Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(41 products)
- Aminopeptidase(67 products)
- CETP(18 products)
- Carbonic Anhydrase(177 products)
- Casein Kinase(130 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(267 products)
- FAAH(63 products)
- FXR(58 products)
- Factor Xa(80 products)
- Fatty Acid Synthase(32 products)
- Ferroptosis(215 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(53 products)
- HIF/HIF Prolyl-Hydroxylase(142 products)
- HMG-CoA Reductase(32 products)
- Hydroxylase(30 products)
- IDO(82 products)
- LDL(8 products)
- Lipase(96 products)
- Lipid(59 products)
- Lipoxygenase(124 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(36 products)
- P450(6 products)
- PAI-1(25 products)
- PDE(165 products)
- PED(1 products)
- PKM(15 products)
- PPAR(164 products)
- Phospholipase(82 products)
- ROR(42 products)
- Retinoid Receptor(29 products)
- SGK(11 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(42 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 8597 products of "Metabolism"
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Rostratin B
CAS:<p>Rostratin B, a cytotoxic disulfide, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an IC50 value of 1.9 μg/mL.</p>Formula:C18H20N2O6S2Color and Shape:SolidMolecular weight:424.49PDHK-IN-5
<p>PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.</p>Formula:C30H31N5O2Color and Shape:SolidMolecular weight:493.6Gcase activator 2
CAS:<p>Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.</p>Formula:C21H24N4O2Purity:99.51% - 99.76%Color and Shape:SolidMolecular weight:364.44Tabimorelin hemifumarate
CAS:<p>orally active ghrelin receptor (GHS-R1a) agonist</p>Formula:C32H40N403C4H404Purity:98%Color and Shape:SolidMolecular weight:586.72Fonadelpar
CAS:<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Formula:C25H23F3N2O4SPurity:98%Color and Shape:SolidMolecular weight:504.52PDHK-IN-3
<p>PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].</p>Formula:C17H16N2O2Color and Shape:SolidMolecular weight:280.32Carbonic anhydrase inhibitor 10
<p>CA inhibitor 10 targets MCF-7 cells, IC50: 11.9 μM; potent h CA IX inhibitor, Ki: 6.2 nM. Anti-cancer research.</p>Formula:C14H17N5O3SColor and Shape:SolidMolecular weight:335.38BMS-185354
CAS:<p>BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM, offering potential for cancer research.</p>Formula:C26H27NO3Color and Shape:SolidMolecular weight:401.497PTP1B-IN-18
<p>PTP1B-IN-18 is an orally active, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 35.2 μM).PTP1B-IN-18 can be used to study type 2 diabetes.</p>Formula:C26H19N3O4SColor and Shape:SolidMolecular weight:469.51CYP11B1-IN-2
<p>CYP11B1-IN-2 selectively inhibits human and rat CYP11B1 (IC50: 9/25 nM) orally to research cortisol-related diseases.</p>Color and Shape:SolidMyxothiazol
CAS:<p>Myxothiazol blocks mitochondrial complex III and triggers SESN2, a gene important for stress response.</p>Formula:C25H33N3O3S2Color and Shape:SolidMolecular weight:487.68Carbonic anhydrase inhibitor 4
<p>CA inhibitor 4, photoprobe; targets hCA I-XIV; Ki: 640-1166 nM.</p>Formula:C21H18N2O4SColor and Shape:SolidMolecular weight:394.44FXIa-IN-8
<p>FXIa-IN-8: potent FXIa blocker (IC50: 14.2 nM), anti-thrombotic, low bleeding/toxicity risk.</p>Color and Shape:SolidFAAH/MAGL-IN-1
<p>FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.</p>Formula:C15H9Cl2N3O3Color and Shape:SolidMolecular weight:350.16PLAP-IN-1
CAS:<p>PLAP-IN-1: Potent, selective inhibitor of PLAP, IC50 of 32 nM; doesn't notably inhibit TNAP.</p>Formula:C25H21Cl2N3O5Color and Shape:SoildMolecular weight:514.36PKR-IN-1
CAS:<p>PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).</p>Formula:C9HCl5N4OS2Color and Shape:SolidMolecular weight:422.525Lp-PLA2-IN-5
CAS:<p>Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.</p>Formula:C23H18F5N3O4Color and Shape:SolidMolecular weight:495.4Cilazaprilat
CAS:<p>Cilazaprilat is the active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.</p>Formula:C20H27N3O5Color and Shape:SolidMolecular weight:389.45Quinapril
CAS:<p>Quinapril is an orally active, non-peptide, and non-thiol angiotensin-converting enzyme (ACE) inhibitor. It primarily blocks the conversion of angiotensin I to angiotensin II in both plasma and tissues. Upon enzymatic hydrolysis, Quinapril is converted into the pharmacologically active Quinaprilat and is effective in hypertension models.</p>Formula:C25H30N2O5Color and Shape:SolidMolecular weight:438.516A-800141
CAS:<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>Formula:C24H30N2O4SColor and Shape:SolidMolecular weight:442.571Complex III-IN-1
<p>Complex III-IN-1 inhibits complex III, has antifungal properties, and an EC50 of 18.53 mg/L against S. sclerotiorum.</p>Formula:C14H20ClNO2S2Color and Shape:SolidMolecular weight:333.9β-Glucuronidase/hCAII-IN-1
CAS:<p>β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50</p>Formula:C30H21NO9Color and Shape:SolidMolecular weight:539.49Lunacalcipol
CAS:<p>Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism.</p>Formula:C28H42O4SColor and Shape:SolidMolecular weight:474.7RXR antagonist 1
<p>RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.</p>Formula:C28H33F3N2O3Color and Shape:SolidMolecular weight:502.57hCAVII/IX-IN-1
CAS:<p>hCAVII/IX-IN-1 (compound 4) functions as an inhibitor of hCAVII/IX, exhibiting Ki values of 56.5 nM and 38.2 nM, respectively. It is applicable in the field of cancer research.</p>Formula:C7H7N3O2S2Color and Shape:SolidMolecular weight:229.279CA IX-IN-1
<p>CA IX-IN-1 (compound 12g) is a potent and highly selective hCA IX inhibitor (IC50: 7 nM) that exhibits antitumour effects.</p>Formula:C16H22N4O8SColor and Shape:SolidMolecular weight:430.43sEH inhibitor-1
<p>TCPU (sEH inhibitor-1) is a potent oral human sEH blocker with IC50s of 0.4 nM (human) and 5.3 nM (mouse).</p>Color and Shape:SolidPAT-347
CAS:<p>PAT-347 is a potent inhibitor of Autotaxin, an enzyme linked to cell survival and diseases like cancer and fibrosis.</p>Formula:C28H21ClF2N2O3SColor and Shape:SolidMolecular weight:538.99Aripiprazole N,N-Dioxide
CAS:<p>AripiprazoleN,N-Dioxide is a metabolite of the atypical antipsychotic drug aripiprazole, formed through its oxidation.</p>Formula:C23H27Cl2N3O4Molecular weight:480.38L 671776
CAS:<p>L 671776 is an inositol monophosphatase inhibitor.</p>Formula:C23H32O5Purity:98%Color and Shape:SolidMolecular weight:388.5DPM-1003
CAS:<p>DPM-1003 is an allosteric inhibitor of PTP1B, targeting the non-catalytic, disordered C-terminal segment of the PTP1B protein, and has shown beneficial effects in reducing pulmonary inflammation in mice.</p>Formula:C35H57N3O3Color and Shape:SolidMolecular weight:567.84511-trans Leukotriene E4
CAS:<p>Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.</p>Formula:C23H37NO5SColor and Shape:SolidMolecular weight:439.61Cgs 25155
CAS:<p>Cgs 25155 is an orally active inhibitor of NEP 24.11.</p>Formula:C25H34N2O6SPurity:98%Color and Shape:SolidMolecular weight:490.61SHP2 IN-1
CAS:<p>SHP2 IN-1 is an allergic SHP2 (PTPN11) inhibitor(IC50 : 3 nM).</p>Formula:C18H22Cl2N6OSPurity:98%Color and Shape:SolidMolecular weight:441.38Benfooxythiamine
CAS:<p>Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.</p>Formula:C19H22N3O7PSColor and Shape:SolidMolecular weight:467.433Mutant IDH1-IN-3
CAS:<p>Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor targeting the mutant isocitrate dehydrogenase 1 (IDH1), with an IC50 of 13 nM for R132HIDH1. It effectively suppresses the production of D-2-hydroxyglutarate (2HG) in cells and is applicable for research in oncology.</p>Formula:C22H30N4OColor and Shape:SolidMolecular weight:366.5Nomelidine
CAS:<p>Nomelidine, the active N-demethylated metabolite of zimelidine, has been used as an antidepressant and analgesic.</p>Formula:C15H15BrN2Purity:98%Color and Shape:SolidMolecular weight:303.20Utibaprilat
CAS:<p>Utibaprilat is the primary degradation product of Utibapril and functions as an ACE inhibitor.</p>Formula:C20H27N3O5SColor and Shape:SolidMolecular weight:421.51FTI-2148
CAS:<p>FTI-2148 blocks RAS-related FT-1 & GGT-1; IC50: 1.4 nM & 1.7 μM.</p>Formula:C24H28N4O3SPurity:98%Color and Shape:SolidMolecular weight:452.57Casein kinase 1δ-IN-25
CAS:<p>Casein kinase1δ-IN-25 (compound 487) is a potent inhibitor of casein kinase1δ. It is applicable in research on neurodegenerative diseases such as Alzheimer's disease.</p>Formula:C20H14FN3O4S2Color and Shape:SolidMolecular weight:443.471Arphamenine A
CAS:<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Formula:C16H24N4O3Color and Shape:SolidMolecular weight:320.387PF-07202954
CAS:<p>PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against</p>Formula:C22H23FN6O3Purity:98%Color and Shape:SolidMolecular weight:438.45MGAT2-IN-1
CAS:<p>MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).</p>Formula:C27H21ClF5N7O3SColor and Shape:SolidMolecular weight:654.01Ro 23-9358
CAS:<p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>Formula:C30H51NO6Color and Shape:SolidMolecular weight:521.729BRD7539
CAS:<p>BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.</p>Formula:C23H22FN3O2Purity:98%Color and Shape:SolidMolecular weight:391.44PDE5-IN-8
CAS:<p>PDE5-IN-8 (compound 2) is an inhibitor of PDEs.</p>Formula:C22H20ClN3O2Color and Shape:SolidMolecular weight:393.87hCAI/II/XII-IN-1
CAS:<p>hCAI/II/XII-IN-1 (compound 7) is an inhibitor of human carbonic anhydrases hCAI, hCAII, and hCAXII, with Ki values of 78.5 nM, 9.1 nM, 605 nM, 7.7 nM, and 3.7 nM.</p>Formula:C12H12N2O2SColor and Shape:SolidMolecular weight:248.301Deamino-NAD sodium
CAS:<p>Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.</p>Formula:C21H25N6NaO15P2Color and Shape:SolidMolecular weight:686.39Homomoschatoline
CAS:<p>Homomoschatoline is an antibacterial isolated from Artabotrys crassifolius.</p>Formula:C19H15NO4Purity:98%Color and Shape:SolidMolecular weight:321.33AubipyOMe
CAS:<p>AubipyOMe serves as an effective inhibitor of Tartrate-resistant Acid Phosphatase (TRAP/ACP5), a metalloenzyme identified in activated osteoclasts and macrophages. It exhibits inhibitory IC50 values of 1.3 μM against TRAP5a and 1.8 μM against TRAP5b. Additionally, it effectively suppresses TRAP activity in extracts from mouse macrophages and human lung tissues.</p>Formula:C12H12AuCl2F6N2O2PColor and Shape:SolidMolecular weight:629.07α-Hydroxy alprazolam
CAS:<p>α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.</p>Formula:C17H13ClN4OColor and Shape:SolidMolecular weight:324.76BRD2879
CAS:<p>BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM).</p>Formula:C30H38FN3O5SPurity:98%Color and Shape:SolidMolecular weight:571.70S-15176
CAS:<p>S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). It effectively suppresses mitochondrial swelling induced by tert-butyl hydroperoxide, with an IC50 value of 45.7 μM. S-15176 prevents the opening of PTP, thus averting the dissipation of mitochondrial membrane potential and the oxidation of NAD(P)H, while enhancing mitochondrial calcium loading capacity. It holds potential for research into ischemia-reperfusion injury.</p>Formula:C31H48N2O4SColor and Shape:SolidMolecular weight:544.79QGC583
CAS:<p>QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.</p>Formula:C13H20NO5PColor and Shape:SolidMolecular weight:301.28DGAT2-IN-3
CAS:<p>DGAT2-IN-3 (compound 9) is an inhibitor of DGAT2 with an IC50 value of 0.4 nM. It is utilized in research related to fatty liver disease, diabetes, and cardiovascular diseases.</p>Formula:C21H20F4N4O5SColor and Shape:SolidMolecular weight:516.47L 691816
CAS:<p>L 691816 is an effective inhibitor of the 5-LO reaction.</p>Formula:C36H35ClN6OSPurity:98%Color and Shape:SolidMolecular weight:635.22Sphingomyelin (d18:1/12:0)
CAS:<p>Sphingomyelin (d18:1/12:0) is a polar lipid known for its role in modulating cell signal transduction. It plays a critical role in cell membranes, influencing their fluidity and stability. Additionally, sphingomyelin (d18:1/12:0) is involved in lipid metabolism and has potential in promoting neuronal cell growth. This compound is essential for the functioning and development of the nervous system.</p>Formula:C35H71N2O6PColor and Shape:SolidMolecular weight:646.92(rel)-Mirogabalin
CAS:<p>(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.</p>Formula:C12H19NO2Color and Shape:SolidMolecular weight:209.28Lecufexor
CAS:<p>Lecufexor is an agonist of the farnesoid X receptor (FXR).</p>Formula:C32H21Cl3N2O5Color and Shape:SolidMolecular weight:619.88CK2-IN-3
<p>CK2-IN-3: potent, selective CK2 inhibitor; Kd=12 nM, IC50: 1.51 μM (CK2α), 7.64 μM (CK2α'). For cancer research.</p>Formula:C22H26N4O7Color and Shape:SolidMolecular weight:458.46RMGPa-IN-1
CAS:<p>RMGPa-IN-1 (Compound 10C) is an inhibitor of rabbit muscle glycogen phosphorylase a (RMGPa), exhibiting an IC50 value of 82.5 μM. This compound holds potential for research in diabetes.</p>Formula:C33H54O4Color and Shape:SolidMolecular weight:514.779AZD 4407
CAS:<p>AZD 4407 is a potent inhibitor of 5-lipoxygenase.</p>Formula:C19H21NO3S2Purity:98%Color and Shape:SolidMolecular weight:375.5NTPDase-IN-2
CAS:<p>NTPDase-IN-2 inhibits h-NTPDase-2/-8 (IC50: 0.04, 2.27 µM), non-competitive for h-NTPDase-1/-2 (Km: 74 µM); useful in cancer, immune, bacterial research.</p>Formula:C24H20FN3OS2Color and Shape:SolidMolecular weight:449.56Xanthosine-5'-monophosphate
CAS:<p>Xanthosine 5'-monophosphate is produced from inosine monophosphate (IMP) through the catalytic action of inosine monophosphate dehydrogenase (IMPDH).</p>Formula:C10H13N4O9PColor and Shape:SolidMolecular weight:364.21NNC 55-0396
CAS:<p>NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.</p>Formula:C30H40Cl2FN3O2Purity:99.00%Color and Shape:SolidMolecular weight:564.56Yck2-IN-1
CAS:<p>Yck2-IN-1 (Compound 2a) is an inhibitor of the fungus Candida albicans Yck2. It has an IC50 of approximately 80 nM for Yck2 and an MIC80 of 12.5 µM for C. albicans, demonstrating good metabolic stability [66% remaining in mouse liver microsomes]. In a mouse model with drug-resistant Candida, Yck2-IN-1 significantly reduced fungal load in the kidneys. Yck2-IN-1 shows potential for research in antifungal infection treatments.</p>Formula:C19H11FN4Color and Shape:SolidMolecular weight:314.316Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Formula:C30H40Cl2N6O4S2Purity:98%Color and Shape:SolidMolecular weight:683.71Casein kinase 1δ-IN-17
CAS:<p>Casein kinase1δ-IN-17 (compound 753) is an inhibitor of casein kinase 1δ (CK1δ). It is applicable in research related to neurodegenerative diseases.</p>Formula:C14H14N4SColor and Shape:SolidMolecular weight:270.353SID 24785302
CAS:<p>SID 24785302 is an inhibitor of hexokinase, which can suppress glycolysis, regulate mitochondrial function, and ultimately inhibit the replication of mutant mitochondrial DNA.</p>Formula:C14H12N2O3S2Color and Shape:SolidMolecular weight:320.387Z57346765
CAS:<p>Z57346765 is a specific PGK1 inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis.</p>Formula:C17H18N4OPurity:99.85%Color and Shape:SolidMolecular weight:294.35Lumirubin
CAS:<p>Lumirubin is a water-soluble photoproduct of bilirubin formed in vivo during phototherapy.</p>Formula:C33H36N4O6Color and Shape:SolidMolecular weight:584.66PPARδ agonist 11
CAS:<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Formula:C19H15F3N2O3S2Color and Shape:SolidMolecular weight:440.46hCAII-IN-4
CAS:<p>hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.</p>Formula:C31H23NO9Color and Shape:SolidMolecular weight:553.52DOCP
CAS:<p>DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a lipid characterized by an opposite charge orientation compared to traditional phosphatidylcholine (PC) lipids, featuring quaternary ammonium near the bilayer interface and phosphate groups projecting into the aqueous environment. This unique structure of iPC lipids presents an excellent opportunity to investigate the biophysical characteristics and biological activities influenced by the reversal of surface charges on bilayers.</p>Formula:C43H82NO8PColor and Shape:SolidMolecular weight:772.09Homodestcardin
CAS:<p>Homodestcardin: cyclic depsipeptide from T. roseum with immunosuppressant properties; inhibits mouse T cell proliferation.</p>Formula:C32H55N5O7Color and Shape:SolidMolecular weight:621.81HIF-1α-IN-5
<p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>Formula:C16H15N3O2Color and Shape:SolidMolecular weight:281.31MD 770222
CAS:<p>MD 770222, the principal plasma O-demethylated metabolite of Cimoxatone, is an orally active selective and reversible inhibitor of MAO A. The potency of MD 770222 is lower than that of Cimoxatone.</p>Formula:C18H16N2O4Color and Shape:SolidMolecular weight:324.33Etoricoxib N1'-oxide
CAS:<p>EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.</p>Formula:C18H15ClN2O3SColor and Shape:SolidMolecular weight:374.841ATX inhibitor 12
<p>Oral ATX inhibitor 12 (IC50: 1.72 nM) at 60 mg/kg prevents lung damage in C57Bl/6J mice.</p>Formula:C30H34FN5O2Color and Shape:SolidMolecular weight:515.622,4-Dihydroxybutanoic acid
CAS:<p>2,4-Dihydroxybutanoic acid is typically not found in extracts of normal human urine and is present only in trace amounts in newborns, while cases of succinic semialdehyde dehydrogenase deficiency consistently exhibit elevated levels of this metabolite.</p>Formula:C4H8O4Color and Shape:SolidMolecular weight:120.10(S)-CPP sodium
CAS:<p>(S)-CPP sodium serves as an inhibitor of the branched-chain α-keto acid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, (S)-CPP (IC50 of 6.3 μM) inhibits BDK, which activates the complex, leading to a significant reduction in the levels of leucine/isoleucine and valine in the plasma of wild-type mice.</p>Formula:C9H8ClNaO2Color and Shape:SolidMolecular weight:206.60ATX inhibitor 22
<p>ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.</p>Formula:C19H17Cl3F2N2O4SColor and Shape:SolidMolecular weight:513.77ABT-046
CAS:<p>ABT-046 is an orally active, selective, and highly efficient Diacylglycerol Acyltransferase 1 (DGAT-1) inhibitor that can be used in metabolic disease research.</p>Formula:C20H22N4O2Purity:98.13%Color and Shape:SolidMolecular weight:350.41OMDM169
CAS:<p>OMDM169: potent/selective MAGL inhibitor, raises 2-AG, analgesic via cannabinoid receptors, IC50: 0.13-0.41μM in rat/COS-7, inactive at CB1/CB2.</p>Formula:C25H45NO5Purity:98%Color and Shape:SolidMolecular weight:439.63FXR/CES2 modulator 1
CAS:<p>Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.</p>Formula:C27H21Cl2NO5Color and Shape:SolidMolecular weight:510.36CB30865
CAS:<p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>Formula:C26H22BrN5O2Purity:99.04%Color and Shape:SolidMolecular weight:516.392R,4S-Sacubitril
CAS:<p>2R,4S-Sacubitril (Sacubitril Enantiomer) is the impurity of Sacubitril which is a neprilysin inhibitor.</p>Formula:C24H28NO51CaPurity:98%Color and Shape:SolidMolecular weight:430.49Calcium 2-hydroxypropanoate pentahydrate
CAS:<p>Calcium 2-hydroxypropanoate (pentahydrate) acts as an activator of the hydroxyl-carboxylic acid receptor 1 (HCAR1) and serves as an epigenetic regulator that induces lysine residue lactylation. This compound, a glycolysis end product, bridges the gap between glycolysis and oxidative phosphorylation and functions as a tumor metabolite with immunoprotective effects of lactate in antitumor immunity.</p>Formula:C3H5O3CaH2OColor and Shape:SolidMolecular weight:154.147JPHM-2-167
CAS:<p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>Formula:C30H28N6O2Color and Shape:SolidMolecular weight:504.5825-Carboxy-2′-deoxycytidine
CAS:<p>5-Carboxy-2′-deoxycytidine is a metabolite of Trifluridine.</p>Formula:C10H13N3O6Color and Shape:SolidMolecular weight:271.227Buspirone N-oxide
CAS:<p>Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone. Buspirone is an orally active 5-HT1A receptor agonist and a dopamine D2 (dopamine D2) autoreceptor antagonist. It is an anxiolytic agent used for research in generalized anxiety disorder.</p>Formula:C21H31N5O3Color and Shape:SolidMolecular weight:401.503DSM705 hydrochloride
<p>DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.</p>Formula:C19H20ClF3N6OColor and Shape:SolidMolecular weight:440.85MRS4458
CAS:<p>MRS4458 is an effective inhibitor of the P2Y14 Receptor.</p>Formula:C24H20F3N5O3SPurity:98%Color and Shape:SolidMolecular weight:515.51Nampt activator-4
CAS:<p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>Formula:C26H22F3N7OSColor and Shape:SolidMolecular weight:537.56α-Glucosidase-IN-63
CAS:<p>α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1]</p>Formula:C16H12FN3O3S2Color and Shape:SolidMolecular weight:377.41ABCB1-IN-4
CAS:<p>ABCB1-IN-4 (Compound C6z) is an orally active inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.63 μM and 0.14 μM, respectively. It holds potential for diabetes research.</p>Formula:C16H14N4SColor and Shape:SolidMolecular weight:294.374ABHD antagonist 1
CAS:<p>ABHD antagonist 1 is an inhibitor of ABHD6 (α/β-Hydrolase domain containing 6), involved in modulating biochemical pathways affected by ABHD6, thereby influencing cell function and inflammatory responses. This compound is applicable for research in fields such as pain, neurological disorders, inflammatory diseases, autoimmune diseases, metabolic disorders, and cancer.</p>Formula:C19H20BrN3O3SColor and Shape:SolidMolecular weight:450.35E234G HYPE-IN-1
CAS:<p>Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].</p>Formula:C14H9N5O2Color and Shape:SolidMolecular weight:279.25EC33
CAS:<p>EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].</p>Formula:C4H11NO3S2Color and Shape:SolidMolecular weight:185.27Carbonic anhydrase inhibitor 8
<p>R-13, a carbonic anhydrase inhibitor, has Ki of 60.7 nM (hCA I), 320.7 nM (hCA II), and 2298 nM (hCA IV).</p>Formula:C20H25N3O4SColor and Shape:SolidMolecular weight:403.5Desmonomethylpromazine
CAS:<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>Formula:C16H18N2SColor and Shape:SolidMolecular weight:270.39EpoY
CAS:<p>EpoY (SD-142) is an irreversible inhibitor of the primary brain microtubule-associated tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and small vasohibin-binding protein (SVBP). By inhibiting TCP with an IC50 value of approximately 500 nM, EpoY effectively reduces the levels of detyrosinated α-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition results in significant differentiation defects and is linked to potential issues related to cancer and cardiomyopathy.</p>Formula:C15H17NO7Color and Shape:SolidMolecular weight:323.30Estradiol 3-glucuronide
CAS:<p>Estradiol 3-glucuronide is an immunogen with antigenic properties. The antiserum induced in rabbits exhibits high affinity and specificity for Estradiol 3-glucuronide. This compound shows promise for use in research involving radioimmunoassay.</p>Formula:C24H32O8Color and Shape:SolidMolecular weight:448.51Glucosylceramide synthase-IN-3
<p>Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.</p>Formula:C21H20FN3O3Color and Shape:SolidMolecular weight:381.4AChE/PDE4-IN-1
<p>AChE/PDE4-IN-1, compound 12c, dual inhibitor; IC50: 0.28μM for AChE, 1.88μM for PDE4D, may reduce Alzheimer's neuroinflammation.</p>Formula:C23H28N2O3Color and Shape:SolidMolecular weight:380.48CK1δ-IN-10
CAS:<p>CK1δ-IN-10 (Compound 85) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ (CSNKID), with an IC50 value of 0.255 μM.</p>Formula:C17H11F4N5Color and Shape:SolidMolecular weight:361.296BAY R3401
CAS:<p>BAY R3401 is an orally active inhibitor of glycogen phosphorylase, leading to irreversible and non-selective inhibition of liver glycogenolysis. It suppresses glycogen breakdown in hepatocytes with IC50 values of 27.06 μM in HL-7702 cells and 52.83 μM in HepG2 cells. BAY R3401 is applicable for research in type 2 diabetes.</p>Formula:C20H22ClNO4Color and Shape:SolidMolecular weight:375.846CK1δ-IN-5
CAS:<p>CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.</p>Formula:C22H21N5Color and Shape:SolidMolecular weight:355.436Pyripyropene A
CAS:<p>Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM).</p>Formula:C31H37NO10Purity:98%Color and Shape:SolidMolecular weight:583.63Glycerophosphoglycerol
CAS:<p>Glycerophosphoglycerol is a precursor in phospholipid synthesis. By enhancing phospholipid formation, it aids in the reconstruction and proliferation of membrane structures in tumor cells. Glycerophosphoglycerol holds promise for research in breast cancer cells.</p>Formula:C6H15O8PColor and Shape:SolidMolecular weight:246.15hCA XII/II/IX-IN-1
<p>hCA XII/II/IX-IN-1 inhibits hCA I/II/IX/XII (IC50: 2.6, 0.004, 0.005, 0.001 μM) with anticancer properties.</p>Formula:C25H34N4O7SColor and Shape:SolidMolecular weight:534.63JA2
CAS:<p>JA2 is an inhibitor of metalloendopeptidase 24.15 that enhances the hypotensive response to bradykinin in rats.</p>Formula:C33H38N4O8Color and Shape:SolidMolecular weight:618.68RO5101576
CAS:<p>RO5101576 is a potent antagonist of LTB4 receptor.</p>Formula:C36H38O8SPurity:98%Color and Shape:SolidMolecular weight:630.75MDL-100240
CAS:<p>MDL-100240 inhibits ACE/neprilysin, effective against hypertension-induced heart/vascular changes.</p>Formula:C26H28N2O5SPurity:98%Color and Shape:SolidMolecular weight:480.58Tovinontrine
CAS:<p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>Formula:C21H26N6O2Purity:98.14%Color and Shape:SolidMolecular weight:394.47Raloxifene N-Oxide
CAS:<p>Raloxifene N-Oxide is a Raloxifene oxidative degradation product.</p>Formula:C28H27NO5SPurity:98%Color and Shape:SolidMolecular weight:489.58IDO antagonist-1
CAS:<p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>Formula:C39H53N7O5Color and Shape:SolidMolecular weight:699.88SHP2-IN-9
<p>SHP2-IN-9: Potent SHP2 inhibitor, IC50=1.174 μM, 85x SHP1 selectivity, crosses blood-brain barrier, hampers cancer growth.</p>Formula:C20H20FN3O2SColor and Shape:SolidMolecular weight:385.46Miaosporone A
<p>Miaosporone A: angucyclic quinone, cytotoxic to MCF-7, NCI-H187, Vero cells; anti-TB and anti-malaria with IC50 of 2.4 μM, 2.5 μM.</p>Formula:C19H18O5Color and Shape:SolidMolecular weight:326.34Complex III-IN-2
<p>Complex III-IN-2 inhibits complex III, with antifungal EC50: 29.31 mg/L vs R. solani, 29.98 mg/L vs S. sclerotiorum.</p>Formula:C15H21ClN2O2SColor and Shape:SolidMolecular weight:328.86Monoamine oxidase/Aromatase-IN-1
<p>Compound 2q: Dual MAO/aromatase inhibitor; IC50: 39 nM (MAO-B), 31 nM (aromatase). Useful in neurological/breast cancer research.</p>Formula:C19H19N3O3SColor and Shape:SolidMolecular weight:369.44RXR antagonist 2
<p>RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.</p>Formula:C29H35F3N2O3Color and Shape:SolidMolecular weight:516.6(E)-10-Hydroxynortriptyline maleate
CAS:<p>(E)-10-Hydroxy Nortriptyline maleate, a derivative of antidepressant Nortriptyline, eases depression symptoms.</p>Formula:C23H25NO5Purity:98%Color and Shape:SolidMolecular weight:395.455LTA4H-IN-3
CAS:<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Formula:C17H15ClN4O3Color and Shape:SolidMolecular weight:358.78(Rac)-OSMI-1
<p>(Rac)-OSMI-1, a racemate, inhibits OGT (IC50: 2.7 μM) affecting O-GlcNAcylation without changing surface glycans.</p>Formula:C28H25N3O6S2Color and Shape:SolidMolecular weight:563.64Fusarisetin A
CAS:<p>Fusarisetin A, a pentacyclic fungal metabolite, is an acinar morphogenesis inhibitor .</p>Formula:C22H31NO5Color and Shape:SolidMolecular weight:389.49IDO1-IN-13
<p>IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.</p>Formula:C20H16BrN5O2SColor and Shape:SolidMolecular weight:470.34AD012
<p>AD012, a dual cACE/NEP inhibitor, leverages lenopril-tryptophan for potential anti-hypertensive and cardioprotective benefits.</p>Formula:C25H32N2O6Color and Shape:SolidMolecular weight:456.53Rosiptor acetate
CAS:<p>Rosiptor (AQX-1125) activates SHIP1, inhibits Akt, and reduces inflammation and allergy in rodents.</p>Formula:C22H39NO4Purity:98%Color and Shape:Solid PowderMolecular weight:381.55BLT-4
CAS:<p>BLT-4 is a specific and reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the SR-BI-mediated transfer of lipids between high-density lipoprotein (HDL) and cells.</p>Formula:C18H16N2O2Color and Shape:SolidMolecular weight:292.332Epoxykynin
CAS:<p>Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].</p>Formula:C19H20BrF3N2O2Color and Shape:SolidMolecular weight:445.27BMS-341400 mesylate
CAS:<p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>Formula:C24H26ClN9O5SColor and Shape:SolidMolecular weight:588.039L-Afegostat
CAS:<p>L-Afegostat (5-epi-Isofagomine), an iminosugar, inhibits glycosidase and β-Glucosidase (K i 30 μM), aids in carbohydrate synthesis.</p>Formula:C6H13NO3Color and Shape:SolidMolecular weight:147.17Turoctocog alfa
CAS:<p>Turoctocog alfa: recombinant FVIII from CHO cells for hemophilia A study.</p>Color and Shape:SolidIDO1 ligand-1
CAS:<p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>Formula:C29H34FN3O2Color and Shape:SolidMolecular weight:475.598Calcipotriol Impurity C
CAS:<p>Calcipotriol Impurity C is the impurity of Calcipotriol. Calcipotriol is a VDR-like receptors ligand.</p>Formula:C27H40O3Purity:98%Color and Shape:SolidMolecular weight:412.614LXRβ agonist-3
CAS:<p>LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM).</p>Formula:C30H33N3O6SColor and Shape:SolidMolecular weight:563.66ICMT-IN-55
CAS:<p>ICMT-IN-55 (compound 31) acts as an ICMT inhibitor, exhibiting an IC50 value of 90 nM [1].</p>Formula:C22H26F3NO2Color and Shape:SolidMolecular weight:393.44EB-0156
<p>EB-0156: potent ER α-glucosidase inhibitor, IC50 of 0.0479/ <0.001 μM, N-substituted valerian, broad-spectrum antiviral potential.</p>Formula:C21H32N6O7Color and Shape:SolidMolecular weight:480.51α-Glucosidase-IN-18
<p>α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM.</p>Formula:C23H19NO2SColor and Shape:SolidMolecular weight:373.47CIT-ALD
CAS:<p>CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.</p>Formula:C18H14FNO2Molecular weight:295.31(R,R)-BMS-986397
CAS:<p>(R,R)-BMS-986397 is a CK1α degrader with a DC50 ranging from 0.1 to 0.5 pM. This compound is applicable in leukemia research.</p>Formula:C21H16ClF3N4O4Color and Shape:SolidMolecular weight:480.82Valerate sodium
CAS:<p>Valerate sodium is a potential Carbonic anhydrase 1/2 inhibitor for biochemical experiments.</p>Formula:C5H9NaO2Purity:99.84%Color and Shape:SolidMolecular weight:124.113,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol]
CAS:<p>The compound 3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] is an SS-cleavable, proton-activated lipid-like substance (SSPalm) that facilitates the delivery of plasmid DNA.</p>Formula:C12H28N2O2S2Color and Shape:SolidMolecular weight:296.493Mucidin
CAS:<p>Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.</p>Formula:C16H18O3Molecular weight:258.31α-Glucosidase-IN-13
<p>α-Glucosidase-IN-13 is an inhibitor of α-glucosidase (IC50: 5.69 μM).</p>Formula:C25H28N4O3S2Color and Shape:SolidMolecular weight:496.64HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Formula:C16H12N2O3Color and Shape:SolidMolecular weight:280.28APOL1-IN-3
CAS:<p>APOL1-IN-3 is an APOL1 inhibitor used for kidney disease research.</p>Formula:C16H19F3N4O2SColor and Shape:SolidMolecular weight:388.41Lipid HTO12
CAS:<p>Lipid HTO12 is an ionizable lipid used for forming lipid nanoparticles (LNP). It facilitates the delivery of siRNA and mRNA.</p>Formula:C41H83NO4Color and Shape:SolidMolecular weight:654.102PTP1B-IN-21
<p>PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.</p>Formula:C22H22O11Color and Shape:SolidMolecular weight:462.4Lp-PLA2-IN-10
<p>Lp-PLA2-IN-10, a potent Lp-PLA2 inhibitor, may research neurodegenerative and cardiovascular diseases.</p>Formula:C21H15F5N4O4Color and Shape:SolidMolecular weight:482.36BMS-214662 mesylate
CAS:<p>BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.</p>Formula:C26H27N5O5S3Color and Shape:SolidMolecular weight:585.718ABD957
CAS:<p>ABD957: covalent ABHD17 depalmitoylases inhibitor, IC50 0.21µM for ABHD17B, blocks N-Ras, halts NRAS-mutant AML cell growth.</p>Formula:C27H36F3N7O5SColor and Shape:SolidMolecular weight:627.68NAZ2329
CAS:<p>NAZ2329: Cell-permeable, targets R5 RPTPs, inhibits hPTPRZ1 (IC50=7.5 μM) & hPTPRG (IC50=4.8 μM), hampers glioblastoma growth, affects stem cell traits.</p>Formula:C21H18F3NO4S3Color and Shape:SoildMolecular weight:501.56AD015
CAS:<p>AD015 is a dual inhibitor of angiotensin-converting enzyme (ACE) and neprilysin (NEP), effectively inhibiting NEP, nACE, and cACE with IC50 values of 0.009, 0.019, and 0.0008 μM, respectively.</p>Formula:C23H26N2O4SColor and Shape:SolidMolecular weight:426.53CYP2C1/CYP2C19-IN-2
<p>CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Formula:C27H28N2O6SColor and Shape:SolidMolecular weight:508.59Darlifarnib
CAS:<p>Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.</p>Formula:C29H20N6OColor and Shape:SolidMolecular weight:468.509PDE4-IN-12
<p>PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).</p>Formula:C34H35NO6Color and Shape:SolidMolecular weight:553.64RORγt inverse agonist 29
<p>RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.</p>Formula:C25H24N2O5SColor and Shape:SolidMolecular weight:464.53GGACK
CAS:<p>GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).</p>Formula:C14H25ClN6O5Molecular weight:392.84Mitapivat hydrochloride
CAS:<p>Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.</p>Formula:C24H27ClN4O3SColor and Shape:SolidMolecular weight:487.014Casein kinase 1δ-IN-26
CAS:<p>Casein kinase1δ-IN-26 (compound 505) is a potent inhibitor of casein kinase 1δ. This compound is applicable in research related to neurodegenerative disorders such as Alzheimer’s disease.</p>Formula:C16H13N3O4SColor and Shape:SolidMolecular weight:343.357D-Citrulline
CAS:<p>D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.</p>Formula:C6H13N3O3Color and Shape:SolidMolecular weight:175.195-LOX/MAOs-IN-1
CAS:<p>Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.</p>Formula:C18H18N2O2Color and Shape:SolidMolecular weight:294.356′SLN
CAS:<p>6′SLN is a characteristic glycan found on the surface of cancer-related extracellular vesicles (EVs) and serves as the primary form of protein glycosylation within EVs. Additionally, 6′SLN, a derivative of sialic acid, interacts with hemagglutinins (HAs) from both human and avian influenza strains, making it relevant in the study of anti-influenza drugs.</p>Formula:C25H42N2O19Color and Shape:SolidMolecular weight:674.6IDO1-IN-25
CAS:<p>IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.</p>Formula:C14H8Cl3NO2SColor and Shape:SolidMolecular weight:360.64PPI-2458
CAS:<p>PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.</p>Formula:C22H36N2O6Color and Shape:SolidMolecular weight:424.53LXR agonist 2
<p>LXR agonist 2 is a potent agonist of the LXR (liver X receptor). LXR agonist 2 stabilises NCOA1 (coactivator), which in turn agonises the LXR.</p>Formula:C35H40ClN3O3Color and Shape:SolidMolecular weight:586.16α-Glucosidase-IN-12
<p>α-Glucosidase-IN-12 is a potent inhibitor of α-glucosidase (IC50: 10.20 μM).</p>Formula:C25H30N4O4S2Color and Shape:SolidMolecular weight:514.66RWJ 22108
CAS:<p>RWJ 22108 is a bronchial-selective calcium channel (calcium channel) blocker that exhibits an IC50 of 5.7 nM in dog bronchial smooth muscle calcium-dependent contractions.</p>Formula:C27H30ClFN2O4SColor and Shape:SolidMolecular weight:533.06BMS-986339
CAS:<p>BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.</p>Formula:C35H41F4N3O4Color and Shape:SolidMolecular weight:643.71Urobilin hydrochloride
CAS:<p>Urobilin hydrochloride, a metabolic byproduct of Hemoglobin, is excreted through urine and feces in various mammals. It also serves as an indicator of human waste contamination.</p>Formula:C33H43ClN4O6Color and Shape:SolidMolecular weight:627.17L-690330 hydrate
<p>L-690330 hydrate inhibits IMPase; Ki: 0.30 μM (human), 0.42 μM (bovine cortex); 0.27 μM (recom. human), 0.19 μM (bovine).</p>Formula:C8H14O9P2Color and Shape:SolidMolecular weight:316.14CYP121A1-IN-1
<p>CYP121A1-IN-1: Strong inhibitor for CYP121A1, hinders Mycobacterium tuberculosis growth (MIC 90 ~6.25 μM), reduces mycocyclosin synthesis.</p>Formula:C22H20N4OColor and Shape:SolidMolecular weight:356.42SelB-1
CAS:<p>SelB-1 acts as a dual inhibitor of Topoisomerase I/II (TopoisomeraseI/II), exhibiting anticancer activity suitable for research on prostate and colon cancers. Additionally, SelB-1 can induce the expression of autophagy (autophagy) genes and lipid peroxidation while reducing GSH levels.</p>Formula:C32H24O5Color and Shape:SolidMolecular weight:488.53Enpp-1-IN-7
<p>Enpp-1-IN-7: potent enpp-1 inhibitor, broad specificity, potential in cancer/infectious disease research. (WO2021203772A1)</p>Formula:C18H19N7O4SColor and Shape:SolidMolecular weight:429.45ent-8-iso-15(S)-Prostaglandin F2α
CAS:<p>Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.</p>Formula:C20H34O5Color and Shape:SolidMolecular weight:354.48CAII-IN-1
<p>CAII-IN-1 (3n) is a selective bovine CA-II inhibitor with 10.3 μM IC50, used in carbonic anhydrase disorder studies.</p>Formula:C19H21FN4SColor and Shape:SolidMolecular weight:356.46TAK-915
CAS:<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Formula:C19H18F4N4O5Purity:98%Color and Shape:SolidMolecular weight:458.36(+)-Potassium Ds-threo-isocitrate monobasic
CAS:<p>(+)-Potassium Ds-threo-isocitrate monobasic is a bioactive compound known for its role in enhancing cellular metabolism and regulating energy production. This substance is also utilized in researching metabolic pathways and the regulation of enzyme activities. Widely applied in biochemical research, (+)-Potassium Ds-threo-isocitrate monobasic is studied for its potential functions in cellular processes and disease mechanisms.</p>Formula:C6H7KO7Color and Shape:SolidMolecular weight:230.21GJG057
CAS:<p>GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.</p>Formula:C21H21F5N4O2Purity:99.8%Color and Shape:SolidMolecular weight:456.41(S)-Dexfadrostat
CAS:<p>(S)-Dexfadrostat ((S)-Fadrozole), an aromatase inhibitor, exhibits an IC 50 of 4.6 nM in in vitro assays using human placental microsomes. It is applicable for research on estrogen-dependent breast cancer, gynecomastia, and systemic lupus erythematosus.</p>Formula:C14H13N3Color and Shape:SolidMolecular weight:223.277-APB hydrochloride
CAS:<p>7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.</p>Formula:C11H14ClNOColor and Shape:SolidMolecular weight:211.688IDX375
CAS:<p>IDX375 is a non-nucleoside inhibitor that selectively targets the HCV NS5B enzyme. It shows promising selectivity for genotypes 1a and 1b. The structure and binding sites of IDX375 have been confirmed through X-ray co-crystallization studies.</p>Formula:C24H37N4O6PSColor and Shape:SolidMolecular weight:540.61MAGL-IN-20
<p>MAGL-IN-20 (compound ±34) is a reversible inhibitor of monoacylglycerol lipase (MAGL). It exhibits significant antiproliferative activity against a range of cancer cell lines, including H460, HT29, CT-26, Huh7, and HCCLM-3.</p>Formula:C23H24N2OColor and Shape:SolidMolecular weight:344.45BAY 3389934
CAS:<p>BAY 3389934 is a dual inhibitor of factor IIa (factor IIa) and factor Xa (factor Xa), providing anticoagulant and organ-protective effects. It alleviates coagulopathy and organ dysfunction in baboon models of Staphylococcus aureus sepsis.</p>Formula:C26H30ClN5O7S2Color and Shape:SolidMolecular weight:624.129IRX5010
CAS:<p>IRX5010 (IRX4647F), an analogue of IRX4647, serves as a highly selective RARγ nuclear receptor agonist. It effectively inhibits the growth of EMT-6 triple-negative breast cancer.</p>Formula:C24H26FNO3Color and Shape:SolidMolecular weight:395.466RORγt/DHODH-IN-3
<p>RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 has</p>Formula:C24H26ClF6N3O3SColor and Shape:SolidMolecular weight:585.99PNPLA3 modifier 1
CAS:<p>PNPLA3 Modifier 1 (Compound 10), a modifier of patatin-like phospholipase domain-containing protein 3 (pnpla3), exhibits a geometric mean EC50 of 4.9 nM.</p>Formula:C16H19ClF2N2O4SColor and Shape:SolidMolecular weight:408.85SAL-0010042
CAS:<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Formula:C15H15FN4OColor and Shape:SolidMolecular weight:286.304T-3764518
CAS:<p>T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).</p>Formula:C20H17F6N5O2Purity:98%Color and Shape:SolidMolecular weight:473.37AChE/BChE-IN-23
<p>AChE/BChE-IN-23 (Compound 6e) is a dual inhibitor of acetylcholinesterase and butyrylcholinesterase, exhibiting IC50 values of 0.91 μM for AChE, 1.19 μM for eqBChE, and 1.01 μM for hBChE. This compound also demonstrates antioxidant properties and inhibits the aggregation of Aβ1-42 and Tau proteins. Moreover, AChE/BChE-IN-23 prevents the activation of microglial cells by inhibiting the release of reactive oxygen species and mitochondrial damage. Additionally, it reduces the levels of the NLRP3 inflammasome in human microglial cells and reverses memory impairment in mice induced by scopolamine.</p>Formula:C19H21N5O3Color and Shape:SolidMolecular weight:367.4SGK1-IN-3
<p>SGK1-IN-3: Potent oral inhibitor of SGK1, may target osteoarthritis.</p>Formula:C23H20Cl2N6O3SColor and Shape:SolidMolecular weight:531.41PHGDH-IN-2
<p>PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.</p>Formula:C22H20N4O3SColor and Shape:SolidMolecular weight:420.48Zaragozic acid C
CAS:<p>Zaragozic acid C is an effective inhibitor of squalene synthase.</p>Formula:C40H50O14Purity:98%Color and Shape:SolidMolecular weight:754.8220-HEDE
CAS:<p>20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.</p>Formula:C20H36O3Purity:98%Color and Shape:SolidMolecular weight:324.50sEH inhibitor-4
<p>Compound B15: potent sEH inhibitor (0.03 nm), reduces inflammation & pain.</p>Formula:C27H28Cl2N4O3Color and Shape:SolidMolecular weight:527.44DH376
CAS:<p>DH376 inhibits DAGLα in a time and dose dependent manner in mouse brain. DH376 shows picomolar activity.</p>Formula:C31H28F2N4O3Color and Shape:SolidMolecular weight:542.58L 668411
CAS:<p>L 668411, the 2,3-ditritiated methyl ester of L 659699, inhibits HMG-CoA synthase.</p>Formula:C19H30O5Purity:98%Color and Shape:SolidMolecular weight:338.44LU 2443
CAS:<p>LU 2443 is an orally active antiepileptic agent that is extensively absorbed, with up to 18% remaining unabsorbed in rats. The active half-life in plasma is 13.17 hours.</p>Formula:C9H8N2S2Color and Shape:SolidMolecular weight:208.3
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