Metabolism

Norathiol (N-methyl-N-dithiocarboxyglucamine) is a metal chelator that promotes the excretion of 109Cd and may be used in the treatment of cadmium poisoning.

Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate

UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.

Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.

RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.

Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in

VAS2870 is an inhibitor of NADPH oxidase (NOX).

BMS309403 is a potent and selective inhibitor of adipocyte fatty acid binding protein aFABP.Cost-effective and quality-assured.

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.

Imidazole-5-propionic acid (Imidazolylpropionic acid) is a product of histidine metabolism and may involve oxidation or transamination.

2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.

BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).

Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM).

AG-120 (racemic) is an oral IDH1 inhibitor with potential anti-cancer effects.

1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) is a synthetic phytogrowth hormone that promotes plant growth and a PLA2 inhibitor.

PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.

MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.

DCBA, an endogenous metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), is utilized to evaluate DEET exposure through its concentration levels

Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.

Methylglutaric acid, a leucine byproduct, is linked to two metabolic disorders, detected in patient urine.

N-Acetylcarnosine (N-Acetyl-L-carnosine) is thought to be able to combat some of the effects of oxidative stress as it has anti-oxidant properties.

1-Naphthyl phosphate potassium salt inhibits non-specific phosphatase.

Florfenicol amine hydrochloride is a veterinary antibiotic with antimicrobial activity that can be used to study diseases caused by Bartonella henselae.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human OPG, and the Human OPG standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human OPG. After TMB substrate solution is added, only those wells that contain Human OPG and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human OPG in the samples is then determined by comparing the OD of the samples to the standard curve.

Cyclic somatostatin (SRIF-14) is a cyclic tetradecapeptide regulating many endocrine and nervous system functions.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ADP, and the Mouse ADP standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Mouse ADP. After TMB substrate solution is added, only those wells that contain Mouse ADP and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse ADP in the samples is then determined by comparing the OD of the samples to the standard curve.

meta-Fexofenadine (meta-MDL-16455) is an isomer of Fexofenadine.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human OC, and the Human OC standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human OC. After TMB substrate solution is added, only those wells that contain Human OC and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human OC in the samples is then determined by comparing the OD of the samples to the standard curve.

3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite present in type I diabetic patients that has the property of regulating membrane

Flumazenil EP Impurity D is a compound that can be used in biochemical experiments as a mitochondrial fusion inhibitor.

D-Glucose-13C6 (Dextrose-13C6), a C13 marker, serves as a metabolic tracer and can be used to study metabolism-related diseases in the body.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LpPLA2, and the Human LpPLA2 standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human LpPLA2. After TMB substrate solution is added, only those wells that contain Human LpPLA2 and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human LpPLA2 in the samples is then determined by comparing the OD of the samples to the standard curve.

ACAT inhibitor TMP-153 reduces cholesterol and LDL in hamsters, with IC50 of 5-10 nM in animals and an ED50 of 0.81 mg/kg/day in diet.

Fmoc-His-OH (FMOC-L-Histidine) is a histidine derivative and a common material for peptide synthesis.

5,6-Dihydroxyindole, a melanin precursor, exhibits wide antibacterial, antiviral, antifungal, and antiparasitic properties, and is cytotoxic to pathogens.

Leucic acid (α-Hydroxyisocaproic acid) is an amino acid widely found in plants and animals that prevents muscle loss and is broken down into glucose.

Oleamide (Oleic acid amide) is an endogenous fatty acid amide and can be used in the synthesis of de novo in the mammalian nervous system.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Lpa, and the Human Lpa standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human Lpa. After TMB substrate solution is added, only those wells that contain Human Lpa and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human Lpa in the samples is then determined by comparing the OD of the samples to the standard curve.

2-(Methylamino)pentanedioic acid (N-Methyl-DL-glutamic acid) inhibits Glutaminase, adds freshness to edible products, and can be used in tuberculosis research.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PSMA, and the Human PSMA standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human PSMA. After TMB substrate solution is added, only those wells that contain Human PSMA and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PSMA in the samples is then determined by comparing the OD of the samples to the standard curve.

This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human 25-OH-D antigen, and the Human 25-OH-D standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human 25-OH-D to each microplate well and incubated . After TMB substrate solution is added, the enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ±10nm. The concentration of Human 25-OH-D in the samples is then determined by comparing the OD of the samples to the standard curve.

Ethyl cis-4,7,10,13,16,19-Docosahexaenoate is DHA's ethyl ester, concentrated from tuna oil via alcoholysis.

Tetrasodium glutamate diacetate (Glutamate diacetate tetrasodium) is a degradable chelating agent used as a dietary ingredient.

Candoxatril is an inhibitor neutral endopeptidase (NEP).

(±)-1,2-Propanediol (Methyl ethyl glycol) is an aliphatic alcohol that is frequently used as an excipient to improve solubility and stability of drugs.

Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction.

This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse 25-OH-D antigen, and the Mouse 25-OH-D standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Mouse 25-OH-D to each microplate well and incubated . After TMB substrate solution is added, the enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ±10nm. The concentration of Mouse 25-OH-D in the samples is then determined by comparing the OD of the samples to the standard curve.

Enasidenib mesylate (AG-221 mesylate) is a IDH2 inhibitor that promotes differentiation of leukemia myeloid cells for the treatment of acute myeloid leukemia.