CymitQuimica logo
GPCR/G-Protein

GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

Show 18 more subcategories

Found 5378 products of "GPCR/G-Protein"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • NAV-2729
    Targetmol
    + Info

    NAV-2729

    CAS:
    <p>NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.</p>
    Formula:C25H17ClN4O3
    Purity:98.83% - 98.91%
    Color and Shape:Solid
    Molecular weight:456.88

    Ref: TM-T5142

  • Isoetharine mesylate salt
    Targetmol
    + Info

    Isoetharine mesylate salt

    CAS:
    Isoetharine mesylate salt (Isoetarine mesilate) is a β-adrenergic receptor agonist.
    Formula:C14H25NO6S
    Purity:99.35% - 99.75%
    Color and Shape:Solid
    Molecular weight:335.42

    Ref: TM-T4983

  • Ataciguat
    Targetmol
    + Info

    Ataciguat

    CAS:
    Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
    Formula:C21H19Cl2N3O6S3
    Purity:99.09%
    Color and Shape:Solid
    Molecular weight:576.49

    Ref: TM-T21607

  • Dimethocaine
    Targetmol
    + Info

    Dimethocaine

    CAS:
    <p>Dimethocaine (Larocaine) is a local anesthetic which also effects on the central nervous system acting as dopamine-reuptake-inhibitor.</p>
    Formula:C16H26N2O2
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:278.39

    Ref: TM-T7118

  • BMY 7378 dihydrochloride
    Targetmol
    + Info

    BMY 7378 dihydrochloride

    CAS:
    <p>BMY 7378 dihydrochloride (BMY7378 HCl) , α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.</p>
    Formula:C22H33Cl2N3O3
    Purity:97.32% - 99.08%
    Color and Shape:Solid
    Molecular weight:458.42

    Ref: TM-T3046

  • AC 187 Acetate
    Targetmol
    + Info

    AC 187 Acetate

    <p>AC 187 Acetate is a potent antagonist of amylin receptor .AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors.</p>
    Formula:C129H209N37O42
    Purity:99.71%
    Color and Shape:Solid
    Molecular weight:2950.26

    Ref: TM-T21581L

  • S1p receptor agonist 1
    Targetmol
    + Info

    S1p receptor agonist 1

    CAS:
    <p>S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.</p>
    Formula:C23H24FN3O3
    Purity:99.07% - 99.9%
    Color and Shape:Solid
    Molecular weight:409.45

    Ref: TM-T4031

  • Mequitazine
    Targetmol
    + Info

    Mequitazine

    CAS:
    Mequitazine (Virginan) is an effective, nonsedative and long-acting histamine H1 antagonist.
    Formula:C20H22N2S
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:322.47

    Ref: TM-T4499

  • MF-766
    Targetmol
    + Info

    MF-766

    CAS:
    <p>MF-766: potent, selective oral EP4 antagonist, Ki=0.23 nM, IC50=1.4 nM; shifts to 1.8 nM with 10% HS. Useful in cancer, inflammation studies.</p>
    Formula:C27H21F3N2O3
    Purity:99.54% - 99.59%
    Color and Shape:Solid
    Molecular weight:478.46

    Ref: TM-T9622

  • S1RA hydrochloride
    Targetmol
    + Info

    S1RA hydrochloride

    CAS:
    <p>S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki &gt;</p>
    Formula:C20H24ClN3O2
    Purity:98% - 99.84%
    Color and Shape:Solid
    Molecular weight:373.87

    Ref: TM-T4229

  • BWX 46 Acetate
    Targetmol
    + Info

    BWX 46 Acetate

    <p>BWX 46 Acetate is a potent, highly selective neuropeptide Y (NPY) receptor agonist with IC50 of 0.5 nM.</p>
    Formula:C118H190N36O30S2
    Purity:96.86%
    Color and Shape:Solid
    Molecular weight:2657.12

    Ref: TM-T21611L

  • Raclopride
    Targetmol
    + Info

    Raclopride

    CAS:
    <p>Raclopride is a selective antagonist of dopamine D2/D3 receptor.</p>
    Formula:C15H20Cl2N2O3
    Purity:99.17%
    Color and Shape:Solid
    Molecular weight:347.24

    Ref: TM-T7635

  • N-Desmethylclozapine
    Targetmol
    + Info

    N-Desmethylclozapine

    CAS:
    N-Desmethylclozapine: 5-HT2C antagonist (IC50: 7.1 nM), dopamine D4 antagonist, δ-opioid agonist.
    Formula:C17H17ClN4
    Purity:97.25% - 99.83%
    Color and Shape:Yellow Crystalline Solid
    Molecular weight:312.8

    Ref: TM-T5158

  • SBI-115
    Targetmol
    + Info

    SBI-115

    CAS:
    <p>SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5</p>
    Formula:C14H13ClN2O4S
    Purity:99.53% - 99.78%
    Color and Shape:Solid
    Molecular weight:340.78

    Ref: TM-T7428

  • OXOMEMAZINE
    Targetmol
    + Info

    OXOMEMAZINE

    CAS:
    <p>Oxomemazine: a phenothiazine antihistamine H1-blocker with strong antimuscarinic and selective M1 antagonist properties, used in cough research.</p>
    Formula:C18H22N2O2S
    Purity:99.58%
    Color and Shape:Solid
    Molecular weight:330.44

    Ref: TM-T9353

  • Clemizole
    Targetmol
    + Info

    Clemizole

    CAS:
    <p>Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.</p>
    Formula:C19H20ClN3
    Purity:98% - 99.65%
    Color and Shape:Solid
    Molecular weight:325.84

    Ref: TM-T1822

  • Taladegib
    Targetmol
    + Info

    Taladegib

    CAS:
    <p>Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.</p>
    Formula:C26H24F4N6O
    Purity:98.75% - >99.99%
    Color and Shape:Solid
    Molecular weight:512.5

    Ref: TM-T2666

  • Aprepitant
    Targetmol
    + Info

    Aprepitant

    CAS:
    <p>Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist.</p>
    Formula:C23H21F7N4O3
    Purity:98% - 99.68%
    Color and Shape:Off-White To Light Yellow Cyrstalline Solid
    Molecular weight:534.43

    Ref: TM-T1743

  • CCG215022
    Targetmol
    + Info

    CCG215022

    CAS:
    <p>CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.</p>
    Formula:C26H22FN7O3
    Purity:97.63% - 99.69%
    Color and Shape:Solid
    Molecular weight:499.5

    Ref: TM-T3498

  • Clemizole hydrochloride
    Targetmol
    + Info

    Clemizole hydrochloride

    CAS:
    Clemizole hydrochloride blocks H1 histamine receptors and inhibits HCV replication and NS4B RNA binding.
    Formula:C19H21Cl2N3
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:362.3

    Ref: TM-T1822L

  • HhAntag
    Targetmol
    + Info

    HhAntag

    CAS:
    <p>HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity</p>
    Formula:C24H23ClN4O3
    Purity:95.73%
    Color and Shape:Solid
    Molecular weight:450.92

    Ref: TM-T3460

  • MRT-10
    Targetmol
    + Info

    MRT-10

    CAS:
    <p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>
    Formula:C24H23N3O5S
    Purity:99.73%
    Color and Shape:Solid
    Molecular weight:465.52

    Ref: TM-T23027

  • RE-640
    Targetmol
    + Info

    RE-640

    CAS:
    <p>NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.</p>
    Formula:C20H16Cl2N4
    Purity:99.60% - 99.87%
    Color and Shape:Solid
    Molecular weight:383.27

    Ref: TM-T3188

  • Felypressin
    Targetmol
    + Info

    Felypressin

    CAS:
    <p>Felypressin, a Lypressin analog with a phenylalanine substitution, acts as a vasoconstrictor with less antidiuretic effect.</p>
    Formula:C46H65N13O11S2
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:1040.22

    Ref: TM-T2568

  • Binodenoson
    Targetmol
    + Info

    Binodenoson

    CAS:
    <p>Binodenoson (WRC 0470), a selective A2A adenosine receptor agonist, aids in coronary imaging.</p>
    Formula:C17H25N7O4
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:391.42

    Ref: TM-T9516

  • Asapiprant
    Targetmol
    + Info

    Asapiprant

    CAS:
    <p>Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor.</p>
    Formula:C24H27N3O7S
    Purity:99.64%
    Color and Shape:Solid
    Molecular weight:501.55

    Ref: TM-T5386

  • Gastrin I (human) acetate
    Targetmol
    + Info

    Gastrin I (human) acetate

    Gastrin I (human) acetate (Gastrin-17 acetate) is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (
    Formula:C99H128N20O33S
    Purity:98.84%
    Color and Shape:Solid
    Molecular weight:2158.25

    Ref: TM-TP2030L1

  • ML-184
    Targetmol
    + Info

    ML-184

    CAS:
    <p>ML-184 (CID2440433) is a potent synthetic agonist of GPR55 with EC50 of 0.26 μM.</p>
    Formula:C25H34N4O3S
    Purity:99.45%
    Color and Shape:Solid
    Molecular weight:470.63

    Ref: TM-T8571

  • AM966
    Targetmol
    + Info

    AM966

    CAS:
    <p>AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.</p>
    Formula:C27H23ClN2O5
    Purity:98.06% - 99.79%
    Color and Shape:Solid
    Molecular weight:490.93

    Ref: TM-T4278

  • Lurasidone hydrochloride
    Targetmol
    + Info

    Lurasidone hydrochloride

    CAS:
    Lurasidone HCl: Atypical antipsychotic, treats schizophrenia & bipolar, affects dopamine, serotonin & adrenergic receptors.
    Formula:C28H36N4O2S·HCl
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:529.14

    Ref: TM-T1735

  • 2-Pyridylethylamine dihydrochloride
    Targetmol
    + Info

    2-Pyridylethylamine dihydrochloride

    CAS:
    <p>2-Pyridylethylamine dihydrochloride is a Histamine H1 receptor agonist.</p>
    Formula:C7H12Cl2N2
    Purity:99.42%
    Color and Shape:Solid
    Molecular weight:195.09

    Ref: TM-T22501

  • ACTH (1-17) acetate
    Targetmol
    + Info

    ACTH (1-17) acetate

    <p>ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM).</p>
    Formula:C97H149N29O25S
    Purity:98.53%
    Color and Shape:Solid
    Molecular weight:2153.47

    Ref: TM-TP1011L

  • PF-04418948
    Targetmol
    + Info

    PF-04418948

    CAS:
    <p>PF-04418948 is a potent EP2 receptor antagonist. Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors.</p>
    Formula:C23H20FNO5
    Purity:98.67% - 99.45%
    Color and Shape:Solid
    Molecular weight:409.41

    Ref: TM-T3306

  • Brexpiprazole
    Targetmol
    + Info

    Brexpiprazole

    CAS:
    <p>Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.</p>
    Formula:C25H27N3O2S
    Purity:99.06% - 99.96%
    Color and Shape:Solid
    Molecular weight:433.57

    Ref: TM-T2306

  • Brimonidine Tartrate
    Targetmol
    + Info

    Brimonidine Tartrate

    CAS:
    <p>Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM).</p>
    Formula:C15H16BrN5O6
    Purity:99.95%
    Color and Shape:Off-White Crystalline Solid
    Molecular weight:442.22

    Ref: TM-T6422

  • IPSU
    Targetmol
    + Info

    IPSU

    CAS:
    <p>IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.</p>
    Formula:C23H27N5O2
    Purity:97.05%
    Color and Shape:Solid
    Molecular weight:405.49

    Ref: TM-T5503

  • CHEMBL241987
    Targetmol
    + Info

    CHEMBL241987

    CAS:
    <p>CHEMBL241987 targets the Adenosine receptor A3 (human)</p>
    Formula:C16H11N3O
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:261.28

    Ref: TM-T8598

  • Tiprenolol
    Targetmol
    + Info

    Tiprenolol

    CAS:
    <p>Tiprenolol is a beta adrenergic receptor antagonist.[1]</p>
    Formula:C13H21NO2S
    Purity:99.43%
    Color and Shape:Solid
    Molecular weight:255.38

    Ref: TM-T50081

  • Conopressin S acetate(111317-90-9 free base)
    Targetmol
    + Info

    Conopressin S acetate(111317-90-9 free base)

    <p>Conopressin S acetate(111317-90-9 free base) (Con-S acetate) is a natural product isolated from Conus striatus, shows high affinity with vasopressin V1b</p>
    Formula:C43H77N17O12S2
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:1088.32

    Ref: TM-TP1192L

  • NAN-190 hydrobromide
    Targetmol
    + Info

    NAN-190 hydrobromide

    CAS:
    <p>NAN-190 hydrobromide is an antagonist of serotonin receptor 5-HT.</p>
    Formula:C23H28BrN3O3
    Purity:95.20%
    Color and Shape:Solid
    Molecular weight:474.39

    Ref: TM-T12172

  • Betaxolol
    Targetmol
    + Info

    Betaxolol

    CAS:
    <p>Betaxolol (Kerlone) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.</p>
    Formula:C18H29NO3
    Purity:99.01%
    Color and Shape:White Crystalline Solid
    Molecular weight:307.43

    Ref: TM-T6408

  • SB-334867 free base
    Targetmol
    + Info

    SB-334867 free base

    CAS:
    <p>SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.</p>
    Formula:C17H13N5O2
    Purity:99.67% - >99.99%
    Color and Shape:Solid
    Molecular weight:319.32

    Ref: TM-T6140

  • 2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
    Targetmol
    + Info

    2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)

    <p>2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) is a potent and selective protease-activated receptor 2 (PAR2) agonist.</p>
    Formula:C38H64F3N11O10
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:891.98

    Ref: TM-TP1378

  • AZ3451
    Targetmol
    + Info

    AZ3451

    CAS:
    <p>AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).</p>
    Formula:C30H27BrN4O3
    Purity:98.12%
    Color and Shape:Solid
    Molecular weight:571.46

    Ref: TM-TQ0012

  • S 38093 HCl
    Targetmol
    + Info

    S 38093 HCl

    CAS:
    <p>S 38093 is a novel brain-penetrant antagonist/inverse agonist of H3 receptors.</p>
    Formula:C17H25ClN2O2
    Purity:97.91%
    Color and Shape:Solid
    Molecular weight:324.85

    Ref: TM-T4087

  • Cetirizine Impurity B dihydrochloride
    Targetmol
    + Info

    Cetirizine Impurity B dihydrochloride

    CAS:
    <p>Cetirizine Impurity B dihydrochloride is a Cetirizine antihistamine byproduct with anti-allergic properties.</p>
    Formula:C19H23Cl3N2O2
    Purity:99.24%
    Color and Shape:Solid
    Molecular weight:417.76

    Ref: TM-T9084

  • Diquafosol tetrasodium
    Targetmol
    + Info

    Diquafosol tetrasodium

    CAS:
    <p>Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film</p>
    Formula:C18H22N4Na4O23P4
    Purity:98.25% - 99.97%
    Color and Shape:Solid
    Molecular weight:878.23

    Ref: TM-T7423

  • CAY10526
    Targetmol
    + Info

    CAY10526

    CAS:
    <p>CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.</p>
    Formula:C12H7BrO3S
    Purity:98.75%
    Color and Shape:Solid
    Molecular weight:311.15

    Ref: TM-T23861

  • SCH442416
    Targetmol
    + Info

    SCH442416

    CAS:
    <p>SCH442416: selective A2A adenosine receptor antagonist; Ki: 0.048 nM (human), 0.5 nM (rat).</p>
    Formula:C20H19N7O2
    Purity:99.58%
    Color and Shape:Solid
    Molecular weight:389.41

    Ref: TM-T23336

  • Galanin Receptor Ligand M35 TFA
    Targetmol
    + Info

    Galanin Receptor Ligand M35 TFA

    <p>Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM).</p>
    Formula:C109H154N27F3O28
    Purity:99.45%
    Color and Shape:Solid
    Molecular weight:2347.62

    Ref: TM-TP1704