Organometallic Ligands
In this category, you will be able to find a large number of organometallic molecules used as ligands in biomolecules. These organometallic ligands can be used in organic chemistry and synthesis in the laboratory. They play a critical role in forming coordination complexes and catalyzing various chemical reactions. At CymitQuimica, we offer a diverse selection of high-quality organometallic ligands to support your research and industrial needs.
Subcategories of "Organometallic Ligands"
- Buchwald Ligands(22 products)
- DPEN(4 products)
- DPHEN(4 products)
- JOSIPHOS(4 products)
- Phosphine(497 products)
- Porphirines(75 products)
Found 2889 products of "Organometallic Ligands"
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DL-Venlafaxine HCl - Bio-X ™
CAS:Controlled ProductVenlafaxine is an antidepressant drug used in the treatment of major depression, anxiety disorder and panic disorder. It is classed as an SNRI drug meaning it inhibits the reuptake of serotonin and norepinephrine so that there is an increased level of the neurotransmitters in the synaptic cleft.Formula:C17H27NO2•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:313.86 g/mol4-Deoxyuridine
CAS:A cytidine analogue and inhibitor of DNA methyl transferases (DNMTs) with anti-cancer activity. This stable, hydrophilic compound forms covalent complexes between DNMT and zebularine-substrate DNA. It causes DNA lesions that block replication and cause replication fork collapse, leading to the formation of DNA double-strand breaks. It was also shown that zebularine-induced DNA methylation decrease in the IL-1β promoter region and disrupts molecular mechanisms of neuroinflammation. Moreover, this molecule down-regulates the DNA-methylation profile in the pluripotency genes’ promoters, which leads to improved development of somatic cell nuclear transfer (SCNT) embryos.Formula:C9H12N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:228.21 g/molD-Fructose-1,6-diphosphate trisodium salt octahydrate
CAS:D-Fructose-1,6-diphosphate trisodium salt octahydrate is a biochemical compound, an important intermediate in carbohydrate metabolism. It is sourced from the glycolytic pathway, where it functions as a phosphorylated sugar derivative formed from fructose-6-phosphate through the action of phosphofructokinase. As an allosteric regulator, it plays a crucial role in glycolysis, acting to accelerate enzyme reactions that convert glucose to pyruvate, thus providing energy to cells.
Formula:C6H11Na3O12P2·8H2OPurity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:550.18 g/molFluocinolone acetonide
CAS:Corticosteroid; anti-inflammatory; treats dermatological conditionsFormula:C24H30F2O6Purity:Min. 97 Area-%Color and Shape:PowderMolecular weight:452.49 g/molPelitinib
CAS:EGFR tyrosine kinase inhibitor; pro-apoptotic; antiproliferative in cancer cellsFormula:C24H23ClFN5O2Purity:Min. 95%Color and Shape:PowderMolecular weight:467.92 g/mol6-Thioguanine - Bio-X ™
CAS:6-Thioguanine is a purine analog used in the therapy for leukemia and for remission consolidation in patients with acute nonlymphocytic anemia. This drug also has antimetabolite action. It replaces guanine during DNA replication. This substitution disrupts the accurate pairing of DNA bases, leading to errors in DNA replication and hinders cell division.Formula:C5H5N5SPurity:Min. 95%Color and Shape:PowderMolecular weight:167.19 g/molPicrotoxin - Bio-X ™
CAS:Picrotoxin is a GABA-A receptor antagonist that is used to relieve respiratory distress. This drug also is used as an antidote from poisoning by CNS depressants. Picrotoxin works by blocking the GABA activated chloride ionophore.Formula:C15H18O7·C15H16O6Purity:Min. 95%Color and Shape:PowderMolecular weight:602.58 g/molBardoxolone methyl
CAS:Activater of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Possible applications have extended to anti-viral treatment of COVID-19.Formula:C32H43NO4Purity:Min. 95%Color and Shape:White PowderMolecular weight:505.69 g/molPF 05214030
CAS:PF 05214030 is a biosimilar monoclonal antibody, which is sourced from recombinant DNA technology and designed to inhibit tumor necrosis factor-alpha (TNF-α). This product functions by binding to TNF-α, a cytokine that plays a critical role in mediating inflammation. By preventing TNF-α from interacting with its receptors on cell surfaces, PF 05214030 effectively reduces the inflammatory response associated with various autoimmune and inflammatory conditions.
Formula:C17H13Cl2FN2O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:431.3 g/molVX 765
CAS:A prodrug of VRT 043198 that inhibits IL-converting enzyme (ICE)/caspase-1. Inhibits LPS-induced secretion of cytokines. It has therapeutic potential in autoinflammatory diseases. VX 765 is cardioprotective in addition to the P2Y12 receptor inhibitor congrelor, resulting in reduced myocardial infarction.
Formula:C24H33ClN4O6Purity:Min. 95%Color and Shape:White PowderMolecular weight:508.99 g/molFTBMT
CAS:FTBMT is a GPR52 receptor agonist with an EC50 value of 71 nM. Studies demonstrate antipsychotic-like effects of FTBMT in murine models of schizophrenia. FTBMT elicits beneficial effects on cognitive processes such as spatial working memory and long-term memory in mice.Formula:C19H16F4N4OPurity:Min. 95%Color and Shape:PowderMolecular weight:392.35 g/molBosentan - Bio-X ™
CAS:Bosentan is a dual endothelin receptor antagonist that is used to treat hypertension. This drug works by blocking the action of endothelin molecules which prevents the narrowing of blood vessels and decreases blood pressure.
Formula:C27H29N5O6SPurity:Min. 95%Color and Shape:PowderMolecular weight:551.62 g/molEptifibatide acetate
CAS:Controlled ProductInhibits platelet glycoprotein IIb/IIIa receptorsFormula:C35H49N11O9S2·xC2H4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:831.96 g/molMeloxicam - Bio-X ™
CAS:Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) which is used to treat various types of pain and inflammation caused by arthritis. It is also a COX-2 inhibitor which reduces gastrointestinal effects of this drug. Inhibiting these enzymes, allow for a decrease in inflammatory symptoms.Formula:C14H13N3O4S2Purity:Min. 95%Color and Shape:PowderMolecular weight:351.4 g/molPimecrolimus
CAS:Immune suppressant; prevents pro-inflammatory cytokine releaseFormula:C43H68ClNO11Purity:Min. 95%Color and Shape:PowderMolecular weight:810.45 g/molHydroxychloroquine sulfate - Bio-X ™
CAS:Hydroxychloroquine is a drug that is used to treat multiple types of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus and discoid lupus. It is a prodrug, which is activated in the liver to hydroxychloroquine. It inhibits the production of inflammatory cytokines and nitric oxide by binding to the toll-like receptor 4 (TLR4) and inhibiting signaling pathways downstream of TLR4 activation. Additionally, Hydroxychloroquine is used to prevent and treat malaria caused by parasitic protozoan from the Plasmodium genus. Furthermore, recent studies revealed that hydroxychloroquine has beneficial effects on COVID-19 patients, as the current evidence shows that hydroxychloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the spike glycoprotein.Formula:C18H28ClN3O5SPurity:Min. 95%Color and Shape:PowderMolecular weight:433.95 g/molParoxetine hydrochloride
CAS:Controlled ProductA serotonin reuptake inhibitor with anticholinergic activity and mild inhibitory activity on noradrenaline reuptake. Paroxetine has been used for the treatment of depression, anxiety disorders, post-traumatic stress disorder, premenstrual dysphoric disorder and obsessive-compulsive disorder. Also inhibits nitric oxide synthase and cytochrome isoenzyme P450 2D6.
Formula:C19H20FNO3·HClPurity:Min. 97%Color and Shape:White PowderMolecular weight:365.83 g/molTraxoprodil
CAS:Controlled ProductNMDA glutamate receptor antagonist; anti-depressant
Formula:C20H25NO3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:327.42 g/molU 0126 monoethanolate
CAS:Inhibitor of MEK1 and MEK2 kinasesFormula:C18H16N6S2•C2H6OPurity:Min. 95%Color and Shape:White To Beige SolidMolecular weight:426.56 g/molEN 6
CAS:Autophagy activator that acts through targeting the ATP6V1A subunit of vATPaseFormula:C19H14F2N4O2Purity:Min. 95%Color and Shape:White To Yellow To Beige SolidMolecular weight:368.34 g/molNolatrexed dihydrochloride
CAS:Thymidylate synthase inhibitorFormula:C14H14Cl2N4OSPurity:Min. 95%Color and Shape:White To Light (Or Pale) Yellow SolidMolecular weight:357.26 g/molEnzalutamide
CAS:Androgen receptor antagonist
Formula:C21H16F4N4O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:464.4 g/mol2-[(2-Ethoxy phenoxy)methyl]morpholine HCl
CAS:2-[(2-Ethoxy phenoxy)methyl]morpholine HCl is a sophisticated chemical compound utilized extensively in scientific research. As a synthetic organic compound, it is derived through a meticulous process involving the reaction of morpholine with ethoxy phenoxy derivatives, followed by hydrochloride salt formation. This synthesis ensures high purity and accurate functionality, making it suitable for precise laboratory studies.Formula:C13H20ClNO3Purity:Min. 95%Color and Shape:PowderMolecular weight:273.76 g/molMK 886 sodium salt
CAS:Inhibitor of 5-lipoxygenase activating protein_x000D_
Formula:C27H33ClNNaO2SPurity:Min. 95%Color and Shape:PowderMolecular weight:494.06 g/molBuflomedil hydrochloride
CAS:Antagonist of α-adrenoceptors; vasoactive agentFormula:C17H25NO4·HClPurity:Min. 95%Color and Shape:PowderMolecular weight:343.85 g/molErismodegib
CAS:Antagonist of Smoothened GPCR; antineoplasticFormula:C26H26F3N3O3Purity:Min. 95%Color and Shape:PowderMolecular weight:485.5 g/molAnabaseine
CAS:Natural neurotoxinFormula:C10H12N2Purity:Min. 95%Color and Shape:Dark Green To Brown LiquidMolecular weight:160.22 g/molVadadustat
CAS:Controlled ProductVadadustat is an orally administered hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), which is a synthetic small molecule. Its mode of action involves the inhibition of prolyl hydroxylase enzymes, which normally facilitate the degradation of hypoxia-inducible factor (HIF) under normal oxygen conditions. By stabilizing HIF, vadadustat effectively mimics a hypoxic response, leading to increased endogenous production of erythropoietin (EPO), a key hormone in red blood cell production.Formula:C14H11ClN2O4Purity:Min. 95%Color and Shape:PowderMolecular weight:306.7 g/molSacubitril calcium
CAS:Inhibitor of metalloendopeptidase neprilysinFormula:C24H29NO5•Ca0Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:431.53 g/molLestaurtinib
CAS:Lestaurtinib is a multitarget tyrosine kinase inhibitor of the JAK, FLT-3 and TrkA families of tyrosine kinases at nanomolar concentrations. It inhibits proliferation and induces apoptosis in vitro. Lestaurtinib is a FDA approved orphan drug for acute myeloid leukemia.Formula:C26H21N3O4Purity:Min. 95%Color and Shape:PowderMolecular weight:439.46 g/molVincamine
CAS:Peripheral vasodilator; nootropic agentFormula:C21H26N2O3Purity:Min. 95%Color and Shape:White PowderMolecular weight:354.44 g/molt-TUCB
CAS:t-TUCB is a potent soluble epoxide hydrolase (sEH) inhibitor, which is a chemically synthesized compound. The mode of action of t-TUCB involves the inhibition of sEH, an enzyme responsible for the degradation of epoxyeicosatrienoic acids (EETs). By inhibiting sEH, t-TUCB effectively increases the levels of EETs, which are signaling molecules involved in numerous physiological processes, including inflammation, blood pressure regulation, and pain perception.Formula:C21H21F3N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:438.4 g/molMYCi975
CAS:MYCi975 is a microbial inoculant, which is a bio-based product designed for agricultural use. It originates from a carefully selected consortium of rhizobial bacteria, specifically tailored to establish a symbiotic relationship with leguminous plants. The mode of action involves the colonization of the plant roots by these rhizobia, which then form nodules. Within these structures, the bacteria convert atmospheric nitrogen into ammonia through biological nitrogen fixation, a process that enriches the soil and provides essential nitrogen to the host plant.Formula:C25H16Cl2F6N2O2Purity:Min. 95%Molecular weight:561.3 g/molPPT
CAS:Estrogen receptor alpha (ERα) agonistFormula:C24H22N2O3Purity:Min. 95%Color and Shape:PowderMolecular weight:386.44 g/molTriptolide
CAS:Inhibits RNAPII-mediated trasncription; immunosuppressant; anti-inflammatoryFormula:C20H24O6Purity:Min. 97 Area-%Color and Shape:PowderMolecular weight:360.4 g/molAzumolene
CAS:Azumolene is a muscle relaxant drug, which is a synthetic derivative of dantrolene originating from hydantoin. The mode of action of Azumolene involves the inhibition of calcium ion release from the sarcoplasmic reticulum of skeletal muscle fibers. By impeding this release, Azumolene effectively reduces muscle contraction, thereby acting as a potent muscle relaxant.Formula:C13H9BrN4O3Purity:Min. 95%Color and Shape:PowderMolecular weight:349.14 g/molApremilast - Bio-X ™
CAS:Apremilast is the commercial name of a phosphodiesterase-4 (PDE4) inhibitor developed to treat chronic inflammatory disorders. Similarly to thalidomide, the apremilast molecule carries a phthalimide ring, but it lacks however the glutarimide ring needed to bind to cereblon, specifically targeted by thalidomide. As a drug, apremilast is indicated for the treatment of psoriasis and psoriatic arthritis.Formula:C22H24N2O7SPurity:Min. 99 Area-%Color and Shape:White/Off-White SolidMolecular weight:460.5 g/molGalloylpaeoniflorin
CAS:Galloylpaeoniflorin is a bioactive compound derived from the roots of Paeonia lactiflora, a plant traditionally used in various herbal medicines. This compound plays a significant role in the realm of natural products, offering intriguing possibilities for research due to its complex chemical structure and biological activities.Formula:C30H32O15Purity:Min. 95%Molecular weight:632.57 g/molN-Acetyl mescaline
CAS:Controlled ProductN-Acetyl mescaline is a synthetic compound derived from the naturally occurring hallucinogen mescaline, which is sourced from the Peyote cactus (Lophophora williamsii) and other cacti. As an N-acetylated derivative, its chemical modification impacts the compound's mode of action, particularly in its interaction with serotonin (5-HT) receptors.This acetylation can alter the pharmacokinetics, potentially influencing its binding affinity and efficacy at various receptor sites, such as 5-HT2A. This receptor is notably implicated in the mechanism of action of classic psychedelics, mediating their sensory and cognitive effects.While mescaline is known for its strong psychotropic effects, N-Acetyl mescaline presents a modified profile, which may alter its psychoactive properties and duration of action. This compound is primarily studied in research settings to investigate its unique interactions with the neural network and its potential implications for neuroscience.Formula:C13H19NO4Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:253.29 g/molBuserelin acetate
CAS:Controlled ProductAgonist of hypothalamic neuropeptide LHRHFormula:C62H90N16O15Purity:Min. 95%Color and Shape:PowderMolecular weight:1,299.48 g/molOndansetron HCl dihydrate - Bio-X ™
CAS:Ondansetron is a serotonin 5-HT3 receptor antagonist that is used to prevent vomiting and nausea in patients undergoing chemotherapy. This drug blocks the initiation of the vomiting reflex.Formula:C18H19N3O•HCl•(H2O)2Purity:Min. 95%Color and Shape:PowderMolecular weight:365.85 g/molMianserin HCl - Bio-X ™
CAS:Controlled ProductMianserin is a tetracyclic antidepressant drug that has antihistaminic and hypnosedative properties. It is used to treat depression in adults and children, as well as other disorders such as chronic pain and irritable bowel syndrome. This drug’s mechanism of action is not fully understood but is said to block alpha-adrenergic, histamine H1 and serotonin receptors.Formula:C18H20N2•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:300.83 g/molNicardipine HCl - Bio-X ™
CAS:Nicardipine is calcium channel blocker drug that is used for the treatment of hypertension and angina. This drug can also be used in the treatment of asthma and is said to enhance the action of various antineoplastic agents.Formula:C26H29N3O6•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:515.99 g/mol2-[4-(Piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide
CAS:2-[4-(Piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide is a synthetic small molecule compound, which is a product of advanced medicinal chemistry. This compound is derived from a structured synthesis process focusing on the indazole core, which is known for its bioactive properties. The piperidin-3-yl phenyl moiety is intricately designed to optimize interaction with biological targets.Formula:C19H20N4OPurity:Min. 95%Color and Shape:PowderMolecular weight:320.39 g/molNaftopidil - Bio-X ™
CAS:Naftopidil is an alpha adrenergic antagonist drug that is used to treat urinary symptoms and conditions related to benign prostatic hypertrophy. This drug works to relax smooth muscles by inhibiting alpha adrenergic receptors, thus allowing an improvement in urine flow.Formula:C24H28N2O3Purity:Min. 95%Color and Shape:PowderMolecular weight:392.49 g/molPamidronic acid disodium hydrate - Bio-X ™
CAS:Pamidronic acid is a bisphosphate used in the treatment of Paget’s disease, osteolytic bone lesions and in the treatment of hypercalcemia of malignancy. This drug inhibits farnesyl diphosphate and induces apoptosis of hematopoietic tumor cells.Formula:C3H9NNa2O7P2·4H2OPurity:Min. 95%Color and Shape:PowderMolecular weight:351.11 g/molAZD 9291
CAS:A potent inhibitor of EGFR with sensitizing and T790M resistance mutations, selective over the wild-type form of the receptor. Causes tumour regression in EGFR mutant T790M transgenic and xenograft models in vivo.Formula:C28H33N7O2Purity:Min. 97%Color and Shape:SolidMolecular weight:499.61 g/molSenicapoc
CAS:Gardos channel inhibitorFormula:C20H15F2NOPurity:Min. 95%Color and Shape:PowderMolecular weight:323.34 g/molAstemizole - Bio-X ™
CAS:Astemizole is an antihistamine drug used to treat allergy symptoms. This drug is a histamine-1 receptor antagonist and does not cross the blood-brain barrier. Its binding to histamine receptors suppresses flare ups and pruritus.Formula:C28H31FN4OPurity:Min. 95%Color and Shape:PowderMolecular weight:458.57 g/molAtorvastatin sodium salt - Bio-X ™
CAS:Atorvastatin is an HMG-CoA reductase inhibitor which is used to lower lipid levels and to reduce the risk of cardiovascular disease. This drug belongs to the class of medicines called statins. It lowers abnormal levels of cholesterol and lipids to reduce the risk of cardiovascular disease by inhibiting the enzyme HMG-CoA.Formula:C33H35FN2O5•NaPurity:(%) Min. 95%Color and Shape:PowderMolecular weight:581.63 g/molA 939572 - Bio-X ™
CAS:A 939572 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It exhibits anticancer activity as it inhibits cell growth and promotes cell death in human non-small cell lung carcinoma cells.Formula:C20H22ClN3O3Purity:Min. 95%Color and Shape:PowderMolecular weight:387.86 g/molBremelanotide acetate - Bio-X ™
CAS:Controlled ProductBremelanotide is a 7 amino acid peptide that is used to treat hypoactive sexual desire disorder in premenopausal women. This drug is an agonist of many melanocortin receptors. Although, its mechanism is unknown, it is said to increase melanin expression which aids in the regulation of sexual arousal.Formula:C52H72N14O12Purity:Min. 95%Color and Shape:PowderMolecular weight:1,085.22 g/molSAG
CAS:Smoothened agonist and activator of the Hedgehog signalling pathway with EC50 of 3 nM. SAG binds to the Smoothened heptahelical bundle and antagonises effects of the Smoothened antagonist cyclopamine. In previous studies, SAG activated neurogenesis and neuronal survival in cell and animal models as well as improved cell differentiation of human induced pluripotent cells into the neuronal lineage.Formula:C28H28ClN3OSPurity:Min. 95%Color and Shape:White PowderMolecular weight:490.06 g/molGNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formula:C20H20N4O2Purity:Min. 95%Molecular weight:348.4 g/molAMG 9810
CAS:Vanilloid receptor 1 antagonistFormula:C21H23NO3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:337.41 g/molAZD9833
CAS:AZD9833 is an oral selective estrogen receptor degrader (SERD), which is a small molecule therapeutic synthesized by AstraZeneca. Its mode of action involves binding to the estrogen receptor, leading to the receptor's conformational change and subsequent degradation. This mechanism significantly downregulates estrogen receptor signaling, which is a crucial pathway in the progression of estrogen receptor-positive breast cancers.Formula:C24H28F4N6Purity:Min. 95%Color and Shape:PowderMolecular weight:476.23 g/mol(-)-Huperzine A
CAS:Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFormula:C15H18N2OPurity:(%) Min. 98%Color and Shape:PowderMolecular weight:242.32 g/mol13:0 Lyso ps
CAS:13:0 Lyso PS is a lysophosphatidylserine, which is a synthetic lipid derivative that serves as a crucial component in biochemical research. It is synthesized from naturally occurring phospholipids, offering a structurally simplified molecule that retains the functional headgroup critical for biological activity. As a single fatty acid chain molecule, its mode of action includes the modulation of cellular processes through interactions with lysophospholipid receptors and participation in signaling pathways. These interactions can influence cell proliferation, apoptosis, or differentiation, depending on the biological context.Formula:C19H37NNaO9PPurity:Min. 95%Molecular weight:477.46 g/molPD 169316
CAS:Inhibitor of p38 kinase
Formula:C20H13FN4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:360.34 g/molLomeguatrib
CAS:Inhibitor and pseudosubstrate of DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). It is used as a sensitizer for the treatment of advanced solid tumors, including prostate, colorectal and central nervous system malignancies. Lomeguatrib inhibits the repair mechanism of DNA damage induced by alkylating agents such as temozolomide, and therefore potentiates its anti-cancer effects.Formula:C10H8BrN5OSPurity:Min. 95%Color and Shape:SolidMolecular weight:326.17 g/molOrelabrutinib
CAS:Orelabrutinib is a small-molecule Bruton’s tyrosine kinase (BTK) inhibitor, which is synthesized chemically. This selective inhibitor targets BTK, a key enzyme involved in the B-cell receptor signaling pathway. By binding covalently to cysteine-481 in BTK, orelabrutinib effectively blocks the downstream signaling, leading to apoptosis of malignant B-cells.Formula:C26H25N3O3Purity:Min. 95%Molecular weight:427.5 g/molEpalrestat - Bio-X ™
CAS:Epalrestat is a carboxylic acid derivative that is used for the treatment of diabetic neuropathy. This drug is an aldose reductase inhibitor and aims to reduce the accumulation of intracellular sorbitol. Studies in rats have shown this drug to improve morphological abnormalities of nerves.Formula:C15H13NO3S2Purity:Min. 95%Color and Shape:PowderMolecular weight:319.4 g/molPimasertib
CAS:A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Formula:C15H15FIN3O3Purity:Min. 95%Color and Shape:White To Yellow SolidMolecular weight:431.2 g/molCHZ868
CAS:CHZ868 is a chemical compound primarily used in experimental research settings. It is synthesized through a series of organic reactions, often involving specific reagents to ensure high purity and stability. The compound operates by interacting with specific cellular pathways, influencing key biochemical processes that are crucial for its intended applications.Formula:C22H19F2N5O2Purity:Min. 95%Color and Shape:PowderMolecular weight:423.42 g/molFeprazone
CAS:Anti-inflammatory; inducer of P450 II B familyFormula:C20H20N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:320.39 g/molRamatroban
CAS:Dual inhibitor of thromboxane receptor and DP2 postanoid receptorFormula:C21H21FN2O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:416.47 g/molA 769662
CAS:Allosteric activator of AMP-activated protein kinase (AMPK) acting on the AMPK-β subunit with therapeutic potential in metabolic disorders such as diabetes, obesity, etc. A769662 also blocks the differentiation of mouse embryonic stem cells (mESCs) and maintains the mESCs in naïve state even in the absence of leukemia inhibitory factor (2i/L).Formula:C20H12N2O3SPurity:Min. 95%Color and Shape:SolidMolecular weight:360.39 g/molUNC 4203
CAS:Potent and specific inhibitor of the tyrosine protein kinase Mer precursor (MERTK) with 38-fold selectivity over the FMS-like protein kinase FLT3. UNC 4203 inhibits MERTK with an IC50 value of 2.4 nM and shows favourable pharmacokinetic properties. In vivo experiments in mice showed that UNC 4203 dramatically decreased the phosphorylation of MERTK in bone marrow leukemia cells.Formula:C30H44N6OPurity:Min. 95%Color and Shape:Yellow PowderMolecular weight:504.71 g/molGW 833972A
CAS:A cannabinoid receptor agonist, which binds more selectively to CB2 than CB1 receptors (1000-fold). GW833972A inhibits vagus nerve depolarization induced by tussive agents, such as hypertonic saline (EC50 = 6.5 μM), capsaicin (EC50 = 33.9 μM) or PGE2 (EC50 = 15.9 μM).Formula:C18H13ClF3N5OPurity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:407.78 g/molGB1107
CAS:Please enquire for more information about GB1107 including the price, delivery time and more detailed product information at the technical inquiry form on this pageFormula:C20H16Cl2F3N3O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:522.3 g/molPARP1 (487-496) peptide
Amino acids 487-496 of Poly(ADP-ribose) polymerase 1 (PARP1). PARP1 is a nuclear DNA repair enzyme that binds to DNA when damage is detected. PARP1 coordinates double and single strand break repair by first cleaving NAD+ into nicotinamide and ADP-ribose, and then synthesising poly-(ADP-ribose) (PAR) chains from ADP-ribose on target proteins (PARylation). PARylation of histone proteins mediates relaxation of the chromatin and recruitment of DNA-break repair enzymes.PARP1 can also act as a transcriptional co-activator, modulating the expression of itself and many other genes by direct binding to or PARylation of enhancers and promoters. PARP1 is also involved in maintaining mtDNA.PARP1 belongs to the PARP family which has 7 known and 10 putative members. PARP1 accounts for >85% of the PARP activity in cellular systems.Purity:Min. 95%Color and Shape:PowderMolecular weight:1,106.6 g/molMevastatin - Bio-X ™
CAS:Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity.
Formula:C23H34O5Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:390.51 g/molAMARA peptide
CAS:AMARA peptide is a fragment containing the phosphorylation site for AMP activated protein kinase (AMPK) and is a substrate for all AMPK subfamily kinases. As such it is used to measure AMPK related kinase activity.Purity:Min. 95%Color and Shape:PowderMolecular weight:1,541.9 g/molEnzastaurin
CAS:Enzastaurin is a synthetic small molecule inhibitor, which is derived from chemical synthesis with a primary mode of action as an inhibitor of protein kinase C beta (PKCβ). As a potent pathway modulator, it disrupts signal transduction pathways involved in cell proliferation and survival. The inhibition of PKCβ is particularly important as this enzyme is linked to the progression and survival of certain cancer types. Through this mechanism, Enzastaurin impedes the downstream activities that promote tumor growth and angiogenesis.Formula:C32H29N5O2Purity:Min. 98 Area-%Molecular weight:515.61 g/molTacrolimus - Bio-X ™
CAS:Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.
Formula:C44H69NO12Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:804.02 g/molCarvedilol - Bio-X ™
CAS:Controlled ProductCarvediol is a nonselective beta-adrenoceptor blocking agent and an alpha 1-adrenoceptor blocker. It can be used as a drug, belonging to the class of beta blockers, in the treatment of heart failure, coronary artery disease, and hypertension. Carvedilol has been shown to reduce the risk of death in patients with heart failure and improve symptoms. Furthermore it has an effect on blood pressure by decreasing peripheral vascular resistance and mean arterial pressure. Carvedilol can be metabolized by cytochrome P450 enzymes and CYP2D6 and CYP2C9 liver enzymes.Formula:C24H26N2O4Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:406.47 g/molLoratadine - Bio-X ™
CAS:Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.Loratadine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C22H23ClN2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:382.88 g/molCP 809101 hydrochloride
CAS:5-HT2C receptor agonist; antipsychotic
Formula:C15H17ClN4O·HClPurity:Min. 95%Color and Shape:Beige PowderMolecular weight:341.24 g/molDeracoxib
CAS:Inhibitor of COX-2 and PDE4 enzymes; NSAID of coxib classFormula:C17H14F3N3O3SPurity:Min. 95%Color and Shape:White To Off-White To Brown SolidMolecular weight:397.37 g/molMalotilate - Bio-X ™
CAS:Malotilate is a pharmacological agent that is used to treat symptoms of hepatitis, bowel disease, and collagen diseases. This drug reduces collagen synthesis and cell migration activity of fibroblasts in vitro. It also has been shown to facilitate liver regeneration in rats.Formula:C12H16O4S2Purity:(%) Min. 95%Color and Shape:PowderMolecular weight:288.39 g/molGefarnate
CAS:Used to treat gastrointestinal ulcersFormula:C27H44O2Purity:Min. 95%Color and Shape:Colourless To Pale Yellow LiquidMolecular weight:400.64 g/molKU 55933
CAS:Inhibitor of ataxia telangiectasia mutated (ATM) kinase and AKT kinase with anti-cancer activity. ATM is a nuclear protein kinase and a signal transducer sensing DNA damage as well as controlling double strand DNA break (DSB) repair. It is a radiotherapy and chemotherapy sensitizer, especially in tumors sensitive to DNA alkylating agents (such as temozolomide). Moreover, KU 55933 inhibits phosphorylation of cytoplasmic AKT kinase, downregulates synthesis of cyclin D1 and induces cell cycle arrest in G1 phase.Formula:C21H17NO3S2Purity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:395.06499Ramipril - Bio-X ™
CAS:Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. It is used in the treatment of high blood pressure, congestive heart failure and other cardiovascular diseases. Ramipril inhibits the conversion of angiotensin I to angiotensin II by blocking ACE, which lowers blood pressure and reduces fluid retention.This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C23H32N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:416.51 g/molMelitracen hydrochloride
CAS:Tricyclic antidepressantFormula:C21H26NClPurity:Min. 95%Color and Shape:White PowderMolecular weight:327.89 g/molNalmefene hydrochloride
CAS:Controlled ProductOpioid receptor antagonistFormula:C21H25NO3•HClPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:375.89 g/molMaleimide-DOTA
CAS:Maleimide-DOTA is a chemical conjugation agent, which is a synthetic compound used in the field of radiopharmaceutical development. It is derived from the combination of maleimide and DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). The maleimide moiety specifically reacts with thiol groups, allowing for the selective conjugation to cysteine residues of peptides or proteins. This reactivity is crucial for precise coupling in biochemical modifications, while the DOTA component serves as a versatile chelator for radiometals.Formula:C22H34N6O9Purity:Min. 95%Color and Shape:PowderMolecular weight:526.5 g/molR-Rolipram
CAS:Inhibitor of PDE4 enzyme; anti-inflammatory
Formula:C16H21NO3Purity:Min. 95%Color and Shape:PowderMolecular weight:275.34 g/molCilastatin
CAS:Cilastatin is a renal dehydropeptidase inhibitor, which is a compound sourced from synthetic processes designed to augment the pharmacokinetic profile of certain beta-lactam antibiotics. Its primary mode of action is to inhibit the enzyme dehydropeptidase I (DHP-I), located in the renal brush border. This enzyme typically degrades antibiotics, like imipenem, within the renal tubules. By inhibiting DHP-I, cilastatin prevents the inactivation of these antibiotics, thereby prolonging their active presence in the body and enhancing their antimicrobial efficacy.Formula:C16H26N2O5SPurity:Min. 95%Color and Shape:PowderMolecular weight:358.45 g/molPD 98059
CAS:MAP kinase kinase (MEK) inhibitor. Binds to MEK-1, preventing phosphorylation and activation by Raf or MEK kinase. PD 098059 enhances self-renewal in stem cells. Has anti-growth and anti-proliferative effects on AML cells. Anti-apoptotic effect on AML cells observed in synergy with Nutlin-3a.
Formula:C16H13O3NPurity:Min. 95%Color and Shape:Off-White PowderMolecular weight:267.28 g/molMibefradil hydrochloride
CAS:Mibefradil is a calcium channel antagonist with the highest selectivity for T- and L-type channels, but also effective for N-, Q-, and R-type calcium channels at micromolar range. It decreases smooth muscle proliferation in response to vascular injury and causes vessel dilatation.Formula:C29H38FN3O3·2HClPurity:Min. 95%Color and Shape:PowderMolecular weight:568.55 g/molDothiepin hydrochloride - Bio-X ™
CAS:Dothiepin is a tricyclic antidepressant used to treat depression in patients who are not responding to alternative therapies. This drug inhibits the reuptake of norepinephrine and serotonin, increasing available neurotransmitter levels at the synaptic cleft. It also exhibits anticholinergic, antihistamine and central sedative properties.Formula:C19H21NS·HClPurity:Min. 98%Color and Shape:PowderMolecular weight:331.9 g/molDocetaxel - Bio-X ™
CAS:Docetaxel is an antineoplastic agent that is used to treat various cancers such as breast and prostate cancer. This drug interferes with the normal function of microtubule growth. It is an anti-mitotic drug used in chemotherapy. Research has shown that this drug also induces programmed cell death in cancer cells.Formula:C43H53NO14Purity:Min. 90 Area-%Color and Shape:White/Off-White SolidMolecular weight:807.88 g/mol(+/-)-Thalidomide - Bio-X ™
CAS:Controlled ProductThalidomide is a piperidinyl isoindole drug that is used to treat various cancers such as myeloma and erythema nodosum leprosum. This drug is immunosuppressive and has anti-angiogenic activity. Thalidomide’s mechanism of action is not fully understood however it is thought to block the activity of tumor necrosis factor-alpha (TNF-α).Formula:C13H10N2O4Purity:Min. 95%Color and Shape:PowderMolecular weight:258.23 g/molVeliparib
CAS:Potently inhibits PARP-1 and PARP-2 enzymes, orally bioavailable and crosses blood-brain barrier. Sensitises cancer cells to DNA-damaging chemotherapy and radiotherapy. Combination therapies investigated in clinical trials for solid and blood malignancies.
Formula:C13H16N4OPurity:Min. 95%Color and Shape:White PowderMolecular weight:244.29 g/molSC 560
CAS:Inhibitor of COX1 cyclooxygenaseFormula:C17H12ClF3N2OPurity:Min. 95%Molecular weight:352.74 g/molAminopterin
CAS:Aminopterin is an antineoplastic agent and antifolate, which is a synthetic derivative of pteroylglutamic acid. It functions as a chemotherapeutic agent by inhibiting dihydrofolate reductase, an enzyme crucial in the folic acid pathway, thereby preventing the conversion of dihydrofolate to tetrahydrofolate. This disruption leads to impaired synthesis of purine nucleotides and thymidylate, which are essential for DNA synthesis and cell division.Formula:C19H20N8O5Purity:Min. 97 Area-%Color and Shape:Slightly Yellow PowderMolecular weight:440.41 g/molKetanserin
CAS:5-HT2A serotonin receptor antagonist; anti-hypertensiveFormula:C22H22FN3O3Purity:Min. 95%Molecular weight:395.43 g/molNateglinide - Bio-X ™
CAS:Nateglinide is used to treat type 2 diabetes mellitus as an oral hypoglycemic, insulinotropic agent. It is a blocker of ATP-dependent potassium channels and works by increasing the body's production of insulin, which lowers blood glucose levels. Nateglinide has been shown to be effective in reducing postprandial blood glucose levels in patients with type 2 diabetes who have not responded well to other treatments. The effects of nateglinide are reversible.Formula:C19H27NO3Purity:Min. 95%Molecular weight:317.42 g/molRiluzole - Bio-X ™
CAS:Riluzole is a glutamate antagonist that is used for the treatment of amyotrophic lateral sclerosis. This drug is also used as an anticonvulsant. Although a complete mechanism of action is unknown, it has an inhibitory effect on glutamate release and it inactivates voltage dependent sodium channels.
Formula:C8H5F3N2OSPurity:Min. 95%Color and Shape:PowderMolecular weight:234.2 g/mol
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