Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(41 products)
- Aminopeptidase(67 products)
- CETP(18 products)
- Carbonic Anhydrase(177 products)
- Casein Kinase(130 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(267 products)
- FAAH(63 products)
- FXR(58 products)
- Factor Xa(80 products)
- Fatty Acid Synthase(32 products)
- Ferroptosis(215 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(53 products)
- HIF/HIF Prolyl-Hydroxylase(142 products)
- HMG-CoA Reductase(32 products)
- Hydroxylase(30 products)
- IDO(82 products)
- LDL(8 products)
- Lipase(96 products)
- Lipid(59 products)
- Lipoxygenase(124 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(36 products)
- P450(6 products)
- PAI-1(25 products)
- PDE(165 products)
- PED(1 products)
- PKM(15 products)
- PPAR(164 products)
- Phospholipase(82 products)
- ROR(42 products)
- Retinoid Receptor(29 products)
- SGK(11 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(42 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 8597 products of "Metabolism"
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Casein kinase 1δ-IN-16
CAS:<p>Casein kinase1δ-IN-16 (compound 506) is an inhibitor of casein kinase 1δ (CK1δ). This compound is applicable in research related to neurodegenerative diseases.</p>Formula:C17H12N4S2Color and Shape:SolidMolecular weight:336.4346-trans-12-epi-Leukotriene B4
CAS:<p>6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, serves as a potent anti-inflammatory agent.</p>Formula:C20H32O4Color and Shape:SolidMolecular weight:336.47AD012
<p>AD012, a dual cACE/NEP inhibitor, leverages lenopril-tryptophan for potential anti-hypertensive and cardioprotective benefits.</p>Formula:C25H32N2O6Color and Shape:SolidMolecular weight:456.53BRD2879
CAS:<p>BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM).</p>Formula:C30H38FN3O5SPurity:98%Color and Shape:SolidMolecular weight:571.70DSM705 hydrochloride
<p>DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.</p>Formula:C19H20ClF3N6OColor and Shape:SolidMolecular weight:440.85HIV-1 inhibitor-40
<p>HIV-1 inhibitor-40 (4ab) is a potent NNRTI (EC50: 1.9 nM), non-toxic in vivo, and a sensitive CYP inhibitor.</p>Formula:C25H18N6O2Color and Shape:SolidMolecular weight:434.45Lumirubin
CAS:<p>Lumirubin is a water-soluble photoproduct of bilirubin formed in vivo during phototherapy.</p>Formula:C33H36N4O6Color and Shape:SolidMolecular weight:584.66MDL-100240
CAS:<p>MDL-100240 inhibits ACE/neprilysin, effective against hypertension-induced heart/vascular changes.</p>Formula:C26H28N2O5SPurity:98%Color and Shape:SolidMolecular weight:480.58L-739750
CAS:<p>L-739,750 is an inhibitor (FTI) of peptidomimetic farnesyltransferase.</p>Formula:C23H39N3O6S2Purity:98%Color and Shape:SolidMolecular weight:517.7Carbonic anhydrase inhibitor 2
CAS:<p>Compound 7c inhibits carbonic anhydrase II, lowering intraocular pressure in glaucomatous rabbits.</p>Formula:C12H16N4O6SColor and Shape:SolidMolecular weight:344.34(S)-CPP sodium
CAS:<p>(S)-CPP sodium serves as an inhibitor of the branched-chain α-keto acid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, (S)-CPP (IC50 of 6.3 μM) inhibits BDK, which activates the complex, leading to a significant reduction in the levels of leucine/isoleucine and valine in the plasma of wild-type mice.</p>Formula:C9H8ClNaO2Color and Shape:SolidMolecular weight:206.60(E)-10-Hydroxynortriptyline maleate
CAS:<p>(E)-10-Hydroxy Nortriptyline maleate, a derivative of antidepressant Nortriptyline, eases depression symptoms.</p>Formula:C23H25NO5Purity:98%Color and Shape:SolidMolecular weight:395.455Diethylumbelliferyl phosphate
CAS:<p>Diethylumbelliferyl phosphate (DEUP) is a potent and selective inhibitor of cholesterol esterase that does not inhibit protein kinase A activity in vitro. It disrupts steroidogenesis by blocking cholesterol transport to mitochondria in steroidogenic cells, with an IC50 of 11.6 μM. This compound may also limit the absorption of dietary cholesterol.</p>Formula:C14H17O6PColor and Shape:SolidMolecular weight:312.25RXR antagonist 2
<p>RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.</p>Formula:C29H35F3N2O3Color and Shape:SolidMolecular weight:516.6NTPDase-IN-2
CAS:<p>NTPDase-IN-2 inhibits h-NTPDase-2/-8 (IC50: 0.04, 2.27 µM), non-competitive for h-NTPDase-1/-2 (Km: 74 µM); useful in cancer, immune, bacterial research.</p>Formula:C24H20FN3OS2Color and Shape:SolidMolecular weight:449.56RORγt Inverse agonist 2
CAS:<p>RORγt Inverse agonist 2 is a selective, orally active inverse agonist of RORγt(EC50 of 119 nM).</p>Formula:C27H25F8NO5SPurity:98%Color and Shape:SolidMolecular weight:627.54PTP1B-IN-19
<p>PTP1B-IN-19, a benzimidazole, selectively inhibits protein tyrosine phosphatase 1B with a Ki of 23.3 μM, potential for type 2 diabetes research.</p>Formula:C26H19N3O4SColor and Shape:SolidMolecular weight:469.51(Rac)-8-Hydroxy-efavirenz
CAS:<p>(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1.</p>Formula:C14H9ClF3NO3Color and Shape:SolidMolecular weight:331.674hMAO-B/MB-COMT-IN-2
<p>Dual inhibitor hMAO-B/MB-COMT-IN-2 targets hMAO-B (IC50: 4.27μM) & MB-COMT (IC50: 2.69μM), aids in neurodegenerative research.</p>Formula:C17H18N2O3Color and Shape:SolidMolecular weight:298.34CYP1B1-IN-2
<p>CYP1B1-IN-2 (compound 9j) is a highly potent and selective inhibitor of CYP1B1, a cytochrome P450 enzyme. It exhibits an IC50 value of 0.52 nM [1].</p>Formula:C20H11F3O2Color and Shape:SolidMolecular weight:340.3Atorvastatin 3-Deoxyhept-2E-Enoic Acid
CAS:<p>Atorvastatin 3-Deoxyhept-2E-Enoic Acid, an impurity in Atorvastatin, lowers blood lipids as an HMG-CoA reductase inhibitor.</p>Formula:C33H33FN2O4Purity:98%Color and Shape:SolidMolecular weight:540.62Casein kinase 1δ-IN-25
CAS:<p>Casein kinase1δ-IN-25 (compound 487) is a potent inhibitor of casein kinase1δ. It is applicable in research on neurodegenerative diseases such as Alzheimer's disease.</p>Formula:C20H14FN3O4S2Color and Shape:SolidMolecular weight:443.471hCAII-IN-4
CAS:<p>hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.</p>Formula:C31H23NO9Color and Shape:SolidMolecular weight:553.52SHP2-IN-9
<p>SHP2-IN-9: Potent SHP2 inhibitor, IC50=1.174 μM, 85x SHP1 selectivity, crosses blood-brain barrier, hampers cancer growth.</p>Formula:C20H20FN3O2SColor and Shape:SolidMolecular weight:385.46CA IX-IN-3
CAS:<p>CAIX-IN-3 (Compound 27) is a selective and potent inhibitor of carbonic anhydrase IX (CAIX), with an IC50 of 0.48 nM.</p>Formula:C21H19N5O4S2Color and Shape:SolidMolecular weight:469.537α-Glucosidase-IN-15
<p>α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM.</p>Formula:C24H24N2SColor and Shape:SolidMolecular weight:372.53LXRβ agonist-2
CAS:<p>LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM.</p>Formula:C32H31F6N3O7Purity:98%Color and Shape:SolidMolecular weight:683.59OMDM169
CAS:<p>OMDM169: potent/selective MAGL inhibitor, raises 2-AG, analgesic via cannabinoid receptors, IC50: 0.13-0.41μM in rat/COS-7, inactive at CB1/CB2.</p>Formula:C25H45NO5Purity:98%Color and Shape:SolidMolecular weight:439.63AChE/hCA I-IN-1
CAS:<p>AChE/hCA I-IN-1 (Compound L3) is an inhibitor of acetylcholinesterase (AChE) and carbonic anhydrase (CA), effectively inhibiting AChE, hCA I, and hCA II with IC50 values of 302 nM, 265 nM, and 283 nM, respectively.</p>Formula:C13H9BrNNaO4SColor and Shape:SolidMolecular weight:378.174Danifexor
CAS:<p>Danifexor is an agonist of the farnesoid X receptor (Farnesoid X receptor).</p>Formula:C29H20Cl2N2O5Color and Shape:SolidMolecular weight:547.386PDE4B/7A-IN-1
CAS:<p>5-HT1A antagonist; Ki=8nM, Kb=0.04nM. PDE4B IC50=80.4μM; PDE7A IC50=151.3μM. Good biofilm penetration, stable, anticognitive, antidepressant.</p>Formula:C25H35N3O3Color and Shape:SolidMolecular weight:425.56MRS4458
CAS:<p>MRS4458 is an effective inhibitor of the P2Y14 Receptor.</p>Formula:C24H20F3N5O3SPurity:98%Color and Shape:SolidMolecular weight:515.51NTPDase-IN-1
<p>NTPDase-IN-1 selectively inhibits NTPDases 1, 2, 8 with IC50 of 0.05, 0.23, 0.54 μM. Non-competitive, K m 21 μM, used in cancer, immune, infection research.</p>Formula:C18H25N3OS2Color and Shape:SolidMolecular weight:363.54hCA XII/II/IX-IN-1
<p>hCA XII/II/IX-IN-1 inhibits hCA I/II/IX/XII (IC50: 2.6, 0.004, 0.005, 0.001 μM) with anticancer properties.</p>Formula:C25H34N4O7SColor and Shape:SolidMolecular weight:534.63Mitochondrial-IN-1
CAS:<p>Mitochondrial-IN (C458) is a potent inhibitor of mitochondrial complex I. It offers significant protection against Aβ toxicity, exhibits favorable pharmacokinetic properties, and has minimal off-target effects.</p>Formula:C22H30N2OColor and Shape:SolidMolecular weight:338.49hCAI/II/XII-IN-1
CAS:<p>hCAI/II/XII-IN-1 (compound 7) is an inhibitor of human carbonic anhydrases hCAI, hCAII, and hCAXII, with Ki values of 78.5 nM, 9.1 nM, 605 nM, 7.7 nM, and 3.7 nM.</p>Formula:C12H12N2O2SColor and Shape:SolidMolecular weight:248.301TNP-470
CAS:<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Formula:C19H28ClNO6Purity:98%Color and Shape:SolidMolecular weight:401.88ZK824859 hydrochloride
<p>ZK824859 hydrochloride: oral uPA inhibitor with IC50 of 79 nM (uPA), 1580 nM (tPA), 1330 nM (fibrin).</p>Formula:C23H23ClF2N2O4Color and Shape:SolidMolecular weight:464.89Casein kinase 1δ-IN-23
CAS:<p>Casein kinase1δ-IN-23 (compound 423) is an effective inhibitor of casein kinase1δ. It is applicable in research related to neurodegenerative diseases such as Alzheimer's disease.</p>Formula:C19H15N3O3SColor and Shape:SolidMolecular weight:365.406Cilazaprilat
CAS:<p>Cilazaprilat is the active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.</p>Formula:C20H27N3O5Color and Shape:SolidMolecular weight:389.45SAR114137
CAS:<p>SAR114137 is a highly effective pharmaceutical compound characterized by potent bioactivity. It exhibits variations in its amorphous content during the physical processing of crystalline active pharmaceutical ingredients (APIs). The amorphous API content of SAR114137 significantly decreases when subjected to various jet milling techniques. Additionally, SAR114137 demonstrates good chemical stability in drug formulations.</p>Formula:C17H24F2N4O2Color and Shape:SolidMolecular weight:354.39BRD7539
CAS:<p>BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.</p>Formula:C23H22FN3O2Purity:98%Color and Shape:SolidMolecular weight:391.44(2S,4S)-Sacubitril
CAS:<p>(2S,4S)-Sacubitril (Sacubitril Impurity C) is a stereoisomer derived from Sacubitril which is a potent NEP inhibitor.</p>Formula:C24H29NO5Purity:98%Color and Shape:SolidMolecular weight:411.49Dihydrokainic acid
CAS:<p>EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake</p>Formula:C10H17NO4Purity:98%Color and Shape:SolidMolecular weight:215.25AXKO-0046
<p>AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.</p>Formula:C25H33N3Color and Shape:SolidMolecular weight:375.55Glucosylceramide synthase-IN-3
<p>Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.</p>Formula:C21H20FN3O3Color and Shape:SolidMolecular weight:381.4Lp(a)-IN-5
CAS:<p>Lp(a)-IN-5 (Compound A) is an orally active inhibitor of lipoprotein (a) [Lp(a)]. It effectively inhibits the assembly of Apo(a) and ApoB proteins, with an IC50 value of 0.41 nM. Lp(a)-IN-5 shows potential for research into diseases associated with elevated plasma Lp(a) levels, such as cardiovascular diseases.</p>Formula:C43H56N4O7Color and Shape:SolidMolecular weight:740.927GlcCer (d18:1/18:0)
CAS:<p>GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a sphingolipid with potential applications in research on Parkinson's disease and Lewy body dementia.</p>Formula:C42H81NO8Color and Shape:SolidMolecular weight:728.094Etiocholanolone glucuronide
CAS:<p>Etiocholanolone glucuronide (Etio-G) is a metabolite of Etiocholanolone, produced through the catalysis by UDP glucuronosyltransferase in the liver. Etiocholanolone glucuronide shows potential for research in metabolic-related diseases.</p>Formula:C25H38O8Color and Shape:SolidMolecular weight:466.564PNPLA3 modifier 1
CAS:<p>PNPLA3 Modifier 1 (Compound 10), a modifier of patatin-like phospholipase domain-containing protein 3 (pnpla3), exhibits a geometric mean EC50 of 4.9 nM.</p>Formula:C16H19ClF2N2O4SColor and Shape:SolidMolecular weight:408.85GKA50 quarterhydrate
<p>GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.</p>Formula:C26H30N2O7Color and Shape:SolidMolecular weight:469.01PSI-7410
CAS:<p>PSI-7410 is a metabolite of PSI-7851. PSI-7851 acts as an inhibitor of the HCV non-structural protein 5B (NS5B) and exhibits antiviral properties.</p>Formula:C10H15FN2O11P2Color and Shape:SolidMolecular weight:420.179Carbonic anhydrase inhibitor 8
<p>R-13, a carbonic anhydrase inhibitor, has Ki of 60.7 nM (hCA I), 320.7 nM (hCA II), and 2298 nM (hCA IV).</p>Formula:C20H25N3O4SColor and Shape:SolidMolecular weight:403.5PFM046
CAS:<p>PFM046 is an antagonist of the liver X receptor (LXR), effectively inhibiting the activation of LXRα and LXRβ, with IC50 values of 2.04 μM and 1.58 μM respectively. It reduces the expression of SCD1 and FASN while increasing ABCA1 expression, and demonstrates antitumor activity in mouse models.</p>Formula:C29H42O2Color and Shape:SolidMolecular weight:422.643E234G HYPE-IN-1
CAS:<p>Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].</p>Formula:C14H9N5O2Color and Shape:SolidMolecular weight:279.25ABCB1-IN-4
CAS:<p>ABCB1-IN-4 (Compound C6z) is an orally active inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.63 μM and 0.14 μM, respectively. It holds potential for diabetes research.</p>Formula:C16H14N4SColor and Shape:SolidMolecular weight:294.374α-Glucosidase-IN-63
CAS:<p>α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1]</p>Formula:C16H12FN3O3S2Color and Shape:SolidMolecular weight:377.41GSK864
CAS:<p>GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).</p>Formula:C30H31FN6O4Purity:97.07%Color and Shape:SolidMolecular weight:558.6Lufironil
CAS:<p>Lufironil (HOE 077) is an inhibitor of prolyl 4-hydroxylase, designed for investigating chronic liver conditions such as alcoholic hepatitis and cirrhosis.</p>Formula:C13H19N3O4Color and Shape:SolidMolecular weight:281.31RORγt inverse agonist 32
CAS:<p>RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.</p>Formula:C24H28F3NO5SColor and Shape:SolidMolecular weight:499.54O-Desmethyl Brinzolamide hydrochloride
CAS:<p>O-Desmethyl Brinzolamide hydrochloride (compound 6a), a potent metabolite derived from Brinzolamide, serves as a carbonic anhydrase (CA) inhibitor. It exhibits a dissociation constant (Kd) of 0.136 nM for CA II and an inhibitory concentration (IC50) of 165 nM for CA IV [1].</p>Formula:C11H20ClN3O5S3Color and Shape:SolidMolecular weight:405.94Nampt-IN-15
CAS:<p>Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.</p>Formula:C24H30N4O2Color and Shape:SolidMolecular weight:406.52Ranosidenib
CAS:<p>Ranolisib is an isocitrate dehydrogenase (IDH) inhibitor known for its antitumor activity.</p>Formula:C15H16F9N5OColor and Shape:SolidMolecular weight:453.31Nampt-IN-14
CAS:<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Formula:C33H35N7O2Color and Shape:SolidMolecular weight:561.68Inosine 5′-diphosphate sodium
CAS:<p>Inosine 5'-diphosphate sodium, a purine ribonucleoside diphosphate with inosine as its nucleobase, plays a role in intracellular energy metabolism and signal transduction processes.</p>Formula:C10H13N4Na3O12P2Color and Shape:SolidMolecular weight:512.15FXR agonist 12
CAS:<p>FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.</p>Formula:C26H44O3Color and Shape:SolidMolecular weight:404.626CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Formula:C27H27F9N2O4Color and Shape:SolidMolecular weight:614.5ATUX-8385
CAS:<p>ATUX-8385 is a potent activator of PP2A. It binds to the PR65 subunit and holds promise for research into cancer and chronic diseases, including Alzheimer's disease and chronic obstructive pulmonary disease (COPD).</p>Formula:C24H20F5N3O4SColor and Shape:SolidMolecular weight:541.49Deamino-NAD sodium
CAS:<p>Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.</p>Formula:C21H25N6NaO15P2Color and Shape:SolidMolecular weight:686.39ZK159222
CAS:<p>ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.</p>Formula:C32H48O5Purity:98%Color and Shape:SolidMolecular weight:512.72DC371739
CAS:<p>DC371739 is an effective oral PCSK9 inhibitor that decreases both PCSK9 and ANGPTL3 mRNA expression. It also reduces PCSK9 protein expression while enhancing that of LDLR. Given its properties, DC371739 has potential applications in the study of hyperlipidemia.</p>Formula:C29H30N2O4Color and Shape:SolidMolecular weight:470.56Etoricoxib N1'-oxide
CAS:<p>EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.</p>Formula:C18H15ClN2O3SColor and Shape:SolidMolecular weight:374.841Implitapide
CAS:<p>Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).</p>Formula:C35H37N3O2Purity:98%Color and Shape:SolidMolecular weight:531.69ABHD antagonist 1
CAS:<p>ABHD antagonist 1 is an inhibitor of ABHD6 (α/β-Hydrolase domain containing 6), involved in modulating biochemical pathways affected by ABHD6, thereby influencing cell function and inflammatory responses. This compound is applicable for research in fields such as pain, neurological disorders, inflammatory diseases, autoimmune diseases, metabolic disorders, and cancer.</p>Formula:C19H20BrN3O3SColor and Shape:SolidMolecular weight:450.35GK420
CAS:<p>GK420 (AVX420) is a potent inhibitor of cytoplasmic phospholipase A2α (cPLA2α), with an XI(50) value of 0.0016. It effectively inhibits the release of arachidonic acid, with an EC50 of 0.09 μM. GK420 plays a significant role in cancer research.</p>Formula:C20H25NO5SColor and Shape:SolidMolecular weight:391.481MAGL-IN-15
CAS:<p>MAGL-IN-15 (Compound 6), a MAGL inhibitor, holds potential for research into diseases and disorders associated with the regulation of endocannabinoid system signaling activities [1].</p>Formula:C16H16F6N4O3Color and Shape:SolidMolecular weight:426.314-MDM
CAS:<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Formula:C14H14OColor and Shape:SolidMolecular weight:198.26JTZ-951 HCl
CAS:<p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>Formula:C17H17ClN4O4Purity:98%Color and Shape:SolidMolecular weight:376.79HIF-2α-IN-5
CAS:<p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].</p>Formula:C15H12F4O3S2Color and Shape:SolidMolecular weight:380.3811-trans Leukotriene E4
CAS:<p>Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.</p>Formula:C23H37NO5SColor and Shape:SolidMolecular weight:439.61Enpp-1-IN-12
<p>ENPP1-IN-12 is a potent, oral ENPP1 inhibitor with a Ki of 41 nM and anti-tumor properties.</p>Formula:C17H19N5O3SColor and Shape:SolidMolecular weight:373.43(+)-Potassium Ds-threo-isocitrate monobasic
CAS:<p>(+)-Potassium Ds-threo-isocitrate monobasic is a bioactive compound known for its role in enhancing cellular metabolism and regulating energy production. This substance is also utilized in researching metabolic pathways and the regulation of enzyme activities. Widely applied in biochemical research, (+)-Potassium Ds-threo-isocitrate monobasic is studied for its potential functions in cellular processes and disease mechanisms.</p>Formula:C6H7KO7Color and Shape:SolidMolecular weight:230.21TAK-915
CAS:<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Formula:C19H18F4N4O5Purity:98%Color and Shape:SolidMolecular weight:458.36Glucokinase activator 7
CAS:<p>Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].</p>Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337BMS-185354
CAS:<p>BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM, offering potential for cancer research.</p>Formula:C26H27NO3Color and Shape:SolidMolecular weight:401.497Propofol sulfate sodium
CAS:<p>Propofolsulfate (sodium) is a metabolite of Propofol.</p>Formula:C12H17NaO4SColor and Shape:SolidMolecular weight:280.316RWJ-445167
CAS:<p>RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.</p>Formula:C18H24N6O5SPurity:98%Color and Shape:SolidMolecular weight:436.49ZK168281
CAS:<p>ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.</p>Formula:C32H46O5Purity:98%Color and Shape:SolidMolecular weight:510.70PTP1B-IN-17
<p>PTP1B-IN-17, a benzimidazole derivative, inhibits PTP1B (Ki: 30.2 μM) and may help study type 2 diabetes.</p>Formula:C26H19N3O4SColor and Shape:SolidMolecular weight:469.514-(4-Bromophenyl)-4-hydroxypiperidine
CAS:<p>4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.</p>Formula:C11H14BrNOColor and Shape:SolidMolecular weight:256.139IDO antagonist-1
CAS:<p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>Formula:C39H53N7O5Color and Shape:SolidMolecular weight:699.88TMX-4113
<p>TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1].</p>Formula:C12H12N4O2S2Color and Shape:SolidMolecular weight:308.38LTA4H-IN-3
CAS:<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Formula:C17H15ClN4O3Color and Shape:SolidMolecular weight:358.78Squalestatin 3
CAS:<p>Squalestatin 3 is an inhibitor of squalene synthase.</p>Formula:C25H30O13Purity:98%Color and Shape:SolidMolecular weight:538.5Epoxykynin
CAS:<p>Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].</p>Formula:C19H20BrF3N2O2Color and Shape:SolidMolecular weight:445.277-Hydroxyrisperidone
CAS:<p>7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone. Risperidone acts as a 5-HT2 receptor blocker, an inhibitor of P-glycoprotein (P-Glycoprotein), and an antagonist of the dopamine D2 receptor.</p>Formula:C23H27FN4O3Color and Shape:SolidMolecular weight:426.4844-Acetylphenylboronic acid
CAS:<p>4-Acetylphenylboronic acid acts as an effective inhibitor targeting carbonic anhydrase II (CAII), displaying inhibitory concentrations (IC50) of 246 μM for bovine CAII (bCA II) and 281.40 μM for human CAII (hCA II).</p>Formula:C8H9BO3Color and Shape:SolidMolecular weight:163.97PF-06795071
CAS:<p>PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).</p>Formula:C18H17F4N3O3Purity:98%Color and Shape:SolidMolecular weight:399.347-Hydroxy-4-phenylcoumarin
CAS:<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Formula:C15H10O3Color and Shape:SolidMolecular weight:238.2382R,4R-Sacubitril
CAS:<p>2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.</p>Formula:C24H29NO5Purity:98%Color and Shape:SolidMolecular weight:411.49
