Metabolism
Metabolism inhibitors are compounds that interfere with metabolic pathways, altering the production and utilization of energy within cells. These inhibitors are used to study the regulation of metabolism, the role of metabolic pathways in diseases like cancer and diabetes, and to develop new therapeutic strategies. Metabolism inhibitors can target various enzymes and processes involved in glycolysis, fatty acid oxidation, and other metabolic functions. At CymitQuimica, we offer a wide range of high-quality metabolism inhibitors to support your research in biochemistry, metabolic disorders, and drug development.
Subcategories of "Metabolism"
- AhR(42 products)
- Aminopeptidase(76 products)
- CETP(20 products)
- Carbonic Anhydrase(195 products)
- Casein Kinase(137 products)
- DHFR(34 products)
- Decarboxylase(4 products)
- Dehydrogenase(302 products)
- FAAH(66 products)
- FXR(62 products)
- Factor Xa(87 products)
- Fatty Acid Synthase(37 products)
- Ferroptosis(226 products)
- GR(3 products)
- GSNOR(4 products)
- Glucokinase(57 products)
- HIF/HIF Prolyl-Hydroxylase(146 products)
- HMG-CoA Reductase(33 products)
- Hydroxylase(35 products)
- IDO(84 products)
- LDL(8 products)
- Lipase(107 products)
- Lipid(61 products)
- Lipoxygenase(134 products)
- MAO(87 products)
- MPO(2 products)
- NAMPT(40 products)
- P450(6 products)
- PAI-1(26 products)
- PDE(167 products)
- PED(1 products)
- PKM(17 products)
- PPAR(169 products)
- Phospholipase(83 products)
- ROR(47 products)
- Retinoid Receptor(28 products)
- SGK(11 products)
- Thioredoxin(12 products)
- Transferase(29 products)
- Transporter(46 products)
- UGT(4 products)
- Xanthine Oxidase (XO) Inhibitors(9 products)
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Found 9274 products of "Metabolism"
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AV-5080
CAS:AV-5080 is an orally active neuraminidase (neuraminidase) inhibitor that is utilized in the research of both Type A and Type B influenza viruses.Formula:C15H25FN4O4Color and Shape:SolidMolecular weight:344.38PDE1-IN-7
CAS:PDE1-IN-7 (Compound 13h), with an IC50 value of 10 nM, selectively inhibits bPDE1. This compound demonstrates significant anti-fibrotic effects in a BDL-induced liver fibrosis rat model and is useful for research purposes in studying liver fibrosis [1].Formula:C32H36F2N2O6SMolecular weight:614.7Dopaminechrome
CAS:<p>Dopaminechrome (DACHR) is an oxidation product of dopamine that promotes the generation of H2O2 at mitochondrial complex I in the brain in a concentration- and respiration-dependent manner. It possesses neurotoxic properties and can be utilized in Parkinson's disease research.</p>Formula:C8H7NO2Color and Shape:SolidMolecular weight:149.147CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Formula:C27H27F9N2O4Color and Shape:SolidMolecular weight:614.5Casein kinase 1δ-IN-25
CAS:Casein kinase1δ-IN-25 (compound 487) is a potent inhibitor of casein kinase1δ. It is applicable in research on neurodegenerative diseases such as Alzheimer's disease.Formula:C20H14FN3O4S2Color and Shape:SolidMolecular weight:443.471EGFR/VEGFR2-IN-2
EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.Formula:C24H15FO3Color and Shape:SolidMolecular weight:370.37AZD 4407
CAS:AZD 4407 is a potent inhibitor of 5-lipoxygenase.Formula:C19H21NO3S2Purity:98%Color and Shape:SolidMolecular weight:375.57-hydroxychlorpromazine
CAS:7-Hydroxychlorpromazine, an active metabolite of Chlorpromazine, can reversibly counteract the suppression of regionally dense dopaminergic neurons induced by Amphetamine.Formula:C17H19ClN2OSColor and Shape:SolidMolecular weight:334.86CS-003 HCl
CAS:CS-003 HCl is a TNRA - triple neurokinin receptor antagonist.Formula:C34H39Cl3N2O6SColor and Shape:SolidMolecular weight:710.1MD 770222
CAS:MD 770222, the principal plasma O-demethylated metabolite of Cimoxatone, is an orally active selective and reversible inhibitor of MAO A. The potency of MD 770222 is lower than that of Cimoxatone.Formula:C18H16N2O4Color and Shape:SolidMolecular weight:324.33SCP1-IN-2
SCP1-IN-2: potent, selective SCP1 inhibitor; induces REST degradation, hinders its activity, may study REST-driven glioblastoma growth.Formula:C19H17F3N2O6S2Color and Shape:SolidMolecular weight:490.47L-Phenylalanyl-L-threonine
CAS:L-Phenylalanyl-L-threonine is a dipeptide composed of phenylalanine and threonine, which can be utilized in the synthesis of the cyclic hexapeptide [Banyascyclamide A].Formula:C13H18N2O4Color and Shape:SolidMolecular weight:266.29PF-06795071
CAS:PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).Formula:C18H17F4N3O3Purity:98%Color and Shape:SolidMolecular weight:399.3415-epi-PGE1
CAS:15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1), a stereoisomer of PGE1, exhibits reduced biological activity [2]. This compound acts as a non-competitive inhibitor of human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH), with an inhibitory concentration 50 (IC50) value of 170 μM [1].Formula:C20H34O5Molecular weight:354.48IDX375
CAS:IDX375 is a non-nucleoside inhibitor that selectively targets the HCV NS5B enzyme. It shows promising selectivity for genotypes 1a and 1b. The structure and binding sites of IDX375 have been confirmed through X-ray co-crystallization studies.Formula:C24H37N4O6PSColor and Shape:SolidMolecular weight:540.61Nampt-IN-13
CAS:Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Formula:C24H30N6O2Color and Shape:SolidMolecular weight:434.53Carbonic anhydrase inhibitor 16
CAS:Carbonic anhydrase inhibitor 16 (compound 1) is a CA I/CA II inhibitor with potential antiviral activity, used in virus infection studies.Formula:C14H10N2O4SPurity:99.65%Color and Shape:SolidMolecular weight:302.31Casein kinase 1δ-IN-19
CAS:<p>Casein kinase1δ-IN-19 (compound 492) is a potent inhibitor of casein kinase 1δ. It is utilized in research related to neurodegenerative disorders, such as Alzheimer's disease.</p>Formula:C21H19N5O3Color and Shape:SolidMolecular weight:389.407MAFP
CAS:MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.Formula:C21H36FO2PColor and Shape:SolidMolecular weight:370.48(S)-Dexfadrostat
CAS:(S)-Dexfadrostat ((S)-Fadrozole), an aromatase inhibitor, exhibits an IC 50 of 4.6 nM in in vitro assays using human placental microsomes. It is applicable for research on estrogen-dependent breast cancer, gynecomastia, and systemic lupus erythematosus.Formula:C14H13N3Color and Shape:SolidMolecular weight:223.27AChE/CA I-IN-1
AChE/CA I-IN-1 (Compound 2g) acts as an inhibitor for both AChE and hCA I, with Ki values of 1.85 µM and 0.53 µM, respectively. It has shown potential applications in the research of Alzheimer's disease, glaucoma, and epilepsy.Formula:C14H19NO6SColor and Shape:SolidMolecular weight:329.379(S)-HEPE
CAS:9(S)-HEPE is a monohydroxy fatty acid derived from EPA. The biological activity of 9(S)-HEPE has not been documented.Formula:C20H30O3Color and Shape:SolidMolecular weight:318.45Tacrolimus anhydrous 8-epimer
CAS:Tacrolimus anhydrous 8-epimer, an immunosuppressive l-pipecolic acid macrolide, blocks T cell growth by hindering IL-2.Formula:C44H69NO12Color and Shape:SolidMolecular weight:804.02Human enteropeptidase-IN-2
Human enteropeptidase-IN-2 is a potent inhibitor of enteropeptidase (enteropeptidase) and can be used in anti-obesity studies.Formula:C20H19F3N4O7Color and Shape:SolidMolecular weight:484.38TKL-IN-2
CAS:TKL-IN-2 (Compound 7m) is a TKL inhibitor with an IC50 of 0.11 mg/L against SvTKL. It exhibits excellent herbicidal activity against Digitaria sanguinalis and Amaranthus retroflexus, while being safe for corn, wheat, soybean, and cotton. TKL-IN-2 is suitable for research in weed control in crop fields.Formula:C23H17ClF3N3OColor and Shape:SolidMolecular weight:443.85ONL-1204
CAS:ONL-1204 is a small molecule, CD95 antigen inhibitor (Fas inhibitor) being developed by ONL Therapeutics for the treatment of retinal detachment.Formula:C71H100N18O16Color and Shape:SolidMolecular weight:1461.66Methyl dotriacontanoate
CAS:Methyl dotriacontanoate (C32:0 FAME; Lacceric acid methyl ester) is a naturally occurring fatty acid methyl ester found in the cuticular wax of P. abies needles. It is also present in sediment samples from the Suwannee River in Florida and Lake Kivu in the East African Rift.Formula:C33H66O2Molecular weight:494.88LU 2443
CAS:LU 2443 is an orally active antiepileptic agent that is extensively absorbed, with up to 18% remaining unabsorbed in rats. The active half-life in plasma is 13.17 hours.Formula:C9H8N2S2Color and Shape:SolidMolecular weight:208.3Tauro-ω-muricholic acid sodium
Tauro-ω-muricholic acid sodium (TωMCA sodium) is an analogue of tauro-α-muricholic acid, a bile acid of hepatic origin.Formula:C26H44NNaO7SColor and Shape:SolidMolecular weight:537.68HSD17B13-IN-84
CAS:HSD17B13-IN-84 (182) serves as an inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13), exhibiting an IC50 of less than 0.1 μM for Estradiol. It is primarily utilized in the study of NAFLD (Nonalcoholic fatty liver diseases) [1].Formula:C19H12Cl2F3N3O3SMolecular weight:490.28Cilazapril HCl
CAS:Cilazapril, also known as Ro 31 2848, is a potent ACE inhibitor used for hypertension.Formula:C22H32ClN3O5Color and Shape:SolidMolecular weight:453.96Lipid 12T-O14
CAS:Lipid 12T-O14 is a lipid nanoparticle that facilitates the delivery of local mRNA vaccines and systemic mRNA agents.Formula:C37H66N2O2SColor and Shape:SolidMolecular weight:603.00Resolvin E4
CAS:RvE4, a bioactive lipid from eicosapentaenoic acid and synthesized by 15-LO, is anti-inflammatory and boosts efferocytosis in human macrophages.Formula:C20H30O4Color and Shape:SolidMolecular weight:334.45COTC
CAS:COTC is an anticancer bacterial metabolite; inhibits glyoxalase with GSH, halts HeLa cell growth, and fights tumor in Ehrlich murine model.Formula:C11H14O6Color and Shape:SolidMolecular weight:242.231-Phenylethanamine
CAS:1-Phenylethanamine, a potential central nervous system stimulant related to β-phenylethylamine (β-phenylethylamine), exhibits diminished glycogenolysis activity in the brain due to its benzene ring being replaced by an indole group. This reduction in activity makes it useful for investigating how the chemical structure of phenylethylamine derivatives influences their effects on the central nervous system. Additionally, 1-Phenylethanamine is also utilized in the synthesis of the tyrosine kinase (tyrosine kinase) inhibitor CLM3.Formula:C8H11NColor and Shape:SolidMolecular weight:121.18Pefcalcitol
CAS:Pefcalcitol is a novel antipsoriatic prodrug candidate containing a 16-en-22-oxa-vitamin D3 structure.Formula:C26H34F5NO4Color and Shape:SolidMolecular weight:519.54HSD17B13-IN-30
CAS:HSD17B13-IN-30 (compound 64) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), exhibiting an IC 50 value of less than 0.1 μM? with estradiol? as substrates. This compound is significantly implicated in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formula:C24H16Cl2F3N3O4Color and Shape:SolidMolecular weight:538.3Herbicide safener-4
CAS:Herbicide safener-4 (Compound I-15) is a herbicide safener designed to enhance crop resistance to herbicides without diminishing the herbicidal effects on target weeds. It competitively binds to the ALS active site alongside Mesosulfuron-methyl. In addition, Herbicide safener-4 boosts the activities of glutathione GSH, glutathione-S-transferase GST, cytochrome P450 CYP450, peroxidase (POD), superoxide dismutase (SOD), and acetolactate synthase (ALS) within plants.Formula:C18H14Cl2N6O2Molecular weight:417.249KDX1381
CAS:KDX1381 is a bivalent CK2α inhibitor with an IC50 of 17 nM and a KD of 54 nM. It demonstrates antitumor activity in murine 786-O and A375 xenograft models. Furthermore, when combined with a vascular endothelial growth factor receptor (VEGFR) inhibitor or DNA-damaging agents, KDX1381 enhances antitumor effects in mouse hepatocellular carcinoma and glioma models.Formula:C32H32F2N6O4SColor and Shape:SolidMolecular weight:634.70Dibutyl phosphate
CAS:Dibutyl phosphate (DBUP) is a metabolite of organophosphate esters (OPEs) found in urine. The presence of dibutyl phosphate is positively correlated with an increased risk of sarcopenia.Formula:C8H19O4PColor and Shape:SolidMolecular weight:210.21Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Formula:C30H40Cl2N6O4S2Purity:98%Color and Shape:SolidMolecular weight:683.71GNTI TFA
CAS:GNTI TFA is a selective kappa opioid receptor antagonist.Formula:C31H31F6N5O7Color and Shape:SolidMolecular weight:699.60D-2-Phosphoglyceric acid
CAS:D-2-Phosphoglyceric acid is a crucial metabolic intermediate known for its role in enhancing cellular energy metabolism and regulating biosynthesis. It plays a key role in both glycolysis and photosynthesis, which are essential for cellular energy supply. Additionally, D-2-Phosphoglyceric acid serves as a biomarker for monitoring metabolic states in various organisms.Formula:C3H7O7PColor and Shape:SolidMolecular weight:186.064-Amino-3-hydroxyphenylalanine
CAS:4-Amino-3-hydroxyphenylalanine (4-AHP) is a photodegradation product of eumelanin. It can be utilized in research focused on the formation of cutaneous melanoma and age-related macular degeneration.Formula:C9H12N2O3Molecular weight:196.203ZMC3
CAS:ZMC3 (NSC328784), a zinc chelator, exhibits properties as a zinc metallochaperone. It shows enhanced sensitivity in cells with the p53-R175H mutation and increases the cellular levels of ROS (reactive oxygen species).Formula:C17H20N6SeColor and Shape:SolidMolecular weight:387.34BRD7539
CAS:BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.Formula:C23H22FN3O2Purity:98%Color and Shape:SolidMolecular weight:391.44HSD17B13-IN-40
CAS:HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formula:C23H14Cl2F3N3O3Molecular weight:508.281,2-Dipentadecanoyl-rac-glycerol
CAS:1,2-Dipentadecanoyl-rac-glycerol (DG(15:0/15:0/0:0)) is a compound referenced in studies examining the effect of insulin on the content of 1,2-diacylglycerol in rat hearts. Insulin is observed to increase the amount of 1,2-diacylglycerol containing specific fatty acid compositions in the heart, which may be linked to cardiac contractility.Formula:C33H64O5Color and Shape:SolidMolecular weight:540.86FXR agonist 9
CAS:FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.Formula:C28H30N2O5Color and Shape:SolidMolecular weight:474.553β,7β-Dihydroxy-5-cholestenoic acid
CAS:3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid whose levels are elevated in Niemann-Pick Type C and B diseases, leading to toxicity in ocular motor neurons. It is synthesized by the enzymatic action of hydroxysteroid 11-β dehydrogenase 1 from 3β-hydroxy-7-oxocholest-5-en-(25R)26-enoic acid (3βH,7O-CA).Formula:C27H44O4Color and Shape:SolidMolecular weight:432.64
