61% - 99.81%Color and Shape:SolidMolecular weight:409.83Linifanib
CAS:<p>Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and</p>Formula:C21H18FN5OPurity:98% - 98.24%Color and Shape:SolidMolecular weight:375.4GW786034B
CAS:<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Formula:C21H23N7O2S·HClPurity:99.87%Color and Shape:SolidMolecular weight:473.98N-Desethylsunitinib hydrochloride
CAS:<p>N-Desethylsunitinib HCl, active sunitinib metabolite, inhibits VEGFR, PDGFRβ, KIT.</p>Formula:C20H24ClFN4O2Purity:99.42%Color and Shape:SolidMolecular weight:406.88Motesanib
CAS:<p>Motesanib (AMG 706) orally blocks VEGFR, PDGFR, Kit, Ret; curbing angiogenesis and cancer cell growth.</p>Formula:C22H23N5OPurity:98% - 99.09%Color and Shape:SolidMolecular weight:373.45Regorafenib
CAS:<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Formula:C21H15ClF4N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:482.82Lenvatinib mesylate
CAS:<p>Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.</p>Formula:C22H23ClN4O7SPurity:99.03% - 99.79%Color and Shape:SolidMolecular weight:522.96Tyrphostin AG1296
CAS:<p>Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.</p>Formula:C16H14N2O2Purity:99.94% - >99.99%Color and Shape:SolidMolecular weight:266.29Dovitinib lactate hydrate
CAS:<p>Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).</p>Formula:C24H27FN6O4Purity:99.82%Color and Shape:SolidMolecular weight:482.51Amuvatinib
CAS:<p>Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.</p>Formula:C23H21N5O3SPurity:99.38% - >99.99%Color and Shape:SolidMolecular weight:447.51Pexidartinib
CAS:<p>Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential</p>Formula:C20H15ClF3N5Purity:98.34% - 99.45%Color and Shape:SolidMolecular weight:417.81Cabozantinib
CAS:<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Formula:C28H24FN3O5Purity:99.68% - 99.88%Color and Shape:SolidMolecular weight:501.51Flumatinib mesylate
CAS:<p>Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.</p>Formula:C30H33F3N8O4SPurity:99.82%Color and Shape:SolidMolecular weight:658.69Cabozantinib hydrochloride
CAS:<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Formula:C28H25ClFN3O5Purity:99.97%Color and Shape:SolidMolecular weight:537.96Dovitinib
CAS:<p>Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.</p>Formula:C21H21FN6OPurity:99.35% - 99.92%Color and Shape:SolidMolecular weight:392.43Sitravatinib
CAS:<p>Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and</p>Formula:C33H29F2N5O4SPurity:98.9% - 99.85%Color and Shape:SolidMolecular weight:629.68Masitinib mesylate
CAS:<p>Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;</p>Formula:C29H34N6O4S2Purity:97.67% - 98.44%Color and Shape:SolidMolecular weight:594.75Toceranib
CAS:<p>Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.</p>Formula:C22H25FN4O2Purity:97.14%Color and Shape:SolidMolecular weight:396.46c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
<p>The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.</p>Color and Shape:Lyophilized PowderMolecular weight:58.60 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Anti-Mouse CD117 Antibody
<p>Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.</p>Purity:98%Color and Shape:Odour SolidBarzolvolimab
CAS:<p>Barzolvolimab (CDX 0159), a humanized IgG1 monoclonal antibody, blocks KIT activation and treats chronic urticaria.</p>Color and Shape:LiquidBriquilimab
CAS:<p>Briquilimab is a humanized antibody that inhibits the SCF-KIT interaction, inducing mast cell apoptosis for research into inflammatory diseases.</p>Purity:95% - 95%Color and Shape:LiquidGW694590A
CAS:<p>GW694590A (UNC10112731) functions as a MYC protein stabilizer that enhances the levels of endogenous MYC protein. It also acts on receptor tyrosine kinases, inhibiting DDR2, KIT, and PDGFRα by 81%, 68%, and 67% at a concentration of 1 μM, respectively. As a protein kinase inhibitor, GW694590A affects both ATP-dependent and ATP-independent luciferases, potentially influencing the Fluc reporter gene [1].</p>Formula:C22H19N5O4Color and Shape:SolidMolecular weight:417.42APcK110
CAS:<p>"APcK110, a potent novel Kit inhibitor, outperforms imatinib/dasatinib in halting OCI/AML3 and HMC1.2 cell growth, also inhibiting Kit-signaling."</p>Formula:C20H16FN3O2Color and Shape:SolidMolecular weight:349.36Bezuclastinib
CAS:<p>Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.</p>Formula:C19H17N5OPurity:99.55%Color and Shape:SolidMolecular weight:331.37AC710
CAS:<p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>Formula:C31H42N6O4Purity:99.67%Color and Shape:SolidMolecular weight:562.7c-Kit-IN-3
CAS:<p>c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).</p>Formula:C26H20ClF3N2O4Purity:99.94%Color and Shape:SolidMolecular weight:516.9c-Kit-IN-2
CAS:<p>c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (</p>Formula:C25H29N9O2SPurity:98%Color and Shape:SolidMolecular weight:519.62KBP-7018
CAS:<p>KBP-7018: potent tyrosine kinase inhibitor targeting c-KIT, RET, PDGFR with IC50s of 10, 7.6, 25nM.</p>Formula:C31H30N4O5Color and Shape:SolidMolecular weight:538.59Sitravatinib malate
CAS:<p>Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5</p>Formula:C37H35F2N5O9SPurity:98%Color and Shape:SolidMolecular weight:763.76Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formula:C27H21N3O3Purity:99.22%Color and Shape:SolidMolecular weight:435.47Tafetinib
CAS:<p>Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.</p>Formula:C24H29FN4O2Purity:96.23%Color and Shape:SolidMolecular weight:424.51Agerafenib hydrochloride
CAS:<p>Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).</p>Formula:C24H23ClF3N5O5Purity:98%Color and Shape:SolidMolecular weight:553.92Henatinib
CAS:<p>Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.</p>Formula:C25H29FN4O4Color and Shape:SolidMolecular weight:468.52c-Kit-IN-8
CAS:<p>C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.</p>Formula:C24H26FN5O4Color and Shape:SolidMolecular weight:467.49AMG-25
CAS:<p>AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.</p>Formula:C23H17N5O2Purity:98.16%Color and Shape:SolidMolecular weight:395.41Protein kinase inhibitor 10
CAS:<p>Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.</p>Formula:C14H9FN6S2Color and Shape:SolidMolecular weight:344.39c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
<p>c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.</p>Color and Shape:Lyophilized PowderMolecular weight:58.50 kDa (predicted); 87.1 kDa (reducing conditions)VEGFR-IN-1
CAS:<p>VEGFR inhibitor</p>Formula:C19H16ClN3OPurity:98%Color and Shape:SolidMolecular weight:337.8
