Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(41 products)
- Aminopeptidase(67 products)
- CETP(18 products)
- Carbonic Anhydrase(177 products)
- Casein Kinase(130 products)
- DHFR(32 products)
- Decarboxylase(4 products)
- Dehydrogenase(267 products)
- FAAH(63 products)
- FXR(58 products)
- Factor Xa(80 products)
- Fatty Acid Synthase(32 products)
- Ferroptosis(215 products)
- GR(3 products)
- GSNOR(3 products)
- Glucokinase(53 products)
- HIF/HIF Prolyl-Hydroxylase(142 products)
- HMG-CoA Reductase(32 products)
- Hydroxylase(30 products)
- IDO(82 products)
- LDL(8 products)
- Lipase(96 products)
- Lipid(59 products)
- Lipoxygenase(124 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(36 products)
- P450(6 products)
- PAI-1(25 products)
- PDE(165 products)
- PED(1 products)
- PKM(15 products)
- PPAR(164 products)
- Phospholipase(82 products)
- ROR(42 products)
- Retinoid Receptor(29 products)
- SGK(11 products)
- Thioredoxin(12 products)
- Transferase(30 products)
- Transporter(42 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 8597 products of "Metabolism"
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FTI 276 TFA
CAS:<p>FTI 276 TFA targets plasmodium falciparum & humans, inhibits PFT with IC50s: 0.9 nM (parasite) & 0.5 nM (human).</p>Formula:C23H28F3N3O5S2Color and Shape:SolidMolecular weight:547.61AD013
<p>AD013 is a selective ACE inhibitor and NEP inhibitor with potential anti-hypertensive and cardioprotective benefits.</p>Formula:C24H28N2O5Color and Shape:SolidMolecular weight:424.49Oxythiamine diphosphate ammonium
<p>Oxythiamin diphosphate ammonium is a potent inhibitor of transketolase (TK).</p>Color and Shape:Solid2-Amino-5-methyl-5-hexenoic acid
CAS:<p>2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) acts as a methionine analog, competing with methionine and thereby hindering cell growth. This compound inhibits protein synthesis in Salmonella typhimurium TA1535 and Escherichia coli K-12 without affecting the synthesis of DNA or RNA.</p>Formula:C7H13NO2Color and Shape:SolidMolecular weight:143.184ent-8-iso-15(S)-Prostaglandin F2α
CAS:<p>Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.</p>Formula:C20H34O5Color and Shape:SolidMolecular weight:354.48RORγt inhibitor 4
CAS:<p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>Formula:C22H16Cl2F3NO4SColor and Shape:SolidMolecular weight:518.3333'-Hydroxy Repaglinide
CAS:<p>'3'-Hydroxy Repaglinide, a CYP2C8 metabolite of Repaglinide, treats type II diabetes.</p>Formula:C27H36N2O5Purity:98%Color and Shape:SolidMolecular weight:468.59PTP1B-IN-19
<p>PTP1B-IN-19, a benzimidazole, selectively inhibits protein tyrosine phosphatase 1B with a Ki of 23.3 μM, potential for type 2 diabetes research.</p>Formula:C26H19N3O4SColor and Shape:SolidMolecular weight:469.51RORγt Inverse agonist 2
CAS:<p>RORγt Inverse agonist 2 is a selective, orally active inverse agonist of RORγt(EC50 of 119 nM).</p>Formula:C27H25F8NO5SPurity:98%Color and Shape:SolidMolecular weight:627.54PTP1B-IN-21
<p>PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.</p>Formula:C22H22O11Color and Shape:SolidMolecular weight:462.4APOL1-IN-3
CAS:<p>APOL1-IN-3 is an APOL1 inhibitor used for kidney disease research.</p>Formula:C16H19F3N4O2SColor and Shape:SolidMolecular weight:388.41Sekikaic Acid
CAS:<p>Sekikaic acid, a phenolic lichen metabolite in H. obscurata, has antioxidant and antiviral properties, inhibiting MLL1-CBP.</p>Formula:C22H26O8Color and Shape:SolidMolecular weight:418.44HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Formula:C16H12N2O3Color and Shape:SolidMolecular weight:280.28Ro 23-9358
CAS:<p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>Formula:C30H51NO6Color and Shape:SolidMolecular weight:521.729SHP2 IN-1
CAS:<p>SHP2 IN-1 is an allergic SHP2 (PTPN11) inhibitor(IC50 : 3 nM).</p>Formula:C18H22Cl2N6OSPurity:98%Color and Shape:SolidMolecular weight:441.38PTP1B-IN-3 diammonium
<p>PTP1B-IN-3 diammonium, an oral enzyme inhibitor, has potent antidiabetic and anticancer effects, with a 120 nM IC50.</p>Formula:C12H13BrF2N3O3PColor and Shape:SolidMolecular weight:396.12α-Glucosidase-IN-13
<p>α-Glucosidase-IN-13 is an inhibitor of α-glucosidase (IC50: 5.69 μM).</p>Formula:C25H28N4O3S2Color and Shape:SolidMolecular weight:496.64CK1δ-IN-6
CAS:<p>CK1δ-IN-6 (Compound 303) is an inhibitor of Casein kinase 1δ, with potential applications in Alzheimer's disease research.</p>Formula:C23H17N3O4Color and Shape:SolidMolecular weight:399.399Carbonic anhydrase inhibitor 4
<p>CA inhibitor 4, photoprobe; targets hCA I-XIV; Ki: 640-1166 nM.</p>Formula:C21H18N2O4SColor and Shape:SolidMolecular weight:394.44RXR antagonist 2
<p>RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.</p>Formula:C29H35F3N2O3Color and Shape:SolidMolecular weight:516.6(E)-10-Hydroxynortriptyline maleate
CAS:<p>(E)-10-Hydroxy Nortriptyline maleate, a derivative of antidepressant Nortriptyline, eases depression symptoms.</p>Formula:C23H25NO5Purity:98%Color and Shape:SolidMolecular weight:395.4559(S)-HETE
CAS:<p>9(S)-HETE is an enantiomer of (±)9-HETE, not an enzymatic product, and doesn't promote cell adhesion like 12(S)-HETE. Identified by chiral HPLC.</p>Formula:C20H32O3Color and Shape:SolidMolecular weight:320.47Casein Kinase II Inhibitor IV Hydrochloride
CAS:<p>Casein Kinase II Inhibitor IV HCl promotes keratinocyte differentiation, potential for skin disorder therapy.</p>Formula:C24H24ClN5O3Purity:98%Color and Shape:SolidMolecular weight:465.93Carbonic anhydrase inhibitor 17
CAS:<p>Carbonic anhydrase inhibitor 17 (compound 7c) is a pyrazine-based sulfonamide that acts as a carbonic anhydrase II inhibitor, with an IC50 value of 0.63 nM.</p>Formula:C18H15ClN4O3S2Molecular weight:434.92SID 24785302
CAS:<p>SID 24785302 is an inhibitor of hexokinase, which can suppress glycolysis, regulate mitochondrial function, and ultimately inhibit the replication of mutant mitochondrial DNA.</p>Formula:C14H12N2O3S2Color and Shape:SolidMolecular weight:320.387Phospho-L-arginine
CAS:<p>Phospho-L-arginine is a derivative of arginine.</p>Formula:C6H15N4O5PMolecular weight:254.18SDX-7539
CAS:<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Formula:C23H38N2O5Molecular weight:422.56Asimicin
CAS:<p>Asimicin is a effective complex I inhibitor.</p>Formula:C37H66O7Purity:98%Color and Shape:SolidMolecular weight:622.924-Acetylphenylboronic acid
CAS:<p>4-Acetylphenylboronic acid acts as an effective inhibitor targeting carbonic anhydrase II (CAII), displaying inhibitory concentrations (IC50) of 246 μM for bovine CAII (bCA II) and 281.40 μM for human CAII (hCA II).</p>Formula:C8H9BO3Color and Shape:SolidMolecular weight:163.97FXIa-6f
CAS:<p>FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species</p>Formula:C31H29ClF2N4O4Color and Shape:SolidMolecular weight:595.04Epoxykynin
CAS:<p>Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].</p>Formula:C19H20BrF3N2O2Color and Shape:SolidMolecular weight:445.27PFM046
CAS:<p>PFM046 is an antagonist of the liver X receptor (LXR), effectively inhibiting the activation of LXRα and LXRβ, with IC50 values of 2.04 μM and 1.58 μM respectively. It reduces the expression of SCD1 and FASN while increasing ABCA1 expression, and demonstrates antitumor activity in mouse models.</p>Formula:C29H42O2Color and Shape:SolidMolecular weight:422.643CAII-IN-2
<p>CAII-IN-2 (3g): potent, selective CA-II inhibitor; IC50-12.1 μM for bovine CA-II; valuable in CA-related disorder research.</p>Formula:C18H19BrN4SColor and Shape:SolidMolecular weight:403.34Porphobilinogen
CAS:<p>Porphobilinogen act as a phytotoxin, a metabotoxin, and a neurotoxin.</p>Formula:C10H14N2O4Purity:98%Color and Shape:SolidMolecular weight:226.23LXRα agonist 1
CAS:<p>LXRα agonist 1 (Compound 40) is a selective activator of LXRα, with an EC50 of 42 nM, and also demonstrates some activation effects on LXRβ, with an EC50 of 266 nM. It promotes target gene transcription by stabilizing the ligand-binding domain (LBD) of LXRα. When combined with the Raf inhibitor Sorafenib, LXRα agonist 1 shows significant antitumor activity in liver cancer cells. This compound is applicable in research focused on lipotoxicity-related cancers.</p>Formula:C28H27N3O2Color and Shape:SolidMolecular weight:437.533α-Amylase/α-Glucosidase-IN-7
CAS:<p>α-Amylase/α-Glucosidase-IN-7 (Compound 3f) serves as a competitive inhibitor for the enzymes α-glucosidase and α-amylase, exhibiting IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, it effectively inhibits AChE and BChE, with IC50 values of 9.25 µM and 10.06 µM, respectively. This compound is useful in research related to diabetes and Alzheimer's [1].</p>Formula:C15H9Cl2FN2OSColor and Shape:SolidMolecular weight:355.21CK2 inhibitor 3
<p>CK2 inhibitor 3: potent CK2 blocker, IC50 of 280 nM, suppresses tumor cell growth, highly selective among 320 kinases.</p>Formula:C13H9BrN4O3SColor and Shape:SolidMolecular weight:381.2LTA4H-IN-3
CAS:<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Formula:C17H15ClN4O3Color and Shape:SolidMolecular weight:358.78Indoluidin E
<p>Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.</p>Formula:C28H30N4O2Color and Shape:SolidMolecular weight:454.56IDO antagonist-1
CAS:<p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>Formula:C39H53N7O5Color and Shape:SolidMolecular weight:699.88Mutant IDH1-IN-3
CAS:<p>Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor targeting the mutant isocitrate dehydrogenase 1 (IDH1), with an IC50 of 13 nM for R132HIDH1. It effectively suppresses the production of D-2-hydroxyglutarate (2HG) in cells and is applicable for research in oncology.</p>Formula:C22H30N4OColor and Shape:SolidMolecular weight:366.5Keto lovastatin
CAS:<p>Keto lovastatin is an impurity of lovastatin with antibacterial properties. Lovastatin is a cell-permeable HMG-CoA reductase (HMG-CoA reductase) inhibitor used to reduce cholesterol levels.</p>Formula:C24H34O6Color and Shape:SolidMolecular weight:418.523ALOX15-IN-1
<p>ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.</p>Formula:C24H31N3O5SColor and Shape:SolidMolecular weight:473.59ICMT-IN-55
CAS:<p>ICMT-IN-55 (compound 31) acts as an ICMT inhibitor, exhibiting an IC50 value of 90 nM [1].</p>Formula:C22H26F3NO2Color and Shape:SolidMolecular weight:393.44Benfooxythiamine
CAS:<p>Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.</p>Formula:C19H22N3O7PSColor and Shape:SolidMolecular weight:467.433Antidiabetic agent 5
CAS:<p>Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].</p>Formula:C17H15N3O4SColor and Shape:SolidMolecular weight:357.38UGT1A1-IN-1
CAS:<p>UGT1A1-IN-1 (compound 2) acts as a non-competitive inhibitor of UGT1A1, effectively inhibiting the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. This compound binds to the same ligand-binding site on UGT1A1 as bilirubin and additionally functions as a 'turn-on' fluorescent probe substrate for UGT1A1 [1].</p>Formula:C22H19NO3Color and Shape:SolidMolecular weight:345.39EC33
CAS:<p>EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].</p>Formula:C4H11NO3S2Color and Shape:SolidMolecular weight:185.27RORγt/DHODH-IN-1
CAS:<p>RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant</p>Formula:C24H26ClF6N3O3SColor and Shape:SolidMolecular weight:585.99NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Formula:C17H21N5O3SColor and Shape:SolidMolecular weight:375.45
